• Journal of the Korean Society of Safety
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• v.29 no.1
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• pp.47-53
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• 2014

The application of advanced Main Control Room(MCR) is accompanied with lots of changes and different forms and features through the virtue of new digital technologies. The characteristics of these digital technologies and devices give many opportunities to the interface management, and can be integrated into a compact single workstation in advanced MCR so that workers can operate the plant with minimum physical burden under any operation conditions. However, these devices may introduce new types of human errors and thus a means to evaluate and prevent such errors is needed, especially those related to characteristics of digital devices. This paper reviewed the new type of human error hazards of tasks based on digital devices and surveyed researches on physiological assessment related to human error. An experiment was performed to verify human error hazards by physiological responses such as EEG which was measured to evaluate the cognitive workload of operators. And also, the performances of four tasks which are representative in human error hazard tasks based on digital devices were compared. Response time, ${\beta}$ power spectrum rate of each task by EEG, and mental workload by NASA-TLX were evaluated. In the results of the experiment, the rate of the ${\beta}$ power was increased in the task 1 and task 4 which are searching and navigating task and memory task of hierarchical information, respectively. In case of the mental workload, in most of evaluation items, task 1 and 4 were highly rated comparatively. In this paper, human error hazards might be identified by highly cognitive workload. Conclusively, it was concluded that the predictive method which is utilized in this paper and an experimental verification can be used to ensure the safety when applying the digital devices in Nuclear Power Plants (NPPs).

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.10a
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• pp.201-204
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• 2017

People live in their everyday life busy with studies, part-time jobs, and searching for an ideal job. In their busy routine, they try to find time for themselves and expose their emotions through diverse social network services(SNS). We made a service that we can plant a virtual tree in places we daily visit and go by. You can keep note on the virtual tree and look through the past records. It is a reality based mobile application service that can be used like a diary.In this project we chose the tree as the metaphor and tried to express time passing in a specific place. As our memory is a part of our daily life, we emphasized the meaning of space important.

• Nutrition Research and Practice
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• v.16 no.2
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• pp.173-193
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• 2022

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is one of the most representative neurodegenerative disease mainly caused by the excessive production of amyloid beta (Aβ). Several studies on the antioxidant activity and protective effects of Populus tomentiglandulosa (PT) against cerebral ischemia-induced neuronal damage have been reported. Based on this background, the present study investigated the protective effects of PT against cognitive impairment in AD. MATERIALS/METHODS: We orally administered PT (50 and 100 mg/kg/day) for 14 days in an Aβ_25-35-induced mouse model and conducted behavioral experiments to test cognitive ability. In addition, we evaluated the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and measured the production of lipid peroxide, nitric oxide (NO), and reactive oxygen species (ROS) in tissues. RESULTS: PT treatment improved the space perceptive ability in the T-maze test, object cognitive ability in the novel object recognition test, and spatial learning/long-term memory in the Morris water-maze test. Moreover, the levels of AST and ALT were not significantly different among the groups, indicating that PT did not show liver toxicity. Furthermore, administration of PT significantly inhibited the production of lipid peroxide, NO, and ROS in the brain, liver, and kidney, suggesting that PT protected against oxidative stress. CONCLUSIONS: Our study demonstrated that administration of PT improved Aβ_25-35-induced cognitive impairment by regulating oxidative stress. Therefore, we propose that PT could be used as a natural agent for AD improvement.

• Journal of the Korean Society of Systems Engineering
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• v.18 no.2
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• pp.94-107
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• 2022

Accidents prevention and mitigation is the highest priority of nuclear power plant (NPP) operation, particularly in the aftermath of the Fukushima Daiichi accident, which has reignited public anxieties and skepticism regarding nuclear energy usage. To deal with accident scenarios more effectively, operators must have ample and precise information about key safety parameters as well as their future trajectories. This work investigates the potential of machine learning in forecasting NPP response in real-time to provide an additional validation method and help reduce human error, especially in accident situations where operators are under a lot of stress. First, a base-case SGTR simulation is carried out by the best-estimate code RELAP5/MOD3.4 to confirm the validity of the model against results reported in the APR1400 Design Control Document (DCD). Then, uncertainty quantification is performed by coupling RELAP5/MOD3.4 and the statistical tool DAKOTA to generate a large enough dataset for the construction and training of neural-based machine learning (ML) models, namely LSTM, GRU, and hybrid CNN-LSTM. Finally, the accuracy and reliability of these models in forecasting system response are tested by their performance on fresh data. To facilitate and oversee the process of developing the ML models, a Systems Engineering (SE) methodology is used to ensure that the work is consistently in line with the originating mission statement and that the findings obtained at each subsequent phase are valid.

