• 대기
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• 제27권4호
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• pp.455-466
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• 2017

In Korea, property and human damages occur annually due to heavy precipitation during the summer. On August 8, 2015, heavy rainfall occurred in the Seoul metropolitan area due to an outflow boundary, and $77mmhr^{-1}$ rainfall was recorded in Gwangju, Gyeonggi Province. In this study, the simulation of the WRF numerical model is performed to understand the cause and characteristics of heavy rainfall using the Conditional Instability of the Second Kind (CISK), potential vorticity (PV), frontogenesis function, and convective available potential energy (CAPE) analyses, etc. Convective cells initiated over the Shandong Peninsula and located on the downwind side of an upper level trough. Large amounts of water vapor were supplied to the Shandong Peninsula along the southwestern edge of a high pressure system, and from the remnants of typhoon Soudelor. The mesoscale convective system (MCS) developed through CISK process and moved over to the Yellow Sea. The outflow boundary from the MCS progressed east and pushed cold pool eastward. The warm and humid air over the Korean Peninsula further enhanced convective development. As a result, a new MCS developed rapidly over land. Because of the latent heat release due to convection and precipitation, strong potential vorticity was generated in the lower atmosphere. The rapid development of MCS and the heavy rainfall occurred in an area where the CAPE value was greater than $1300Jkg^{-1}$ and the fronto-genesis function value of 1.5 or greater coincided. The analysis result shows that the MCS driven by an outflow boundary can be identified using CISK process.

• 한국전산구조공학회논문집
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• 제24권5호
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• pp.577-588
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• 2011

본 논문은 복합 불연속면을 갖는 포텐셜 문제의 해석을 위해 확장된 MLS(Moving Least Squares) 차분법을 제시한다. 계면경계를 따라 해(solution)와 수직방향, 접선방향 미분들이 모두 불연속 특이성을 나타내는 복합 불연속면을 묘사하기 위해 계단함수, 쐐기함수, 가위함수와 같은 불연속 특이함수를 추가하여 기존의 MLS 차분법을 개선했다. 계면경계조건은 기지의 조건으로서 지배방정식의 이산화과정에서 추가의 미지계수를 발생시키지 않는다. 포아송 방정식 형태의 지배미분 방정식을 풀기 위해 내부영역과 경계에 절점을 배치하고 차분식을 구성한다. 차분식을 조립한 계 방정식을 직접 풀기 때문에 계산효율성이 매우 우수하다. 수치예제는 제시된 해석기법의 우수성을 잘 보여주며, 균열전파, 이동경계, 상호작용 문제 등 다양한 불연속 문제로의 확장이 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3573-3577
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• 2015

Background: Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is implicated in various processes, such as aging, DNA damage repair and cell signaling transduction. There is some evidence that SIRT7 may function as a tumor trigger for human malignancy. Here, we aimed to explore the biological function of SIRT7 in ovarian carcinoma cells and its potential mechanism. Materials and Methods: Expression of SIRT7 in ovarian cancer cell lines was detected by western blotting. Transduced cell lines with SIRT7 knockdown or overexpression were constructed. Cell viability, cologenic, apoptosis-associated and motility assays were performed to elucidate the biological function of SIRT7 in ovarian cancer cells. Results: SIRT7 demonstrated a higher level in ovarian cancer cell lines compared with normal cells. On the one hand, down-regulation of SIRT7 significantly reduced ovarian cancer cell growth, repressed colony formation and increased cancer cell apoptosis; on the other hand, up-regulation promoted the migration of cancer cells. Additionally, repression of SIRT7 also induced change in apoptosis-related molecules and subunits of the NF-${\kappa}B$ family. Conclusions: In the present study, our data indicated that SIRT7 might play a role of oncogene in ovarian malignancy and be a potential therapeutic target.

• IMMUNE NETWORK
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• 제22권2호
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• pp.14.1-14.17
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• 2022

Osteoarthritis (OA) is a common degenerative joint disease characterized by breakdown of joint cartilage. Mitochondrial dysfunction of the chondrocyte is a risk factor for OA progression. We examined the therapeutic potential of mitochondrial transplantation for OA. Mitochondria were injected into the knee joint of monosodium iodoacetate-induced OA rats. Chondrocytes from OA rats or patients with OA were cultured to examine mitochondrial function in cellular pathophysiology. Pain, cartilage destruction, and bone loss were improved in mitochondrial transplanted-OA rats. The transcript levels of IL-1β, TNF-α, matrix metallopeptidase 13, and MCP-1 in cartilage were markedly decreased by mitochondrial transplantation. Mitochondrial function, as indicated by membrane potential and oxygen consumption rate, in chondrocytes from OA rats was improved by mitochondrial transplantation. Likewise, the mitochondrial function of chondrocytes from OA patients was improved by coculture with mitochondria. Furthermore, inflammatory cell death was significantly decreased by coculture with mitochondria. Mitochondrial transplantation ameliorated OA progression, which is caused by mitochondrial dysfunction. These results suggest the therapeutic potential of mitochondrial transplantation for OA.

