Characterization of Human Epidermal Stem Cells and Living Skin Equivalents

  • Kim, Dong-Seok (Department of Dermatology. Seoul National University College of Medicine) ;
  • Youn, Sang-Woong (Department of Dermatology. Seoul National University College of Medicine) ;
  • Choi, Hye-Ryung (Department of Dermatology. Seoul National University College of Medicine) ;
  • Cho, Hyun-Ju (Department of Dermatology. Seoul National University College of Medicine) ;
  • Jeon, Sang-Eun (Department of Dermatology. Seoul National University College of Medicine) ;
  • Park, Kyoung-Chan (Department of Dermatology. Seoul National University College of Medicine)
  • Published : 2002.10.01

Abstract

Human epidermal keratinocytes consist of stem cells. transit amplifying cells. and postmitotic differentiating cells. Among them, stem cells playa critical role in cell renewal. wound healing. and neoplasia. However. till now, specific markers of human epidermal keratinocytes are not clearly defined. In the present study. we separated putative stem cells from other cells using fluorescence activated cell sorting (FACS). based on differences in a6-integrin and CD71 expression. (omitted)

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