• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6023-6026
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• 2012

The incidence of hepatocellular carcinoma (HCC) in Malaysia for the year 2001 was 2.8 per 100,000 people. The mortality rate is increasing. A retrospective cohort study measuring the survival of HCC patients who received treatment in Selayang Hospital was conducted from 1 January 2003 to 31 December 2006. The main objectives of the study were to measure the survival of the patients and to understand the influencing factors, especially ethnicity. The subjects were newly diagnosed cases of HCC by CT scan and histopathological assessment who underwent futher investigations and treatments in Hospital Selayang (inception cohort). The survival time was measured from the date of diagnosis until the subjects died, or failed to follow-up at the end of the study period (31 December 2007). A total of 299 patients were selected with 95 patients dying, the majority among Chinese (39.1%). Subgroup analysis according to ethnicity proved significantly that Chinese patients who had smaller tumor, less number of nodules, low AFP level, Child Pugh Class A and received surgical treatment had a better median survival rate compared to other ethnic groups. Malay (cHR: 1.3, 95%CI; 0.89-1.85) and Indian (cHR: 1.3, 95%CI; 0.74-2.26) patients had a poor survival compared to Chinese patients, but not in the final model. Therefore ethnicity may play a role in survival of HCC patients, but not as a main hazard prognostic factor.

• Safety and Health at Work
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• 제3권3호
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• pp.155-165
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• 2012

Reflecting the current international trends toward proactive risk assessment and control at work with practical procedures, participatory action-oriented approaches are gaining importance in various sectors. The roles of these approaches in promoting the safety and health at work are discussed based on their recent experiences in preventing work-related risks and improving the quality of work life, particularly in small-scale workplaces. The emphasis placed on the primary prevention at the initiative of workers and managers is commonly notable. Participatory steps, built on local good practices, can lead to many workplace improvements when the focus is on locally feasible low-cost options in multiple aspects. The design and use of locally adjusted action toolkits play a key role in facilitating these improvements in each local situation. The effectiveness of participatory approaches relying on these toolkits is demonstrated by their spread to many sectors and by various intervention studies. In the local context, networks of trainers are essential in sustaining the improvement activities. With the adequate support of networks of trainers trained in the use of these toolkits, participatory approaches will continue to be the key factor for proactive risk management in various work settings.

• Toxicological Research
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• 제24권3호
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• pp.161-167
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• 2008

Recently, arsenic-toxicity has become the major focus of strenuous assessment and dynamic research from the academy and regulatory agency. To elucidate the cause and the mechanism underlying the serious adverse health effects from chronic ingestion of arsenic-contaminated drinking water, numerous studies have been directed on the investigation of arsenic-toxicity using various in vitro as well as in vivo systems. Neverthless, some questions for arsenic effects remain unexplained, reflecting the contribution of unknown factors to the manifestation of arsenic-toxicity. Interestingly, very recent studies on arsenic metabolites have discovered that trivalent methylated arsenicals show stronger cytotoxic and genotoxic potentials than inorganic arsenic or pentavalent metabolites, arguing that these metabolites could play a key role in arsenic-associated disorders. In this review, recent progress and literatures are summarized on the metabolism of trivalent methylated metabolites and their toxicity on body systems including cardiovascular system in an effort to provide an insight into the future research on arsenic-associated disorders.

• 말소리와 음성과학
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• 제6권4호
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• pp.161-169
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• 2014

This study investigated changes in the prelinguistic vocal production of typically developing infants aged 5-20 months based on Stark Assessment of Early Vocal Development-Revised (SAEVD-R). Fifty-eight typically developing infants participated in the study, and they were divided into four age groups, 5-8 months, 9-12 months, 13-16 months, and 17-20 months of age. Vocalization samples were collected from infants' play activities and were classified into 5 levels and 23 types using SAEVD-R. The results revealed that the four age groups showed significant differences in production proportion of vocalization levels. Level 1, 2, 4, and 5 vocalizations exhibited significantly different across the four age groups. Level 3 was predominantly produced across every age group. Therefore, the vocalization level was not significantly different across the four age groups. Especially, vowels in Level 3 vocalization predominantly produced across all ages during a long period. Also, significant increases in the proportion of Levels 4 and 5 occurred after 9 months, which suggested that the production of cannonical syllables is a key indicator of advancement in prelinguistic vocal development. The results have clinical implication in early identification and speech-language intervention for young children with speech delays or at risk.

