• Journal of Pharmaceutical Investigation
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• 제21권1호
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• pp.23-32
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• 1991

Dissolution profiles of ketoconazole in solid dispersion system (SDS) were investigated in the second fluid (pH 6.8) for the dissolution test (KPV). PVP K-30 and methyl cellulose were used as carriers in SDS, and chloroform as a solvent. Computer optimization technique was applied to obtain an optimum formula of SDS, and the following results were obtained; 1) Dissolution rate of ketoconazole in SDS was larger than that of pure ketoconazole in the second fluid of pH 6.8. 2) PVP K-30 and methyl cellulosr were good carriers for SDS of ketoconazole. Moerover PVP K-30 was better than methyl cellulose. 3) The optimum formula of ketoconazole SDS obtained from computer optimization technique was chloroform 175 ml, PVP K-30 5g and methyl cellulose 0.2g per 1g of ketoconazole. 4) The experimental value of $A_{60}$ (Amount released from ketoconazole tablet during 60 minutes) obtained from SDS by optimum formula agreed well with the value calculated by polynomial regression equation.

• 한국자동차공학회논문집
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• 제21권3호
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• pp.15-23
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• 2013

Weight reduction of a automobile has been steadily tried in automotive industry to improve fuel efficiency, driving performance and the production profits. Since the weight of BIW takes up a large portion of the total weight of the automobile, reducing the weight of BIW greatly contributes to reducing the total weight of the vehicle. To reduce weight, vehicle manufacturers have tried to apply lightweight materials, such as aluminum and high-strength steel, to the components of BIW instead of conventional steel. In this research, material arrangement of an automotive BIW was optimized by formulating a design problem to minimize weight of the BIW while satisfying design requirements about bending and torsional stiffness and perform a metamodel-based design optimization strategy. As a result of the design optimization, weight of the BIW is reduced by 45.7% while satisfying all design requirements.

• Agricultural and Biosystems Engineering
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• 제2권2호
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• pp.63-68
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• 2001

The objective of this study was to develop a real-time soil moisture meter using RF impedance. The impedance suchas capacitance and resistance (or conductance) was analyzed using parallel cylinder type capacitance probe(C-probe) and Q-meter (HP4342). The capacitance and conductance of soil increased as volumetric water content increased. The 5 MHz of modified Colpitts type crystal oscillator was designed to detect the capacitance change of the C-probe with moist soil. A third order polynomial regression model was proposed to describe the relationship between RF impedance and volumetric water content. The prototype real time moisture meter consisted of the C-probe, sample container, oscillator, frequency counter and related signal processing units. The calibration equation for measurement of volumetric moisture content of soil was developed and validated. The correlation coefficient and root mean square error between measured volumetric water content by oven method and predicted values by prototype moisture meter for unknown soil samples were 0.984 and 0.032$cm^3$$cm\^3$, respectively.

• Geomechanics and Engineering
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• 제20권4호
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• pp.345-358
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• 2020

Numerous studies have repeatedly demonstrated the efficiency of using skirts to increase the bearing capacity and to reduce settlement of shallow foundations subjected to static loads. However, no efforts have been made to study the efficiency of using these skirts to reduce settlement produced by machine vibration, although machines are very sensitive to settlement and the foundations of these machines should be designed properly to ensure that the settlement produced due to machine vibration is very small. This research has been conducted to investigate the efficiency of using skirts as a technique to reduce the settlement of a strip foundation subjected to machine vibration. A two-dimensional finite element model has been developed, validated, and employed to achieve the aim of the study. The results of the analyses showed that the use of skirts reduces the settlement produced due to machine vibration. However, the percentage decrease of the settlement is remarkably influenced by the density of the soil and the frequency of vibration, where it rises as the frequency of vibration increases and declines as the soil density rises. It was also found that increasing skirt length increases the percentage decrease of the settlement. Importantly, the results obtained from the analyses have been utilized to derive new dynamic impedance values that implicitly consider the presence of skirts. Finally, novel design equations of dynamic impedance that implicitly account to the effect of the skirts have been derived and validated utilizing a new intelligent data driven method. These new equations can be used in future designs of skirted strip foundations subjected to machine vibration.

• Journal of the Korean Wood Science and Technology
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• 제46권4호
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• pp.380-392
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• 2018

The importance of polysaccharides is increasing globally due to their role as a significant source of dietary prebiotics in the human diet. In the present study, in order to maximize the yield of crude polysaccharides from Pinus densiflora, response surface methodology (RSM) was used to optimize a two-stage extraction process consisting of steam explosion and water extraction. Three independent main variables, namely, the severity factor (Ro) for the steam explosion process, the water extraction temperature ($^{\circ}C$), and the ratio of water to raw material (v/w), were studied with respect to prebiotic sugar content. A Box-Behnken design was created on the basis of the results of these single-factor tests. The experimental data were fitted to a second-order polynomial equation for multiple regression analysis and examined using the appropriate statistical methods. The data showed that both the severity factor (Ro) and the ratio of water to material (v/w) had significant effects on the prebiotic sugar content. The optimal conditions for the two-stage process were as follows: a severity factor (Ro) of 3.86, a water extraction temperature of $89.66^{\circ}C$, and a ratio of water to material (v/w) of 39.20. Under these conditions, the prebiotic sugar content in the extract was 332.45 mg/g.

