• Journal of Yeungnam Medical Science
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• 제37권4호
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• pp.296-301
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• 2020

The geriatric population is at a greater risk of postoperative complications than young adults. This risk is associated with the physiologic decline seen in this population known as frailty. Unlike fitter patients, frail patients who undergo operative treatment have a greater likelihood of developing postoperative complications and endure prolonged hospital stays. This circumstance is comparable to the urological status. Therefore, tolerable measurement of frailty as a domain of preoperative health status has been suggested to ascertain vulnerability in elderly patients. In this review, we will elaborate on the concept of frailty and examine its importance with respect to surgical complications, focusing on the urological status.

• 한국임상수의학회지
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• 제16권2호
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• pp.422-427
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• 1999

We are proposed for the computation of disease frequency measures and of their associated variances from data collected through prospective study of multiple dynamic cohort (herds) with a National Animal Health Monitoring System (NAHMS) in Gyeongnam. We can be estimated and calculated the annual incidence density for a group of herds and the 1-month risk of disease from the same within herd measure of monthly incidence density. We are proposed that the choice of measure to be estimated depend on the intended use of the information. From results in this study, Our study demonstrate that risk estimates are appropriates for producers and clinic veterinarian making decisions at the animal or herd level. Incidence density measures are appropriate for extrapolation to reference populations used for state and regional-level decision making.

• 한국지역사회생활과학회지
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• 제21권3호
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• pp.351-364
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• 2010

This study was aimed to investigate the relationship between abuse and suicide risk focused on the Korean elderly over 65 years old living with their families. The data for the study was collected from 1,193 people in Incheon metropolitan city, Kyunggi and Chungnam province. Among them, 711 elderly adults who experienced abuse within their families, were analysed for the study. The results were as follows: First, the group who had experienced abuse was revealed at 29.8%, and the group who had experienced suicide was revealed at 23.1%. Second, the victims of abuse at older ages affects the risk of suicide. Moreover, considering the elderly population under the control of influencing variables such as socioeconomic traits, ADL and depression, the risk of suicide for the group of being abused was higher than the group that was never abused. Third, four groups of elderly(groups without both abuse and suicide risks, the group with only abuse victims, the group with only suicide risks, and the group with both abuse and suicide risk) were divided based on the victims of abuse and the risk of suicide. The group without abuse and suicide risk was positive in subjective economic status, ADL, number of diseases and depression. On the contrary, the group with both abuse and suicide risk was negative in the above indices. The study indicated that there were some similar traits between abuse risk groups and suicide risk groups, but the group with suicide risk was lower than the group with abuse risk in ADL and depression.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1419-1422
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• 2014

Objective: To summarize the endoscopic screening findings in high-risk population of esophageal and gastric carcinoma and analyze influential factors related to screening. Methods: In seven selected cities and counties with high incidences of esophageal carcinoma, people at age of 40-69 were set as the target population. Those with gastroscopy contradictions were excluded, and all who were voluntary and willing to comply with the medical requirements were subjected to endoscopic screening and histological examination for esophageal, gastric cardia and gastric carcinoma in accordance with national technical manual for early detection and treatment of cancer. Results: In three years, 36,154 people were screened, and 16,847 (46.60%) cases were found to have precancerous lesions. A total of 875 cases were found to have cancers (2.42%), and among them 739 cases had early stage with an early diagnosis rate is 84.5%. Some 715 patients underwent prompt treatment and the success rate was 81.8%. Conclusions: In a high-risk population of esophageal and gastric carcinoma, it is feasible to implement early detection and treatment by endoscopic screening. Screening can identify potential invasive carcinoma, early stage carcinoma and precancerous lesions, improving efficacy through early detection and treatment. The exploratory analysis of related influential factors will help broad implementation of early detection and treatment for esophageal and gastric carcinoma.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5567-5577
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• 2013

