• Journal of Ginseng Research
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• v.32 no.2
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• pp.89-98
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• 2008

There are increasing evidences in the literatures on the potential role of ginsenosides in treating cardiovascular diseases. In this article, current information about ginsenosides-mediated vascular relaxation are reviewed. From the published studies using isolated organs, cell culture systems and animal models, ginsenosides are shown to relax blood vessels and improve blood flow through diverse mechanisms, including nitric oxide release by activating eNOS phosphorylation via PI3K/Akt and/or ERK1/2 pathways in endothelial cells, induction of inducible nitric oxide synthase through activation of NF-${\kappa}$B, reducing the intracelluar Ca$^{2+}$ levels by activating Ca$^{2+}$-activated K$^{+}$ channels in vascular smooth muscle cells and reducing platelet aggregation by decreasing thromboxane A$_2$ formation and intracelluar Ca$^{2+}$in platelets. In addition, the relevant clinical trials regarding the effects of ginsenosides on the cardiovascular disease are summarized, particulary focusing on managing hypertension and improving thrombotic disorders. Finally, antagonistic effects of ginsenosides on the prostaglandin H$_2$ receptor and scavenging effects on the generation of oxygen-derived free radicals in spontaneously hypertensive rats (SHR) are discussed.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2008.11a
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• pp.310-313
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• 2008

Magnetohydrodynamics (MHD) devices have received considerable attention in recent years as a means to either improve the propulsive characteristics of hypersonic cruise missiles or as a means to generate power at low cost in drag and weight aboard scramjet powered vehicles. Based on more complete physical models than previously used, it is here argued that the use of MHD is not valuable in improving the performance of hypersonic propulsion systems through prevention of boundary layer separation or power bypass. This is due to the inevitable high amount of Joule heating accompanying MHD flow control having considerable undesired adverse effects on the engine performance. On the other hand, preliminary estimates indicate that MHD is likely to succeed in generating high amounts of power with little additional drag to feed megawatt-class energy weapons on-board scramjet engines.

• Nuclear Engineering and Technology
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• v.40 no.1
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• pp.77-86
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• 2008

This paper describes the nonlinear analyses of a 1:4 scale model of a prestressed concrete containment vessel (PCCV) using an axisymmetric model and a three-dimensional model. These two models are refined by comparison of the analysis results and with testing results. This paper is especially focused on the analysis of behavior under pressure and the temperature effects revealed using an axisymmetric model. The temperature-dependent degradation properties of concrete and steel are considered. Both geometric and material nonlinearities, including thermal effects, are also addressed in the analyses. The Menetrey and Willam (1995) concrete constitutive model with non-associated flow potential is adopted for this study. This study includes the results of the predicted thermal and mechanical behaviors of the PCCV subject to high temperature loading and internal pressure at the same time. To find the effect of high temperature accident conditions on the ultimate capacity of the liner plate, reinforcement, prestressing tendon and concrete, two kinds of analyses are performed: one for pressure only and the other for pressure with temperature. The results from the test on pressurization, analysis for pressure only, and analyses considering pressure with temperatures are compared with one another. The analysis results show that the temperature directly affects the behavior of the liner plate, but has little impact on the ultimate pressure capacity of the PCCV.

• International Journal of Highway Engineering
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• v.8 no.1 s.27
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• pp.139-152
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• 2006

Many experimental and numerical approaches have been developed to evaluate paving materials and to predict pavement response and distress. Micromechanical simulation modeling is a technology that can reduce the number of physical tests required in material formulation and design and that can provide more details, e.g., the internal stress and strain state, and energy evolution and dissipation in simulated specimens with realistic microstructural features. A clustered distinct element modeling (DEM) approach was implemented In the two-dimensional particle flow software package (PFC-2D) to study the complex behavior observed in asphalt mixture fracturing. The relationship between continuous and discontinuous material properties was defined based on the potential energy approach. The theoretical relationship was validated with the uniform axial compression and cantilever beam model using two-dimensional plane strain and plane stress models. A bilinear cohesive displacement-softening model was implemented as an intrinsic interface and applied for both homogeneous and heterogeneous fracture modeling in order to simulate behavior in the fracture process zone and to simulate crack propagation. A disk-shaped compact tension test (DC(T)) with heterogeneous microstructure was simulated and compared with the experimental fracture test results to study Mode I fracture. The realistic arbitrary crack propagation including crack deflection, microcracking, crack face sliding, crack branching, and crack tip blunting could be represented in the fracture models. This micromechanical modeling approach represents the early developmental stages towards a 'virtual asphalt laboratory,' where simulations of laboratory tests and eventually field response and distress predictions can be made to enhance our understanding of pavement distress mechanisms, such its thermal fracture, reflective cracking, and fatigue crack growth.

• Journal of Drive and Control
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• v.17 no.3
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• pp.26-32
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• 2020

In modern society, the energy-saving problem of industrial vehicles is economically and environmentally critical. Energy savings using the potential energy of forklifts are one of the viable solutions to resolving this problem. The basic concept of this study is to operate the hydraulic motor and recharge the battery using the flow rate from the cylinder when loading heavy objects and lowering the fork. To save energy, the torque and rotational speed of the generator should be optimized according to the load and descent speed to increase efficiency. To this end, we propose a system that optimizes energy saving efficiency by controlling the swashplate angle of the variable hydraulic motor through the GA(Genetic-Algorithm). The results were verified by building and comparing fixed motor models and variable motor models using the AMEsim. The results of the study show that the proposed optimized swashplate angle increases the energy saving efficiency by approximately 6%-8%, depending on the working conditions.

