• Food Science and Biotechnology
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• v.14 no.6
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• pp.709-714
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• 2005

Alteration of molecular markers related to apoptosis of in vivo normal system and in vitro cancerous system by soy-isoflavonoid with estrogen was investigated. Down-regulation of Bcl-2 was accompanied by decreased expression of COX-2 (cyclooxygenase-2) in mature female rats treated with soy-isoflavonoid and estrogen. In ovariectomized rat system, Bax was regulated by higher concentration of soy treatment. Bax up-regulation by soy-isoflavonoid genistein treatment was observed in MCF-7 mammary cancer cell system. Estrogen without soy induced similar pattern of Bax expression as soy-isoflavonoid in vivo, but exhibited opposite trend in vitro. These findings suggest soy-isoflavonoid may have potential to induce apoptosis at higher concentrations through up-regulation of Bax or down-regulation of Bcl-2 expressions depending on normal or cancerous state, and physiological status of rats.

• Food Science and Biotechnology
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• v.18 no.6
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• pp.1528-1531
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• 2009

In this study, we investigated a dose-dependent hypolipidemic and antioxidant effects of tocotrienol-rich fraction (TRF) from grape seeds. After induction of hyperlipidemia for 4 weeks, rats were supplemented with different dose (5, 25, and 50 mg/kg BW/day) of TRF for 1 week. Oral administration of TRF (50 mg/kg BW/day) decreased the plasma triglyceride (TG, 162.6 mg/dL), total cholesterol (TC, 83.7 mg/dL), low density lipoprotein-cholesterol (LDL-C, 20.3 mg/dL), malondialdehyde contents (MDA, 3.3 nmol/dL), and atherogenic index (AI, 2.0) compare to high-fat diet group. These data suggest that TRF supplementation has significant health benefits through the modulation of physiological functions that include various atherogenic lipid profiles and antioxidative status in hyperlipidemia.

• International Journal of Oral Biology
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• v.43 no.3
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• pp.113-121
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• 2018

Taste is closely related to intake of food. Taste perception is also influenced by type of food ingested, and nutrition and health status. Bitter taste plays an important role in the survival of human and animals to avoid probable toxic and harmful substances. Vertebrate animals recognize bitter taste through type 2 taste receptors (T2Rs). Several T2Rs have been expressed extra-oral such as the gastrointestinal tract, respiratory tract, urogenital tract, brain and immune cells, and parts of their functions are being revealed. This review will discuss physiological roles of T2Rs in relation to innate immunity, secretion and smooth muscle contraction expressed in extra-oral cells and tissues, and we summarize relationships between polymorphisms in T2Rs and general or oral diseases. It is not a coincidence that animals pay much genetic costs for taste and smell during evolution.

• Journal of Korean Medicine for Obesity Research
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• v.6 no.1
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• pp.11-26
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• 2006

Hair tissue mineral analysis is widely accepted for assessing essential and toxic elements which can give information about disease, metabolic disorder, nutritional imbalance, drug abuse, environmental exposure and so on. In Oriental Medicine, hair have been used as a diagnostic method which reflects the physiological and pathological status of body, especially kidney system(腎臟) and blood(血) like the quotations from Donguibogam(東醫寶鑑), 'hair belongs to kidney system(髮屬腎)' and 'hair is the remainder of blood(髮者血之餘)' Therefore we have suggested that HTMA have possibility to be utilized for screening and treatment for obesity, growth disorder, general deficiency syndrome(諸虛證), etc. in Oriental Medicine.

• Journal of Obesity & Metabolic Syndrome
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• v.27 no.4
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• pp.223-232
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• 2018

Vitamin D, a free sunshine vitamin available for mankind from nature, is capable to avert many health-related critical circumstances. Vitamin D is no more regarded as a nutrient involved in bone metabolism alone. The presence of vitamin D receptor in a number of tissues implies that vitamin D has various physiological roles apart from calcium and phosphorus metabolism. Low serum vitamin D has been found to be associated with various types of metabolic illness such as obesity, diabetes mellitus, insulin resistance, cardiovascular diseases including hypertension. Various studies reported that vitamin D insufficiency or deficiency in linked with metabolic syndrome risk. This review focuses on various metabolic diseases and its relationship with serum vitamin D status.

• Journal of the Korea Convergence Society
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• v.9 no.12
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• pp.401-409
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• 2018

The purpose of this study was to examine the oral health care and self-rated health status of adults visiting dental clinics in the region of Busan and influential factors for their dental fear from January to May, 2017, in an effort to obtain some information on how to relieve fear. As for dental fear, adults who were in their 30s, who were homemakers and whose monthly income ranged from 4 to 4.99 million won. In regard to fear according to oral health care, dental fear caused by the treatment avoidance factor was stronger among the adults who didn't receive dental checkups and who brushed their teeth in the wrong way. Dental fear that was attributed to the physiological reaction factor and the stimuli-inducing factor was severer among the adults who didn't receive dental checkups and who had no scaling experience. Overall fear was severer among the adults who didn't receive dental checkups and who changed their toothbrushes every four or more months. The factors that affected dental fear were self-rated health status, self-rated oral health status, gender, age, whether to receive dental checkups on a regular basis or not, and oral health education experience. Therefore in order to alleviate dental fear, self-rated health status should be improved, and the kind of system that encourages regular dental checkups and provides oral health education should be prepared.

