• Asian-Australasian Journal of Animal Sciences
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• v.24 no.7
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• pp.1019-1025
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• 2011

Toll-like receptors (TLRs) play an important role in the recognition of invading pathogens and the modulation of innate immune responses in mammals. The TLR4 and TLR7 are well known to recognize the bacterial lipopolysaccharide (LPS) and single stranded (ssRNA) ligands, respectively and play important role in host defense against Gram-negative bacteria and ssRNA viruses. In the present study, coding exon fragments of these two TLRs were identified, cloned, sequenced and analyzed in terms of insertion-deletion polymorphism, within bovine TLRs 4 and 7, thereby facilitating future TLR signaling and association studies relevant to bovine innate immunity. Comparative sequence analysis of TLR 4 exons revealed that this gene is more variable, particularly the coding frame (E3P1), while other parts showed percent identity of 95.7% to 100% at nucleotide and amino acid level, respectivley with other Bos indicus and Bos taurus breeds from different parts of the world. In comparison to TLR4, sequence analysis of TLR7 showed more conservation among different B. indicus and B. taurus breeds, except single point mutation at 324 nucleotide position (AAA to AAM) altering a single amino acid at 108 position (K to X). Percent identity of TLR7 sequences (all 3 exons) was between 99.2% to 100% at nucleotide and amino acid level, when compared with available sequence database of B. indicus and B. taurus. Simple Modular Architecture Research Tool (SMART) analysis showed variations in the exon fragments located in the Leucine Rich Repeat (LRR) region, which is responsible for binding with the microbial associated molecular patterns and further, downstream signaling to initiate anti-microbial response. Considering importance of TLR polymorphism in terms of innate immunity, further research is warranted.

• Journal of the Korean Institute of Navigation
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• v.16 no.2
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• pp.41-52
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• 1992

It is, as everyone knows, very important for human beings to protect and conserve marine environment. We has believed the ocean is so wide and deep that it cannot be polluted. But it has begun to doubt the capacity of self-purification of the ocean due to pollution arising from marine casualities. It has proved that semi-enclosed sea is likely to be polluted and cannot be restored easily once pollution occurs. Therefore, first of all it is important to take preventive measures for prevention of marine pollution in the semi-enclosed sea like the Yellow Sea. Many of regional conventions for prevention of marine pollution have come into existence. this dissertation was set out for the fact that the Yellow Sea is semi-enclosed sea which is vulnerable to marine pollution. It is desirable not to deal with marine preservation of the Yellow Sea by a single exclusively but to deal with it by cooperation of all coastal states under the present circumstances. I proposed a program of regional cooperation to protect and conserve the Yellow Sea. This program must be progressed with gradual arrangements. First, they must establist a basic cooperation committee to work basic affairs on the protection of marine environment within the Yellow Sea. The Committee Mainly play parts of study and research concerned with pollution of the Yellow Sea in the non-governmental side and consist of legal and scientific experts. Second, they must establish the control Committee to prevent marine pollution of the Yellow Sea substantially. There is a reason that regional cooperation cannot be directly concluded with the regional tready. Because there is a problem of Recognition of States left. In principle, a subject of tready must be a state in the International Law. But they have not made Recognition of State which is demanded by International Law between North and South Koreas. Therefore, the Control committee must play a substantial part of prevention from pollution instead of the treaty. Finally, we concluded tentatively named $\ulcorner$Convention on Regional Cooperation for Protection of Marine Environment of the Yellow Sea from Pollution$\lrcorner$ if the matter is settled which is related to Recognition of States in the International Law.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.19 no.1
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• pp.171-184
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• 2016

Suncheonman-Bay and its surrounding areas play important roles as habitats for migratory birds. However, sustainable management of these areas is difficult because of the development pressure of private lands. Therefore, the areas surrounding Suncheonman-Bay must be classified as additional protected areas; for this, it is necessary to gather concrete and objective evidence and ensure protected area management. Further, compensation measures must be considered when acquiring a private property as an additional protected area. In this study, we distinguish protected areas, such as core, buffer, and transition areas, within a private area by using data from the Winter Waterbird Census of Korea and MARXAN software, a spatial conservation prioritization tool. We applied ecosystem services to apply Payment for Ecosystem services (PES) as compensation measures. Watershed conservation (supply), climate control (regulation), supporting habitats (support), and recreation (culture) etc. were evaluated by calculating the economic value of these ecosystem services. Eastern, western, and northern forests and rice fields of Suncheonman-Bay were shown to have a number of core areas for the preservation of endangered species. The ecosystem service value of the additional protected areas was estimated at 17.5 million KRW/ha/year. We believe that our study result could be used to establish protected areas to preserve major habitats, as well as include areas adjacent to such major habitats that play a vital role in endangered species conservation. In addition, through this study, we highlight the need for an objective basis to establish protected areas.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2005.10a
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• pp.133-164
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• 2005