• Korean Journal of Agricultural Science
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• v.49 no.1
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• pp.137-149
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• 2022

We investigated the effects of Cirsium japonicum var. maackii (CJM) against oxidative stress-induced C6 glial cells and cognitive impairment in mice. To evaluate the anti-oxidative effect of the extract and fractions from CJM, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), reactive oxygen species (ROS), and nitric oxide (NO) assays were conducted in H₂O₂-treated C6 glial cells. Furthermore, we identified the protective mechanisms of CJM with a scopolamine-treated mice model. The results revealed that H₂O₂ decreased the cell viability in C6 glial cells, indicating that H₂O₂ induced oxidative stress in glial cells. However, CJM fractions significantly increased cell viability in H₂O₂-treated C6 glial cells, which suggested that CJM protected against oxidative stress. CJM extract and fractions also reduced ROS and NO production, which were increased by H₂O₂ in C6 glial cells. In particular, the EtOAc fraction from CJM (EACJM) effectively protected against oxidative stress by increasing the cell viability and decreasing ROS and NO. Therefore, we carried out further in vivo experiments with EACJM. Scopolamine caused increases of ROS, thiobarbituric acid reactive substances (TBARS), and NO production. However, EACJM effectively alleviated ROS, TBARS, and NO levels compared to scopolamine-injected mice. In addition, EACJM up-regulated protein expressions of superoxide dismutase and glutathione peroxidase, indicating that EACJM enhanced the antioxidative system. Our results demonstrated that CJM had protective effects against oxidative stress in glial cells and memory dysfunction in mice. Based on these results, we propose that CJM could be a potential AD preventive and therapeutic agent.

• Korean Journal of Environment and Ecology
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• v.20 no.3
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• pp.311-318
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• 2006

In an estuary, ecological dynamic is modified for a long time and memorized in soils and landscapes. As landscape memory, ecological motif is defined with dominance and rarity of vegetation. The purpose of the study is to investigate the existing vegetation character and to propose the ecological motif of this area. The present salt-water plants, community species composition and constancy degree around the estuary in Buandam watershed Buan-gun, Jeollabuk-do were analyzed. The results are as follows. The flora of the salt-water plants was listed as 16 taxa; 6 families,13 genera,14 species and 2 varieties. 5 taxa were Gramineae, 4 taxa Chenopodiaceae, and 4 taxa Comrositae. The salt-water plant communities are a total of 10 communities as listed; Zoysia sinica-Artemisia scoparia community, Phacelurus latifolius community, Artemisia scoparia Cnidium japonicum community, Limonium tetragonum -Artemisia scoparia community, Artemisia scoparia community, Suaeda japonica community, Elymus dahuricus community, Suaeda asparagoides community, Zoysia sinica community, and Zoysia sinica-Suaeda japonica community. Analyzed by the community classification species class of constancy degree, Phacelurus latifolius, Cnidium japonicum, Limonium tetragonum, Suaeda japonica, Elymus dahuricus and Suaeda asparagoides belong to I, Zoysia sinica and Artemisia scoparia to II. Elymus dahuricus, Setaria viridis var. pachystachys, Echinochloa crusgalli var. oryzicola, Phacelurus latifolius, Atriplex gmelini, Salicornia herbacea, Calystegia soldanella and Aster tripolium belong to the accompaniment species to I: Zoysia sinica, Suaeda asparagoides, Artemisia capillaris to II; Suaeda japonica, Artemisia scoparia to III ; Cnidium japonicum to IV: Limonium tetragonum, Artemisia fukudo to V. And the ecological motif is the Phacelurus latifolius community.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.4
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• pp.361-370
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• 2017

Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM symptoms, we constructed a FM animal model induced by restraint stress with intermittent cold stress. All mice underwent nociceptive assays using electronic von Frey anesthesiometer and Hargreaves equipment. To assess the relationship between tianeptine and expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), and phosphorylated cAMP response element-binding protein (p-CREB), western blotting and immunohistochemistry analyses were performed. In behavioral analysis, nociception tests showed that pain threshold was significantly decreased in the FM group compared to that in the control group. Western blot and immunohistochemical analyses of medial prefrontal cortex (mPFC) and hippocampus showed downregulation of BDNF and p-CREB proteins in the FM group compared to the control group. However, tianeptine recovered these changes in behavioral tests and protein level. Therefore, this FM animal model might be useful for investigating mechanisms linking BDNF-CREB pathway and pain. Our results suggest that tianeptine might potentially have therapeutic efficacy for FM.

• Journal of the Korean Institute of Landscape Architecture
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• v.38 no.4
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• pp.1-10
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• 2010

The scientific verification of the physiological and psychological effects that result from interaction with green plants would not only provide objective knowledge on the psychological effect of green but would also establish useful grounds for the creation of green spaces that consider human emotions. The present study measured the cerebral activity(cerebral blood flow) and the autonomic nervous system activity (blood pressure, pulse rate, amylase) of fifteen Korean male subjects as they inhaled the natural scent diffused by pine needles. Impression and mood state evaluations of the reactions to the pine scent were carried out using the SD method and POMS. Cerebral activity was observed to be significantly activated in the feeling, judgment, and motor areas of the frontal lobe, as well as the memory area in the temporal lobe. Verbal evaluations by the SD method and POMS indicated a pine scent left natural but stimulated and active impressions, provided vigor, and also reduced confusion. The autonomic nervous system activities, however, showed no significant differences. These findings verified scientifically that a pine scent vitalizes humans both physiologically and psychologically. These results could be useful as fundamental data for the design of green spaces that consider human emotional aspects.

• Korean Journal of Remote Sensing
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• v.31 no.5
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• pp.395-408
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• 2015

High-resolution satellite image mosaics are becoming increasingly important in the field of remote sensing image analysis as an essential image processing to create a large image constructed from several smaller images. In this paper, we present an automatic seamline extraction technique and the procedure to generate a mosaic image by this technique. For more effective seamline extraction in the overlap region of adjacent images, an NDVI-based seamline extraction technique is developed, which takes advantage of the computational time and memory. The Normalized Difference Vegetation Index(NDVI) is an index of plant "greeness" or photosynthetic activity that is employed to extract the initial seamline. The NDVI can divide into manmade region and natural region. The cost image is obtained by the canny edge detector and the buffering technique is used to extract the ranging cost image. The seamline is extracted by applying the Dijkstra algorithm to a cost image generated through the labeling process of the extracted edge information. Histogram matching is also conducted to alleviate radiometric distortion between adjacent images acquired at different time. In the experimental results using the KOMPSAT-2/3 satellite imagery, it is confirmed that the proposed method greatly reduces the visual discontinuity caused by geometric difference of adjacent images and the computation time.

• Proceedings of the Ginseng society Conference
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• 1984.09a
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• pp.97-105
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• 1984

Effect of water extract of red ginseng (Panax ginseng C.A. Meyer) from Nagano prefecture on (1) forced exercise in mice using rope climbing test, (2) extinction of memory in hanging stressed mice and rectal temperature during the exposure to hanging stress, (3) sex and learning behavior of chronic hanging stressed mice, (4) sex cycle in the adult female mice using chronic hanging stress, and (5) motor coordination and one trial passive avoidance response in $40\%$ alcohol administered mice using rotar-rod and step-through tests, were studied. Drugs tested were given orally. (1) When it was given before the forced exercise, it potentiated the performance of the forced exercise. When it was given just after the forced exercise once a day for 2 weeks, it protected the mice against the reduction of the performance on the forced exercise. (2) When it was given just after the stress once a day for 4 days, it delayed the extinction of passive avoidance response in both step through and stepdown tests, and protected the stressed mice against the decrease in rectal temperature slightly. (3) It protected the stressed mice against the decrease of sex behaviour and the increase in the failure of performance of passive avoidance response, and delayed the extinction of passive avoidanc