• Journal of Preventive Medicine and Public Health
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• 제18권1호
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• pp.25-39
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• 1985

도시 영세지역 주민의 이환 및 의료이용 양상을 파악하기 위하여 1984년 7월 한 달 동안에 대구시 중구 남산 4동 영세지역 468가구의 가구원 2,002명과 대조지역 374가구의 가구원 1,709명을 대상으로 가구원의 일반적 특성, 질병이환 및 의료이용 양상 등을 면담조사 하였다. 영세지역과 대조지역의 성별, 연령별 분포는 비슷하였으나, 경제수준, 교육수준, 주거밀집도, 의료보장 종류별 분포는 유의한 차이를 보였다. 15일간의 상병 이환율은 영세지역이 1,000명당 131로 대조지역의 71보다 유의하게 높았고, 연령이 증가함에 따라 이환율도 증가하는 경향을 보였으나 65세이상의 노인층에서는 오히려 감소하였다. 년간 만성병 이환율도 영세지역이 1,000명당 134로 대조지역의 89보다 유의하게 높았고 나이가 증가함에 따라 이환율이 증가하였다. 15일간의 상병은 영세지역과 대조지역 모두 호흡기계 질환이 각각 24.0%, 29.8%로 가장 많았고 그 다음은 소화기계 질환으로 21.0%, 20.6%였으며 손상 및 중독은 영세지역이 10.3%인데 비해 대조지역은 3.3%였다. 만성병은 영세지역과 대조지역 모두 소화기계질환이 22.1%, 21.7%로 가장 많았고 그 다음으로 영세지역은 근골격계 질환으로 12.3%, 대조지역은 신경통으로 14.5%였으며, 순환기계 질환은 대조지역이 11.8%로 영세지역의 5.6% 보다 더 많은데 비해 손상 및 중독은 영세지역이 10.8%로 대조지역의 4.6%보다 더 많았다. 15일간의 상병으로 활동제한을 받은 일수는 영세지역이 평균 4.0일로 대조지역의 평균 2.2일보다 유의하게 높았다. 15일간의 상병이나 만성병을 치료받기 위해 영세지역은 약국을 더 많이 이용하고 대조지역은 병의원 외래를 더 많이 이용하였으며, 특히 의료보장 종류별로는 의료보험 가입자는 병의원 외래를, 그리고 일반환자는 약국을 더 많이 이용하였으며, 미치료율은 의료보장 종류에 관계없이 15일 이환의 경우 영세지역이 17.9%, 대조지역은 11.6%, 그리고 만성병은 영세지역이 15.2%, 대조지역은 9.2%로 영세지역의 미치료율이 대조지역보다 더 높았다. 15일간의 상병이나 만성병 모두 경제적인 이유로 치료받지 않은 경우가 가장 많았다. 영세지역의 이환율이 대조지역보다 높은 것은 경제수준, 교육정도, 주거밀집도 등 여러가지 사회 경제적인 요소가 관련된 것으로 나타났으므로, 영세민을 위한 보건사업 계획에는 이러한 사회 경제적인 요소들을 개선하는 노력을 병행해야 효과적인 보건사업이 추진될 것으로 생각된다.

• 대한임상독성학회지
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• 제18권2호
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• pp.57-65
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• 2020

