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Bioactive Constituents from the Leaves of Zanthoxylum schinifolium  

Jeong, Su Yang (College of Pharmacy, Catholic University of Daegu)
Nguyen, Phi Hung (College of Pharmacy, Catholic University of Daegu)
Zhao, Bing Tian (College of Pharmacy, Catholic University of Daegu)
Min, Byung Sun (College of Pharmacy, Catholic University of Daegu)
Ma, Eun Sook (College of Pharmacy, Catholic University of Daegu)
Woo, Mi Hee (College of Pharmacy, Catholic University of Daegu)
Publication Information
Natural Product Sciences / v.21, no.1, 2015 , pp. 1-5 More about this Journal
Abstract
Activity-guided separation of the methylene chloride-soluble fraction of the leaves of Zanthoxylum schinifolium, resulted in the isolation of four coumarinoids (1 - 4), two triterpenoids (5, 6) and three fatty acid derivatives (7 - 9) as active principles. Their chemical structures were identified as collinin (1), 8-methoxyanisocoumarin (2), 7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)-coumarin (3), (E)-4-methly-6-(coumarin-7'-yloxy) hex-4-enal (4), lupeol (5), epi-lupeol (6), phytol (7), hexadec-3-enoic acid (8) and palmitic acid (9), on the basis of spectroscopic (1D, 2D and MS) data analyses and comparing with the data published in the literatures. Compounds 1 and 7 showed potent cytotoxicity against Jurkat T cells with $IC_{50}$ values of 45.58 and $47.51{\mu}M$, respectively. The others showed moderate activity with $IC_{50}$ values ranging around 80.58 to $85.83{\mu}M$, while the positive control, auraptene, possessed an $IC_{50}$ value of $55.36{\mu}M$.
Keywords
Zanthoxylum schinifolium; Rutaceae; Cytotoxicity; Collinin; Phytol;
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