• 제목/요약/키워드: phase-out

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생쥐 LP1-1 세포에서 S phase 동안 nuclear matrix에 고정되어 있는 복제 끝점 (Termination Sites of fleplication Are Anchored to the Nuclear Matrix during S Phase in Mouse LPI-1 Cells)

  • 이형호;이갑열
    • 한국동물학회지
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    • 제37권3호
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    • pp.318-323
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    • 1994
  • The association of replication origins/termini with nuclear matrix during S phase was investigated by DNase digestion of halo structures in synchronized mouse LPI-1 cells. The binding of parental DNA to nuclear matrix was constant throughout S phase. When nuclear matrix was isolated from the cells pulse-labeled with 3H-thvmidine at various stases of S phase, total 3H-labels associated with nuclear matrix were specifically higher at So, Sa and Ss stages than other stases of S phase, suggesting that the newly synthesized DNAs at those stages are not excluded out of nuclear matrix. Similar patterns were obsenred from the pulse-chase experiments, in which cells were pulse-labeled at each stage of S phase and further incubated for 1 hr. These results suggest that the replication origins and termini are fixed at the nuclear matrix, and that the nuclear matrix binding fractions of DNA at 3C-pause may contain a large population of replication origins and termination sites.

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Mw 5.5~6.5 지진동의 위상특성과 계속시간 및 PGA와의 관계 (Relationship between Phase Properties, Significant Duration and PGA from the Earthquake Records of Mw 5.5~6.5)

  • 최항;윤병익
    • 한국지진공학회논문집
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    • 제23권1호
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    • pp.55-70
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    • 2019
  • The phase properties of ground acceleration records from Mw 5.5~6.5 earthquakes are analyzed. The interrelationships between phase properties and significant durations, as well as PGA, are clarified through both of theoretical and empirical approaches. The probabilistic characteristics of phase information is also discussed based on previous studies and it is shown that circular normal distribution is the most appropriate probability distribution for the phase angle and phase difference. Whereas those variates can be modeled by Gaussian random variables. From the survey results on the frequency dependency of the phase statistics, a simple model is introduced, which is possible to express the frequency dependency of phase information. It is also shown that the significant duration can be controlled by appropriately chosen standard deviation of phase difference for 4~8Hz frequency band and additional consideration of phase scattering in higher frequency band through a series of Monte Carlo simulations. The source of phase scattering effect is also pointed out and discussed.

그라운드 레슬링 가로들기 공격 시 수비 유형의 운동학적 분석 (A Kinematic Analysis of the Defence Types during Body Lock Technique in the Ground Wrestling)

  • 하종규;류지선
    • 한국운동역학회지
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    • 제17권1호
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    • pp.155-164
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    • 2007
  • This study is to find out effective defensive type by analysis on differences among three different defence types of the body lock technique in the ground wrestling. The subjects are 5 athletes who are in 60kg weight class. To get the kinematic analysis seven ProReflex MCU-240(Motion Capture Unit), infrared rays cameras, which was produced by Qualisys, were used to get a two-dimensional coordinate. Following are the analysis result from kinematic factors such as time element, speed element and angular element. 1. During position of ground wrestling, the average necessary time until defender's hip joint touches the mat for Phase1 was $0.34{\pm}0.14sec$ at side position was the shortest space of time out of three types, and Phase2 was $0.21{\pm}0.02sec$ at front position was the shortest space of time out of three types. Moreover, side defence position was the shortest for total average necessary time with $0.78{\pm}0.05sec$. 2. The movement change for hip joint was $57.21{\pm}20.17cm$ for front, $43.35{\pm}7.13cm$ for rear, and $18.67{\pm}10.24cm$ for side at Phase1 and $42.08{\pm}17.56cm$ for side, $16.61{\pm}6.34cm$ for front, and $1.48{\pm}1.29cm$ for rear at Phase2. 3. Movement speed of hip joint at defensive type were most effective in success and fail rate at Phase 1 and its frontal average speed was fastest with $1.01{\pm}0.23m/s$ following by $0.52{\pm}0.15m/s$ for side, and $0.62{\pm}0.15m/s$ for rear. The average for total change of speed is $0.79{\pm}0.32m/s$ for front, $0.78{\pm}0.17m/s$ for side, and $0.49{\pm}0.08m/s$ for rear. 4. The joint angle gets smaller in a order by rear, front, and side for the size of hip joint angle and knee angle for different defensive type. 5. As a result of one-way ANOVA on linear velocity for hip joint in frontal defence(phase1) was significance ($\alpha$=.05), but phase 2 was not significance. Synthetically, analyzing on differences among three different defence types which were front, rear, and side of the body lock technique in the ground wrestling, front defensive type was the most effective. In future, there should be more studies regarding on defence at not a laboratory study but a field study to help out wrestler to pertinent techniques to improve the game of wrestling.