Purpose: Since 2012, acetaminophen can be accessed easily not only at pharmacies but also at convenience stores. The relationship between the easy access of acetaminophen and the risk of poisoning has been controversial. Several studies also reported different results regarding the risk of acetaminophen poisoning after access to acetaminophen was relaxed. This study examined the long-term effects on the risk of acetaminophen poisoning after easy access to acetaminophen was implemented. Methods: This was a retrospective analysis of an emergency department (ED)-based in-depth Injury Surveillance Cohort by the Korea Center for Disease Control and prevention from 2011 to 2018. Poisoning cases were selected from the Cohort, and the incidence of acetaminophen poisoning and the characteristics of the cases of acetaminophen poisoning were analyzed. The purchase path and the amount of ingestion in acetaminophen poisoning were sub-analyzed from data of six EDs. Results: Of 57,326 poisoning cases, 4.0% (2,272 cases) were acetaminophen poisoning. Of 2,272 cases of acetaminophen poisoning, 42.8% (974 cases) required in-patient care after ED management. Two hundred and sixty-four of these 964 cases required intensive care. The rates of cases that required in-patient treatment and the rates of cases that required intensive care increased from 29.4% in 2011 to 48.1% in 2018, and from 3.1% in 2011 to 15.2% in 2018, respectively (p<0.001, p<0.001). In the poisoning group with in-depth toxic surveillance (n=15,908), the incidence and proportion of acetaminophen (AAP) poisoning increased from 55 cases per year to 187 cases per year and 4.9% to 6.1%, respectively (p=0.009, p<0.001, respectively). The most common age group of acetaminophen poisoning was teenagers, which is different from the most common age group of other pharmaceutical agents: the middle age group of 40-49 years (p<0.001). Of 15,908 in-depth toxic surveillance patients, 693 patients had AAP poisoning, of whom 377 cases (54.2%) purchased acetaminophen from a non-pharmacy. The proportions of the purchase path from non-pharmacy were 41.4% at 2011-12 and 56.4% (2013-18) (p=0.004). The amount of acetaminophen ingestion was 13.5±14.3 g at 2011-12 and 13.9±15.1 g at 2013-18 (p=0.794). Conclusion: Although the incidence of acetaminophen poisoning did not increase remarkably in the short term after the implementation of the new regulation, the incidence of acetaminophen poisoning has increased slightly during the study period of 2017-18. In addition, the proportion of the purchase path from non-pharmacies has increased since the emergence of new regulations for the easy access of acetaminophen in 2012. The incidence of acetaminophen poisoning might have been affected after the increasing accessibility of acetaminophen in convenience stores. Continuous control of acetaminophen poisoning is required. Furthermore, the prevention of acetaminophen poisoning should be focused on teenagers with specialized school education programs.

• 동아시아식생활학회지
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• 제11권6호
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• pp.455-465
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• 2001

In a rapidly changing society, the rise in standard of living and level of education has brought about a Qualitative change in consumption, especially food consumption. Accordingly, consumers' interest in and the consumption of health foods has also grown at a rapid pace, expanding the health food market. However. because of the consumer's lack of understanding and knowledge about health foods, the reality is a difficulty in establishing sound consumption. Accordingly, this study was conducted to analyze the consumers' purchase behavior for health food. Through this study, consumers will be able to rationally plan for the use of health food items and further to provide necessary information for planning and executing effective marketing strategies producers and distributors of health foods items. The subjects of this study are the 473 Seoul residents over the age of 20 who have used health food items in the past year. The result of this study showed the use of fatigue rehabilitators, with 93.2% of the respondents saying they have used it. was the highest. with natural products honey, vitamin supplements. restorative foods, mineral supplements, young-gi fellowing in order. Recovery from fatigue. with 3.81, was the top reason the respondents started using health food items, followed by maintenance of health, supplement nutrition. and prevent disease. Family and relatives topped the list of information sources with 3.76. followed by TV and friends. On the other the Internet(2.32) and radio(2.35) were shown to be the lowest information sources. Those surveyed listed quality(4.00), safety(3.99). and nutrition(3.93) as evaluative criteria for health food items, in order of importance. The place of purchase most frequented by consumers in the survey were specialty stores(35.3%) leading the way with department stores and door-to-door sales, pharmacy following behind. On the other hand. purchases from direct mail were the lowest with 1.5% The people who bought health food Items were shown to be parent/siblings(37.2%) , self(33.6%) followed by spouse(23.7%) Purchases made by children were very low with only 4.9%. Finally, the level of satisfaction after using health food products were generally not very high. Consumers seem to be satisfied with the effectiveness(3.37) and safety (3.15) of the products. which is very minute, and they were slightly dissatisfied with the quality of the products.

• BMB Reports
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• 제53권2호
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• pp.100-105
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• 2020

