• 대한수학회지
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• 제34권4호
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• pp.949-957
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• 1997

The purpose of this paper is to establish connection between certain complex of modules of generalized fractions and the concept of cosequence in commutative algebra. The main theorem of the paper leads to characterization, in terms of modules of generalized fractions, of regular (co) sequences.

• 천문학회보
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• 제38권2호
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• pp.76-76
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• 2013

The current hierarchical model of galaxy formation predicts that galaxy halos contain merger relics in the form of long stellar streams. In order to find stellar substructures in galaxy, we focused our investigation on the stellar spatial density around globular clusters and on the quantitative properties of the evolved sequences in the color-magnitude diagrams (CMDs). First, we investigated the spatial configuration of stars around five metal-poor globular clusters in halo region (M15, M30, M53, NGC 5053, and NGC 5466) and one metal-poor globular cluster in bulge region (NGC 6626). Our findings indicate that all of these globular clusters show strong evidence of extratidal features in the form of extended tidal tails around the clusters. The orientations of the extratidal features show the signatures of tidal tails tracing the clusters' orbits and the effects of dynamical interactions with the galaxy. These features were also confirmed by the radial surface density profiles and azimuthal number density profiles. Our results suggest that these six globular clusters are potentially associated with the satellite galaxies merged into the Milky Way. Second, we derived the morphological parameters of the red giant branch (RGB) from the near-infrared CMDs of 12 metal-poor globular clusters in the Galactic bulge. The photometric RGB shape indices such as colors at fixed magnitudes, magnitudes at fixed colors, and the RGB slope were measured for each cluster. The magnitudes of the RGB bump and tip were also estimated. The derived RGB parameters were used to examine the overall behavior of the RGB morphology as a function of cluster metallicity. The behavior of the RGB shape parameters was also compared with the previous observational calibration relation and theoretical predictions of the Yonsei-Yale isochrones. Our results of studies for stellar spatial distribution around globular clusters and the morphological properties of RGB stars in globular clusters could add further observational evidence of merging scenario of galaxy formation.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4395-4399
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• 2016

The FLT3-ITD mutation is one of the most frequent genetic abnormalities in acute myeloid leukemia (AML) where it is associated with a poor prognosis. The FLT3-ITD mutation could, therefore, be a potential molecular prognostic marker important for risk-stratified treatment options. We amplified the FLT3 gene at exon 14 and 15 in 52 AML patients (aged between 2 months and 74 years) from 4 referral centers (a university hospital and 3 regional hospitals in Northeast Thailand), using a simple PCR method. FLT3-ITD mutations were found in 10 patients (19.2%), being more common in adults than in children (21.1% vs. 14.3%) and more prevalent in patients with acute promyelocytic leukemia (AML-M3) than AML-non M3 (4 of 10 AML-M3 vs. 6 of 42 AML-non M3 patients). Duplication sequences varied in size-between 27 and 171 nucleotides (median=63.5) and in their location. FLT3-ITD mutations with common duplication sequences accounted for a significant percentage in AML patients in northeastern Thailand. This simple PCR method is feasible for routine laboratory practice and these data could help tailor use of the national protocol for AML.

• 한국음향학회지
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• 제14권5호
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• pp.5-10
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• 1995

본 논문에서는 단어를 발음하는 방법 이 각각 다른 화자들의 변이성을 잘 흡수하도록 복수개의 통계적인 모델들을 구성하기 위하여 HMM을 기본으로 하는 집단화 방법을 제시한다. 또한 개발된 방법으로부터 얻어진 HMM집단화된 모델들이 불특정화자 고립단어 인식에 응용된다. HMM 집단화 방법은 학습용 데이타로부터 어떤 경계치 보다 낮은 유사도를 갖는 관측열들을 분리하여 새로운 집단을 만들고 이 집단내에 있는 관측열들을 이용하여 새로운 모델들을 학습시키는 방법이다. 집단화 과정은 반복되는데 최고의 유사도를 갖는 모델의 집단에 관측열들을 재분배하고 집단내 관측열들이 변화하면 새로운 모델을 재 추정하여 기존의 모델을 대신한다. 그러므로 이 집단화 방법은 집단화 과정과 파라미터 추정이 일체화되어 기존의 패턴에 의한 집단화 방법보다 더욱 효율적이 된다. 실험결과 HMM에 의한 집단화 방법이 기존의 패턴에 의한 집단화 방법보다. 고립 숫자음 인식에 있어서 $1.43\%$의 인식률을 향상시킬 수 있었으며 단일 모델의 사용보다는 $2.08\%$의 인식률이 향상되었다.

