• Korean Journal of Pharmacognosy
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• v.46 no.1
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• pp.84-92
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• 2015

Tyrosinase is a key enzyme to control the biosynthesis of melanin pigments and has two enzyme activities, namely of 1-tyrosine hydroxylase and of 1-dopa oxidase. Thus, tyrosinase is regarded as a target in skin-whitening and therapeutic intervention of local hyperpigmentation diseases. We have tested tyrosinase inhibitory activity on the water extracts of 50 species oriental medicinal plant. Among them, five medicinal plants, Linderae Radix, Clematidis Radix, Cinnamomi Cortex Spissus, Fritillariae Thunbergii Bulbus and Bulbus Fritillariae Cirrhosae were investigated strong inhibition effect. Five medicinal plants were fractionated using organic solvents (methylene chloride, ethyl acetate, n-butanol, water). Cinnamomi Cortex Spissus (ethyl acetate fraction) was investigated strong inhibition effect. Tyrosinase inhibitory activity below $IC_{50}\;40{\mu}g/ml$ is confirmed in five herbal plants that are Linderae Radix, Clematidis Radix, Cinnamomi Cortex Spissus, Fritillariae Thunbergii Bulbus and Bulbus Fritillariae Cirrhosae. Tyrosinase inhibitory levels ($IC_{50}\;{\mu}g/ml$) of each plants were 15.56, 35.02, 25.14, 15.20 and 39.77. We also investigate the effect of effective plant's fraction. in dose of $100{\mu}g/ml$, Cinnamomi Cortex Spissus (P-36) EtOAc fraction significant inhibitory effect over 50%. Clematidis Radix (P-35) and Cinnamomi Cortex Spissus (P-36) MC fraction inhibit tyrosinase each 36.60% and 43.21%. inhibitory rates of Fritillariae Thunbergii Bulbus (P-40) EtOAc and $H_2O$ fraction are 31.40% and 31.51%. Bulbus Fritillariae Cirrhosae (P-45) BuOH fraction regulate tyrosinase activity to 37.71%. We examined tyrosinase inhibitory activity of natural products and these results suggest that several herbs have potential as a new whitening material.

• The Journal of Pediatrics of Korean Medicine
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• v.29 no.2
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• pp.59-77
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• 2015

Objectives Medical plant has a big role in Herbal Medicines, and most medical plant has phytoestrogens. Therefore some estrogenic effects have been reported in a lot of Korean Medicine literature. Phytoestrogens should be used carefully in children. The objective of this study is to identify reported phytoestrogenic effects in Herbal Medicines and to evaluate the characteristics of the phytoestrogens in Herbal Medicines. Methods A literature search was done with using 8 databases with a limit of reports until 12/31/2013. The estrogenic effects were summarized by each individual Korean Medicine. The frequency of the phytoestrogens was also investigated depending on the Korean medical categorization by the treatment effect. Results and Conclusions Phytoestrogenic effects were reported in 89 Herbal Medicines. Phytoestrogens were act bidirectionally, and the effect was fairly weak compared to estrogen. Phytoestrogenic effect was variable on different cells and tissues. The most frequent phytoestrogenic effect was in tonifying and replenishing medicinal, the following orders were heat-clearing, exterior-releasing, and blood-activating and stasis-dispelling medicinal. Phytoestrogens were not reported in dampness-resolving, digestant, orifice-opening, emetic medicinal.

• Proceedings of the Plant Resources Society of Korea Conference
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• 1996.09a
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• pp.16-26
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• 1996

• Korean Journal of Plant Resources
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• v.31 no.1
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• pp.1-9
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• 2018

As a part of an infrastructure project on medicinal herb-based remedies, we conducted a phytohemical investigation of the 100% MeOH extract from the aerial part of Boehmeria quelpaertense; our findings resulted in the isolation of flavonoids (1-2), isoquercitrin (1) and hyperoside (2). The identification and structural elucidation of these compounds were based on $^1H$-, $^{13}C-NMR$, and LC ESI IT-TOF MS data. All the compounds isolated from this plant were reported for the first time. In this study, we examined the antioxidant activity of the 1 and 2 on the hydrogen peroxide ($H_2O_2$)-induced oxidative stress in a Rat Cardiomyoblast cell line (H9c2). The pretreatment of the flavonoids showed that it protects against $H_2O_2$-mediated cell death in the H9c2 cell line. Also, it decreases the intracellular reactive oxygen species (ROS) levels by the flavonoids in the $H_2O_2$-treated H9c2 cell line. These results showed that the 1 and 2 are a source of antioxidants. As a result, they might be helpful in preventing the progress of various oxidative stress mediated diseases, including myocardial infarction.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2002.07a
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• pp.242-242
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• 2002

