• Biomedical Science Letters
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• v.27 no.4
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• pp.329-333
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• 2021

We previously identified that tumor cells genetically modified with a 4-1BBL co-stimulatory molecule had anticancer effects in a CT26 mouse colorectal tumor model. To identify the distinction between immune cells in a mouse tumor model treated with tumor cells genetically modified with 4-1BBL or β-gal, we examined the immune cells in CT26-WT, CT26-βgal, and CT26-4-1BBL tumor bearing mice 21 days after tumor cell administration. The CD8+ T cells population in mice treated with tumor cells genetically modified with 4-1BBL was significantly increased on day 21 compared to that of tumor cells genetically modified with β-gal in the spleen and tumor tissue. The CD4+ T cell population was not different between the two mice groups. The Foxp3+CD25^high CD4 T cell population decreased on day 21 in tumor tissues, but the decrease was not significant. We also found that CD8 T cells had pivotal roles in inhibiting tumor growth by treating mice with ant-CD4 and CD8 antibodies. These results suggest that tumor cells genetically modified with 4-1BBL could inhibit tumor growth by affecting on CD8 T lymphocytes.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.394-394
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• 2023

The world's sustainable growth is being severely hampered by the inefficient use of water resources. Despite the widely acknowledged importance of trade in global and regional water and food security, societal reliance on local production as well as international trade remains inadequately assessed. Therefore, using South Korea as a case study, this study fills in this research gap by applying the virtual water concept, the logarithmic mean divisia index (LMDI) method, and the Tapio decoupling model. The virtual water concept was used to estimate South Korea's net virtual water trade for major grain crops from 1992 to 2017. Then, the LMDI method was utilized to assess the driving factors causing changes in net virtual water trade. Lastly, the Tapio decoupling model was used to investigate the decoupling relationships between economic growth and the driving factors of net virtual water trade. Results showed that South Korea remains a net importer of virtual water flows with respect to grain crops, with an average import of 16,559.24 million m³ over the study period. In addition, the change in net virtual water trade could be attributed to water intensity effect, product structure effect, economic effect, and population effect. However, water intensity and economic effects were the major decisive factors for decrease and increase in net virtual water trade respectively, while the population and product structure effects had minor positive influences on the net virtual water trade. Furthermore, water intensity and economic growth showed a strong decoupling in most periods, while the decoupling state between product structure and economic growth was observed as expansive negative decoupling. Likewise, population size and economic growth showed a weak decoupling in most periods. The results reveal South Korea's status as it concerns the virtual water trade of grain crops, thus providing valuable insights into the sustainability of trade activities for the management of local water resources.

• Health Policy and Management
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• v.14 no.4
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• pp.21-47
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• 2004

There is general agreement that the Korean health care delivery system has two basic structural problems. One is the limited capacity and role of public hospitals, and the other is the absence of functional differentiation and referral arrangement between the clinics and hospitals of various technological sophistication levels. This study is intended to make an empirical observation of the system's growth process from the viewpoint of the population ecology model of organizations so as to understand the background of these problems and to find out ways of approaching them. As predicted from the population ecology model of organizations, all the types of medical care facilities have expanded in response to the environmental changes for the past three decades or so, and the differences in the extent and pattern of expansion among the types are related to what have taken place in the environment. These findings suggest that the efforts for reforming the health care delivery system should be directed not only to medical care institutions but also to the environmental context under which they function. It is believed that the usefulness of the population ecology perspective on organizations for studying the health care delivery system has been demonstrated. Thus further studies along this line based upon more strict design would improve systematic understanding of the system that is needed for developing policy approaches needed to increase its effectiveness.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.4
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• pp.155-162
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• 2020

The paper aims to examine the association between information and communication technology (ICT), economic growth and population health based on health production model in Malaysia. This theoretical health production function is represented as follows: where the output is an individual health outcome, and the inputs are determinants of health, such as income, education, health care costs, medical facilities, the environment, and lifestyle. The development of information and communication technologies are represented as of mobile cellular subscriptions (per 100) and fixed telephone subscriptions (100) using time series data from 1993-2017 from the World Bank database. Using the bound testing technique of cointegration, this study finds that ICT affects population health significantly and positively in the long- and short-run. This is because ICT inclusion improves human health and longevity. Whereas, economic growth has no significant impact on the population's health both in the short- and long-run. The findings indicate that a weak global economy affects Malaysia's economic growth and reduces the health expenditure per capita. The results of this study suggest that policymakers must develop policies that improves public health by increasing health literacy, disseminating health information and facilitating medical facilities. This study also suggests that health care systems should to concentrate on digital inclusion.

• Journal of Korean Society on Water Environment
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• v.24 no.3
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• pp.306-310
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• 2008

Characteristics of microalgal growth was investigated using anaerobic effluent from two-phase animal waste digestor as substrate. Batch experiments were carried out to investigate the effect of the initial nitrogen and phosphorus concentrations on growth of Microcystis aeruginosa, Chlorella sp. and Euglena gracilis. In 400 times diluted anaerobic effluent (TN 3 mg/L), single cell growth of the Euglena gracilis population increased twice without delay, although Chlorella sp. and Microcystis aerugenos take over 144 hours. Similar appearance with single cell growth was observed in mixed cultures. However, microalgae population did not increase under condition of 10 times diluted influent (TP 3 mg/L) in both pure and mixed cultures, which was affected by high organic and nitrogen concentration. Logistic growth model successfully fitted to determine biokinetic parameters such as ${\lambda}$: lag time, ${\mu}m$: maximal specific growth rate, A: asymptote of growth.

