• 한국항행학회논문지
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• 제16권2호
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• pp.271-277
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• 2012

본 논문에서는 재난모니터링, 환경감시 및 재난구호 등의 정보 수집 및 정찰 등의 임무를 수행하는 다수의 UAV들로 구성된 편대비행 네트워크를 위해 동적 트리 형성 프로토콜을 제안하였다. 특히 무선 동적 환경에 적응한 최적의 트리를 구성하기 위한 링크 비용을 구하기 위해 거리에 따른 무선 신호 감쇄현상을 적용하여 Hop-LQI Weight 알고리즘을 고안하였으며 이를 MSP430 K-mote 센서 플랫폼에 TinyOS 코드를 구현하였다. 이를 무선 통신에서 링크 비용 산출 기법인 Minimum LQI 방법과 노드 수에 따른 평균 경로 설정시간을 비교를 통하여 성능을 검증하였다.

• Journal of Microbiology and Biotechnology
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• 제23권6호
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• pp.779-784
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• 2013

Leptospirosis is a worldwide zoonosis of global concern caused by Leptospira interrogans. The availability of ligand libraries has facilitated the search for novel drug targets using chemogenomics approaches, compared with the traditional method of drug discovery, which is time consuming and yields few leads with little intracellular information for guiding target selection. Recent subtractive genomics studies have revealed the putative drug targets in peptidoglycan biosynthesis pathways in Leptospira interrogans. Aligand library for the murD ligase enzyme in the peptidoglycan pathway has also been identified. Our approach in this research involves screening of the pre-existing ligand library of murD with related protein family members in the putative drug target assembly in the peptidoglycan biosynthesis pathway. A chemogenomics approach has been implemented here, which involves screening of known ligands of a protein family having analogous domain architecture for identification of leads for existing druggable protein family members. By means of this approach, one murC and one murF inhibitor were identified, providing a platform for developing an anti-leptospirosis drug targeting the peptidoglycan biosynthesis pathway. Given that the peptidoglycan biosynthesis pathway is exclusive to bacteria, the in silico identified mur ligase inhibitors are expected to be broad-spectrum Gram-negative inhibitors if synthesized and tested in in vitro and in vivo assays.

• Molecules and Cells
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• 제39권2호
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• pp.77-86
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• 2016

Cancer is a heterogeneous disease caused by diverse genomic alterations in oncogenes and tumor suppressor genes. Despite recent advances in high-throughput sequencing technologies and development of targeted therapies, novel cancer drug development is limited due to the high attrition rate from clinical studies. Patient-derived xenografts (PDX), which are established by the transfer of patient tumors into immunodeficient mice, serve as a platform for co-clinical trials by enabling the integration of clinical data, genomic profiles, and drug responsiveness data to determine precisely targeted therapies. PDX models retain many of the key characteristics of patients' tumors including histology, genomic signature, cellular heterogeneity, and drug responsiveness. These models can also be applied to the development of biomarkers for drug responsiveness and personalized drug selection. This review summarizes our current knowledge of this field, including methodologic aspects, applications in drug development, challenges and limitations, and utilization for precision cancer medicine.

• 한국산학기술학회논문지
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• 제13권5호
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• pp.2338-2346
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• 2012

향후 모바일 어플리케이션 규모는 커질 것으로 예상되며 이에 따라 다른 모바일 어플리케이션과 또는 서버와의 결합도가 커질 것이다. 모바일 어플리케이션 규모의 증가는 가변성을 위한 예측 설계가 수반되어야 함을 의미한다. 현재 모바일 어플리케이션 변경이 발생할 경우 어플리케이션 전체를 재설치 해야 한다. 그러나 이러한 재설치는 결합도가 큰 어플리케이션인 경우 부작용(Side-Effect)이 발생할 가능성이 높다. 따라서 본 논문에서는 안드로이드 플랫폼 기반에서 어플리케이션 가변성에 대해 설계할 수 있는 기법을 제안한다. 이러한 모바일 가변성 기법은 선택 기법과 플러그인 기법으로 구분한다.

• 한국콘텐츠학회논문지
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• 제12권6호
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• pp.92-99
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• 2012

모바일 어플리케이션 규모는 급성장하고 있으며, 이에 따라 모바일과 웹 서비스와의 결합도가 높은 어플리케이션들이 증가하고 있다. 이러한 모바일 어플리케이션의 증가는 가변성을 고려한 개발이 이루어져야 함을 의미한다. 현재 웹 서비스와 연동하는 모바일 어플리케이션을 변경할 경우 어플리케이션 전체를 재설치 해야 한다. 그러나 이러한 재설치는 결합도가 큰 어플리케이션인 경우 부작용이 발생할 가능성이 높다. 따라서 본 논문에서는 안드로이드 플랫폼 기반에서 웹 서비스와 연동 시 웹 서비스 프로토콜을 변경하기 위한 커스터마이제이션 기법을 제안한다. 프로토콜 커스터마이제이션 기법은 선택 기법과 플러그인 기법으로 구분한다.

