• Journal of Ginseng Research
• /
• 제32권2호
• /
• pp.89-98
• /
• 2008

There are increasing evidences in the literatures on the potential role of ginsenosides in treating cardiovascular diseases. In this article, current information about ginsenosides-mediated vascular relaxation are reviewed. From the published studies using isolated organs, cell culture systems and animal models, ginsenosides are shown to relax blood vessels and improve blood flow through diverse mechanisms, including nitric oxide release by activating eNOS phosphorylation via PI3K/Akt and/or ERK1/2 pathways in endothelial cells, induction of inducible nitric oxide synthase through activation of NF-${\kappa}$B, reducing the intracelluar Ca$^{2+}$ levels by activating Ca$^{2+}$-activated K$^{+}$ channels in vascular smooth muscle cells and reducing platelet aggregation by decreasing thromboxane A$_2$ formation and intracelluar Ca$^{2+}$in platelets. In addition, the relevant clinical trials regarding the effects of ginsenosides on the cardiovascular disease are summarized, particulary focusing on managing hypertension and improving thrombotic disorders. Finally, antagonistic effects of ginsenosides on the prostaglandin H$_2$ receptor and scavenging effects on the generation of oxygen-derived free radicals in spontaneously hypertensive rats (SHR) are discussed.

• 한국추진공학회:학술대회논문집
• /
• 한국추진공학회 2008년도 제31회 추계학술대회논문집
• /
• pp.310-313
• /
• 2008

스크램젯 비행체에서 극초음속 순항미사일의 추진 특성을 향상시키고 항력을 적게 발생하면서 전력을 생산하는 장치로써 MHD 장치가 최근 들어 큰 관심을 받아왔다. 이전에 보였던 것보다 보다 완전한 물리적 모델을 바탕으로 하면, 경계층 박리 억제나 파워 바이패스를 통해 극초음속 추진 시스템의 성능 향상을 하는 MHD의 쓰임새를 논의하는 것은 불필요한 일이 된다. MHD 유동 제어를 하게 되면 엔진 성능에 상당한 역효과를 미치는 불가피한 Joule 가열이 크게 발생한다. 하지만, 예비 조사에 따르면 MHD는 약간의 항력만을 더 발생하면서 스크램젯 엔진을 장착한 무기에 메가와트 단위의 큰 전력을 생산해 낼 수 있을 것으로 여겨진다.

• Nuclear Engineering and Technology
• /
• 제40권1호
• /
• pp.77-86
• /
• 2008

This paper describes the nonlinear analyses of a 1:4 scale model of a prestressed concrete containment vessel (PCCV) using an axisymmetric model and a three-dimensional model. These two models are refined by comparison of the analysis results and with testing results. This paper is especially focused on the analysis of behavior under pressure and the temperature effects revealed using an axisymmetric model. The temperature-dependent degradation properties of concrete and steel are considered. Both geometric and material nonlinearities, including thermal effects, are also addressed in the analyses. The Menetrey and Willam (1995) concrete constitutive model with non-associated flow potential is adopted for this study. This study includes the results of the predicted thermal and mechanical behaviors of the PCCV subject to high temperature loading and internal pressure at the same time. To find the effect of high temperature accident conditions on the ultimate capacity of the liner plate, reinforcement, prestressing tendon and concrete, two kinds of analyses are performed: one for pressure only and the other for pressure with temperature. The results from the test on pressurization, analysis for pressure only, and analyses considering pressure with temperatures are compared with one another. The analysis results show that the temperature directly affects the behavior of the liner plate, but has little impact on the ultimate pressure capacity of the PCCV.