Mobile games have emerged as the most innovative entertainment technology, adding new revenue streams, taking advantage of the potential of wireless applications and service offerings. Mobile games, like any other types of computer game, offer a unique value for users in providing an exciting digital experience in virtual worlds. Players can become empowered through the development of new characters and strategies within games to achieve rewarding successes against the computers and other players. The overall trend for mobile games is towards bigger, more colorful, more involving and exciting contents, which will build upon the developing capabilities of mobile phones and networks in order to bring new styles, concepts and experiences of game play to the users. In this paper, we attempt to investigate the demographic factors which play critical roles in determining the level of playing times; classify mobile gamers based on their motives for playing games; and empirically test differences in their demographic factors and mobile game usage. Statistical results show that significant differences in playing times exist, depending upon their age, gender, mobile device, mobile phone usage, mobile game experiences, and preferred games genres. Applying Factor analysis, we have identified Escape, Social interaction, Challenge and Competition, Fantasy, Diversion and Relaxation, Ease of Accessibility as key motivators for playing mobile games. Additional cluster analysis shows that the categorization of gamers, according to their usage habits and the key motivators for playing, can be made as follows: M-gamers, Multi-gamers and Communication-focused gamers. Further correlation of these grouping with socio-economic data shows the significant differences in gaming habits and patterns of mobile phone use.

• The Journal of the Korea Contents Association
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• v.18 no.9
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• pp.510-520
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• 2018

This study explored the phenomenon of heterosexual women embracing Boys' Love manga within the heteronormativity context from a feminist psychological perspective. Specifically, the issue of genre characteristics of Boys' Love manga, women's psychological mechanism of reading Boys' Love manga, and the functions and effects of embracing Boys' Love manga were discussed. As a theoretical framework of analysis, I started from the classical psychoanalysis and critically adopted the concepts of the various camps of feminism, queer theory, and Huizinga's Homo Rudens. The results show that Boys' Love manga can be classified as a sub-category of the romance genre, which fulfills heterosexual women's desires of eternal love and equal partnership. From these wish-fulfilling fantasies, heterosexual women attempt to be decontextualized from the heteropatriarchism, to enjoy distancing and voyeuristic separation from the characters in the texts, and to disturb the dichotomous gender system through gender reversal identification. These processes, which can be regarded as a women's play challenging sexual rigorism, ultimately bring about an awareness of the female sexual subjectivity.

• Preventive Nutrition and Food Science
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• v.7 no.4
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• pp.454-460
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• 2002

While atherosclerosis is a major killer, there is now concern that mortality from the disease will increase due to the rising incidence of type II diabetes. Because diet can potentially influence both diseases, it is important to elucidate the role of diet in the progression of atherosclerosis. In addition, the mechanisms involved in dietary-related alterations of the disease need to be defined to guide public health recommendations to reduce athero-sclerosis incidence and limiting unwanted side effects. Since diet is thought to play a role in atherosclerosis even without added complications due to type II diabetes, reducing the incidence of that metabolic disease will not be enough. While evidence is increasing that high intake of carbohydrate can lead to type II diabetes and atherosclerosis, the preponderance of existing evidence indicates that intake of specific fats as a major dietary causal factor. It has recently been hypothesized that a dietary fat link to atherosclerosis may depend partly on the activity of a transcriptional regulator, the peroxisome proliferator activated receptors (PPAR). Thusfar, PPAR $\alpha$, $\beta$/$\delta$ and ${\gamma}$, have been shown to play a major role in metabolism, inflammation, and cancer. Furthermore, PPAR may regulate specific processes associated with atherosclerosis such as triglyceride and low density lipoprotein (LDL) metabolism; the reverse cholesterol transport pathway; lipid accumulation within plaques; the local inflammatory response and plaque stability. Synthetic ligands for PPAR have been developed; however, natural ligands include specific fatty acids and their metabolites. Though the role of PPAR in atherosclerosis has been reported with respect to synthetic ligands, additional studies need to be done with established and possible natural ligands. In this review, we will focus on the relation of dietary fat to PPAR alteration of atherosclerosis.

