• Reproductive and Developmental Biology
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• v.33 no.3
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• pp.163-169
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• 2009

Many biological systems are regulated by an intricate set of feedback loops that oscillate with a circadian rhythm of roughly 24 h. This circadian clock mediates an increase in body temperature, heart rate, blood pressure, and cortisol secretion early in the day. Recent studies have shown changes in the amplitude of the circadian clock in the hearts and livers of streptozotocin (STZ)-treated rats. It is therefore important to examine the relationships between circadian clock genes and growth factors and their effects on diabetic phenomena in animal models as well as in human patients. In this study, we sought to determine whether diurnal variation in organ development and the regulation of metabolism, including growth and development during the juvenile period in rats, exists as a mechanism for anticipating and responding to the environment. Also, we examined the relationship between changes in growth factor expression in the liver and clock-controlled protein synthesis and turnover, which are important in cellular growth. Specifically, we assessed the expression patterns of several clock genes, including Per1, Per2, Clock, Bmal1, Cry1 and Cry2 and growth factors such as insulin-like growth factor (IGF)-1 and -2 and transforming growth factor (TGF)-${\beta}1$ in rats with STZ-induced diabetes. Growth factor and clock gene expression in the liver at 1 week post-induction was clearly increased compared to the level in control rats. In contrast, the expression patterns of the genes were similar to those observed after 5 weeks in the STZ-treated rats. The increase in gene expression is likely a compensatory change in response to the obstruction of insulin function during the initial phase of induction. However, as the period of induction was extended, the expression of the compensatory genes decreased to the control level. This is likely the result of decreased insulin secretion due to the destruction of beta cells in the pancreas by STZ.

• Korean Journal of Exercise Nutrition
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• v.24 no.2
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• pp.1-5
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• 2020

[Purpose] Lactate has several beneficial roles as an energy resource and in metabolism. However, studies on the effects of oral administration of lactate on fat metabolism and glycogen synthesis are limited. Therefore, the purpose of the present study was to investigate how oral administration of lactate affects fat metabolism and glycogen synthesis factors at specific times (0, 30, 60, 120 min) after intake. [Methods] Male Sprague Dawley (SD) rats (n = 24) were divided into four groups as follows: the control group (0 min) was sacrificed immediately after oral lactate administration; the test groups were administered lactate (2 g/kg) and sacrificed after 30, 60, and 120 min. Skeletal muscle and liver mRNA expression of GLUT4, FAT/CD36, PDH, CS, PC and GYS2 was assessed using reverse transcription-polymerase chain reaction. [Results] GLUT4 and FAT/CD36 expression was significantly increased in skeletal muscle 120 min after lactate administration. PDH expression in skeletal muscle was altered at 30 and 120 min after lactate consumption, but was not significantly different compared to the control. CS, PC and GYS2 expression in liver was increased 60 min after lactate administration. [Conclusion] Our results indicate that exogenous lactate administration increases GLUT4 and FAT/CD36 expression in the muscle as well as glycogen synthase factors (PC, GYS2) in the liver after 60 min. Therefore, lactate supplementation may increase fat utilization as well as induce positive effects on glycogen synthesis in athletes.

• Korean Institute of Interior Design Journal
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• v.14 no.3 s.50
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• pp.139-146
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• 2005

This paper focuses on the response of architectural form to the technological characteristics in the institute facilities. For this, we study the meaning of technology in the aspect of physical, formal and social concepts and their architectural expression and sort by grouping through analyzing 27 cases of foreign current Institute facilities. Conclusions can be summarized as followings: 1) Vocabulary of technology in physical concept is presented by the environmental control through the experimental surface such as louver and glazing and the independent exposed equipment. 2) Vocabulary of technology in physical concept is presented using the machine like aesthetics by exposing the structural members and designing the exterior form using dynamical images. 3) The expression of social meaning in technology is presented by standardization, parts assembling through mass production system, the unit material for expression of today's industrial society. The expressions of technological language in the institute facilities are used not only one vocabulary but comprehensive ones.

