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검색결과 372건 처리시간 0.032초

Ribosomally Synthesiszed Antimicrobial Peptides (Bacteriocins) in Lactic Acid Bacteria: A Review

  • Nes, Ingolf F.;Yoon, Sung-Sik;Diep, Dzung B.
    • Food Science and Biotechnology
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    • 제16권5호
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    • pp.675-690
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    • 2007
  • Bacteriocins in Gram-positive bacteria have attracted much attention because many have a strong antimicrobial activity also against bacteria outside the genera of the producers. Lantibiotics and the pediocin-like bactericins have attracted most attention since they kill a broad spectrum of Gram-positive bacteria including important pathogens. But many other promising Gram-positive bacteriocins have been thoroughly characterized. Recent studies have shown that bacteriocins may playa role in the intestinal flora to protect us against the food-borne pathogens. Bacterial genome sequencing has demonstrated that there may be an arsenal of such compounds and we are only seeing the top of the iceberg. The present review gives a short outlook of the field of bacteriocins with focus on lactic acid bacteria and includes recent findings.

Detection of Human Cytomegalovirus in patients with Colorectal Cancer by Nested-PCR

  • Tafvizi, Farzaneh;Fard, Zahra Tahmasebi
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권3호
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    • pp.1453-1457
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    • 2014
  • Background: The association of colorectal cancer with human cytomegalovirus (HCMV) is a controversial issue in cancer research. This study aimed to identify the HCMV virus in colorectal cancer tissues and to investigate the association of HCMV with colorectal cancer. In this study, 50 cancer tissue samples and 50 samples without colon cancer were studied in order to identify the HCMV virus through nested-polymerase chain reaction. The virus was identified in 15 cases of colorectal cancer tissues (15/50) and in 5 cases of normal tissues (5/50). Eight cases of adenocarcinoma tissues were in a moderately differentiated stage, and 7 cases had well-differentiated stage tissues that were positive for viral DNA. The findings were statistically evaluated at a significance level of p<0.05. The HCMV virus could playa role in creating malignancy and the progress of cancer through the process of oncomodulation.

조직특성, IS 기반, IS 기획능력 및 IS 품질이 CRM 성과에 미치는 영향 (The Impact of the Organizational Characteristics, IS Basis, IS Planning Capability and IS Quality on the CRM Performance)

  • 이승명;김은홍
    • 한국IT서비스학회지
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    • 제4권1호
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    • pp.71-105
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    • 2005
  • The purpose of this study was to test various variables that affect CRM performance in order to evaluate CRM performance. The results of the proposed research hypotheses are as follows; First, the IS based factors perform more important roles on system and information quality compared to organizational factors. Second, the variables of IS and planning capability playa role as a parameter. Third, among organizational factors, non-structural factors such as degrees of acceptance of business transition, support of CEO, and customer-orientation perform more important roles on CRM. Fourth, IS based factors have bigger Impact on information quality than system quality. Fifth, it was proven that IS quality, proposed as a parameter and as a dependant variable, and CRM have significant relations.

서지 데이터 입력 시스템의 인터페이스 설계에 관한 연구 (Interface Design for the Bibliographic Data Entry System)

  • 최석두
    • 정보관리학회지
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    • 제7권1호
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    • pp.40-58
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    • 1990
  • 서지 데이터 입력 시스템의 인터페이스를 설계할 때 여러 가지 측면과의 관계를 고 려해야 할 것이다. 입력 계획, 레코드 포맷, 화면 설계, 액세스 포인트의 자동 생성, 에러 체 킹, 기존 데이터베이스의 다운로드, 사용 문자 코드, 카드 목록 생산, 전거 데이터의 이용 등 이 그것이다. 본고에서는 이와 같은 사항들을 어떻게 실제의 서지 데이터 입력 시스템에 적 용시킬 것인가에 대해 실례를 들어 논한다.

