• Title/Summary/Keyword: population interaction

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Gene-gene Interaction in Cerebral Infarction Patients : A Study on Relationship Between Apolipoprotein E, ACE Gene Polymorphism and Sasang Constitution

  • Kim Jong Kwan;Kim Hyoung Soon;Bae Young Chun;Lee Sang Min;Kim Kyung Yo;Joo Jong Cheon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.4
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    • pp.1192-1198
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    • 2004
  • Sasang Constitutional Medicine is a major branch of Korean Traditional Medicine. The differences of disease susceptibility to be shown in Sasang constitution may be due to genetic factors. Therefore, I examined interrelationship among cerebral infarction (CI), apolipoprotein E (apo E) gene polymorphism, and Sasang constitutional classification. Apo E is a key protein modulating the highly atherogenic apoB containing lipoproteins and is a candidate gene for the development of coronary artery disease (CAD). The ε2 and/or ε4 alleles were the first to be implicated in premature CAD, which resulted in this polymorphism being extensively studied. I investigated the association between apo E genotype and CI by case-control study in a Korean population. I also classified CI patients and control group into groups according to Sasang Constitutional Medicine. 218 CI patients and 379 controls without CI were examined. Apo E genotype was determined by 8% polyacrylamide gel separation after DNA amplification. A frequency of apo E ε3/ε3 in the apo E genotype distribution was higher in the CI patients compared with that in controls. Also, it was widely known that Taeumin was easily attacked with CI, but there was no association between apo E polymorphim and Taeumin. However, the Taeumin constitution did not enhance the relative risk for CI in the subjects with apo E ε2 and/or ε4 alleles. No differences in the apo E genotypes frequencies were observed in the Taeumin compared with that in the other constitutions. In addition, I investigated whether the DD(deletion/deletion) or ID(insertion/deletion) genotype of angiotensin converting enzyme (ACE) gene, a candidate gene for CI, was associated with CI, Taeumin constitution, and apo E polymorphism. As a result, the frequency of Taeumin constitution was significantly higher in CI patients with both apo E ε3/ε4 and ACE ID/DD genotypes than in the remaining Sasang constitutions. In summary, it was concluded that the apo E polymorphism is a major risk factor for CI in Koreans and the ACE ID/DD genotype enhanced the relative risk for CI in the subjects with apo E ε3/ε4 genotype and Taeumin constitution.

Application of Stable Isotopes in Studies of Gas Exchange Processes Between Biosphere and the Atmosphere (생태계와 대기 간의 가스 교환 메카니즘 규명을 위한 안정동위원소의 응용)

  • Han, Gwang-Hyun;Chung, Doug-Young
    • Korean Journal of Soil Science and Fertilizer
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    • v.43 no.2
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    • pp.242-251
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    • 2010
  • In comparison with other terrestrial ecosystems, rice paddies are unique because they provide the primary food source for over 50% of the world's population, and act as major sources of global methane. The present paper summerizes a long-term field study that combine carbon isotopes, and canopy-scale flux measurements in an irrigated rice paddy, in conjugation with continuous monitoring of environmental, and vegetational factors. Both $CO_2$, and methane fluxes were largely influenced by soil temperature, and moisture conditions, especially across drainage events. Soil-entrapped $CO_2$, and methane showed a gradually increasing trend throughout growing season, but rapidly decreased upon flood water drainage. These variations in flux were well correlated with changes in concentration, and isotope ratio of soil $CO_2$, and methane, and of atmospheric $CO_2$, and methane within, and above the canopy. The isotopic signature of the gas exchange process varied markedly in response to change in contribution of soil respiration, belowground storage, fraction of $CO_2$ recycled, magnitude, and direction of $CO_2$ exchange, transport mechanism, and fraction of methane oxidized. Our results clearly demonstrate that stable isotope analysis can be a useful tool to study underlying mechanisms of gas exchange processes under natural conditions.

The Effects of Pollutants into Sub-basin on the Water Quality and Loading of Receiving Streams (하천 수질 및 부하량에 미치는 유역 내 오염원의 영향)

  • Han, Mideok;Son, Jeeyoung;Ryu, Jichul;Ahn, Kihong;Kim, Yongseok
    • Journal of Korean Society of Environmental Engineers
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    • v.36 no.9
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    • pp.648-658
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    • 2014
  • We examined the effects of pollutants into sub-basin on the water quality and loading based on data surveyed during January-December 2013 from 13 sites of 5 streams in the Jinwi watershed. We used the contour plot and Kruskal-Wallis rank sum test to analyze seasonal variation of water quality and loading and Pearson correlation analysis to assess the relationships between pollutants and loadings. The significantly higher seasonal variation were SS, TN and TOC as compared to other water quality constituents (P < 0.001). A significant interaction existed between the effects of human population and the effects of discharge of Sewage Treatment Plant (STP) on water quality and loading, especially for the spring and winter seasons. It is necessary to control discharge water of sewage and wastewater from industrial facilities and to make full use of the watershed management system such as TMDLs in operation since 2012 for improvement in stream water quality.