• Korean Institute of Interior Design Journal
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• v.23 no.1
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• pp.3-13
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• 2014

After The Industrial Revolution in 18th century, constructions were done with universal material (concrete) in everywhere instead of using materials that are produced in each country because of development of industry material and transportation. This change caused the buildings to become trite with no local characteristics. Hereupon, the study intends to understand the essence of matter and restore various construction methods of each matter with the topic of 'Immateriality'. Immateriality is the revealed concept based on Materiality. Consequently the process and characteristics of immateriality shown on the works of Kuma Kengo and Herzog & de Meuron, three kinds of features can be found of immateriality expression mode. They are as in the following. First, there is a mode of transforming the shape and properties in physical or psychological way by observer. Second, there is a mode of conflating the shape and properties in physical or psychological way by observer. Third, there is a mode of mixing the shape and properties in physical or psychological way by observer.

• Journal of Magnetics
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• v.17 no.3
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• pp.225-228
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• 2012

Muscle contusion usually results from a direct blunt impact and is frequently associated with contact sports. Muscle contusion results from microscopic muscle fiber and capillary disruption causing a microhemorrhage dissecting torn fibers and remaining viable muscle fibers. Recent studies concluded that some physical methods, including pulsed ultrasound (PU) and pulsed electromagnetic field (PEMF) treatment, accelerate and facilitate wound healing, improve scar quality and have beneficial effects on muscle and tendon healing. However, there are few studies on the effects of the early use of physical methods, such as PU and PEMF, on the expression of neurotrophic factors. The objective of this study was to investigate the effects of the early application of PU and PEMF, measured through the expression of BDNF in the muscles (gastrocnemius) and spinal cords of rats after skeletal muscle contusion. In the spinal cords and muscles, there was a significant increase of BDNF expression in the PEMF and PU groups, a greater increase was found in the PEMF group than in the PU group. In conclusion, PEMF is a useful therapeutic method that improves muscle healing after muscle contusion.

• Journal of the Korean Society of Physical Medicine
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• v.5 no.3
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• pp.455-465
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• 2010

Purpose : This study is intended to examine the motor skill learning on balance and coordination in the cerebellar injured rats by 3AP. Methods : This study selected 60 Sprague-Dawley rats of 8 weeks. Experiment groups were divided into four groups and assigned 15 rats to each group. Group I was a normal control group(induced by saline); Group II was a experimental control group(cerebellar injured by 3AP); Group III was a group of motor skill learning after cerebellar injured by 3AP; Group IV was a group of treadmill exercise after cerebellar injured by 3AP. In each group, motor performance test, histologic observations, synaptophysin expression and electron microscopy observation were analyzed. Results : In motor performance test, the outcome of group II was significantly lower than the group III, IV(especially group III)(p<.001). In histological finding, the experimental groups were destroy of dendrities and nucleus of cerebellar neurons. Group III, IV were decreased in degeneration of cerebellar neurons(especially group III). In immunohistochemistric response of synaptophysin in cerebellar cortex, experimental groups were decreased than group I. Group III's expression of synaptophysin was more increased than group II, IV. In electron microscopy finding, the experimental groups were degenerated of Purkinje cell. Conclusion : These result suggest that improved motor performance by motor skill learning after harmaline induced is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity.

• The Journal of Korean Physical Therapy
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• v.22 no.3
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• pp.93-98
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• 2010

Purpose: To investigate temporal changes in IL-1${\beta}$ mRNA expression in spinal dorsal horn (DH) and dorsal root ganglion (DRG) in a rat lumbar disc herniation (LDH) model. Methods: Autologous nucleus pulposus, harvested from the tail disc between the second and third coccygeal vertebrae (Co2-3), was implanted next to the left L5 nerve root just proximal to the DRG after partial laminectomy. IL-1${\beta}$ mRNA expression was investigated in DRG and DH in our LDH model. Real-time PCR assays were done using a 7500 Real Time PCR system (Applied Biosystems, USA). Results: Expression of IL-1${\beta}$ in DRG and DH was observed for 30 days postoperatively. Expression of IL-1${\beta}$ mRNA in the ipsilateral DRG of the LDH group gradually increased from 5 to 30 days after surgery. The amount of IL-1${\beta}$ in the contralateral DRG peaked 10 days after surgery and then gradually decreased. However, there was no difference in IL-1${\beta}$ mRNA expression in spinal DH between the LDH group and the sham-operated group. Conclusion: Long-term expression of IL-1${\beta}$ in the LDH model may worsen the chronic pain state. Future studies on inhibition of IL-1${\beta}$ expression in the LDH model will be needed to develop selective treatment strategies for patients with LDH.

