The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
권호 표지

Effects of Enriched Enviroment on Expression of BDNF and Motor Performence after Alcohol-induced Brain Injury in Neonatal Rats

신생흰쥐의 알콜성 뇌손상 후 환경강화가 BDNF 발현 및 운동수행력에 미치는 영향

  • Lee Sun-Min (Major in Physical Therapy, Dept. of Rehabilitation Science, Graduate School, Daegu University) ;
  • Koo Hyun-Mo (Major in Physical Therapy, Dept. of Rehabilitation Science, Graduate School, Daegu University) ;
  • Kim Jin-Sang (Department of Physical Therapy, College of Rehabilitation Science, Daegu University)
  • 이선민 (대구대학교 대학원 재활과학과 물리치료학) ;
  • 구현모 (대구대학교 대학원 재활과학과 물리치료학) ;
  • 김진상 (대구대학교 물리치료학과)
  • Published : 2003.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

Alcohol exposure during development leads to significant long-term neurobehavior dysfunction and central nervous system alteration. The purpose of this study was to determine the effects of enriched enviroment in developmental period through motor behavior test and expression of BDNF. Neonatal rat exposed to alcohol on postnatal days 4 through 10 were studied. Female Sprague-Dawley pups were assigned to two groups. Experimental group(EG) via 4.5 g kg-1day-1 of ethanol was housed in enriched enviornment for 9 weeks. The main result of this study were as follows: 1. There was significant difference in the mean of weight change between control and experimental group. 2. In motor behavior test, there was significant difference in the mean of weight change between control and experimental group. 3. Regarding the immunoreactivity of BDNF were higher appeared experimental group than control group. In conclusion, the present results reveals that enriched enviroment in developmental period is to be extremely useful in neuronal reprganization and motor behavior improvement after alcohol exposure.

Keywords