• Journal of the Optical Society of Korea
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• 제19권1호
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• pp.102-111
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• 2015

This paper proposes an algorithm for recovering the colors of objects from multiple near-infrared (near-IR) images. The International Commission on Illumination (CIE) color coordinates of objects are recovered from a series of gray images captured under multiple spectral near-IR illuminations using polynomial regression. The feasibility of the proposed algorithm is tested experimentally by using 24 color patches of the Color Rendition Chart. The experimental apparatus is composed of a monochrome digital camera without an IR cut-off filter and a custom-designed LED illuminator emitting multiple spectral near-IR illuminations, with peak wavelengths near the red edge of the visible band, namely at 700, 740, 780, and 860 nm. The average color difference between the original and the recovered colors for all 24 patches was found to be 11.1. However, if some particular patches with high value are disregarded, the average color difference is reduced to 4.2, and this value is within the acceptability tolerance for complex image on the display.

• 대한기계학회논문집A
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• 제24권3호
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• pp.661-666
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• 2000

Optimization of the elastic joint of train is performed according to the minimization of ten responses which represent driving safety and ride comfort of train and analyzed by using the each response se surface model from stochastic design of experiments. After the each response surface model is constructed, the main effect and sensitivity analyses are successfully performed by 2nd order approximated regression model as described in this paper. We can get the optimal solutions using by nonlinear programming method such as simplex or interval optimization algorithms. The response surface models and the optimization algorithms are used together to obtain the optimal design of the elastic joint of train. the ten 2nd order polynomial response surface models of the three translational stiffness of the elastic joint (design factors) are constructed by using CCD(Central Composite Design) and the multi-objective optimization is also performed by applying min-max and distance minimization techniques of relative target deviation.

• 대한화학회지
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• 제56권4호
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• pp.406-415
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• 2012

The corrosion inhibition of copper-nickel alloy by Ethylenediamine (EDA) and Diethylenetriamine (DETA) in 1.5M HCl has been investigated by weight loss technique at different temperatures. Maximum value of inhibitor efficiency was 75% at $35^{\circ}C$ and 0.2 M inhibitor concentration EDA, while the lower value was 4% at $35^{\circ}C$ and 0.01 M inhibitor concentration DETA. Two mathematical models were used to represent the corrosion rate data, second order polynomial model and exponential model respectively. Nonlinear regression analysis showed that the first model was better than the second model with high correlation coefficient. The reactivity of studied inhibitors was analyzed through theoretical calculations based on density functional theory (DFT). The results showed that the reactive sites were located on the nitrogen (N1, N2 and N4) atoms.

• 한국소음진동공학회논문집
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• 제12권6호
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• pp.461-468
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• 2002

Computer simulation is essential to design the suspension elements of railway vehicle. By computer simulation, engineers can assess the feasibility of the given design factors and change them to get a better design. But if one wishes to perform complex analysis on the simulation, such as railway vehicle dynamic, the computational time can become overwhelming. Therefore, many researchers have used a surrogate model that has a regression model performed on a data sampling of the simulation. In general, metamodels(surrogate model) take the form y($\chi$)＝f($\chi$)＋$\varepsilon$, where y($\chi$) is the true output, f($\chi$) is the metamodel output, and is the error. In this paper, a second order polynomial equation is used as the RSM(response surface model) for high speed train that have twenty-nine design variables and forty-six responses. After the RSM is constructed, multi-objective optimal solutions are achieved by using a nonlinear programming method called VMM(variable matric method) This paper shows that the RSM is a very efficient model to solve the complex optimization problem.

• 전기학회논문지
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• 제66권4호
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• pp.692-700
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• 2017

In this paper, we propose the structural design of Interval Type-2 FCM based RBFNN. Proposed model consists of three modules such as condition, conclusion and inference parts. In the condition part, Interval Type-2 FCM clustering which is extended from FCM clustering is used. In the conclusion part, the parameter coefficients of the consequence part are estimated through LSE(Least Square Estimation) and WLSE(Weighted Least Square Estimation). In the inference part, final model outputs are acquired by fuzzy inference method from linear combination of both polynomial and activation level obtained through Interval Type-2 FCM and acquired activation level through Interval Type-2 FCM. Additionally, The several parameters for the proposed model are identified by using differential evolution. Final model outputs obtained through benchmark data are shown and also compared with other already studied models' performance. The proposed algorithm is performed by using Iris and Vehicle data for pattern classification. For the validation of regression problem modeling performance, modeling experiments are carried out by using MPG and Boston Housing data.