While liver histopathology is heterogeneous in diabetes, the underlying mechanisms remain unclear. We investigated whether glycemic variation resulting from differential diets can induce heterogeneity in diabetic liver and the underlying molecular mechanisms. We generated end-stage non-obese diabetic model rats by subtotal-pancreatectomy in male Sprague-Dawley rats and ad libitum diet for 7 weeks (n = 33). The rats were then divided into three groups, and fed a standard- or a low-protein diet (18 or 6 kcal%, respectively), for another 7 weeks: to maintain hyperglycemia, 11 rats were fed ad libitum (18AL group); to achieve euglycemia, 11 were calorie-restricted (18R group), and 11 were both calorie- and protein-restricted with the low-protein diet (6R group). Overnight-fasted liver samples were collected after the differential diets together with sham-control (18S group), and histology and molecular changes were compared. Hyperglycemic-18AL showed glycogenic hepatopathy (GH) without steatosis, with the highest GSK-3β inactivation because of Akt activation during hyperglycemia; mitochondrial function was not impaired, compared to the 18S group. Euglycemic-18R showed neither GH nor steatosis, with intermediate GSK-3β activation and mitochondrial dysfunction. However, euglycemic-6R showed both GH and steatosis despite the highest GSK-3β activity and no molecular evidence of increased lipogenesis or decreased ApoB expression, where mitochondrial dysfunction was highest among the groups. In conclusion, heterogeneous liver histopathology developed in end-stage non-obese diabetic rats as the glycemic levels varied with differential diets, in which protein content in the diets as well as glycemic levels differentially influenced GSK-3β activity and mitochondrial function in insulin-deficient state.

• 정보관리학회지
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• 제34권3호
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• pp.251-267
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• 2017

본 연구는 KCI 등재지 1,890종을 대상으로 국내 학술지의 오픈액세스의 주요 특성을 분석하고자 하였다. 이를 위해서 학술지의 오픈액세스 특성을 무료접근과 자유로운 재사용이라는 2가지 측면으로 구분하였다. 분석결과, 국내 학술지의 오픈액세스 특성은 무료접근적 성향이 강하였다. 학술지 홈페이지를 기준으로 보면 67%가 로그인 없이 무료로 접근할 수 있었고 무료DB를 기준으로 보면 48%가 무료로 접근할 수 있었다. 반면 자유로운 재사용적 성향은 무료접근적 성향에 비해 약한 것으로 나타났다. 전체 등재지 중에서 14%만이 CC 라이선스를 부여하고 있었다. 또한 주제분야간에 오픈액세스 성향의 차이가 분명하게 나타났다. 의약학, 자연과학, 농수해양, 공학 분야가 인문학, 사회학, 예술체육, 복합학 분야에 비해 오픈액세스 성향이 상대적으로 강한 것으로 나타났다. 그 이유는 해당 주제분야의 학술지 유통을 지원해 주는 기관의 존재 유무에 따라 차이가 발생한 것으로 보인다. 이런 문제를 해결하기 위해서는 주제분야와 상관없이 국내 학술지의 오픈액세스 정책을 수립하고 지원하는 오픈액세스 거버넌스 체제가 구축될 필요가 있다.

• 농촌의학ㆍ지역보건
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• 제21권2호
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• pp.231-241
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• 1996

The estimation of medical care status and the planning of health service program should be done according to each community resident's socio-medical background and public health service. In this point, it is most necessary to be set the exact and new socio-economic statistics data in Nepal, one of the worst countries in national health status. We surveyed 668 house, 3,425 residents in Dolka area, Nepal from January 25th to February 1st, 1995. 1. In personal characteristics, the ratio of men and women was similar, the person who were below 19 years old were 28.1% and the single were 52.4%. The illeterate person were 50.3% and the lower group in economic status which had been estimated by interviewers were 46.9%. 2. In sanitational characteristics, the person who used stream water or rainwater to drink were 42.2% and the person who always boiled water to drink were only 8.3%. The person who had not toilet in their house were 67.3% and the lower group in sanitational status which had been estimated by interviewers were 61.8%. 3. The prevalence rate of illness during the last one month were 8.6% and the chronic were 26.1% and the acute were 72.5%. The distribution of sickness symptom were headache, fever and joint pain in order and the person who took no medical treatment among the sick were 37.0%. The patterns of medical utilization were public health center, hospital and pharmacy in order. 4. Illness prevalence was significantly related to sex, age, merital status and educational experience. The residents who were women, 40 years old or more, married and had not educational experience were apt to take illness. 5. Medical utilization was significantly related to educational experience, job, distance from home to medical facilities and economic status. The person who had educational experience, were officer workers or merchants, lived near by medical facilities and had higher economic status took medical treatment very well.