• Biomolecules & Therapeutics
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• v.32 no.2
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• pp.249-260
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• 2024

New supplements with preventive effects against skin photodamage are receiving increasing attention. This study evaluated the anti-photoaging effects of salmon nasal cartilage proteoglycan (SPG), acting as a functional material for skin health. We administered SPG to in vitro and in vivo models exposed to ultraviolet B (UVB) radiation and assessed its moisturizing and anti-wrinkle effects on dorsal mouse skin and keratinocytes and dermal fibroblasts cell lines. These results showed that SPG restored the levels of filaggrin, involucrin, and AQP3 in the epidermis of UVB-irradiated dorsal skin and keratinocytes, thereby enhancing the keratinization process and water flow. Additionally, SPG treatment increased the levels of hyaluronan and skin ceramide, the major components of intercellular lipids in the epidermis. Furthermore, SPG treatment significantly increased the levels of collagen and procollagen type 1 by down-regulating matrix metalloproteinase 1, which play a crucial role in skin fibroblasts, in both in vitro and in vivo models. In addition, SPG strongly inhibited mitogen-activated protein kinase (MAPKs) signaling, the including extracellular signal-regulated kinase, c-Jun N-terminal kinase (JNK), and p38. These findings suggest that dietary SPG may be an attractive functional food for preventing UVB-induced photoaging. And this SPG product may provide its best benefit when treating several signs of skin photoaging.

• Journal of the Korean Society of Hazard Mitigation
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• v.7 no.4
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• pp.59-66
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• 2007

The bridge crossing river is the one of the major factors causing backwater level rising. Furthermore, the bridges in the mountainous areas increase the flood damage in the upstream of the bridge due to the blockage by debris. In this research, the effects of debris to the magnitude of flood damage in the study river basin were simulated by using HEC-RAS and HEC-GeoRAS models. With assumption that the backwater caused by debris blocking the space between bridge piers is the only factor causing inundation, the unsteady flow simulation was carried out with various case studies. The potential inundation area with the overflow locations and volumes could be estimated as the results of simulation. However, the simulation results also reveal the limitations of inaccurate estimation of inundation area and depth. To overcome these hindrances, DEM and satellite images were applied to the simulation. By readjusting the inundation area using digital maps and satellite images and calibrating overflow volume and depth using DEM, the accuracy of simulation could be increased resulting more accurate flood damage estimation.

• Journal of the Society of Naval Architects of Korea
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• v.59 no.4
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• pp.214-224
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• 2022

It is necessary to estimate manoeuvring characteristics of submerged bodies at the design stage in order to ensure the safe operations. In this study, added mass coefficients in the mathematical model of submerged bodies are estimated by captive model tests and numerical calculations. Two kinds of models, MARIN 'BB2'submarine model and AUV (Autonomous unmanned vehicle) model are utilized in the forced oscillation tests. Compared to BB2 submarine, AUV with cylindrical type hull form shows relatively small added masses in roll, pitch, and yaw directions. Next, numerical calculations based on potential theory are performed under the assumption that viscous effects on inertia forces are negligible. Added masses obtained by numerical calculations are in good agreements with forced oscillation test results. And if slow manoeuvres of submerged bodies are presumed, some of velocity coupled terms can be approximated by combinations of added mass coefficients.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10397-10400
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• 2015

Stigmalactam, an aristolactam-type alkaloid extracted from Orophea enterocarpa, exerts cytotoxicity against several human and murine cancer cell lines, but the molecular mechanisms remain elusive. The aims of this study were to identify the mode and mechanisms of human cancer cell death induced by stigmalactam employing human hepatocellular carcinoma HepG2 and human invasive breast cancer MDA-MB-231 cells as models, compared to normal murine fibroblasts. It was found that stigmalactam was toxic to HepG2 and MDA-MB-231 cells with $IC_{50}$ levels of $23.0{\pm}2.67{\mu}M$ and $33.2{\pm}4.54{\mu}M$, respectively, using MTT assays. At the same time the $IC_{50}$ level towards murine normal fibroblast NIH3T3 cells was $24.4{\pm}6.75{\mu}M$. Reactive oxygen species (ROS) production was reduced in stigmalactam-treated cells dose dependently after 4 h of incubation, indicating antioxidant activity, measured by using 2',7',-dichlorohydrofluorescein diacetate and flow cytometry. Caspase-3 and caspase-9 activities were increased in a dose response manner, while stigmalactam decreased the mitochondrial transmembrane potential dose-dependently in HepG2 cells, using 3,3'-dihexyloxacarbocyanine iodide and flow cytometry, indicating mitochondrial pathway-mediated apoptosis. In conclusion, stigmalactam from O. enterocarpa was toxic to both HepG2 and MDA-MB-231 cells and induced human cancer HepG2 cells to undergo apoptosis via the intrinsic (mitochondrial) pathway.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.4
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• pp.1533-1539
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• 2013

In the present study, we compared the theory with CFD data about the boundary layer thickness, displacement thickness and momentum thickness. According to the freestream velocity, larminar and turbulent is decided and affect to the flow patterns around the airfoil The boundary layer thickness, displacement thickness and momentum thickness affect to the aerodynamic characteristics of the airfoil(e.g. lift, drag and pitching moment). The separation point is affected by varying angle of attack. In the present study, we used the Joukowski airfoil(c=1), and NACA0012 airfoil was used at CFD. The chord Reynolds number is $Re_c$=3,000, 700,000, respectively and the freestream velocity is 0.045, 10 m/s, respectively. In this paper, the data was a good agreement with that of experimental results, so we can analyze the various airfoil models.