• Knowledge Management Research
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• v.21 no.3
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• pp.105-121
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• 2020

With regard to the development of new drugs, what is most important for a Korean Biotech, where no global sales network has been established, is decision-making related to out-licensing of new drugs. The probability of success for each clinical phase is different, and the licensing amount and its royalty vary depending on which clinical phase the licensing contract is made. Due to the nature of such a licensing contract and Biotech's weak financial status, it is a very important decision-making issue for a Biotech to determine when to license out to a Big Pharma. This study defined a model called 'optimal timing for out-licensing of new drugs' and the results were derived from the decision tree analysis. As a case study, we applied to a Biotech in Korea, which is conducting FDA global clinical trials for a first-in-class new drug. Assuming that the market size and expected market penetration rate of the target disease are known, it has been shown that out-licensing after phase 1 or phase 2 of clinical trials is a best alternative that maximizes Biotech's profits. This study can provide a conceptual framework for the use of management science methodologies in pharmaceutical fields, thus laying the foundation for knowledge and research on out-licensing of new drugs.

• Journal of Oral Medicine and Pain
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• v.26 no.1
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• pp.17-25
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• 2001

The purpose of this study is to evaluate the relationship of menstrual cycle and halitosis by measuring the concentrations of Voltile Sulfur Compounds, secretion rate of unstimulated saliva, secretion rate of stimulated saliva and viscosity of saliva during the menstrual cycle. The subjects were 19 female dental students of Yonsei University who had relatively good alignment of the teeth. They hadn't taken antibiotics or oral contraceptive pills during the few months prior to the experiment, and they didn't have any dental caries involving the pulp or periodontal disease. Lady-$Q^{(R)}$(Alpain Korea, Korea), which confirms the ovulation using saliva, was used to find out the menstrual cycle of subjects. Their history was taken and their basal body temperature was measured. On the basis of these data, the amount of Volatile Sulfur Compounds, secretion rate of unstimulated saliva, secretion rate of stimulated saliva, viscosity of saliva were measured during 1 day of the proliferative phase, 3 days of ovulatory phase and 1 day of the luteal phase within the menstrual cycle. The results were as follows : 1. The amount of Volatile Sulfur Compounds, secretion rate of unstimulated saliva, secretion rate of stimulated saliva, and viscosity of saliva showed no statistically significant cyclic change during proliferative phase, ovulatory phase, and luteal phase(p<0.05). 2. Between the secretion rate of unstimulated saliva and secretion rate of stimulated saliva, there was significant correlation during proliferative phase and luteal phase(p<0.05) and there was no significant correlation during ovulatory phase but relatively close result was seen. 3. The amount of Volatile Sulfur Compounds during proliferative phase and luteal phase had statistically significant correlation(p<0.05). 4. Secretion rate of stimulated saliva during proliferative phase and ovulatory phase, proliferative phase and luteal phase, ovulatory phase and luteal phase had significant correlations (p<0.01).

• Korean Journal of Applied Biomechanics
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• v.16 no.3
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• pp.65-74
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• 2006

This study was attempted to Kinematical characteristics of the Endo $360^{\circ}$El-grip Swing on the horizontal bar. To do this, we selected and analyzed the performance of two athletes who did Endo $360^{\circ}$El-grip Swing in the horizontal bar competition of male artistic gymnastic in the 22nd Universiad Games 2003 Daegu. We drew the conclusions from the kinematical factors that were came out through analyzing three-dimensional cinematography of the athletes' movements, by using two video cameras. In point of analyzing the actual competition situation, it is expected that gymnastics and coaches have the effective informations, and the following conclusion had resulted. 1. When performing Endo $360^{\circ}$El-Grip, the average for entire required time was $1.93{\pm}0.06sec$. The average for descent phase time was $0.24{\pm}0.02sec$, ascent phase time was 0.22${\pm}0.07sec$, connecting phase time was $0.87{\pm}0.07sec$, and El-Grip phase time was $0.61{\pm}0.02sec$. The descent phase need short period of time but however to have a stable performance, ensuring ascent and connecting phase time are needed. El-Grip phase need short period of time to have a stable re-grasp. 2. To have a convenient preparation for El-Grip in descent and ascent phase, lowering CM, and ease up in sway and plunge from the High Bar would make descent and ascent even more faster and would have increase effect in trunk rotation. 3. In descent and ascent phase, if shoulder angle and arm slope is dwindling then it would effect rotation angle so might risk it from hitting a Bar when putting legs in and out. 4. In connecting phase, it requires some time to show stable performance when El-Grip phase is continued by using hip angle which would make trunk rotation angle bigger and make descent and ascent time slower. 5. In El-Grip phase, when doing motions like hand standing. using hip angle more than maximum would make CM even faster and it is stable position while performing.