• Corrosion Science and Technology
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• 제16권2호
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• pp.76-84
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• 2017

In the construction of subsea oil and gas developments, it is increasingly common that subsea oil and gas equipment will be installed in subsea well before final hookup and production. Installation of wellheads, subsea hardware, pipelines, and surface facilities (platforms, FPSO, FLNG, connected terminals, or gas plants) are increasingly driven by independent cost and vessel availability schedules; this gives rise to requirements that the subsea facilities must be stored in the seabed for a specific time. In addition, schedule delays, particularly in the installation or startup of the connected platform, FPSO, FLNG, or onshore plant may cause unexpected extensions of the intended storage period. Currently, there are two methods commonly used for storage subsea facilities in the seabed: dry parking and wet parking. Each method has its own risks, challenges, and implications for the facility life and its integrity. The corrosion management and preservation method selection is a crucial factor to be considered in choosing the appropriate storage method and achieving a successful seabed storage. An overview of those factors is presented, along with a discussion on the internal corrosion threats and assessments.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권9호
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• pp.3034-3055
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• 2014

Wireless Sensor Networks have extensively been utilized for ambient data collection from simple linear structures to dense tiered deployments. Issues related to optimal resource allocation still persist for simplistic deployments including linear and hierarchical networks. In this work, we investigate the case of dimensioning parameters for linear and tiered wireless sensor network deployments with notion of providing extended lifetime and reliable data delivery over extensive infrastructures. We provide a single consolidated reference for selection of intrinsic sensor network parameters like number of required nodes for deployment over specified area, network operational lifetime, data aggregation requirements, energy dissipation concerns and communication channel related signal reliability. The dimensioning parameters have been analyzed in a pipeline monitoring scenario using ZigBee communication platform and subsequently referred with analytical models to ensure the dimensioning process is reflected in real world deployment with minimum resource consumption and best network connectivity. Concerns over data aggregation and routing delay minimization have been discussed with possible solutions. Finally, we propose a node placement strategy based on a dynamic programming model for achieving reliable received signals and consistent application in structural health monitoring with multi hop and long distance connectivity.

• 한국컴퓨터정보학회논문지
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• 제25권4호
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• pp.71-77
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• 2020

블록체인의 핵심기술인 합의알고리즘을 통하여 연결 노드 간 동일한 데이터를 정확하게 공유한다. 사용자 및 활용 환경을 고려한 적절한 합의 알고리즘 사용은 데이터 무결성 및 정확성 등을 효율적으로 유지하도록 한다. 본 논문에서는 프라이빗 블록체인 플랫폼의 특징을 고려하여 허가된 노드 간 합의 알고리즘 효율적 선정을 위한 성능평가방법을 제시하였으며 권위를 가진 연결노드의 수를 고려하여 해당 항목을 기존 공개된 수식에 변형하여 적용하였다. 이러한 과정을 통하여 노드 간 안정성을 고려한 합의과정의 단순화가 가능하였다. 제안한 연구내용을 통한 적절한 합의 알고리즘 선정을 통하여 합의 과정의 안정성을 높일 수 있다.

• Journal of Power Electronics
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• 제19권3호
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• pp.655-664
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• 2019

In order to analyze the nonlinear phenomena of the bifurcation and chaos caused by the switching of nonlinear switching devices in inductively coupled power transfer (ICPT) systems, a Jacobian matrix model, based on discrete mapping numerical modeling, is established to judge the system stability of the periodic closed orbit and to study the nonlinear behavior of Hopf bifurcation in a system under full resonance. The general flow of the parameter design, based on the stability principle for ICPT systems, is proposed to avoid the chaos and bifurcation phenomena caused by unreasonable parameter selection. Firstly, based on the state equation of SS-type compensation, a three-dimensional bifurcation diagram with the coupling coefficient as the bifurcation parameter is established with a numerical simulation to observe the nonlinear phenomena in the system. Then Filippov's method based on a Jacobian matrix model is adopted to deduce the boundary of stable operation and to judge the type of the bifurcation in the system. Then the general flow of the parameter design based on the stability principle for ICPT systems is proposed through the above analysis to realize stable operation under the conditions of weak coupling. Finally, an experimental platform is built to confirm the correctness of the numerical simulation and modeling.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권6호
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• pp.2069-2085
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• 2021

A Social Networking Service (SNS) platform provides digital footprints to discover users' interests and track the social diffusion of product adoptions. How to identify a small set of seed users in a SNS who is potential to adopt a new promoting product with high probability, is a key question in social networks. Existing works approached this as a social influence maximization problem. However, these approaches relied heavily on text information for topic modeling and neglected the impact of seed users' relation in the model. To this end, in this paper, we first develop a general product adoption function integrating both users' interest and social influence, where the user interest model relies on historical user behavior and the seed users' evaluations without any text information. Accordingly, we formulate a product adoption maximization problem and prove NP-hardness of this problem. We then design an efficient algorithm to solve this problem. We further devise a method to automatically learn the parameter in the proposed adoption function from users' past behaviors. Finally, experimental results show the soundness of our proposed adoption decision function and the effectiveness of the proposed seed selection method for product adoption maximization.