• Natural Product Sciences
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• 제21권1호
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• pp.1-5
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• 2015

Activity-guided separation of the methylene chloride-soluble fraction of the leaves of Zanthoxylum schinifolium, resulted in the isolation of four coumarinoids (1 - 4), two triterpenoids (5, 6) and three fatty acid derivatives (7 - 9) as active principles. Their chemical structures were identified as collinin (1), 8-methoxyanisocoumarin (2), 7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)-coumarin (3), (E)-4-methly-6-(coumarin-7'-yloxy) hex-4-enal (4), lupeol (5), epi-lupeol (6), phytol (7), hexadec-3-enoic acid (8) and palmitic acid (9), on the basis of spectroscopic (1D, 2D and MS) data analyses and comparing with the data published in the literatures. Compounds 1 and 7 showed potent cytotoxicity against Jurkat T cells with $IC_{50}$ values of 45.58 and $47.51{\mu}M$, respectively. The others showed moderate activity with $IC_{50}$ values ranging around 80.58 to $85.83{\mu}M$, while the positive control, auraptene, possessed an $IC_{50}$ value of $55.36{\mu}M$.

• 한국식품영양학회지
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• 제25권2호
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• pp.274-283
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• 2012

The volatile flavor compounds of the essential oils from Ixeris dentate (Thunb.) Nakai and I. stolonifera A. Gray were investigated. The essential oils were extracted by hydro distillation extraction method. Ninety-three volatile flavor components were identified from I. dentate (Thunb.) Nakai essential oil. Hexadecanoic acid(33.73%) was the most abundant compound, followed by (Z,Z,Z,)-9,12,15-octadecatrienoic acid(18.59%), 6,10,14-trimethyl-2-pentadecanonel(10.39%) and phytol(5.21%). Ninety-seven volatile flavor components were identified from the essential oil of I. stolonifera A. Gray. Hexadecanoic acid was the most abundant component(39.7%), followed by (Z,Z,Z)-9,12,15-octadecatrienoic acid(12.63%), 9,12-octadecadienoic acid, ethyl ester(12.36%), pentacosane(5.2%) and 6,10,14-trimethyl-2-pentadecanone(3.18%). The volatile composition of I. dentate (Thunb.) Nakai was characterized by higher contents of phytol and phthalides than those of I. stolonifera A. Gray. The volatile flavor composition of I. stolonifera A. Gray can easily be distinguished by the percentage of sesquiterpene compounds against I. dentate (Thunb.) Nakai essential oil.

• 한국식품영양학회지
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• 제35권3호
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• pp.185-192
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• 2022

This study investigated the volatile flavor components of the essential oil from Chrysanthemum coronarium var. spatiosumBailey. The essential oil obtained from the aerial parts of the plant by the hydrodistillation extraction method was analyzed by gas chromatography and gas chromatography-mass spectrometry. One hundred and one (99.11%) volatile flavor components were identified in the essential oil from the Chrysanthemum coronarium var. spatiosum Bailey. The major compounds were hexanedioic acid, bis(2-ethylhexyl) ester (12.45%), 6.10.14-trimethyl-2-pentadecanone (7.94%), 1-(phenylethynyl)-1-cyclohexanol (6.34%), α-farnesene (5.55%), phytol (4.99%), and α-caryophyllene (4.39%). When the volatile flavor components of Chrysanthemum coronarium var. spatiosum Bailey were classified by functional group, the content was high in the order of hydrocarbons, alcohols, esters, ketones, aldehydes, and phthalides. Sesquiterpene hydrocarbons were the most common hydrocarbons, mainly due to α-farnesene and α-caryophyllene. Among the alcohols, the content of aliphatic alcohols was significantly higher, mainly due to 1-(phenylethnyl)-1-cyclohexanol (6.34%) and phytol (4.99%). The analysis of the volatile flavor components of Chrysanthemum coronarium var. spatiosum Bailey in this study will provide useful information to consumers when purchasing food and to industries using fragrance ingredients.

• 한국식품영양학회지
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• 제36권3호
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• pp.163-171
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• 2023

The purpose of this study was to investigate the flavor characteristics of Gondre (Cirsium setidens Nakai) essential oil. The essential oil was isolated from the aerial parts of the plant by the hydrodistillation extraction method and analyzed by gas chromatography (GC) and GC-mass spectroscopy (MS). Seventy-eight (90.28%) volatile flavor components were identified in the essential oil from Gondre harvested in May. The major compounds were hexadecanoic acid (44.84%), phytol (15.57%), 6,10,14-trimethyl-2-pentadecanone (5.62%), and tertadecanoic acid (4.77%). Seventy (90.72%) volatile flavor components were identified in the essential oil from Gondre harvested in September. The major compounds were phytol (24.18%), 6,10,14-trimethyl-2-pentadecanone (15.59%), tetracosane (8.87%), 2-methyl eicosane (3.55%), 6,10,14-trimethyl-5,9,13-pentadecatrien-2-one (3.12%), dibuthyl phthalate (2.35%), and viridiflorol (2.33%). The flavor components of the essential oil from Gondre harvested in May and September were characterized by higher proportions of aliphatic fatty acids and terpene compounds, respectively.