A Study on the Possibility of Family Particpation Education through the "Educational Culture Festival" at the Educational Museum (교육박물관에서의 "교육문화 페스티벌" 개최를 통해 본 가족 참여 교육 가능성 고찰)

  • Eom, Hye-Yoon
    • The Journal of the Korea Contents Association
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    • v.18 no.5
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    • pp.545-553
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    • 2018
  • As the share of leisure culture increases these days, expectations are rising for the high quality of culture while increasing interest in leisure and tourism. The percentage of the population going on weekend trips to broaden the horizons of elementary, middle and high school students has continued to rise in proportion to the expectations for cultural enjoyment. We expect that visitors' weekend family activities will include relaxing, playing and educational purposes. Recent educational programs have moved from the past where only children were allowed to be onsite, to a shared style in which parents can engage in educational activities, potentially leading to the implicit involvement of family ties and family elasticity. The effects of education are not expressed by the period that ends in a single moment of experience, but by the continuity of training and experience. The same holds true for family affinity, communication and empathy. Providing opportunities for family experience and education is a national responsibility for broken family and restoring solidarity with the growing number of single-person households. Furthermore, it is a duty of museums and galleries today, and it is necessary to come up with methods to enhance family solidarity and family affinity. In particular, it is imperative to develop and provide educational programs for educational purposes at the Education Museum, and to develop " education for family " at the social level. This paper aims to analyze the results of all family participating education programs provided by family education programs at the Education Museum through family surveys and interviews, and to enhance the activation of family types education programs more actively.

Exploring a Direction of the Development of an Education Program for Health Improvement of the Unemployed Elderly (미취업 노인의 건강 개선 교육 프로그램의 개발 방향 탐색)

  • Park, Hyeok;Kim, Gawon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.5
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    • pp.428-435
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    • 2017
  • The purpose of this study is to propose a health improvement education program for the majority of elderly people who could not work due to health issues. This study focused on the fact that employment has a positive influence on the health outcomes of the elderly. The paper compares the health outcomes of employed elderly versus that of the unemployed, and suggests directions for future lifelong education programs related to health for the unemployed elders. The study results show more positive health outcomes for employed elders in terms of nutrition status and ability to perform daily tasks. Furthermore, their cognitive ability was more active (orientation, peripheral concentration, awareness of daily life) and their overall quality of life. Therefore, the study aims to develop health outcomes in the unemployed elderly population through safety education, improving health habits, performance improvement education via cognitive activation and socializing, and to secure the professionalism of lifelong education programs for the elderly which is currently only seen as a leisure activity. The object of the proposed program in this study is to maintain health by providing opportunities employment - a core component of successful aging - and relevant social interaction. This will greatly improve the quality of life of the elderly and provide a basis for widening the social role of elderly people in the future.

A Study on Value Orientation of Health of Rural Health Center Milieu (농촌지역 보건소 환경에 있어서의 건강가치관에 관한 일 조사연구)