• The Journal of Korean Physical Therapy
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• v.15 no.3
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• pp.251-264
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• 2003

Alcohol exposure during development leads to significant long-term neurobehavior dysfunction and central nervous system alteration. The purpose of this study was to determine the effects of enriched enviroment in developmental period through motor behavior test and expression of BDNF. Neonatal rat exposed to alcohol on postnatal days 4 through 10 were studied. Female Sprague-Dawley pups were assigned to two groups. Experimental group(EG) via 4.5 g kg-1day-1 of ethanol was housed in enriched enviornment for 9 weeks. The main result of this study were as follows: 1. There was significant difference in the mean of weight change between control and experimental group. 2. In motor behavior test, there was significant difference in the mean of weight change between control and experimental group. 3. Regarding the immunoreactivity of BDNF were higher appeared experimental group than control group. In conclusion, the present results reveals that enriched enviroment in developmental period is to be extremely useful in neuronal reprganization and motor behavior improvement after alcohol exposure.

• Journal of Korean Physical Therapy Science
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• v.19 no.1
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• pp.17-25
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• 2012

Purpose : The aim of this study was from data collection to item development in the first study before developing a valid and reliable instrument reflecting Korean's own language expression and culture. Methods : The fist survey was 140 osteoarthritis(OA) patients in 2 Cites was studied from November to December 2009. Open-ended questionnaire was decided 39 items from the first open survey. Questionnaire on the Korean Osteoarthritis Impact Measurement Scale(KAIMS) was recruited 2 professors and 5 physical therapists. Second survey was applied to 133 OA patients. Results : OA patients's average age${\pm}$standard deviation was $66.08{\pm}11.10$ years. The internal consistency reliability of 3 items. As estimated by Cronbach's alpha coefficient(${\alpha}$), was high(range, 0.86~0.96). 0.43~0.91 ${\alpha}$ coefficient for the internal consistency reliability of item-each scale was also high. However, item-discriminant validity on 3 items was low(${\alpha}$, 0.92~0.97). The construct validity by factor analysis was a little low. Conclusion : This study revealed that we confirmed a generation for 39 items on KAIMS reflecting Korean's own language expression and culture. Also, those of reliability were a little high. And, we will have to study the last instrument development (3rd study) by more subjects in the future.

• Steel and Composite Structures
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• v.31 no.5
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• pp.469-488
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• 2019

We in this paper study nonlinear bending of a functionally graded porous nanobeam subjected to multiple physical load based on the nonlocal strain gradient theory. For more reasonable analysis of nanobeams made of porous functionally graded magneto-thermo-electro-elastic materials (PFGMTEEMs), both constituent materials and the porosity appear gradient distribution in the present expression of effective material properties, which is much more suitable to the actual compared with the conventional expression of effective material properties. Besides the displacement function regarding physical neutral surface is introduced to analyze mechanical behaviors of beams made of FGMs. Then we derive nonlinear governing equations of PFGMTEEMs beams using the principle of Hamilton. To obtain analytical solutions, a two-step perturbation method is developed in nonuniform electric field and magnetic field, and then we use it to solve nonlinear equations. Finally, the analytical solutions are utilized to perform a parametric analysis, where the effect of various physical parameters on static bending deformation of nanobeams are studied in detail, such as the nonlocal parameter, strain gradient parameter, the ratio of nonlocal parameter to strain gradient parameter, porosity volume fraction, material volume fraction index, temperature, initial magnetic potentials and external electric potentials.