• 한국식품과학회지
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• 제49권4호
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• pp.390-395
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• 2017

Mixed A, Chlorella vulgaris, Nannochloropsis oculata, Chaetoceros calcitrans 등 4종류의 미세조류로부터 99.9% 에탄올로 추출한 성분의 항균활성을 검증하기 위해 그람음성세균 2종(E. coli, S. Typhimurium)과 그람양성세균 2종(S. aureus, B. cereus)에 대하여 paper disk diffusion assay, MIC, MBC를 측정하였다. 4종류의 미세조류 추출물은 공시균주에 대하여 0.62-1.66 mg/mL의 MIC를 나타내었으며, C. vulgaris 추출물이 4종의 공시균주에 대한 MIC가 0.62 mg/mL로 가장 강한 항균활성을 나타내었으며, MBC 또한 C. vulgaris 에탄올 추출물이 E. coli에 대해 2.50 mg/mL, S. aureus, B. cereus와 S. Typhimurium에 대해서는 4.16-5.00 mg/mL로 가장 강한 항균활성을 나타내었다. 항균활성이 가장 강한 C. vulgaris 에탄올 추출물의 성분을 분석한 결과, 함량이 가장 많은 성분은 9,12-octadecadienoic acid (linoelaidic acid, peak 5, 7)로 38.8%이었으며, 그 다음이 2-Hexadecen-1-o1, 3,7,11,15-tetramethyl (phytol, peak 2,6)로 30.0%이었다. Octadecadienoic acid는 일명 linoelaidic acid로 탄소수 18개의 고도불포화지방산이며, 두 번째로 함량이 많은 Phytol은 클로로필을 구성하는 불포화 제1급 알코올의 일종으로서(엽록소의 구성 성분) 병원성 대장균 및 황색포도상구균에 항균활성을 나타낸다는 보고로 볼 때, 이 2가지 성분이 항균활성의 주성분인 것으로 사료된다.

• 생약학회지
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• 제35권2호통권137호
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• pp.116-121
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• 2004

Seven compounds, euscaphic acid (1), nepehinol (2), ursolic acid (3), phytol (4), ${\beta}-amyrin$ (5), scopoletin (6), and rutin (7) were isolated from the aerial parts of Synurus excelsus which has been used as Korean traditional medicine to treat rheumatic arthritis and dysmenorrhea. Their structures were established by chemical and spectroscopic methods. All compounds were isolated for the first time from this plant.

• Bulletin of the Korean Chemical Society
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• 제29권11호
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• pp.2267-2269
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• 2008

• 약학회지
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• 제48권1호
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• pp.65-69
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• 2004

The chromatographic separation of MeOH extract of the aerial parts of Aster glehni (Compositae) led to the isolation of three sesquiterpenes, two sterols and four terpenes. Their structures were determined to be $\beta$-amyrin acetate (1), phytol (2), alismol (3), $\alpha$-tocopheryl quinone (4), $\alpha$-spinasterol (5), 10-O-methyl alismoxide (6), alismoxide (7), and 3-O-(6'-O-palmitoyl-$\beta$-D-glucosyl)-spinasta 7,22-diene (8) by physicochemical and spectroscopic methods . These compounds (1-8) were first isolated from the Aster glehni.

• 약학회지
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• 제47권1호
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• pp.10-13
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• 2003

The phytochemical study of Cacalia koraiensis Nakai (Compositae) led to the isolation of eight compounds, $\beta$-sitosterol (1), stigmasterol (2), phytol (3), $\beta$-sitosterol-3-Ο-glucopyranoside (4), adenostylol (5), campesterol (6), germacradien-4$\alpha$-ol (7), and quercetin-3-rhamnoside (8). Their structures were established by chemical and spectroscopic methods. The cytotoxicity of the isolated compounds was evaluated by SRB assay against five cultured human tumor cell lines.

• 한국약용작물학회지
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• 제2권2호
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• pp.168-173
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• 1994

배초향의 지상부로 부터 수증기 증류법에 의해 정유성분을 분리한 다음 silica gel column chromatography에 의해 탄화수소화합물 분획과 함산소화합물 분확으로 나눈후 GC 및 GC-MS에 의해 각 분획의 성분조성을 분석한 결과는 다음과 같다. 1. 배초향의 정유함량은 건물증량으로 잎에서는 0.29%, 꽃에서는 0.38%였으나 줄기에서는 전혀 검출되지 않았다. 2. 잎의 정유에서 분리한 탄화수소화합물 분획에서 확인된 13종의 성분중 주성분은 ${\beta}-caryophyllene(59.3%)$, limonene(13.1%), ${\delta}adinene$ (10.7%) 이었고, 함산소화합물 분획에서 확인된 44종의 성분중 주성분은 methyl chavicol(79.1%), cis-3-(l-propenyl)phenol(4.5%) 등이었다. 3. 잎과 꽃의 정유성분 조성에서 양적으로 가장 많이 함유된 성분은 methylchavicol 이었고, limonene, trans-2-hexenal, 1-octen-3-one, 6,10,14-trimethylpentadecan-2-one 및 phytol등은 잎에서 특징적으로 검출된 반면 jasmone 및 p-methoxyacetophenone등은 양적으로 미량이지만 꽃에서 많이 검출되었다.