• Journal of applied mathematics & informatics
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• v.30 no.1_2
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• pp.183-200
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• 2012

A two-strain epidemic model with an age structure mutation and varying population is studied. By means of the spectrum theory of bounded linear operator in functional analysis, the reproductive numbers according to the strains, which associates with the growth rate ${\lambda}^*$ of total population size are obtained. The asymptotic stability of the steady states are obtained under some sufficient conditions.

• Animal cells and systems
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• v.13 no.1
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• pp.83-89
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• 2009

Investigations were made on population biology of Pampus echinogaster (Basilewsky, 1855) in the coastal areas of Korea, Yellow Sea, between August 2005 and July 2006. Population structure was not significantly different between male and females. Monthly variation of gonadosomatic index (GSI) of both sexes defined spawning period extending from March through July. A similar pattern was also observed in change at maturity stages. For males and females GSI was positively correlated with hepatosomatic index (HSI). Fecundity, ranging from 41,250 to 103,610 eggs, was related to body size, indicating that body size is the useful determinant of fecundity. The sexual maturity ($L_{50}$) was estimated as 14.98 cm TL for males and 19.32 cm TL for females. Parameters of growth estimated by the modified von Bertalanffy growth function model showed that the values of $L_{\infty}$ and K for combined data were 39.12 cm TL and 0.65 $yr^{-1}$. The growth performance index of this study (2.75) was higher than that of the previous study (2.45). This difference could be attributed to sampling method. The recruitment patterns indicated one normally distributed group. Percentage of the recruitment was 51.04% in the spawning season and the highest in August (19.78%).

• Korean Journal of Environment and Ecology
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• v.20 no.4
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• pp.391-399
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• 2006

The population dynamics of Zacco koreanus in the upstream and downstream of Hoengseong Lake, Korea were investigated from April to October 2005. As the result of a comparison of variations regarding the time of I koreanus populations, it was confirmed that downstream was a place to remain compared to upstream Also the b value, assessed by Length-weight relationship in upstream and downstream, were $3.21{\sim}3.35,\;and\;2.94{\sim}3.37$, respectively indicating the fish in downstream had better than upstream. Additionaly condition factor(K) of each population in upstream and downstream were $0.0292{\sim}0.0693\;and\;-0.0165{\sim}0.0499$, respectively, K value in upstream lower than downstream. On the other hand, the maximum-growth value$(L_{\infty})$ calculated by von Bertalanffy's growth model in upstream and downstream were 279.7mm and 303.9mm, respectively, indicating that the potential-growth ability of population in downstream was higher than population in upstream. Therefore, Z. koreanus population in upstream became worse based on matters of age structure, Length-weight relationship, and von Bertalanffy's growth model. These results are considered to show the change of the physical environment by the constructing of Hoengseong Dam.

• Journal of the Korean Regional Science Association
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• v.13 no.2
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• pp.93-118
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• 1997

Main findings of this study are as follows. Time-space model of Korea for urban growth model is established. The variables of space model resulted in job and education, which both are significant at 0.01 level and positive. The effect of job and education on the urban growth are 0.76 and 0.29 respectively in average. the determinants for deciding the influences for job variable are income variable and price-level variable. Income variable contributes 68.66% and the direction is negative while contribution of price-level variable is 29.90% and the direction is positive. The determinants for education variable are income, unemployment and wage difference between university graduates and high school graduates. The contribution and the high school graduates. The contribution and the direction of each variable for education variable are 63.6% and positive for the unemployment variable, 15.99% and negative for the income variable and 13.75% and positive for the wage difference variable. This study in different from previous works in three ways. The first is to establish the time-space model which could consider the time and space factor simultaneously. The second is to build data bases which contain the data of almost every city and every year in Korea during the objective period, which make the analysis continuous. The third is that the general analytic framework for the study is macrosocial one rather than a behavioral one, which means the unit of analysis is the metropolitan community and each city occupies population actively through it's potential power such as jobs, education and so on rather than a city population is the passive result of migration.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.36 no.2
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• pp.144-150
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• 2003

Reproductive biology and population dynamics of Latreutes planirostris were investigated on the south western waters of Korea from June 2001 to May 2002. This paper describes sex ratio, population growth, and reproductive aspects of Latreutes planirostris. Brood size was an isometric function of female carapace length. Based on dry weight, reproduction effort (mass of eggs/mass of female) averaged 0.23. Ovarian examination showed that there was significantly higher gonadosomatic index from May to September, with a peak in June. Statistical analysis revealed that the ovarian dry weight of females with eyed eggs was significantly higher than that of those with non-eyed eggs. This suggests that females were potentially consecutive breeders. Sex ratio showed that female is more numerous than male. Growth parameters mortality and recruitment were estimated by monthly length-frequency data. Growth parameters were estimated, using the seasonalized von Bertalanffy growth function model $(L\infty\;=\;12.70\;mm\;CL,\;K\;=\;0.87yr^{-1},\;C\;=\;0.96,\;WP\;=\;0.59)$. The recruitment pattern was twice a year.