• Journal of Biosystems Engineering
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• v.24 no.5
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• pp.425-430
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• 1999

Complex environmental control systems were developed, which control properly the pig's environment in windowless pig-housing based on the thermoregulatory behaviors of pigs and concentrations of noxious gases (CO2 and NH3). The this study was conducted to assess the performance of complex environmental control systems by raising weaned piglets and growing pigs under different seasonal conditions. Average daily gain of pigs in the experimental pig-housing was slightly higher than that of pigs in the conventional pig-housing. Average daily gain was not significantly different in winter and spring(P＞0.05), but was significantly different in summer(P＜0.05). Feed conversion rate of pigs in the experimental pig-housing was smaller than that of pigs in the conventional pig-housing. Feed conversion rate was not significantly different in environment for weaned piglets and growing pigs resulted in the improved daily gain, feed conversion rate, and carcass quality of the finishing pigs. These results showed that the performance of the complex environmental control systems in windowless pig-housing was excellent for weaned piglets and growing pigs.

• Journal of Mechanical Science and Technology
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• v.15 no.8
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• pp.1165-1173
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• 2001

This paper deals with dynamic analysis of Pipeline Inspection Gauge (PIG) flow control in natural gas pipelines. The dynamic behaviour of PIG depends on the pressure differential generated by injected gas flow behind the tail of the PIG and expelled gas flow in front of its nose. To analyze dynamic behaviour characteristics (e.g. gas flow, the PIG position and velocity) mathematical models are derived. Tow types of nonlinear hyperbolic partial differential equations are developed for unsteady flow analysis of the PIG driving and expelled gas. Also, a non-homogeneous differential equation for dynamic analysis of the PIG is given. The nonlinear equations are solved by method of characteristics (MOC) with a regular rectangular grid under appropriate initial and boundary conditions. Runge-Kutta method is used for solving the steady flow equations to get the initial flow values and for solving the dynamic equation of the PIG. The upstream and downstream regions are divided into a number of elements of equal length. The sampling time and distance are chosen under Courant-Friedrich-Lewy (CFL) restriction. Simulation is performed with a pipeline segment in the Korea gas corporation (KOGAS) low pressure system. Ueijungboo-Sangye line. The simulation results show that the derived mathematical models and the proposed computational scheme are effective for estimating the position and velocity of the PIG with a given operational condition of pipeline.

• Journal of Mechanical Science and Technology
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• v.15 no.9
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• pp.1302-1310
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• 2001

This paper introduces modeling and simulation results for pipeline inspection gauge (PIG) with bypass flow control in natural gas pipeline. The dynamic behaviour of the PIG depends on the different pressure across its body and the bypass flow through it. The system dynamics includes: dynamics of driving gas flow behind the PIG, dynamics of expelled gas in front of the PIG, dynamics of bypass flow, and dynamics of the PIG. The bypass flow across the PIG is treated as incompressible flow with the assumption of its Mach number smaller than 0.45. The governing nonlinear hyperbolic partial differential equations for unsteady gas flows are solved by method of characteristics (MOC) with the regular rectangular grid under appropriate initial and boundary conditions. The Runge-Kuta method is used for solving the steady flow equations to get initial flow values and the dynamic equation of the PIG. The sampling time and distance are chosen under Courant-Friedrich-Lewy (CFL) restriction. The simulation is performed with a pipeline segment in the Korea Gas Corporation (KOGAS) low pressure system, Ueijungboo-Sangye line. Simulation results show us that the derived mathematical model and the proposed computational scheme are effective for estimating the position and velocity of the PIG with bypass flow under given operational conditions of pipeline.

• BMB Reports
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• v.52 no.12
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• pp.718-727
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• 2019

Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell transplant. Functional NK cells may impact engraftment success of life-saving procedures such as bone marrow transplantation in human SCID patients. Therefore, in animal models, a T cell-/B cell-/NK cell+ environment provides a valuable tool for understanding the function of the innate immune system and for developing targeted NK therapies against human immune diseases. In this review, we focus on underlying mechanisms of human SCID, recent progress in the development of SCID animal models, and utilization of SCID pig model in biomedical sciences. Numerous physiologies in pig are comparable to those in human such as immune system, X-linked heritability, typical T-B+NK- cellular phenotype, and anatomy. Due to analogous features of pig to those of human, studies have found that immunodeficient pig is the most appropriate model for human SCID.

• BMB Reports
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• v.52 no.11
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• pp.625-634
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• 2019

Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell transplant. Functional NK cells may impact engraftment success of life-saving procedures such as bone marrow transplantation in human SCID patients. Therefore, in animal models, a T cell-/B cell-/NK cell＋ environment provides a valuable tool for understanding the function of the innate immune system and for developing targeted NK therapies against human immune diseases. In this review, we focus on underlying mechanisms of human SCID, recent progress in the development of SCID animal models, and utilization of SCID pig model in biomedical sciences. Numerous physiologies in pig are comparable to those in human such as immune system, X-linked heritability, typical T-B＋NK- cellular phenotype, and anatomy. Due to analogous features of pig to those of human, studies have found that immunodeficient pig is the most appropriate model for human SCID.

