• Journal of the Korea Institute of Military Science and Technology
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• v.25 no.2
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• pp.135-143
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• 2022

In this paper, the compact waveguide slot array antenna for interferometric radar altimeter is proposed. The proposed antenna structure consist of corrugation structure which is applied between each channel to improve isolation, three-channel waveguide slot array antenna and feeder. In addition, to reduce the occurrence of phase ambiguity, the baseline spacing of the three-channel antenna is analyzed and the results are applied to the design. For compact design, reduced height and SMP connector structure are used and the dip brazing method which is the conjugation method after dipping to flux is used for the fabrication of the lightweight antenna. The measurement result of the proposed antenna shows less than 1.41 : 1 (VSWR) and 48.3 dBc (isolation). The antenna gain is higher than 20.2 dBi and the side lobe levels are lower than 18.8 dB (vertical plane) and 10.0 dB (horizontal plane).

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.1
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• pp.24-30
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• 2014

A digital RDA(Retrodirective Antenna) system is a retransmit system that received signal without prior information turn back by estimated phase of the signal to received direction. The RDA can decrease consumption of power by increase of directivity because signal concentrates on received direction compare to omni-direction antenna which transmit power all direction. Generally, the RDA is known to show better performance than the single-antenna system in multi-path environment. However, the RDA occurs performance degradation in serious ISI channel. In this paper, to solve this problem, we propose retrodirective antenna combined with turbo equalizer combined which can compensate serious ISI channel, we increase the BER performance through proposed retrodirective antenna combined with turbo equalizer in serious ISI channel.

• Journal of Advanced Navigation Technology
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• v.22 no.3
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• pp.240-245
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• 2018

A flexible dispersion-managed link configuration is proposed by using single-mode fibers (SMFs) and dispersion-compensating fibers (DCFs) with irregular dispersion coefficients and lengths over all fiber spans for compensating of WDM channels distortion due to the group velocity dispersion and nonlinear effects of optical fibers. The flexibility of link is enabled by artificially distributing of these fibers based on the dispersion coefficients of DCFs in each half transmission section. The simultaneous ascending and descending (AD) distribution of the DCF's coefficients before and after the optical phase conjugator, respectively, best compensates the distorted wavelength division multiplexed signals in the optical link. Therefore, to improve the compensation effect of the distorted WDM channels, AD distribution is needed to choice regardless of fiber lengths and the residual dispersion per span and fiber's dispersion coefficients.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.191-191
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• 1998

It has been hypothesized that formation of oxygen-derived free radicals may play an important part in ischemically induced tissue injury. In this study, the effects of vitamin C treatment on hepatic reperfusion model were investigated. Livers isolated from 18 hrs fasted rats were subjected to low flow hypoxia (1 $m\ell$/g liver/min, for 45min) followed by reoxygenation (for 30min). The perfusion medium used was Krebs-Henseleit bicarbonate buffer (KHBB, pH 7.4) and vitamin C (0.25, 0.5, 1.0 and 2.0 mM) was added to perfusate. 7-Ethoxycoumarin was used as substrate of phase and metbolism. After hypoxia oxygen consumption significantly dropped but vitamin C 0.25, 0.5 and 1.0 mM treatments restored oxygen consumption to the level of control group. LDH and lipid peroxidation were not changed in all experimental groups. Oxidation, phase metabolism, significantly decreased following hypoxia but improved during reoxygenation. Vitamin C 0.25 mM treatment significantly improved the oxidation of 7-ethoxycoumarin during hypoxia and reoxygenation, but the oxidation significantly decreased by vitamin C 2.0 mM treatment. Similarly, sulfate conjugation decreased in hypoxic group, but this decrease was inhibited by vitamin C 0.25, 0.5 and 1.0 mM treatments. Our findings suggest that hypoxia/reoxygenation diminishes hepatic drug metabolizing function, vitamin C at concentration of 0.25-1.0 mM ameliorates but at higher concentration aggravates these hypoxia/reoxygenation-induced changes.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38A no.2
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• pp.209-216
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• 2013