• 말소리와 음성과학
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• 제9권4호
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• pp.59-67
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• 2017

Regardless of their intention, listeners tend to assess speakers' personalities based on the sounds of the speech they hear. Assessment criteria, however, have not been fully investigated to indicate whether there is any relationship between the acoustic cue of produced speech sounds and perceived personality impression. If properly investigated, the potential relationship between these two will provide crucial insights on the aspects of human communications and further on human-computer interaction. Since human communications have distinctive characteristics of simultaneity and complexity, this investigation would be the identification of minimum essential factors among the sounds of speech and perceived personality impression. The purpose of this study, therefore, is to identify significant associations between the speech sounds and perceived personality impression of speaker by the listeners. Twenty eight subjects participated in the experiment and eight acoustic parameters were extracted by using Praat from the recorded sounds of the speech. The subjects also completed the Neo-five Factor Inventory test so that their personality traits could be measured. The results of the experiment show that four major factors(duration average, pitch difference value, pitch average and intensity average) play crucial roles in defining the significant relationship.

• Child Health Nursing Research
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• 제24권2호
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• pp.186-198
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• 2018

Purpose: The purpose of this study was to determine the needs for children's health promotion education programs as perceived by child care center teachers and mothers. Methods: This study conducted a survey of 88 child care center teachers and 70 mothers of preschool children in Seoul from January 4 to February 5, 2016. This study aimed to characterize the current conditions of health promotion education for preschool children and the needs for health promotion education as perceived by child care center teachers and mothers of preschool children. Results: Areas of high need for health promotion education included lifestyle improvements for preventing diseases in children and awareness of the importance of health in educational objectives, standardized educational manuals, health educators as educators, child care centers as educational places, local health centers as educational support organizations, regular class hours as educational time, role play for training, and actual models in the educational medium. The educational subjects for which a high need was reported included safety and accident prevention, the role of smartphones and TV watching in mental health, and personal hygiene and disease prevention. Conclusion: These findings suggest that it is necessary to develop a health promotion education program for preschool children.

• 수면정신생리
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• 제13권1호
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• pp.22-26
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• 2006

Circadian rhythms have been observed to be disturbed in mood disorders, especially seasonal affective disorder (SAD). Clock related gene variants also have been suggested to be associated with seasonality (seasonal variations in mood and behavior). This study tested the potential association between a length polymorphism of Period3 gene and seasonal variations in mood and behavior. 297 Korean college students were genotyped for the Period3 polymorphism and were for evaluated the seasonal variation by Seasonal Pattern Assessment Questionnaire (SPAQ). The genotype frequencies were 0.76 for 4R/4R, 0.22 for 4R/5R and 0.013 for 5R/5R. The global seasonality score was not different among Period3 gene variants (4R/4R, 4R/5R and 5R/5R) except for 'sleep length' subscore. The 5R/5R genotype showed the higher 'sleep length' subscore than others (p=0.024). The comparison between seasonals (syndromal plus subsyndromal SAD determined by SPAQ) and non-seasonals did not show any significant difference in frequencies of genotypes. These findings suggest that there is a possibility that the investigated Period3 polymorphism may play a partial role in the susceptibility of seasonal variations in a Korean population.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.4813-4820
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• 2015

Gastric cancer (GC) is one of the most common cancers, with high incidences in East Asia countries. Most GC patients have been reported with low early diagnosis rate and show extremely poor prognosis. Therefore, it is necessary to develop novel and more sensitive biomarkers to improve early diagnosis and therapy in order to provide longer survival and better quality of life for gastric cancer patients. MicroRNAs (miRNAs) play crucial roles in GC development and progression. miRNAs have emerged as a novel molecular biomarker for cancer diagnosis, prognosis and therapy with surprising stability in tissues, serum or other body fluids. This review summarizes major advances in our current knowledge about potential miRNA biomarkers for GC that have been reported in the past two years.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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• pp.121-122
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• 2001

According to the epidemiological studies in chromium workers, hexavalent chromium is associated with the risk of lung cancer. Genotoxicity such as chromosome aberration, and cellular oxidative damages by reactive oxygen species produced by hexavalent chromium exposure may play an important role in the carcinogenesis process. We investigated the availabilities of several kinds of biological markers to assess the genotoxicity and oxidative damages from chromium exposure in Korean chromium plating workers.(omitted)

• 한국작물학회:학술대회논문집
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• 한국작물학회 2005년도 국제학술회의
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• pp.75-87
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• 2005

Remote sensing(RS)- and geographic information system(GIS)-based information management to measure and assess agri-environment schemes, and to quantify and map environment indicators for nature and land use, climate change, air, water and energy balance, waste and material flow is in high demand because it is very helpful in assisting decision making activities of farmers, government, researchers, and consumers. The versatility and ability of RS and GIS containing huge soil database to assess agricultural environment spatially and temporally at various spatial scales were investigated. Spectral and microwave observations were carried out to characterize crop variables and soil properties. Multiple sources RS data from ground sensors, airborne sensors, and also satellite sensors were collected and analyzed to extract features and land cover/use for soils, crops, and vegetation for support precision agriculture, soil/land suitability, soil property estimation, crop growth estimation, runoff potential estimation, irrigated and the estimation of flooded areas in paddy rice fields. RS and GIS play essential roles in a management and monitoring information system. Biosphere-atmosphere interection should also be further studied to improve synergistic modeling for environment and sustainability in agri-environment schemes.