• Biomolecules & Therapeutics
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• 제12권4호
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• pp.198-201
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• 2004

This review focuses on finding neurochemical changes in physical dependence on butorphanol, a relatively potent mixed agonist-antagonist opioid analgesic agent that is five times more potent than morphine in antinociceptive effects. The chronic administration of butorphanol induces physical dependence. Withdrawal from such dependence can be reliably precipitated by administration of a narcotic antagonist, e.g., naloxone. Evidence for critical involvement of excitatory aminoacid (glutamate), opioid receptors, and phosphorylation of proteins in these phenomena is summarized.

• The Journal of Korean Physical Therapy
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• 제14권1호
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• pp.139-158
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• 2002

컴퓨터를 이용하여 MEDLINE, AMED, CINAHL과 Cochrane Libra를 검색하여 요통환자를 위한 다양한 형태의 운동치료 효과에 대해서 발표된 연구 보고서 중 1991년부터 2001년 사이에 영문으로 출판된 보고서를 중심으로 본 연구에 합당한 주제를 충족시키는 연구 보고서 40편을 선택하였다. 수집된 자료를 통하여 요통 관리의 운동치료 효과에 대하여 연구하였으며 일반적인 요통환자들만을 대상으로 급성, 아급성, 만성단계로 구분하였다. 실험논문은 수정된 rating system을 이용하여 논문의 질 수준과 연구결과를 측정하였으며 고찰 논문과 관찰 연구는 grading system을 사용하여 주요 연구 결과를 측정하였다. 본 연구의 결과는 운동치료가 통증감소와 기능 향상에 효과적임이 증명되었고, 총괄적으로 타당도를 지지하는 정도는 중등도에 해당되었다. 연구보고서들을 scale system을 통해서 세부적으로 분석했을 때, 상급의 연구 방법론적 질을 충족시켰다. 결과에 따르면 급성, 아급성과 만성요통에 대한 운동치료가 효과적이었다라는 확실한 증거를 나타냈다. 본 연구의 결론은 요통환자에 대한 운동치료는 효과적으로 입증되었으며, 특별히 만성요통환자의 경우에 더욱 더 효과적인 것으로 나타났다. 이러한 결론을 더욱 지지하기 위해서는 더 많은 고질의 연구 논문들이 이루어져야 할 것이다.

• 한국전문물리치료학회지
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• 제8권3호
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• pp.35-41
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• 2001

In-shoe measurement systems allow the clinician and researcher to examine the pressure parameters within the shoe. The purpose of this study was to investigate the test-retest reliability of plantar pressures using the Parotec system over speeds and plantar regions. Seventeen healthy subjects were recruited for the study. Sampling rate was 100 Hz, and data of six variables (pressure on medial heel, lateral heel, 1st metatarsal head, 5th metatarsal head, and great toe and total impulse) were collected in four different gait speed (1.0 m/sec, 1.5 m/sec, 2.0 m/sec, and comfortable walking speed) in each day. The result indicates fair to excellent reliability between the two day test. Intraclass correlation coefficients (ICCs) ranged from .693 to .979, and range of reliability was similar depending on the speed and plantar region. In most cases, data recorded by the Parotec systems provide good evidence for the reliability.

• Natural Product Sciences
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• 제3권2호
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• pp.106-107
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• 1997

Indole-3-methylethanoate was isolated for the first time form natural source i.e. from the leaves of Camellia sinensis (L.) O. Kuntz and fully characterized by physical and chemical evidence, the biological activity of the compound was studied by wheat coleoptile bioassay which showed growth promoting activity.

• 대한물리의학회지
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• 제13권3호
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• pp.141-150
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• 2018

PURPOSE: This study was conducted to understand the adaptive responses of different modes of physical exercises utilizing skeletal muscle and the comprehensive relevance of AMPK signaling that can be activated by physical exercise as a potential molecular target in human health problems such as neuromuscular disorders (NMDs). METHODS: Most of the contents in this review article are based on recent publications concerning the main topics of interest. The reference literatures cited were obtained by basic searches of overseas academic databases such as PubMed and ScienceDirect using EndNote X7.8. RESULTS: The phenotypic adaptive responses of skeletal muscle during endurance- and resistance-based exercise training (ET and RT respectively) appear to be distinct. To explain the adaptive responses in each single mode of exercises (ET, RT) along with combined exercise training (CT), AMPK signaling is proposed as an important molecular link among those differential modes of exercise and a promising molecular target of NMDs. CONCLUSION: Based on the available evidence, intracellular AMPK signaling activated by diverse stimuli including physical exercise can be a potential and promising therapeutic target for the prevention, amelioration or cure of various human health problems including NMDs and may also be beneficial for physical rehabilitation and emergency situations that may elicit acute metabolic stresses.