  • 김순자
    • Journal of Korean Academy of Nursing
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    • v.5 no.1
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    • pp.17-30
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    • 1975
  • The concept and definition of nursing and her role have been changing in accordance with the socio-cultural factors of the initial society. At present, nursing is conceptualized as a health care profession assisting man to restore, maintain and promote health by providing knowledge, wilt strength and resources through various processes of interaction. Man′s behavior, of individual and group activities for health inclusive, is driven by the initial man′s value orientation. The purpose of this study is to investigate the value orientation regarding health of rural health center milieu in order to give data for; 1. the planning for the delivery of community nursing service, 2. the health education plan at all level of nursing care activities, and 3. the planning of curriculum for nursing education. A hundred opinion leaders among the labor population residing in rural areas (P-group), hundred and six professional nurses at rural health centers (N-group) were indirectly interviewed through questionaries. And ninety five of N-group were interviewed likewise of their perceptions of P-group (NP-group) from July 15, to October 15, 1974. The result is as follows: 1. Maintenance of health is revealed to be the most valued component for man′s happiness in all the three groups. (P-group: 7.30 S. D.=1.31), (N-group :7.84 S. D. =49), and (NP-group : 5.93 S. D. =2.28) 2. The average value score of the maintenance of health revealed significant difference by P〈.001 level between each of the three groups. (Between N-group and P-group : T= -4.07 P and NP ; T=-6.93, N and NP: T=-9.35) 3. Basic health maintenance activities necessary for maintenance and promotion of personal health were moderately valued by all the three groups, P-group ; 3.74 (S. D. =.43) , N-group: 3.52 (S. D. =.34), NP-group: 3.07 (S. D. :.55) Among the 8 categories of basic health maintenance activities, "food intake" was highly valued by P-group (mean value score; 4.00 S. D=.51) , "exercise and rest" and "personal cleanliness" was highly valued by both P-group (4.02, 4.08) and N-group (4.08, 4.22). 4. The mean value score of basic health maintenance activities revealed significant difference by P〈.001 level between each of the three groups (between P-group and N-group: T=-4, 07, N-and NP: T=-6.93, P and NP T=-9.35) 5. Among the 30 questionaries, dynamic activities for health maintenance were more valued in comparison to passive activities in an tile three groups. 6. In N-group, correlation between the value of basic health maintenance activities and the personal health status personal revealed moderate significance. Correlation between the value of basic health maintenance activities and the age revealed low significance. 7. In group, correlation between the value of basic health maintenance activities and; perception of personal health status revealed non significance, between the age and sex revealed low sign affiance, and between the educational status revealed moderate significance. Recommendations are as follows ; 1. The efforts towards alteration of value orientation concerning health in general in community nursing practice de focussed be that of family Planning. 2. In order to prepare professional nurses competent in understanding individual and group, social science and behavioral science be strength ended in planning nursing curriculum. 3. Milieu of nursing experience during nursing education be Planned to begin at simple nursing problem and move towards complex, f. e. home care towards health crisis situation in order to achieve dynamic role mastery.

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A Descriptive Study on Job satisfaction and its Related Factors for Clinical Nurses in Goneral Hospital (일 대학병원 간호사의 직업만족도와 그에 관련된 요인 조사연구)

  • 김조자;박지원
    • Journal of Korean Academy of Nursing
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    • v.18 no.1
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    • pp.5-18
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    • 1988
  • Herzberg and his associates concluded from their findings that job satisfaction consisted on two independent dimension ; the first dimension was related to job satisfaction, the second to job dissatisfaction. According to the Herzberg theory, the satisfiers are related to the nature of the work itself and the rewards that flow directly from the performance of that work. The dissatisfaction factors are associated with the individual's relation to the context or environment in which he works. The purpose of this study was to investigate selected factors which result in job satisfaction / dissatisfaction of nurses employed in general hospital. In a study of this nature, it is important that the population be as homogenous as possible in order to reduce the effects of the different environments and backgrounds on job satisfaction. A job satisfaction questionnaire developed by Slabitt et als. was used for this study. It contains 45 statements and utilizes a Likert type scale of 5. Participants were asked to select response which were congruent with their perceptions of the item. It was decided to conduct the study in one general hospital in Seoul. A sample of 505 clinical nurses were selected to participate in this study. The results of this study were as follows ; 1. The overall mean score for the 45 five-point scales of job satisfaction items was 2.945, showing that the subjects of this study were neither satisfied nor dissatisfied. 2. To identify the specific job related factors that result in Job satisfaction / dissatisfaction, the 45 items of job satisfaction were divided into 6 areas and the mean scores and % of agreement were compared. The specific job related factor that resulted in job satisfaction was the job status and those that resulted in job dissatisfaction were salaries, task requirements and organization requirements. But the areas of autonomy and interaction did not belong to either side of the specific job related factors. 3. To identify the relationship between the job satisfaction and the subject's general characteristic, data was analyzed using the t-test and the Pearson correlation coefficient. It was found that the relationship between the job satisfaction and the request for rotation and intention to remain on the job were statistically significant at .05 level, but the relationship between the job satisfaction and age, work experience, and educational background were nor statistically significant at the .05 level.