• Korean Journal of Materials Research
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• v.26 no.4
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• pp.200-206
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• 2016

This study was carried out to investigate the effect of W substitution on the precipitation behavior of ${\chi}$ and ${\sigma}$ phases in super duplex stainless steel. The ${\chi}$ phase was precipitated at the interface of ferrite / austenite phases and inside the ferrite phase at the initial stage of aging. With an increase in the aging time, the volume fraction of the ${\chi}$ phase increased, and then decreased with the transformation from the ${\chi}$ phase to the ${\sigma}$ phase. The ${\sigma}$ phase was precipitated later than the ${\chi}$ phase, and the volume fraction of x phase increased with the increase in the aging time. The ferrite phase was decomposed into the new austenite (${\gamma}2$) and ${\sigma}$ phases by aging treatment. The decomposition of the ferrite phase into the ${\gamma}2$ and ${\sigma}$ phases was retarded by W substitution for Mo. The volume fraction of the ${\chi}$ phase increased and that of the ${\sigma}$ phase decreased due to W substitution. The ${\chi}$ and ${\sigma}$ phases were intermetallic compounds, which had lower nickel concentration, and higher chromium, molybdenum, and tungsten concentrations. The ${\chi}$ phase has higher molybdenum and tungsten concentrations than those of the ${\sigma}$ phase. The amounts of chromium and nickel in the ${\chi}$ and ${\sigma}$ phases did not change, but these phases have higher concentrations of molybdenum and tungsten due to W substitution for Mo.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• autumn
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• pp.265-270
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• 2002

Frequent design changes or unnecessary project executions due to illogical practice, lack of feasibility study and, hasty drive have raised problems of budget waste in Korean construction projects. Since the MOCT (Ministry of Construction & Transportation) published Master Plan for budget efficiency for government projects, there have been a lot of policy efforts for budget saving. However, it has been pointed out that cost management at the pre-construction phase, which greatly influences the cost still remains imperfect. The target cost for government clients is not being estimated reasonably, and cost controlling at the pre-construction phase is not yet being carried out properly for keeping the budget. Therefore, improved construction cost management at the pre-construction phase was proposed in this paper. The cost management systems of advanced countries were investigated for it, and the issues were drawn from the cost management systems of these countries. On the basis of the issues, the present conditions and problems of domestic construction cost management at the pre-construction phase were analyzed for suggestion.

• Journal of IKEEE
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• v.5 no.1 s.8
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• pp.16-23
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• 2001

Passive noise reduction is a classical approach to attenuate industrial noise, and an active noise cancellation has several advantages over the passive noise cancellation. The active noise reduction system offers a better low frequency performance with a smaller and lighter system. This paper presents a simple active closed loop control system which consists of an controller for inverting and compensating the phase delay, a microphone for picking up the external noise, and a loudspeaker for radiating the acoustic out of phase signal to reduce the external noise, and external noise can be reduced after compensating the phase difference to be $180^{\circ}$ in the frequency of maximum value in the amplitude response. The noise of the phase delay covered from $50^{\circ}\;to\;310^{\circ}$ tends to be reduced in the active noise control system and it is possible to obtain a noise cancelling of up to approximately 20[dB] at the ears in the enclosurer.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2007.11a
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• pp.797-800
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• 2007

Value Engineering(VE) is being applied as an useful tool to eliminate the waste of cost and noneffective factors previously in construction projects. Ministry of construction and transportation' has been accordingly enforcing extensionally design phase VE to the construction costing more than 10 billion won, an importance of design phase VE. Although there are legal supports and technical effects, an effect about an introduction of design phase VE can not be applied properly because of several problems at the process. So, in this study, try to find out competency factors of design phase VE to enforce a competency of VE team as a basic database for developing a check list, and estimate weight. For the result, find out a competency evaluation item and organize as a team knowledge, a team work skill and a team attitude. Perform a first survey to verify a reliability and propriety regarding the found competency evaluation, perform the second survey competency as to evaluation item of the found 1, 2, 3 class and then estimate the weight by AHP.

• Transactions of the Society of Information Storage Systems
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• v.3 no.3
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• pp.118-122
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• 2007

Phase-change wet-etching technology using GeSbTe phase-change films is developed. Selective etching between an amorphous and a crystalline phase can be carried out with an alkaline etchant of NaOH. Etching selectivity is dependent not only on the concentration of the alkaline etchant but also on the film structure. Specifically, metal films for heat control cause marked effects on the etching properties of GeSbTe film. Surviving amorphous pits can be obtained with Al metal layer, however etched amorphous pits are seen with Ag metal layer. An opposite selective etching behavior can be observed between samples with two different metal layers.

• Proceedings of the KIEE Conference
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• 2004.07c
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• pp.1936-1938
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• 2004

In this paper, we discussed measurement method of PD (Partial Discharge) of 22.9[kV] cable. Cable rail track laying portable detector that can detect partial discharge of cable connection ashes by on-line done spot way to detect Lemke equipment and high broadcasting CT sensor that use antenna sensor using ICM mounting was explained. Because measurement corona signal is very big, analysis of partial discharge is difficult state, we used connector. It could be attenuated by 2 times. We found out that corona signal which generated on B phase is flowed on A phase and C phase. It could measure that partial discharge of A phase happens actually. We could confirm that partial discharge of about 250 ${\sim}$ 300 [pC] on A phase is dangerous.

• Journal of the Korean Ceramic Society
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• v.49 no.5
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• pp.469-474
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• 2012

The crystallinity and phase ratio of anatase to rutile in $TiO_2$ were estimated by x-ray diffraction (XRD) and x-ray absorption spectroscopy (XAS). Traditionally, the structural characterization of $TiO_2$ powders has been carried out by XRD techniques, which are comparatively easy in use and analysis. However, materials with amorphous phase, nano-sized or nano-structured crystallinities cannot be fully characterized by XRD because XRD analysis has a limit for abnormal contributions of the nano-crystal such as the surface contribution. From the comparison with the experimental and calculated Ti K-edge XAS spectra, we found the possibility of efficient estimation in the crystalinites and the phase ratio of anatase to rutile for nano-sized $TiO_2$ mixture.