UNCERTAINTY AND SENSITIVITY ANALYSIS OF TMI-2 ACCIDENT SCENARIO USING SIMULATION BASED TECHNIQUES

  • Rao, R. Srinivasa;Kumar, Abhay;Gupta, S.K.;Lele, H.G.
    • Nuclear Engineering and Technology
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    • 제44권7호
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    • pp.807-816
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    • 2012
  • The Three Mile Island Unit 2 (TMI-2) accident has been studied extensively, as part of both post-accident technical assessment and follow-up computer code calculations. The models used in computer codes for severe accidents have improved significantly over the years due to better understanding. It was decided to reanalyze the severe accident scenario using current state of the art codes and methodologies. This reanalysis was adopted as a part of the joint standard problem exercise for the Atomic Energy Regulatory Board (AERB) - United States Regulatory Commission (USNRC) bilateral safety meet. The accident scenario was divided into four phases for analysis viz., Phase 1 covers from the accident initiation to the shutdown of the last Reactor Coolant Pumps (RCPs) (0 to 100 min), Phase 2 covers initial fuel heat up and core degradation (100 to 174 min), Phase 3 is the period of recovery of the core water level by operating the reactor coolant pump, and the core reheat that followed (174 to 200 min) and Phase 4 covers refilling of the core by high pressure injection (200 to 300 min). The base case analysis was carried out for all four phases. The majority of the predicted parameters are in good agreement with the observed data. However, some parameters have significant deviations compared to the observed data. These discrepancies have arisen from uncertainties in boundary conditions, such as makeup flow, flow during the RCP 2B transient (Phase 3), models used in the code, the adopted nodalisation schemes, etc. In view of this, uncertainty and sensitivity analyses are carried out using simulation based techniques. The paper deals with uncertainty and sensitivity analyses carried out for the first three phases of the accident scenario.

하루 중 시간변화(時間變化)에 따른 한출(汗出)의 기전(機轉)에 대한 연구(硏究) (A Study on Perspirations(汗出) in Daily Time Cycle)

  • 유정아;정창현
    • 대한한의학원전학회지
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    • 제22권3호
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    • pp.271-289
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    • 2009
  • This thesis intend to help the eastern medical doctor to understand body condition from interpretation of perspirations(汗出) in daily time cycle. The conclusion is followed. 1. In most Eastern Medical classic and clinic literatures, the time of fever and perspirations are described as a result of disease's position at human body. Following this description, in daytime the perspirations must come from the Gi phase and night time the perspirations must come from the blood phase. Because in daytime the skin pores are opening and the defensive Gi is going out to the superficial portion of the body. In night time the skin pores are shutting and the defensive Gi is going in to the five solid organs. So a sweat in daytime comes out from the Gi phase and superficial portion of the body. And in night time comes out from the blood phase and five solid organs. But in recent real clinic cases, in daytime, there are so many perspirations from the five solid organs. Comparatively, the perspirations from the superficial portion of body are very little. And in same daytime perspirations, when the heat pathogens mixed with moist, the symptom revelation time delay to the afternoon. Therefore it can be concluded that the time of perspirations are combination of disease's Gi or blood phase and characteristics of pathogens. The position of disease at human body cannot simply judge the symptom revelation time. 2. The exchange of climate following time cycle of a day effect to the condition of human body. At same time it activates or not activates the pathogens in human body. So we can consider the kinds and characteristics of pathogens by distinguishing the symptom revelation time. In general differentiation of syndromes[辨證] pathogen's kinds and location are generally judged. By understanding the characteristics of pathogen, doctor can devise more correct and delicate prescription.