• Journal of Embryo Transfer
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• v.30 no.4
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• pp.305-313
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• 2015

Xenotransplantation of pig islet regarded as a good alternative to allotransplantation. However, cellular death mediated by hypoxia-reoxygenation injury after transplantation disturb success of this technique. In the present study, we produce transgenic pig expressing human heme oxygenase 1 (HO1) genes to overcome cellular death for improving efficiency of islet xenotransplantation. Particularly, Korean miniature pig breed, Micro-Pig, was used in the present study. Somatic cell nuclear transfer (SCNT) technique was used to produce the HO1 transgenic pig. Six alive transgenic piglets were produced and all the transgenic pigs were founded to have transgene in their genomic DNA and the gene was expressed in all tested organs. Also, in vitro cultured fibroblasts derived from the HO1 transgenic pig showed low reactive oxygen species level, improved cell viability and reduced apoptosis level.

• Journal of the Korean Home Economics Association
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• v.47 no.1
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• pp.85-91
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• 2009

Dyeability and antimicrobial property of dyed pig skin with Coptis chinensis Franch was investigated. Dyestuff was extracted with water and concentrated. Pig skin was dyed and mordanted according to various dyeing temperature, dyeing time, dyestuff concentration, mordanting methods and kinds of mordants. The results of this experiment were as follows: 1. Dyeability of pig skin with Coptis chinensis Franch was best at 200%(owf) dyestuff concentration, 50${^{\circ}C}$ dyeing temperature, and 20min. dyeing time. 2. Pre-mordanting by Cu improved the K/S values of dyed pig skin. 3. Surface color and color difference of dyed pig skin showed various results according to the mordants used : generally their color was yellow, Al post-mordanted pig skin showed the greatest color difference. 4. Color fastness to drycleaning was considerably high in case of staining compared to fading. Fastness to light was improved by Cu-mordanting while other treatments were not effective. 5. Antimicrobial property of samples was not different (99.9%) between untreated and treated.

• Animal Bioscience
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• v.37 no.4_spc
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• pp.742-754
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• 2024

Asia is not only the primary region for global pig production but also the largest consumer of pork worldwide. Although the pig production in Asia has made great progress in the past, it still is confronted with numerous challenges. These challenges include: inadequate land and feed resources, a substantial number of small-scale pig farms, escalating pressure to ensure environmental conservation, control of devastating infectious diseases, as well as coping with high temperatures and high humidity. To solve these problems, important investments of human and financial capital are required to promote large-scale production systems, exploit alternative feed resources, implement precision feeding, and focus on preventive medicine and vaccines as alternatives to antibiotics, improve pig breeding, and increase manure recycling. Implementation of these techniques and management practices will facilitate development of more environmentally-friendly and economically sustainable pig production systems in Asia, ultimately providing consumers with healthy pork products around the world.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.5
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• pp.632-637
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• 2006

Oviduct-specific glycoprotein 1 (OVGP1) is implicated in playing a role in fertilization and early embryo development. In this study, we have obtained the sequence of intron 9 of OVGP1 gene in swine. Comparative sequencing of Meishan (a native Chinese breed) and Large White pig breeds revealed an A/T substitution at position 943. A PCR-EcoRI-RFLP assay was developed to detect this mutation. Polymorphism analysis in Qingping animals showed that pigs with BB genotype had lower number of piglets born alive (NBA) in multiple parities than pigs with AA (p<0.05) and AB genotype (p<0.01). In Large $White{\times}Meishan$ ($LW{\times}M$) $F_2$ offspring, the weight of both ovaries (OW) of the BB genotype was significantly lighter than that of AB (p = 0.05) and AA (p<0.01) genotypes. Analysis of the data also revealed that the mutation locus affected these two traits mostly by additive effects. These studies indicated that the polymorphism was associated with NBA and OW in two distinct populations and further investigations in more purebreds or crossbreds are needed to confirm these results.

• Journal of Animal Science and Technology
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• v.63 no.3
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• pp.640-650
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• 2021

Particulate matter (PM) produced in pig houses may contain microbes which can spread by airborne transmission, and PM and microbes in PM adversely affect human and animal health. To investigate the microbiome in PM from pig houses, nine PM samples were collected in summer 2020 inside and outside of pig houses located in Jangseong-gun, Jeollanam-do Province, Korea, comprising three PM samples from within a nursery pig house (I-NPH), three samples from within a finishing pig house (I-FPH), and three samples from outside of the pig houses (O-PH). Microbiomes were analyzed using 16S rRNA gene amplicon sequencing. Firmicutes was the most dominant phylum and accounted for 64.8%-97.5% of total sequences in all the samples, followed by Proteobacteria (1.4%-21.8%) and Bacteroidetes (0.3%-13.7%). In total, 31 genera were represented by > 0.3% of all sequences, and only Lactobacillus, Turicibacter, and Aerococcus differed significantly among the three PM sample types. All three genera were more abundant in the I-FPH samples than in the O-PH samples. Alpha diversity indices did not differ significantly among the three PM types, and a principal coordinate analysis suggested that overall microbial communities were similar across PM types. The concentration of PM did not significantly differ among the three PM types, and no significant correlation of PM concentration with the abundance of any potential pathogen was observed. The present study demonstrates that microbial composition in PM inside and outside of pig houses is similar, indicating that most microbe-containing PM inside pig houses leaks to the outside from where it, along with microbe-containing PM on the outside, may re-enter the pig houses. Our results may provide useful insights regarding strategies to mitigate potential risk associated with pig farming PM and pathogens in PM.