The prevalence of oral cancers (OC) is high in Asian countries, especially in South and Southeast Asia. Asian distinct cultural practices such as betel-quid chewing, and varying patterns of tobacco and alcohol use are important risk factors that predispose to cancer of the oral cavity. The aim of this review is to provide an update on epidemiology of OC between 2000 and 2012. A literature search for this review was conducted on Medline for articles on OC from Asian countries. Some of the articles were also hand searched using Google. High incidence rates were reported from developing nations like India, Pakistan, Bangladesh, Taiwan and Sri Lanka. While an increasing trend has been observed in Pakistan, Taiwan and Thailand, a decreasing trend is seen in Philippines and Sri Lanka. The mean age of occurrence of cancer in different parts of oral cavity is usually between 51-55 years in most countries. The tongue is the leading site among oral cancers in India. The next most common sites in Asian countries include the buccal mucosa and gingiva. The 5 year survival rate has been low for OC, despite improvements in diagnosis and treatment. Tobacco chewing, smoking and alcohol are the main reasons for the increasing incidence rates. Low socioeconomic status and diet low in nutritional value lacking vegetables and fruits contribute towards the risk. In addition, viral infections, such as HPV and poor oral hygiene, are other important risk factors. Hence, it is important to control OC by screening for early diagnosis and controlling tobacco and alcohol use. It is also necessary to have cancer surveillance at the national-level to collect and utilise data for cancer prevention and control programs.

• Journal of Genetic Medicine
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• 제13권1호
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• pp.26-30
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• 2016

Purpose: Genetic disorders can be prevented by basic public health measures and activities that focus primarily on education and approaches in Primary Health Care. Premarital screening is one such approach that can identify asymptomatic carriers of hemoglobinopathies and provide genetic counseling to couples for a healthy reproductive life. This study aimed to estimate the prevalence of beta thalassemia and sickle cell disorders in the adult population screened as a part of the United Arab Emirates Premarital Screening Program and to measure the effectiveness of the program in decreasing high-risk marriages in Ras Al Khaimah (RAK). Materials and Methods: A retrospective, population-based study was conducted at the RAK Primary Health Care Center, where the National Premarital Screening Program is implemented. The study included data collected from the premarital screening records of all couples who had applied for a marriage license during 2008-2015. Results: Of the 17,826 individuals screened during the studied period, 4.02% (717) were diagnosed as positive for hemoglobinopathies. The prevalence of beta thalassemia and sickle cell disorders among the total study population was 2.98% and 1.05%, respectively. The hemoglobinopathy trait was more prevalent than the disease. Among these 8,913 couples who were issued certificates for compatibility based on screening tests, 28 (0.31%) couples were declared high-risk (unmatched). Seventy percent of these unmatched couples reported consanguineous marriages. Conclusion: The program was successful in achieving its objective of identifying high-risk marriages. In spite of the counseling, however, all of the high-risk couples still married each other.

• Nutrition Research and Practice
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• 제6권1호
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• pp.78-85
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• 2012

Whether the $FTO$ polymorphisms interact with environmental factors has not yet been evaluated in associations with metabolic syndrome (MS) risk. The present study investigated the association of the $FTO$ rs9939609 genotypes, body mass index (BMI), and lifestyle-related factors including smoking, alcohol drinking, physical activity, and diet with MS incidence. A population-based prospective cohort study comprised 3,504 male and female Koreans aged 40 to 69 years. At the beginning of the study, all individuals were free of MS and known cardiovascular disease. Incident cases of MS were identified by biennial health examinations during a follow-up period from April 17, 2003 to April 15, 2009. Pooled logistic regression analysis was applied to obtain relative odds (RO) of MS with its 95% confidence interval (CI). After controlling for potential MS risk factors, we observed no association between the rs9939609 genotypes and MS incidence. In analysis stratified by BMI, however, carriers with the $FTO$ risk allele whose BMI is $29kg/m^2$ or greater showed an approximately 6-fold higher RO (95% CI: 3.82 to 9.30) compared with non-carriers with BMI less than $25kg/m^2$. In particular, the association between the rs9939609 variants and MS risk was significantly modified by high BMI (P-value for interaction < 0.05). Such significant interaction appeared in associations with central obesity and high blood pressure among the MS components. Because carriers of the $FTO$ risk alleles who had BMI of $29kg/m^2$ or greater are considered a high risk population, we suggest that they may need intensive weight loss regimens to prevent MS development.