• Korean Institute of Interior Design Journal
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• v.16 no.5
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• pp.71-80
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• 2007

Although the history of the contemporary museum architecture is relatively short, the concept of its existence has changed owing to its openness to the spectators at large. Within the short period of time, it has developed into a multi functional architecture with eduinfortainment function for the general publics in concert of the changes of its social activities in addition to its innate function as a museum to meet the intellectual desires of the spectators. Therefore, this study looks Into how to suffice the ever changing Intellectual desires of the spectators and the various spatial correspondences in accordance with the social and cultural roles of the museum with purpose to present the materials of the typological characteristics of the third generation museum architecture, which shows diversifying propensity, by means of an analytical study on the characteristics of the third generation museum architecture with confidence in mind that such materials are needed in the early planning stage. The chapter 2 divides the museum architecture into three generations for a comparative analytical study and presents the three classification standards thru the preceding studies related to the museum typological classifications. In accordance with the standards, 60 selective art museums have been classified by their typological patterns. The chapter 3 shows the result of the typological space classification of the 60 art museums through an analyzation on the typological characteristics and the interrelations of them. Such study is considered to furnish important measures for the realization of the substance of the museum architecture. At the same time, it Is also judged to play an instrumental role for the theoretical system of the communication function and classification required in the early designing stage as well as to play an educational role important as the designing guide line.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.13
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• pp.699-733
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• 2000

This article analyzes the state-of-play of WTO dispute settlement for first four and a half years. Remarkable points found on this analysis are as follows: First, the Quad consisting of the United States, the European Community (EC), Canada and Japan has participated in the WTO dispute settlement mechanism more frequently than any other WTO member. Second, among developing country members some leading countries such as Korea, Brazil and India have relied actively upon the mechanism to claim and defend their rights and obligations under the WTO rules. Third, bilateral dispute settlements generally have been preferred to multilateral dispute settlements by the panel or Appellate Body. Fourth, observation of the Appellate Body proceedings well shows WTO members' strategy to use every process available to them. Fifth, the provisions of GATT 1994 have been most frequently invoked by the members. GATS and TRIPS Agreement disputes are mainly involved in developed countries, in particular the U.S. and the EC. Sixth, very high winning ratio in the panel and Appellate Body process indicates that complaining parties review the possibility to get favorable rulings even before referring to the Dispute Settlement Body (DSB) and prepare for the case very thoroughly. Seventh, roughly speaking, disputes were settled within two or three years. Therefore, seeking bilateral dispute settlement can be more advantageous to a complaining party than referring to a panel or an arbitrator because of low costs and short time period in dispute settlement. Finally, the DSB approved retaliatory actions for winning complaining parties against the defending parties who had rejected implementation of its rulings and recommendations. In conclusion, it can be said that the WTO dispute settlement mechanism has been operated very successfully for the first four and a half years. It is hoped that continued study on state-of-play of WTO dispute settlement mechanism will be contributory to improved national interest of Korea.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.15 no.4
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• pp.97-109
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• 2012

In this study this writer carried out survey and analysis on paving materials of children's playground for 40 apartment buildings with each of such apartment containing 100 households or more and which were built within last 15 years in Jeonju. As a result of analysis of such questionnaires this author could draw following conclusion. In the second half of 1990s pavement materials which were used mainly were sand and during first half of 2000s they were mixture of sand and rubber block and around 2010 they were rubber block or rubber chip pavements. Such change seemed to be a result of consideration of convenience for management and safety rather than in deference to diversity of children's outing places. Survey on the current status of pavement materials revealed need for directives by the main entity for management and their firm resolve for its implementation. And there was need for their coping with problems such as pressure of treading or lack of it or poor condition of drainage in case of sand and phenomena of pitting or dipping down, discoloring and poor drainage in case of rubber chips and rubber blocks and loosening of gaps between rubber blocks etc. Result of analysing status of usage disclosed that 50.4% of the respondents to questionnaires stated that they had experience of accidents. With regard to cause of such accident it was found that 47.5% of accidents were attributable to play facilities and 19.5% were due to paving (floor) materials thus it was disclosed that not only play facilities but also pavement materials had impact on safety for the children. Result of analysing level of satisfaction with pavement materials showed that pavement by rubber chips and blocks had higher level of satisfaction which was reflection of fear on cleanness of sand. In terms of preference rubber chip and rubber block pavements were highest and the next one was sand. Reason for such preference was based on concern with safety.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.22 no.10
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• pp.1340-1346
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• 2018

There have been researches on game continuance intention based on consumer behaviour theory of management science. Such macro access of computer game analysis might be insufficient to draw valuable results due to complex subsystem structure of recent computer games. In this paper, we choose 'Blade and Soul' game that was first published in 2012 and has been within top 20 MMORPG in Korea but known as a 'long time users' only game'among game players recently. Three user groups - long loyalty, concentrated, casual - are classified based on their play history and play time per day of Blade and Soul. The first survey with 222 subjects revealed that the real strength of the game was not the combat - Dungeon, Arena, Battleground competition - but very cohesive game community Blade and Soul has. Thus, we conduct another survey on the game community issues among 148 long time users (over 3 years playing history) and analyze their traits and behaviour patterns.