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http://dx.doi.org/10.5142/JGR.2008.32.2.089

Ginsenosides-mediated Vascular Relaxation and Its Molecular Mechanisms  

Kim, Nak-Doo (Seoul National University)
Publication Information
Journal of Ginseng Research / v.32, no.2, 2008 , pp. 89-98 More about this Journal
Abstract
There are increasing evidences in the literatures on the potential role of ginsenosides in treating cardiovascular diseases. In this article, current information about ginsenosides-mediated vascular relaxation are reviewed. From the published studies using isolated organs, cell culture systems and animal models, ginsenosides are shown to relax blood vessels and improve blood flow through diverse mechanisms, including nitric oxide release by activating eNOS phosphorylation via PI3K/Akt and/or ERK1/2 pathways in endothelial cells, induction of inducible nitric oxide synthase through activation of NF-${\kappa}$B, reducing the intracelluar Ca$^{2+}$ levels by activating Ca$^{2+}$-activated K$^{+}$ channels in vascular smooth muscle cells and reducing platelet aggregation by decreasing thromboxane A$_2$ formation and intracelluar Ca$^{2+}$in platelets. In addition, the relevant clinical trials regarding the effects of ginsenosides on the cardiovascular disease are summarized, particulary focusing on managing hypertension and improving thrombotic disorders. Finally, antagonistic effects of ginsenosides on the prostaglandin H$_2$ receptor and scavenging effects on the generation of oxygen-derived free radicals in spontaneously hypertensive rats (SHR) are discussed.
Keywords
Ginsenosides; nitric oxide; blood vessels; Ca$^{2+}$-activated K$^{+}$ channels; antiplatelet aggregation;
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