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Estimating Interregional Trade Coefficient of Service Industry using the Gravity Model (중력모형을 이용한 서비스업의 지역간 교역계수 추정)

  • Yun, Kap-Sik;Kim, Jae-Koo
    • Journal of the Economic Geographical Society of Korea
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    • v.13 no.3
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    • pp.457-469
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    • 2010
  • The study aims to estimate interregional trade coefficient of service industry using the gravity model. The gravity model has been widely used for prediction of the level of human interaction between two regions which is positively related to attraction of them and negatively related to the distance between them. To apply the gravity model for explaining the interregional trade flow of service industry, the choice of proper proxy variables which represent a dependent variable and independent variables is most important. However, the literature shows that there are few studies on this issue. Four models concerned to the choice of proxy variables are considered. Finally, this paper employs the least-squares regression analysis to test the model's goodness-of-fit, and suggests the most appropriate model based on the result from the analysis. The result shows that the interregional trade of service industry in regional input-output table developed by The Bank of Korea is desirable as a dependent variable, the service industry output of export region, the population of import region, and the spatial distance between regions are desirable as independent variables.

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Effects of Dietary Buffering Characteristics and Protected or Unprotected Acids on Piglet Growth, Digestibility and Characteristics of Gut Content

  • Bosi, P.;Jung, H.J.;Han, In K.;Perini, S.;Cacciavillani, J.A.;Casini, L.;Creston, D.;Gremokolini, C.;Mattuzzi, S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.12 no.7
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    • pp.1104-1110
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    • 1999
  • We condicted two experiments to evaluate the interaction among fumaric acid (FA), protected acids (PA), or no additional acid (NO) and two different levels of acid buffering capacity (BC) in diets for 14-d-old weaned pigs. BC was varied substituting mono-calcium phosphate and calcium sulfate for dicalcium phosphate and calcium carbonate. In the high BC diet plus PA, FA was also added. In Exp. 1, 48 gilts were raised for 31 days on the six diets, evaluating growth performance and fecal digestibility. In Exp. 2, 42 gilts were raised. With each diet three subjects were sacrificed after 19 days and four after 38 days. In addition, six subjects were sacrificed at weaning. Growth and carcass performance, ileal digestibility, bacterial populations and pH in the gut were assessed. The piglet performance and stomach, ileal and cecal pH, and empty body composition were not affected by the diets. Empty body composition other than ash content was affected by piglet age (p<0.01). The BC did not influence digestibility. The dietary inclusion of PA improved fecal digestibility of protein (p<0.05) compared to the addition of FA and NO. Ileal digestibility slightly increased with both acid additions (p<0.10), the groups receiving PA showing the higher values. Piglets fed diets with low BC had lower Lactobacillus and E. coli counts in the ileum (p=0.07) and higher Lactobacillus in the colon (p=0.08). Acidified diets tended to reduce E. coli counts in the ileum (p=0.10) and increased Lactobacillus in the colon (p=0.09). The addition in the diet of PA increased Lactobacillus in the ileum compared to the sole addition of free fumaric acid (p=0.07). The addition of protected acids, combined with free fumaric acid in the case of high BC diets, increased protein digestibility and Lactobacillus counts and reduced E.coli counts. Only some changes in the concentration of bacterial population can be expected with a diet of low BC.

Analysis of MC1R genotypes in three different colored Korean cattle (Hanwoo) (한우 후보종모우 및 칡소와 흑소에서 MC1R 유전자의 유전자형 분석)

  • Jin, Shil;Shim, Jung-Mi;Seo, Dong-Won;Jung, Woo-Young;Ryoo, Seung-Heui;Kim, Jin-Ho;Lee, Jun-Heon
    • Korean Journal of Agricultural Science
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    • v.38 no.3
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    • pp.453-458
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    • 2011
  • The MC1R (Melanocortin 1 receptor) gene has been known as a causative gene of the coat colors in mammals and responsible for the E (Extension) locus which has three alleles ($E^D$, $E^+$, e) that determines coat colors. The dominant allele $E^D$ produces black or brown colors due to the missense mutation and the recessive e allele has frameshift mutation which shows red or yellow coat colors. Whereas the wild type $E^+$ produces variety of colors due to the interaction with A (Agouti) locus. In this study, PCR-RFLP was performed using two restriction enzymes (BsrF I and MspA1 I) in order to obtain MC1R genotypes in Korean brindle cattle and black cattle. The results showed that all of the animals have the $E^+$ alleles, indicating the $E^+$ allele might related with black coat colors. Later on, the experiments expanded to the 260 Korean candidate bulls whether these animals have the same $E^+$ allele. Among 260 samples investigated, 5% (13/260) of the animals had $E^+$e genotypes, indicating the $E^+$ allele is also present in the candidate bulls in a low frequency. Even though we expected that A locus also affect the black coat color in cattle, all the black coat color animals (brindle and black) have $E^+$ alleles in this study. Therefore, the genotyping of the MC1R gene in candidate bulls will recommended be applied for eliminating of black coat colors in Hanwoo population, if the farmers need to have the brown coat colors only.