• 한국도로학회논문집
• /
• 제8권1호
• /
• pp.139-152
• /
• 2006

Many experimental and numerical approaches have been developed to evaluate paving materials and to predict pavement response and distress. Micromechanical simulation modeling is a technology that can reduce the number of physical tests required in material formulation and design and that can provide more details, e.g., the internal stress and strain state, and energy evolution and dissipation in simulated specimens with realistic microstructural features. A clustered distinct element modeling (DEM) approach was implemented In the two-dimensional particle flow software package (PFC-2D) to study the complex behavior observed in asphalt mixture fracturing. The relationship between continuous and discontinuous material properties was defined based on the potential energy approach. The theoretical relationship was validated with the uniform axial compression and cantilever beam model using two-dimensional plane strain and plane stress models. A bilinear cohesive displacement-softening model was implemented as an intrinsic interface and applied for both homogeneous and heterogeneous fracture modeling in order to simulate behavior in the fracture process zone and to simulate crack propagation. A disk-shaped compact tension test (DC(T)) with heterogeneous microstructure was simulated and compared with the experimental fracture test results to study Mode I fracture. The realistic arbitrary crack propagation including crack deflection, microcracking, crack face sliding, crack branching, and crack tip blunting could be represented in the fracture models. This micromechanical modeling approach represents the early developmental stages towards a 'virtual asphalt laboratory,' where simulations of laboratory tests and eventually field response and distress predictions can be made to enhance our understanding of pavement distress mechanisms, such its thermal fracture, reflective cracking, and fatigue crack growth.

• 드라이브 ㆍ 컨트롤
• /
• 제17권3호
• /
• pp.26-32
• /
• 2020

In modern society, the energy-saving problem of industrial vehicles is economically and environmentally critical. Energy savings using the potential energy of forklifts are one of the viable solutions to resolving this problem. The basic concept of this study is to operate the hydraulic motor and recharge the battery using the flow rate from the cylinder when loading heavy objects and lowering the fork. To save energy, the torque and rotational speed of the generator should be optimized according to the load and descent speed to increase efficiency. To this end, we propose a system that optimizes energy saving efficiency by controlling the swashplate angle of the variable hydraulic motor through the GA(Genetic-Algorithm). The results were verified by building and comparing fixed motor models and variable motor models using the AMEsim. The results of the study show that the proposed optimized swashplate angle increases the energy saving efficiency by approximately 6%-8%, depending on the working conditions.

• Biomolecules & Therapeutics
• /
• 제32권2호
• /
• pp.249-260
• /
• 2024

New supplements with preventive effects against skin photodamage are receiving increasing attention. This study evaluated the anti-photoaging effects of salmon nasal cartilage proteoglycan (SPG), acting as a functional material for skin health. We administered SPG to in vitro and in vivo models exposed to ultraviolet B (UVB) radiation and assessed its moisturizing and anti-wrinkle effects on dorsal mouse skin and keratinocytes and dermal fibroblasts cell lines. These results showed that SPG restored the levels of filaggrin, involucrin, and AQP3 in the epidermis of UVB-irradiated dorsal skin and keratinocytes, thereby enhancing the keratinization process and water flow. Additionally, SPG treatment increased the levels of hyaluronan and skin ceramide, the major components of intercellular lipids in the epidermis. Furthermore, SPG treatment significantly increased the levels of collagen and procollagen type 1 by down-regulating matrix metalloproteinase 1, which play a crucial role in skin fibroblasts, in both in vitro and in vivo models. In addition, SPG strongly inhibited mitogen-activated protein kinase (MAPKs) signaling, the including extracellular signal-regulated kinase, c-Jun N-terminal kinase (JNK), and p38. These findings suggest that dietary SPG may be an attractive functional food for preventing UVB-induced photoaging. And this SPG product may provide its best benefit when treating several signs of skin photoaging.

• 한국방재학회 논문집
• /
• 제7권4호
• /
• pp.59-66
• /
• 2007

하천을 횡단하는 교량은 하천의 배수위를 증가시키는 중요한 요인으로 작용한다. 더욱이 산지하천에 시공된 교량은 유송잡물에 의한 폐색으로 인하여 교량 직상류부에 홍수피해를 가중시킨다. 본 연구에서는 교각에 집적되는 유송잡물의 영향으로 인해 발생할 수 있는 홍수피해 규모를 확인하고자 대상하천에 대한 HEC-RAS 모형과 HEC-GeoRAS 모형을 구축하여 모의하였다. 교각에 집적된 유송잡물에 의한 폐색이 하천의 범람을 일으키는 원인으로 가정하여 범람 시나리오 별로 부정류 모의를 실시한 결과 월류지점 및 홍수용량을 산정하였고, 이에 따라 대략적인 범람예상구역을 작성하였다. 그러나 범람구역의 침수면적과 침수심에 대하여 실제 분석결과를 제대로 반영하지 못하는 한계가 있었다. 따라서 수치지형도와 위성사진을 이용하여 범람예상구역을 재설정하고 수치고도자료 내에서 월류용량과 동일 용량의 침수면적과 침수심을 갖는 범람구역을 재작성하는 과정을 수행함으로써 좀 더 정확한 홍수피해 규모를 산정하였다.