In this paper, we design and analyze digital retrodirective array antenna (RDA) system in 60GHz wireless communication for low power consumption and high quality. Digital RDA can automatically make beam toward source without information about the direction of incoming signal, this system is able to do low power communication thanks to increased signal to interference noise ratio (SINR) because making the beam toward source can reduce interference signals. The frequency offset seriously arises when millimetric wave band like 60GHz is used to communicate for high-speed transmission. The proposed system is robustly designed to frequency offset through designing digital phase lock loop in order to solve the problem of frequency offset. In this paper, we analyze the performance of the proposed system according to the number of array antenna and frequency offset. striking space.

• Genomics & Informatics
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• v.16 no.3
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• pp.52-58
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• 2018

In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials. During conducting a first-in-human trial for a new molecular entity, we were able to determine the mechanism of dichotomized variability in plasma drug concentrations, which appeared closely related to adverse drug reactions (ADRs) through integrated omics analysis. The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. Metabolomics profiling was performed from plasma samples using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A GSTM1 null polymorphism was identified in pharmacogenomics test and the drug concentrations was higher in GSTM1 null subjects than GSTM1 functional subjects. The apparent drug clearance was 13-fold lower in GSTM1 null subjects than GSTM1 functional subjects (p < 0.001). By metabolomics analysis, we identified that the study drug was metabolized by cysteinylglycine conjugation in GSTM functional subjects but those not in GSTM1 null subjects. The incidence rate and the severity of ADRs were higher in the GSTM1 null subjects than the GSTM1 functional subjects. Through the integrated omics analysis, we could understand the mechanism of inter-individual variability in drug exposure and in adverse response. In conclusion, integrated multi-omics analysis can be useful for elucidating the various characteristics of new drug candidates in early phase clinical trials.

• Journal of the Korean Applied Science and Technology
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• v.31 no.3
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• pp.367-374
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• 2014

In this study, skin permeation enhancement was confirmed by designing it to have a structure and composition similarity to the intercellular lipids that improve miscibility with skin by cross-linked lipids poloxamer. The cross-linked lipids poloxamer was synthesized and analyzed by 1H NMR that structure dose had conjugated pluronic with ceramide3. Active component is released by modification of liquid crystal structure because PPO part, large-scale molecule block of pluronic, has hydrophobic nature at skin temperature of $35^{\circ}C$. Conjugated pluronic with ceramide3 was synthesized using Pluronic F127 and p-NPC (4-nitrophenyl chloroformate) at room temperature yielded 89%. Pluronic(Ceramide 3-conjugated Pluronic) was synthesized by reaction of p-NP-Pluronic with Ceramide3 and DMAP. The yield was 51%. This cross-linked lipids poloxamer was blended and dissolved at isotropic state with skin surface lipids, phospholipid, ceramide, cholesterol and anhydrous additive solvent. Next step was preceded by ${\alpha}$-Transition at low temperature for making the structure of Meso-Phase Lamella, and non-hydrous skin analogue liquid crystal using thermo-sensitivity smart sensor, lamellar liquid crystal structure through aging time. For confirmation of conjugation thermo-sensitivity smart sensor and non-hydrous skin analogue liquid crystal, structural observation and stability test were performed using XRD(Xray Diffraction), DSC(Differential Scanning Calorimetry), PM (Polarized Microscope) And C-SEM (Cryo-Scanning Electron Microscope). Thermo-sensitivity observation by Franz cell revealed that synthesized smart sensor shown skin permeation effect over 75% than normal liquid crystal. Furthermore, normal non-hydrous skin analogue liquid crystal that not applied smart sensor shown similar results below $35^{\circ}C$ of skin temperature, but its effects has increased more than 30% above $35^{\circ}C$.