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PZT 박막의 급속열처리시 Pb 함량이 상변태에 미치는 영향 (Effect of Pb Content on the Phase Transformation of Sputter-Deposited PZT Thin Film During RTA)

  • 주재현;길덕신;주승기
    • 한국세라믹학회지
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    • 제30권10호
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    • pp.803-810
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    • 1993
  • PbxZr0.4Ti0.6O3 thin films were prepared by reactive co-sputtering and annealed by RTA(Rapid Thermal Annealing) process. Effect of Pb content in PbxZr0.4Ti0.6O3 films on the phase transformation was intensively studied. It has been found out that depending on the Pb content as well as RTA temperature, crystal structure of PbxZr0.4Ti0.6O3 films change greatly. It turned out that transformation temperature for perovskite can be lowered and the width of transition temperature region was reduced by increasing Pb content in the film. And the lattice was expanded with increasing Pb content. With increasing RTA temperature, as-deposited phase was transformed into perovskite through three different transformation paths depending on Pb content. It was confirmed that activation energies for nucleation of perovskite structure are much larger than those of its growth.

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Antibradykinin Effects of the Non-peptide Antagonists of Mixture Libraries Prepared by Solution-phase Combinatorial Synthesis

  • KAM Yoo Lim;CHOO Hea-Young P.
    • Biomolecules & Therapeutics
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    • 제13권3호
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    • pp.181-184
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    • 2005
  • The solution-phase combinatorial synthesis of iminodiacetic acid triamide libraries linked to 1-(4-chlorobenzhydryl)piperazine has been reported. Ten mixture libraries, each containing 5 components, were synthesized in 4 steps from N-BOC-iminodiacetic acid anhydride. Antibradykinin effects of the mixture and individual libraries were compared using guinea-pig ileum smooth muscle. The changes in the inhibition were also observed by testing the combination of two different compounds from the same library. We found out the correlation between the inhibition of mixtures and that of individual libraries. It is possible to choose the mixtures with relatively high inhibitory effects to find out the most effective individual compound for further synthesis.

열간압연 고강도강의 온도 및 재질제어 (Temperature and Property Control of High Strength Steel in Hot Strip Mills)

  • 박철재
    • 한국생산제조학회지
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    • 제20권6호
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    • pp.817-823
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    • 2011
  • This paper proposes a cooling stop temperature control(CST) and a phase transformation control(PTR) which aim at obtaining the uniform temperature and quality along the longitudinal direction of the high strength steel on the run-out table(ROT) process. The problems of the temperature control are analyzed for the conventional steel and the new control concepts are derived from a time-temperature transformation(TTT) diagram. The proposed control technologies are verified from the simulation results under the temperature prediction model by the heat transfer governing equation, and the temperature estimation simulator. It is shown through the field test of the hot strip mills that the phase transformation ratio of the high strength steel is considerably improved by the proposed temperature controls.

Ultra High-speed 3-dimensional Profilometry Using a Laser Grating Projection System

  • Park, Yoon-Chang;Ahn, Seong-Joon;Kang, Moon-Ho;Kwon, Young-Chul;Ahn, Seung-Joon
    • Journal of the Optical Society of Korea
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    • 제13권4호
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    • pp.464-467
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    • 2009
  • The grating projection method with phase-shifting technique is very useful in measuring the 3-dimensional (3D) shape with high accuracy and speed. In this work, we have developed an ultra high-speed digital laser grating projection system using a high-power laser diode and a highsensitivity CMOS camera. With our system, the optical measurement required to find out the profile of a 3D object could be carried out within 2.6 ms, which is a significant ($\sim$10 times) improvement compared with those of the previous studies.

다목적연구로 반응도 제어장치의 제어봉에 대한 내진해석 (Seismic Analysia of Absorber Rod in KMRR Reactivity Control Mechanism)

  • 조영갑;유봉;김태룡;안규석
    • 한국전산구조공학회:학술대회논문집
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    • 한국전산구조공학회 1990년도 봄 학술발표회 논문집
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    • pp.44-49
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    • 1990
  • This study is a seismic analysia of absorber rod in KMRR Reactivity Control Mechanism. The model being studied i8 two coaxial tubes (control absorber rod and flow tube) immersed in the water and partially coupled (overlap) by water Hap. The hydrodynamic mass effects by the water in each surrounding conditions are considered in the model. The natural frequencies, stresses and displacements of the system due to Safe Shutdown Earthquake are computed in the cases of in-phase modes and out-of-phase modes of two coaxial tubes. The results show that maximum stresses are well below the allowable limit and maximum displacements at the ends of both tubes in out-of-phase modes are so huck that the tubes contact each other in the overlap zone.

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