• 한국정보통신학회논문지
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• 제16권6호
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• pp.1260-1265
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• 2012

본 연구에서는 가우스분포함수의 형태에 따라 DGMOSFET에 스켈링이론을 적용하였을 때 문턱전압이하특성의 변화를 분석하고자 한다. 포아송방정식의 분석학적 해를 구할 때 사용하는 전하분포함수에 가우시안 함수를 적용함으로써 보다 실험값에 가깝게 해석하였으며 이때 가우시안 함수의 변수인 이온주입범위 및 분포편차에 대하여 문턱전압이하 특성의 변화를 관찰하였다. 본 연구의 모델에 대한 타당성은 이미 기존에 발표된 논문에서 입증하였으며 본 연구에서는 이 모델을 이용하여 문턱전압이하 특성을 분석할 것이다. 스켈링이론은 소자파라미터의 변화에 대하여 출력특성을 변함없이 유지하기 위하여 적용하는 이론이다. DGMOSFET에 스켈링이론을 적용한 결과, 가우스함수의 형태에 따라 문턱전압이하 특성이 매우 크게 변화하였으며 특히 문턱전압의 변화는 상대적으로 매우 크게 나타난다는 것을 관찰하였다.

• 한국표면공학회지
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• 제37권2호
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• pp.110-118
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• 2004

The corrosion of pure titanium (CP- Ti Grade 2) and titanium alloy (Ti6Al4V ELI) were studied under various conditions of simulated body fluids. The static immersion test and the electrochemical test were performed in accordance with ISO 10271 : 2001. For the electrochemical test, the open circuit potential was monitored as a function of time, and the cyclic polarization curve was recorded. The corrosion resistance was evaluated from the values of corrosion potential, passivation current density, breakdown potential, and the shape of hysteresis etc. The effects of alloy type, surface condition, temperature, oxygen, and constituents in the fluids such as acid, chloride were estimated. Both specimens had extremely low dissolution rate in the static immersion test. They showed strong passivation characteristics in the electrochemical test. They maintained negligible current density throughout the wide anodic potential range. The passive layer was not broken up to 2.0 V (vs. SCE). The hysteresis and the shift of passivation potential toward the anodic direction was observed during the reversed scan. The passivation process appeared to be accelerated by oxygen in air or that dissolved in the fluids. The passivation also proceeded without oxygen by the reaction of constituents in the fluids. Acid or chloride in the fluids, specially later weakened the passive layer, and then induced higher passivation current density and less shift of passivation potential in the reversed scan. CP-Ti Grade 2 was more reactive than Ti6Al4V ELI in the fluids containing acid or chloride, but thicker layer produced on its surface provided higher corrosion resistance.

• 농촌계획
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• 제10권3호
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• pp.41-51
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• 2004

This study aims to develop a potential evaluation method for urban spatial expansion using remote sensing (RS) and geographic information system (GIS). A multi-criteria evaluation method with several criteria and their weighting values was introduced to evaluate the score and quantification of the potential surface around the existing cities. The six criteria with one geographic factor, slope, and five accessibility factors, time distance from center of the city, national road, interchange of expressway, a big city, and station, were defined for the potential. RS techniques were applied for classification of the actual urban expansion maps between two periods, and GIS functions were used for score of accessibility criteria with a distance decay function from geographic, road and several point maps, which was developed in this study. The new methodology was applied to a test area, Suwon, between 1986 and 1996. In order to optimize the six weighting values, this study made new findings to search the optimal combination of the weighting values from new methodology, weighted scenario method for intensity order (WSM), combined with intensity order and AHP method, including a trial and error method for sensitivity analysis to make the intensity order. The optimal combination of the weighting values by the new method generated the optimal potential surface, considering spatial trend of urban expansion in the test area.

• 대한의용생체공학회:의공학회지
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• 제15권4호
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• pp.481-488
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• 1994

시각 및 손가락의 전기자극에 의해 머리표면에서 발생하는 유발전위를 검출하여 Source Tracing Method를 이용하여 뇌의 시각인지영역 및 손가락 감각인지영역을 추정하였다. 본 과정에서 유발전위 검출방식은 average method를 이용하였고, 흥분뉴런군에 대한 물리적 모델로 Single Current Dipole Model을 이용하고, 머리기하에 대한 3중구각모델을 이용하여 Forward Problem을 풀었다. Inverse Problem은 current dipole의 6개의 parameter에 대한 Least Square Error Method를 이용하여 신견흥분의 위치를 추정하였다. 이러한 결과와 생리학적으로 밝혀진 시각 및 체성감각 신경로와의 비교결과 유사성이 확인되었다.

• 전기학회논문지
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• 제64권10호
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• pp.1479-1485
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• 2015

Robot's technology was very simple and repetitive in the past. Nowadays, robots are required to perform intelligent operation. So, path planning has been studied extensively to create a path from start position to the goal position. In this paper, potential field algorithm was used for path planning in dynamic environments. It is used for a path plan of mobile robot because it is elegant mathematical analysis and simplicity. However, there are some problems. The problems are collision risk, avoidance path, time attrition. In order to resolve path problems, we amalgamated potential field algorithm with the artificial neural network system. The input of the neural network system is set using relative velocity and location between the robot and the obstacle. The output of the neural network system is used for the weighting factor of the repulsive potential function. The potential field algorithm problem of mobile robot's path planning can be improved by using artificial neural network system. The suggested algorithm was verified by simulations in various dynamic environments.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 전기설비
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• pp.27-28
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• 2006

This paper deals with an approach to the reduction of potential rise according to the buried depth of structure. In order to analyze the surface potential rise of structure, an electrolytic tank which simulates the semi-infinite earth has been used. The potential rise has been measured and analyzed for types of structure using an electrolytic tank experimental apparatus in real time. The structure models were designed through reducing real buildings and fabricated with two types on a scale of one-one hundred sixty When a test current flowed through structure models, the potential rise of outline frame type(structure model A) was more high than that of electric cage type(structure model B). The distributions of surface potential rise are dependent on the buried depth of structure model.