• 대한조선학회논문집
• /
• 제59권4호
• /
• pp.214-224
• /
• 2022

It is necessary to estimate manoeuvring characteristics of submerged bodies at the design stage in order to ensure the safe operations. In this study, added mass coefficients in the mathematical model of submerged bodies are estimated by captive model tests and numerical calculations. Two kinds of models, MARIN 'BB2'submarine model and AUV (Autonomous unmanned vehicle) model are utilized in the forced oscillation tests. Compared to BB2 submarine, AUV with cylindrical type hull form shows relatively small added masses in roll, pitch, and yaw directions. Next, numerical calculations based on potential theory are performed under the assumption that viscous effects on inertia forces are negligible. Added masses obtained by numerical calculations are in good agreements with forced oscillation test results. And if slow manoeuvres of submerged bodies are presumed, some of velocity coupled terms can be approximated by combinations of added mass coefficients.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권23호
• /
• pp.10397-10400
• /
• 2015

Stigmalactam, an aristolactam-type alkaloid extracted from Orophea enterocarpa, exerts cytotoxicity against several human and murine cancer cell lines, but the molecular mechanisms remain elusive. The aims of this study were to identify the mode and mechanisms of human cancer cell death induced by stigmalactam employing human hepatocellular carcinoma HepG2 and human invasive breast cancer MDA-MB-231 cells as models, compared to normal murine fibroblasts. It was found that stigmalactam was toxic to HepG2 and MDA-MB-231 cells with $IC_{50}$ levels of $23.0{\pm}2.67{\mu}M$ and $33.2{\pm}4.54{\mu}M$, respectively, using MTT assays. At the same time the $IC_{50}$ level towards murine normal fibroblast NIH3T3 cells was $24.4{\pm}6.75{\mu}M$. Reactive oxygen species (ROS) production was reduced in stigmalactam-treated cells dose dependently after 4 h of incubation, indicating antioxidant activity, measured by using 2',7',-dichlorohydrofluorescein diacetate and flow cytometry. Caspase-3 and caspase-9 activities were increased in a dose response manner, while stigmalactam decreased the mitochondrial transmembrane potential dose-dependently in HepG2 cells, using 3,3'-dihexyloxacarbocyanine iodide and flow cytometry, indicating mitochondrial pathway-mediated apoptosis. In conclusion, stigmalactam from O. enterocarpa was toxic to both HepG2 and MDA-MB-231 cells and induced human cancer HepG2 cells to undergo apoptosis via the intrinsic (mitochondrial) pathway.

• 한국산학기술학회논문지
• /
• 제14권4호
• /
• pp.1533-1539
• /
• 2013

본 논문에서는 층류 및 난류 유동 특성 중 경계층 두께와 배제 두께, 그리고 모멘텀 두께에 대한 기존의 이론값과 실제 CFD 해석을 통한 수치해석의 데이터를 비교하였다. Freestream velocity는 Reynolds 수에 영향을 주게 되고, airfoil 주변에서의 유동의 층류 및 난류에 영향을 주게 된다. 층류 및 난류의 경우 유동특성이 달라 경계층 두께 및 배제두께, 그리고 모멘텀 두께가 달라지게 되고, 결국 airfoil의 공력특성인 양력과 항력, 그리고 pitching moment에 영향을 주며, separation point도 다양한 angle of attack에서 바뀌게 된다. 이번 연구에서의 목적은 비점성 유동과, 층류 및 난류 각 경우에 대한 유동특성에 대해 알아보는 것이다. 연구에서 사용된 airfoil의 경우 c=1인 Joukowski airfoil을 사용하였으며, CFD는 상용 프로그램인 Fluent 6.0을 통해 NACA-0012 airfoil을 사용하였다. 층류 및 난류에서의 $Re_c$는 $Re_c$=3,000, 700,000이며 각각에 해당하는 속도는 0.045, 10 m/s이다. 본 연구를 통해 기존의 실험값과 수치해석의 결과가 잘 일치함을 알 수 있으며, 이를 통해 다양한 airfoil의 형상을 모델링할 수 있는 근거를 마련하였다.