• Archives of Pharmacal Research
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• v.22 no.2
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• pp.99-107
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• 1999

A series of organosulfur compounds were synthesized with the aim of developing chemopreventive compounds active against hepatotoxicity and chemical carcinogesis. 2-(Allylthio) prazine (2-AP) was effective in inhibiting cytochrome P450 2E1-mediated catalytic activities and protein expression, and in inducing microsomal epoxide hydrolase and major glutathione S-transferases. 2-AP reduced the hepatotoxicity caused by toxicant sand elevated cellular GSH content. Development of skin tumors, pulmonary adenoma and aberrant crypt foci in colon by various chemical carcinogens was inhibited by 2-AP pretreatment. Anticarcinogenic effects of 2-AP at the stage of initiation of tumors were also observed in the aflatoxin B1 ($AFB_1$)-induced three-step medium-term hepatocarcinogenesis model. Reduction of $AFB_1$-DNA adduct by 2-AP appeared to result from the decreased formation of $AFB_1$-8,9-epoxide via suppression of cytochrome P450, while induction of GST 2-AP increases the excretion of glutathione-conjugated $AFB_1$ . 2-AP was a radioprotective agent effective against the lethal dose of total body irradiation and reduced radiation-induced injury in association with the elevation of detoxifying gene expression. 2-AP produces reactive oxygen species in vivo, which is not mediated with the thiol-dependent production of oxidants and that NF-KB activation is not involved in the induction of the detoxifying enzymes. the mechanism of chemoprotection by 2-AP may involve inhibition of the P450-mediated metabolic activation of chemical carcinogens and enhancement of electrophilic detoxification through induction of phase II detoxification enzymes which would facilitate the clearance of activated metabolites through conjugation reaction.

• Journal of Environmental Analysis, Health and Toxicology
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• v.21 no.4
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• pp.243-251
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• 2018

Pharmaceuticals in wastewater effluents have been recognized as emerging pollutants threatening freshwater organisms. To extend understanding for bioaccumulation and toxicity in those organisms, information on biotransformation products (or metabolites) and their metabolic pathway are crucial. The aim of the present study is to identify and elucidate metabolites of pharmaceuticals formed in exposed organisms using suspect and nontarget screening approach using LC-HRMS. As the target pharmaceuticals, carbamazepine, ketoprofen, metoprolol, propranolol, and verapamil were selected whereas Daphnia magna and Gammarus pulex were used as test organisms. After 24h exposure, metabolites formed in the organisms were identified using LC-HRMS. The structures of metabolites were elucidated via analysis of MS/MS fragment pattern and the comparison with fragment database. As the results, a total of 10 metabolites were identified for 5 parent compounds (C253/C356 for carbamazepine, K211 for ketoprofen, M256 for metoprolol, P218/P276/P306 for propranolol, V196/V291/V441 for verapamil). Among them, the presence of C253 and V291 was confirmed using standard materials. Most of the identified metabolites were formed through oxidative reactions such as hydroxylation, N-demethylation, and dealkylation. Cysteine conjugation (phase II reaction) metabolite (C356) for carbamazepine was found in daphnia. The metabolic pathway of verapamil showed similar metabolic pathways and metabolic pathways for both species. Although the toxicological information on the identified metabolites could not be confirmed, the molecular structure information of the proposed metabolites can be used for future evaluation and prediction of toxicity.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.4
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• pp.971-980
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• 2013

System performance improvement through the concentrated residual dispersion per span (RDPS) in special transmission fiber spans in optical transmission links with dispersion management (DM) for wavelength division multiplexed (WDM) transmission is investigated through the comparison with the performance in optical transmission links with uniform RDPS in every fiber spans. It is confirmed that, in optical links with RDPS of 0 ps/nm uniformly distributed in the rest fiber spans, if RDPS of 300 ps/nm and 1,320 ps/nm are concentrated in 5th-13th fiber spans and 6th-13th fiber spans, respectively, then the best performance is obtained. It is also confirmed that optimal net residual dispersion (NRD) controlled by precompensation and postcompensation are 10 ps/nm and -10 ps/nm, respectively, in all two cases, and the effective launching power range below 1 dB eye opening penalty (EOP) in the concentrated RDPS of 300 ps/nm and 1,320 ps/nm are improved by 2 dB and 6 dB than optical transmission links with the uniformly distributed RDPS, respectively.