• 한국균학회지
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• 제47권1호
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• pp.13-18
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• 2019

A fungal strain, designated PTT-2, was isolated from the bark of the trunk of a persimmon (Diospyros kaki) tree in Cheongdo, Korea. The isolate showed morphological similarities with Leptosphaerulina saccharicola. Strain PTT-2 had more rapid growth on potato dextrose agar medium than on oatmeal agar, malt extract agar, and synthetic nutrient poor agar media, with colony sizes of 53.8 mm, 49.8 mm, 48.4 mm, and 28.1 mm after 7 days at $25^{\circ}C$ temperature, respectively. Strain PTT-2 produced ascospores, which had irregular wavy edges, oblong to ellipsoidal shape, hyaline appearance and $23.6{\times}10{\mu}m$ size. The black ascomata were developed on PDA medium, and asci were recorded. A BLAST search of the internal transcribed spacer (ITS) region, TEF1-${\alpha}$ and RPB2 gene sequences revealed that strain PTT-2 showed more than 99% nucleotide similarity with a strain of Leptosphaerulina saccharicola previously reported from Thailand. A neighbor-joining phylogenetic tree was constructed by concatenating the above-mentioned sequences, and showed that strain PTT-2 clustered in the same clade with L. saccharicola. Based on these findings, this is the first record of Leptosphaerulina saccharicola occurring in Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2305-2309
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• 2012

Crocin, the main pigment of Crocus sativus L., has been shown to have antiproliferative effects on cancer cells, but the involved mechanisms are only poor understood. This study focused on probable effect of crocin on the immortality of hepatic cancer cells. Cytotoxicity of crocin ($IC_{50}$ 3 mg/ml) in hepatocarcinoma HepG2 cells was determined after 48 h by neutral red uptake assay and MTT test. Immortality was investigated through quantification of relative telomerase activity with a quantitative real-time PCR-based telomerase repeat amplification protocol (qTRAP). Telomerase activity in 0.5 ${\mu}g$ protein extract of HepG2 cells treated with 3 mg/ml crocin was reduced to about 51% as compared to untreated control cells. Two mechanisms of inhibition, i.e. interaction of crocin with telomeric quadruplex sequences and down regulation of hTERT expression, were examined using FRET analysis to measure melting temperature of a synthetic telomeric oligonucleotide in the presence of crocin and quantitative real-time RT-PCR, respectively. No significant changes were observed in the $T_m$ telomeric oligonucleotides, while the relative expression level of the catalytic subunit of telomerase (hTERT) gene showed a 60% decrease as compared to untreated control cells. In conclusion, telomerase activity of HepG2 cells decreases after treatment with crocin, which is probably caused by down-regulation of the expression of the catalytic subunit of the enzyme.

• Geomechanics and Engineering
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• 제21권2호
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• pp.207-213
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• 2020

Umbrella Arch Method (UAM) often employed in the tunnel construction under poor rock mass conditions in Korea. Insertion of steel pipes at the periphery of the tunnel and infiltration of grouts along the pipes into the rock masses increases tunnel stability. There are two major effects of grouts expected at the tunnel face: 1) increase of face stability by enhancing the frictional resistance of discontinuities and 2) decrease of permeability along the rock masses. Increase of resistance and decrease of permeability requires a certain curing time for the grout. In Korea, we require 24 hours for curing of grout, which means no progress of excavation for 24 hours after infiltration of grouts. This step delays the tunnel construction sequences. To eliminate such inefficiency, we propose MTG (Method for Tunnel construction using Grouting technology), which uses extended length of steel pipes (14 m) compared to conventional pipe roof method (12 m). The merit of MTG is the reduction of curing time. Because of the approximately 2 m extension of the length of steel pipe, blasting can be done after infiltration of grouting. For this paper, we conducted experiments on the shear strength behaviors of grout infilled rock joint with elapsing of curing time and blasting induced vibration. The results show that blasting induced vibration under MTG does not influence the mechanical features of grout material, which indicates no influence on the mechanical behaviors of grout, contributing to the stability of tunnels during excavation. This result indicates that MTG is a cost effective and fast construction method for tunneling in Korea.

• 한국발생생물학회지:발생과생식
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• 제11권3호
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• pp.253-261
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• 2007

Lactadherin은 모유의 유지방구막의 당단백질의 하나로 mucin, butyrophilin과 결합된 복합체이다. 특히 모유중의 mucin과 lactadherin은 출생 직후 면역력이 약한 유아를 병균의 침입으로부터 효율적으로 방어하여 초기 유아의 생존과 성장 및 발달에 매우 중요한 역할을 수행한다. Lactadherin은 유아 설사의 원인이 되는 rotavirus의 번식과 성장을 억제한다. 아울러 이 단백질은 새로운 혈관의 형성을 촉진하는 주요한 단백질로 알려져 있으며, 이 단백질의 결핍이 치매의 발생과 관련되는 것으로 보고되고 있다. 본 연구는 이처럼 중요성이 강조되는 lactadherin에 대한 생화학적 및 생리학적인 연구를 하기 위한 기초연구를 진행하였다. 한국 여성의 유선조직에서 mRNA를 분리하였고, 1.2 kb lactadherin cDNA 유전자를 cloning하여 염기서열과 아미노산 배열을 결정하였다. 이 cDNA를 pET vector에 삽입하여 E. coli에서 43 kD 단백질을 발현시켰으며 Western blot으로 확인하였으며, 이 단백질을 정제하여 토끼에서 항체를 생산하여, 한국 여성의 모유에서 발현되는 70, 55, 46, 30 kD의 band를 확인하였다. 아울러 백인 여성의 lactadherin 유전자와 한국 여성의 정상 및 유방암 조직의 유전자 비교에서 다양한 SNP가 관찰되었고 변이의 다형성이 관찰되었다.