• 한국노년학
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• v.29 no.3
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• pp.899-915
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• 2009

The purpose of this study was examined effect of physical fitness and exercise participation on healthy aging of the elderly. The subjecrts were a total 319 people that they were participate in the regular exercise, and go to welfare center in Seoul. Data were collected during the period from November 1 to November 30, 2006. The collected data were analyzed frequency, descriptive statistics, correlation and hierarchical regression analysis using the SPSS-Win 12.0 program. The results of hierarchical regression analysis were appeared as follows. According to the results of hierarchical regression analysis, significant factors influencing healthy aging were monthly income, monthly pocket money, self-perceived health status, leg muscle strength, exercise behavior and period of exercise. 2. According to the results, significant factors influencing physiological health were age, marital status, self-perceived health status, exercise behavior and period of exercise. 3. According to the results, significant factors influencing cognitive-mental health were monthly income, monthly pocket money, self-perceived health status, leg muscle strength, exercise behavior and period of exercise. 4. According to the results, significant factors influencing social-support health were monthly income, age, education, self-perceived health status, leg muscle strength, exercise behavior and period of exercise. In conclusion, First, this questionnaire demonstrates good reliability and validity and therefore it is an appropriate measurement of healthy aging for the elderly in Korea. Second, it is important that exercise behavior is main factor to healthy aging life on the elderly. Third, There is important mean values of the items for healthy aging.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.1
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• pp.97-103
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• 2009

The status and the property of a tongue are the important indicators to diagnose one's health like physiological and clinicopathological changes of inner organs. However, the tongue diagnosis is affected by examination circumstances like a light source, patient's posture, and doctor's condition. To develop an automatic tongue diagnosis system for an objective and standardized diagnosis, classifying tongue coating is inevitable but difficult since the features like color and texture of the tongue coatings and substance have little difference, especially in the neighborhood on the tongue surface. The proposed method has two procedures; the first is to acquire the color table to classify tongue coatings and substance by automatically separating coating regions marked by oriental medical doctors, decomposing the color components of the region into hue, saturation and brightness and obtaining the 2nd order discriminant with statistical data of hue and saturation corresponding to each kind of tongue coatings, and the other is to apply the tongue region in an input image to the color table, resulting in separating the regions of tongue coatings and classifying them automatically. As a result, kinds of tongue coatings and substance were segmented from a face image corresponding to regions marked by oriental medical doctors and the color table for classification took hue and saturation values as inputs and produced the classification of the values into white coating, yellow coating and substance in a digital tongue diagnosis system. The coating regions classified by the proposed method were almost the same to the marked regions. The exactness of classification was 83%, which is the degree of correspondence between what Oriental medical doctors diagnosed and what the proposed method classified. Since the classified regions provide effective information, the proposed method can be used to make an objective and standardized diagnosis and applied to an ubiquitous healthcare system. Therefore, the method will be able to be widely used in Oriental medicine.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.7
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• pp.951-955
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• 2001

The behaviour of 6 Toggenburg and 6 Saanen female goats, grazing on natural vegatation in a modified sub-humid tropical environment of Kenya, was studied during the dry (January and February) and wet (April and May) seasons in 1997. The two exotic breeds grazed for 12 h daily. Observation on feeding, standing, lying and ruminating was done chronometrically at five minute intervals between 0600 and 1800 h. These grazing times were based on the current practice of small holder farmers. During the dry period, the average feeding, standing, lying and ruminating time per 12 h period for Saanens was 5.63, 4.57, 1.80 and 1.50 h respectively while that for Toggenburgs was 7.26, 3.21, 1.53 and 1.96 h, respectively. In the wet(Green) season, the mean feeding, standing, lying and ruminating time for Saanens was found to be 5.08, 4.63, 2.29 and 0.72, respectively.Toggenburgs spent more time feeding (p<0.05) than Saanens in both seasons. It was also observed that standing occured more often in Saanens than the Toggenburgs in the dry season. During the wet period, Saanens ruminated significantly longer than the Toggenburgs. The health status of the animals was determined by analyzing the respiratory frequency, heart rate, rectal temperature, hemoglobin, erythrocytes and leucocytes of the experimental animals. All the clinical and physiological parameters were within the normal physiological range of healthy goats. It was concluded that differences in the grazing behaviour of Saanens and Toggenburgs in the modified tropical environment of Kenya, do exist.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.4
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• pp.491-495
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• 2001

The behaviour of 5 Jersey and 5 Guernsey heifers, grazing on natural vegetation in a sub-humid tropical environment in Kenya, was studied during the dry (January and February) and wet (April and May) seasons in 1999. The heifers grazed for 12 hours daily in both seasons. Observations on feeding, standing, lying and ruminating were done chronometrically, at five-minute intervals, between 0600 and 1800 h. During the dry season, the average feeding, standing, lying and ruminating times per 12 h period for Jerseys was 8.0, 3.13, 0.87, and 1.40 respectively, while those for Guernseys were 8.6, 3.26, 0.4, and 1.35 respectively. In the wet (green) season, the mean feeding, standing, lying and ruminating times for Jerseys were found to be 7.54, 3.07, 1.39, and 1.27 respectively, and for Guernseys were 8.42, 3.10, 0.48, and 0.44 respectively. In both seasons Guernseys spent more time feeding (p<0.05) in comparison with the Jerseys. It was also observed that lying occurred more often in Jerseys than the Guernseys (p<0.05) in both seasons. During the wet season, Jerseys ruminated longer (p<0.05) than the Guernseys. The health status of the animals was determined by examining the respiratory frequency, heart rate, rectal temperature, haemoglobin erythrocytes and leucocytes of the experimental animals. All the clinical and physiological parameters were within the normal physiological range of healthy cattle. It was concluded that there are differences in grazing behaviour between Jerseys and Guernseys in the sub-humid tropical environment of Kenya and Jerseys seem to be more adapted to the tropical climatic conditions.