The root of Rumex crispus(Polygonaceae) has been used as one of many oriental medicines ofr the treatment of cathartics, juandice and skin diseases etc. Recently, it is reported as one of anticancer agents and a remedy of acute hepatitis in many traditional medicines. Also, the seed of this plant has been used as a folk medicine for the treatment of digestion problems, liver diseases and many sorts of tumors. In this study we have collected the seed of this plant in rural area and investigated the efficacy of hepatoprotective activity from liver cell damage induced by carbon tetrachloride on mice with methanol extracts, ethylacetate and butanol fractions of this plant

• Korean Journal of Plant Resources
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• v.3 no.2
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• pp.107-114
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• 1990

In view of the results to have measured metallic elements which is included in 45 sorts of herb medicines and surveyed their distribution, 8 kinds ofmetals including Co, Ge, Ga, TL, Cd, As, 8i, Pb, are never or little includedin almost herb medicines . Other twenty-five sorts of elements (Mo, Sc, Be, V,Ni, Sn, Se, Ba, Cr, Sb, Si, Ti, B, Li, Mg, Ca, Cr, Mn, Fe, Cu, Zn, p, Al, Na,K) are more or Less included in all herb Bedicines ana Na, Ca, p and K aremetals that are included in Large quentities in comrarison with others . Patri-uiae Radix Contains 7 kinds of metal lic elements more than other herb medicinesdoes .

• The Journal of Internal Korean Medicine
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• v.15 no.2
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• pp.70-108
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• 1994

The kinds and remedies of intoxication were investigated throughout total 22 books of oriental medicine. The results are as follows 1. The kinds of intoxication were 91, most of which were plant intoxications and animal intoxications. 2. The kinds of detoxication medicines was 203, the most popularly prescribed of which were Radix Glycyrrhizae Semen Glycine. 3. The prescribed medicines were most nonpoisonous ones, but some of them were poisonous. 4. The medicines with Han seong(寒性) were most popularly prescribed. The ones with On seong(溫性), Pung seong(平性), Youl seong(熱性), Yang seong(凉性) follows 5. The most popularly prescribed medicine was sweet taste(甘味). The nest ones were pungent taste(辛味), bitter taste(苦味), sour taste(酸味), salty taste(鹹味). 6. The most popularly prescribed medicine was Chung Youl(淸熱) medicines.

• Korean Journal of Pharmacognosy
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• v.42 no.4
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• pp.371-378
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• 2011

Aldose reductase (AR) has been implicated in the development of the diabetic complications. To discover novel treatments for diabetic complications from natural sources, 65 Korean herbal medicines have been investigated for inhibitory activities on AR. Of these, 23 herbal medicines exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid (TMG). Particularly, 8 herbal medicines, Acer tataricum (twig, stem and leaf), Acer tataricum (fruit), Rhododendron schlippenbachii (twig, stem and leaf), Weigela subsessilis (twig, stem and leaf), Acer mono (branch and leaf), Ailanthus altissima (twig, stem and leaf), Lindera obtusiloba (branch and leaf), Solidago serotina (whole plant) showed three times more potent inhibitory activity than the positive control, TMG.

• Natural Product Sciences
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• v.17 no.1
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• pp.38-44
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• 2011

The quality inspections items such as loss on drying, total ash, and acid-insoluble ash contents in herbal medicines, have a correlation with external sources of pollution, but are not themselves hazardous factors. Z-scores for standard normal distribution were used to investigate herbal medicines requiring quality control, which exceeds the regulatory limits of quality inspection. In total, 7,773 samples were analyzed based on plant parts. For the loss on drying, the numbers of items of herbal medicines requiring quality control are like these; 15 items for above-ground parts and 5 items for underground parts. For the total ash, 21 items for above-ground parts and 4 items for underground parts. For the acid-insoluble ash, 8 items for above-ground parts and 1 item for underground parts.

• Korean Journal of Pharmacognosy
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• v.40 no.4
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• pp.388-393
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• 2009

Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications. The AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 64 herbal medicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, eight herbal medicines ($IC_{50}$<50 ${\mu}g$/ml) were found to have strong AGEs inhibitory activity compared with aminoguanidine (14 days, $IC_{50}$=75.98 ${\mu}g$/ml; 28 days, $IC_{50}$=88.27 ${\mu}g$/ml). Particularly, four herbal medicines, Buddleja officinalis (whole plant), Syzygium cuminii (leaf), Eugenia caryophyllate (seed), and Paeonia suffruticosa (root) showed more potent inhibitory activity (approximately 5-6 fold) than the positive control aminoguanidine.