• 생물정신의학
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• 제13권2호
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• pp.103-109
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• 2006

Objective : Associations of vascular risk/disease or apolipoprotein E ${\varepsilon}4$(APOE4) with geriatric depression has been unclear at a population level. This study aimed to evaluate whether there would be interactions of vascular risk/disease and APOE4 on depression in a Korean elderly population. Methods : 732 community residents aged 65 or over were assessed for depression(GMS), information on vascular risk/disease(reported stroke, transient ishemic attack, heart disease, hypertension, diabetes, smoking), examinations for vascular risk/disease(blood pressure, blood tests for glucose and lipid profiles, body size), APOE genotypes, demographic characteristics(age, gender, education), physical health, and cognitive function(MMSE). Results : Previous stroke and lower level of high density lipoprotein(HDL) cholesterol were significantly associated with geriatric depression independent of demographic characteristics, physical illnesses, and cognitive function. These associations were statistically significant only in those with APOE4, although the interaction terms didn't reach to statistical significance. Conclusion : Associations between vascular risk/disease and geriatric depression might be more prominent in those with APOE4. However further research would be needed to clarify this issue.

• 한국환경보건학회지
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• 제49권6호
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• pp.362-371
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• 2023

Background: PM_2.5 pollution has been a persistent problem in South Korea, with concentrations consistently exceeding World Health Organization (WHO) guidelines. The aging of the population in the country further exacerbates the health impacts of PM_2.5 since older adults are more susceptible to the adverse effects of air pollution. Objectives: This study aims to evaluate how the health impact (premature death) due to long-term exposure to PM_2.5 in South Korea could change in the future according to the trend of change in the country's population structure. Methods: The study employs a relative risk function, which accounts for age-specific relative risks, to assess the changes in premature deaths by age and region at the average annual PM_2.5 concentration for 2022 and at PM_2.5 concentration improvement levels. Premature deaths were estimated using the Global Exposure Mortality Model (GEMM). Results: The findings indicate that the increase in premature deaths resulting from the projected population structure changes up to 2050 would significantly outweigh the health benefits (reduction in premature deaths) compared to 2012. This is primarily attributed to the rising number of premature deaths among the elderly due to population aging. Furthermore, the study suggests that the effectiveness of the current domestic PM_2.5 standard would be halved by 2050 due to the increasing impact of population aging on PM_2.5-related mortality. Conclusions: The study highlights the importance of considering trends in population structure when evaluating the health benefits of air pollution reduction measures. By comparing and evaluating the health benefits in reflection of changes in population structure to the predicted PM_2.5 concentration improvements at the provincial level, a more comprehensive assessment of regional air quality management strategies can be achieved.

• 해양환경안전학회지
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• 제30권2호
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• pp.200-208
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• 2024

승선 인원이 많은 실습선은 화재가 발생하는 경우 대형 인명피해로 확장될 수 있으며 이에 따라 선원법 및 Safety Life At Sea(SOLAS)에서는 퇴선 훈련에 대한 중요성을 강조해 왔다. 따라서 본 연구에서는 승선 인원이 많은 국립목포해양대학교의 세계로호를 대상선박으로 선정하여 preliminary hazard analysis(PHA) 정성적 위험성 평가 기법을 통해 각 deck의 화재 사고 위험빈도와 심각성에 대하여 예측하였다. 또한 위험성이 높은 구역에서의 화재를 가정 한 뒤, 그 위험성을 정량적으로 예측하기 위하여 대피 시간 및 인구 밀도에 대한 시뮬레이션을 수행하였다. 그 결과, 총 대피시간이 인구 분포가 한 구역에 집중되어 있던 식사 시간을 가정한 시나리오에서 501초로 가장 길게 예측되었으며 시나리오에 따라 일부 deck에서 1.4pers/m² 이상의 상대적으로 높은 인구밀도를 나타내며 대피 인원이 정체되는 현상을 보였다. 본 연구 결과는 다양한 피난 시나리오에 따른 대피시간 및 인구밀도를 정량화하여 실습선의 상황에 맞는 훈련 시나리오를 개발하기 위한 기초자료로서 사용될 것으로 보이며 추후 수학적 모델과 실험값의 비교를 통하여 연구를 확장할 수 있을 것으로 예상된다.