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The Differential Roles of Glutamine Synthetase in Methylmercury Neurotoxicity

  • Park, Young-Jin;Lee, Seung-Taek;Kwon, Oh-Seung
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.228.2-229
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    • 2002
  • Methylmercury (MeHg). a potent neurotoxicant. produces neuronal death that may be partially mediated by glutamate. Glutamine synthetase (GS), a glial-specific enzyme. catalyzes the synthesis of glutamine from glutamate and ammonia and is associated with ischemic injury and neurological diseases. Objectives of this experiment are to investigate whether in vivo and in vitro MeHg exposure have adverse effects on GS and whether duration of exposure to MeHg and glutamate co-treatment playa role in MeHg-induced toxicity. (omitted)

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Estrogen receptor expression and behavioral changes in immature mice treated with bisphenol A

  • Seong, Min-Je;Song, Youn-Sook;Lee, Yoot-Mo;Jeon, Gye-Hyun;Shin, Im-Chul;Oh, Ki-Wan;Kim, Tae-Seong;Han, Soon-Young;Hong, Jin-Tae
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.134.2-135
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    • 2003
  • A large number of chemical pollutants including phthalates, alkylphenolic compounds, organochlorine pesticides and bisphenol A have the ability to disrupt endocrine function in animals. and alter cognitive function. Because hormone mediated events playa important role in central nervous system development and functions. The speculations that the changes in cognitive function are mediated by the endocrine-like action of these chemicals. (omitted)

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Characterization of Human Epidermal Stem Cells and Living Skin Equivalents

  • Kim, Dong-Seok;Youn, Sang-Woong;Choi, Hye-Ryung;Cho, Hyun-Ju;Jeon, Sang-Eun;Park, Kyoung-Chan
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.273.2-274
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    • 2002
  • Human epidermal keratinocytes consist of stem cells. transit amplifying cells. and postmitotic differentiating cells. Among them, stem cells playa critical role in cell renewal. wound healing. and neoplasia. However. till now, specific markers of human epidermal keratinocytes are not clearly defined. In the present study. we separated putative stem cells from other cells using fluorescence activated cell sorting (FACS). based on differences in a6-integrin and CD71 expression. (omitted)

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틸팅판토그라프의 틸팅 메커니즘 및 가이드 트랙형상 설계에 관한 연구 (The Study for Design of Tilting Mechanism and Guide Track of Tilting Pantograph)

  • 고태환;김남포;한성호
    • 한국철도학회:학술대회논문집
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    • 한국철도학회 2004년도 춘계학술대회 논문집
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    • pp.798-803
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    • 2004
  • The development of tilting train is required for speedup on the conventional electric railroad due to the characteristic of Korean railroad with a lot of curve track. The study and development of a tilting system and a tilting bogie which have a different mechanism with high speed train will playa important role for enhancement of technology for Korean railway. The study for tilting pantograph mechanism to decrease the displacement between a catenary and a center of pantograph happened when the carbody is tilted in order to maintain the ride comfort and stability on a curving track is proceeding with the development of tilting train. In this paper. we introduce the design concept for the tilting mechanism of a tilting pantograph and the role and characteristics for several devices adopted in the tilting pantograph mechanism. Through the kinematic analysis of tilting mechanism. we will obtain and calculate the optimal tilting angular velocity and acceleration in order to keep the contact behavior of a pantograph and a catenary according to tilting of a carbody.

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전철시스템에서의 보호시스템에 관한 연구 (A study on the protection system in electrified railways system)

  • 이희용;이종우
    • 한국철도학회:학술대회논문집
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    • 한국철도학회 2004년도 춘계학술대회 논문집
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    • pp.1342-1346
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    • 2004
  • Recently, the load increasement and regenerative system of electrified railway system make a difficult to distinguish between the load current and fault current and it need a new intelligent protection system. The failure of traction system cause collapse of the other systems from high tension current. The over current from abnormal situation produces high tension current flow, high temperature are, voltage instability and current cutting, and break down railway systems. Protective system of traction system playa role of which detect and isolate failure points. In this paper, we proposed intelligent algorithm for discriminating normal and abnormal situation instead of the system being operated abnormally.

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철도차량내의 전시공간 디자인에 관한 연구 (A Study on Design of the Exhibition Space in the Railroad Car)

  • 최철주;홍석기;권태수
    • 한국철도학회:학술대회논문집
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    • 한국철도학회 2003년도 추계학술대회 논문집(II)
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    • pp.197-202
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    • 2003
  • A Railroad Cars playa prominent role in a matter of transportation yet it cannot be discussed here for cultural space. On the other hand, considering railroad customers' increaced desire(craving) for cultural space, we design it in the train so that we provide customers not only transportation but also fullfil them desire for culture. In the competitive cultural era. The aim of the new strategy for railroad bussiness is both inspiving art and operating exhibition facilities in the train(railroad). Through analysis of exhibition space and environment, we design exhibition space to equip cultural facilities in the train then lead to make railroad business' new social education role by the inside and outside of the country.

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