• The Journal of Korean Physical Therapy
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• 제13권3호
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• pp.603-611
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• 2001

This study was performed. using EGF, to observated the effect of GaAIAs laser on wound model induced designedly in lumbar region. The results of this study were as following: 1. In expression of EGF which used marker of wound healing, laser irradiating group made EGF to more induce significantly than laser non-irradiating group at 3 days. 2. EGF immunoreactivity in epidermis were increased markedly 3 days after wound, and increased gradually from 1 day to 2 days in wound which is laser irradiation. Therefore, EGF immunoreactivity which increased after wound with GaAIAs laser irradiation indicate that GaAIAs laser have wound healing effect. This study also can become a part of scientific evidence on electrotherapy through measuring quantitively effects of GaAIAs laser in wound

• 대한가정학회지
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• 제36권2호
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• pp.47-60
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• 1998

The effects of personal(gender, physical growth) and environmental(communication with parent, intimacy of friendship, school performance, and satisfaction of school-life) factors on adolescent's self-esteem were examined in a samlpe of 525 first and second grades in middle school. The subdomains of the self-esteem were peer-related self, home self, teacher-related self, academic self, physical appearance self, physical competence self, personality self, and general self. T-test, Pearson's correlation, and regression were used as statistical analysis. Results were as follows. First, there was evidence of a gender difference in the level of the subsdomains of self-esteem: teacher-related, physical-appearance, physical-competence, and personality. Second, the factor which was the most powerful predictor of each subdomain of the self-esteem was as follows 1) the most powerful predictor of the peer-related self was the intimacy of friendship, 2) the most powerful predictor of the home self was the communication with parent, 3) the most powerful predictor of the teacher-related self was the satisfaction of school-life, 4) the most powerful predictor of the academic self was the school performance, 5)the most powerful predictor of the physical-appearance self, the physical competence self, and the personality self was the satisfaction of school-life, 6) the most powerful predictor of the general self was the school performance.

• Physical Therapy Rehabilitation Science
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• 제11권3호
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• pp.363-369
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• 2022

Objective: The purpose of this study was to prepare evidence for the prevention and management of nonspecific chronic neck pain (NSCNP) by examining the correlation between activity of daily living and physical activities of office workers with NSCNP. Design: Crossed-sectional study Methods: 89 patients with NSCNP were recruited for this study. But 2 subjects met the exclusion criteria and were dropped out, and 86 subjects finally participated. Numerical pain rating scale (NPRS) and neck disability index (NDI) were used to check the pain intensity and disability of patients with neck pain, respectively. For the activity of daily living, computer use time, sleep time, and driving time were used. To find out the physical activities of the subjects, International Physical Activity Questionnaires (IPAQ-SF) was used. Correlation analysis was performed to find out the correlation of each variable. Results: A clear positive correlation was established between computer use time and pain (p<0.05), and a clear positive correlation was established between computer use time and disability index (p<0.05). The correlation between NPRS and NDI and physical activity total time, high intensity activity score, moderate intensity activity score, and walking score were not statistically significant (p>0.05). Conclusions: In treating patients with NSCNP, it is necessary to reduce the computer usage time as a professional factor or to educate the proper posture. In addition, rather than emphasizing physically comprehensive physical activity, grafting therapeutic exercise directly related to neck pain could have a more positive effect on NSCNP patients.

• 대한통합의학회지
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• 제10권2호
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• pp.13-25
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• 2022

Purpose : This study compared the cost-effectiveness ratio of physical therapy in health centers and home physical therapy, two physical therapy methods for home-bound stroke patients, and clarified the economic validity regarding the effect of home physical therapy. Methods : To measure and compare the cost and effectiveness of the two physical therapy methods for stroke patients, subjects were recruited based on in-hospital and home physical therapy. Among the entire data collected, 82 and 90 participants were selected for in-hospital and home physical therapy, respectively. To measure costs, regarding both in-hospital and home physical therapy, direct cost and indirect cost for patients, family, medical institutes, and the government were measured. In addition, activities of daily living were measured in both methods to measure their effectiveness. Through collected data, the cost-effectiveness and incremental cost-effectiveness ratios were analyzed. Results : Based on the analysis of cost-effectiveness, home physical therapy showed lower cost-effectiveness than in-hospital physical therapy. Furthermore, the incremental cost-effectiveness ratio also showed a difference, which implied home physical therapy could have high effectiveness compared to cost. Conclusion : Based on these results, home physical therapy could be considered as an alternativeto other methods of physical therapy, for home-bound stroke patients. In addition, the result of thisstudy contribute by providing evidence that home physical therapy offers economic benefits and canbe more effective in treating home-bound patients when policy decisions are made to establish a home physical therapy system.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.501-516
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• 2014

Background: Our aim was to identify gaps and limitations in the current literature and to make recommendations for future research required to address these. Materials and Methods: We reviewed occupational exposures and related factors associated with the risk of prostate cancer between 2000 and 2012. These included chemical, ergonomic, physical or environmental, and psychosocial factors which have been reported by epidemiological studies across a range of industries. Results: The results are inconsistent from study to study and generally this is due to the reliance upon the retrospectivity of case-control studies and prevalence (ecological) studies. Exposure assessment bias is a recurring limitation of many of the studies in this review. Conclusions: We consider there is insufficient evidence to implicate prostate cancer risk for ergonomic, physical, environmental or psychosocial factors, but there is sufficient evidence to implicate toxic metals, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs). More research is required to identify specific pesticides that may be associated with risk of prostate cancer.