• 대한약리학회지
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• 제23권2호
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• pp.95-100
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• 1987

본 연구는 측좌각, 봉선핵 및 후구 등 서로 다른 뇌 부위의 손상으로 야기된 공격성에 대한 약물의 효과를 비교 검토하여 다음과 같은 결과를 얻었다. 1. 측좌각, 봉선핵 및 후구 손상으로 야기된 muricide는 atropine으로 억제되었으나 hyperirritability는 억제되지 않았다. 2. 측좌각, 봉선핵 손상으로 인한 muricide는 L-DOPA, L-5-HTP에 의하여 현저히 억제되었으나 후구 손상으로 인한 muricide는 거의 억제되지 않았다. 3. 측좌각, 봉선핵 및 후구 손상으로 인한 muricide는 항우울제에 의하여 현저히 억제되었다. 특히 측좌각 및 봉선핵 손상으로 인한 muricide 억제에는 nomifensine과 clomipramine이 효과적이었으며 후구 손상으로 인한 muricide 억제에는 imipramine이 가장 효과적이었다. 그러나 hyperirritability는 항우울제에 의하여 거의 억제되지 않았다. 이상의 결과에서 측좌각 손상으로 인한 공격성의 약물학적 특징은 후구보다는 봉선핵 손상으로 인한 공격성과 유사하였으며 muricide 억제에 대한 항우울제의 효과가 서로 다른 것을 이용하여 항우울제의 작용평가에 도움이 될 것으로 사료된다.

• 한국약용작물학회지
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• 제11권2호
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• pp.89-96
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• 2003

기주목(상수리나무, 밤나무, 자작나무, 버드나무)별 겨우살이 ethanol추출물과 5가지 분획물 (hexane fr., chloroform fr., ethyl acetate fr., butanol fr., aqueous fr.)을 이용하여 in vitro에서 DPPH를 이용한 수소전자공여능, DNA에 대한 산화적 손상 및 손상억제 효과 등에 미치는 영향을 연구하기 위하여 comet assay를 실시하였다. 4종의 한국산 겨우살이의 ethanol추출물과 분획물 중 ethyl acetate fr.들이 높은 수소전자공여능을 보였다. Comet assay분석에서 head DNA의 형태를 유지하거나 또는 tail DNA의 생성을 억제하는 겨우살이 fr.들이 DNA에 대하여 항산화적 기능이 있음을 보여 주었다. 또는 comet assay 유용한 parameter인 $tail\;length({\mu}m)$는 positiye control인 $H_2O_2\;(10^{-3}M)$로 40min동안 세포에 처리하여 산화적 손상을 준 결과, $149{\mu}m$의 tail length를 보였으며 , 상수리나무 겨우살이의 ethyl acetate fr.(0.1mg/ml)을 $H_2O_2\;(10^{-3}M)$와 동시 처리에는 $110{\mu}m$, 자작나무 겨우살이 ethyl acetate fr.은 $104{\mu}m$, 상수리나무 겨우살이 butanol fr.은 $123{\mu}m$, 자작나무 겨우살이 butanol fr.은 $118{\mu}m$로 tail length가 감소하는 것으로 보아 겨우살이가 산화적 DNA손상을 방어한다는 것을 알 수 있었다. 이상의 결과로 볼 때 한국산 겨우살이는 산화적 stress를 일으키는 활성 산소 자유라디칼의 생성에 대해 보호활성을 나타내어 유용한 chemopreventive agent의 기능이 기대된다.

• Korean Journal of Acupuncture
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• 제19권2호
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• pp.63-78
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• 2002

Kupunggibodan(KU), Gamisamul-tang(GA) and Whangryunhaedok-tang(WH) are clinically the most popular prescriptions as an herbal medicine in the treatment of ischemia. In order to compare and evaluate their protective effects on the ischema-induced cognitive deficits by middle cerebral artery occlusion (MCAO), we examined its ability to improve ischemia-induced cell loss and impairements of learning and memory in the Morris water maze and eight-arm radial arm maze. Focal cerebral ischemia produced a marked cell loss, decrease in acetylcholinesterase(AchE) reactivity in the hippocampus, and learning and memory deficits in two behavioral tasks. Pretreatment with WH (100 mg/kg, p.o.) produced a substantial increase in acquisition in the Morris water maze. Pretreatment with KU increased the perfomance of the resention test in the Morris water maze. WH, KU and GA caused a significant improvement in choice accuracy in radial arm maze test. WH was superior to KU and GA in perfomance of the radial arm maze test. Consistent with behavioral data, staining with cresyl violet showed that pretreatments with WH, but not KU and GA significantly recovered the ischemia-induced cell loss in the hippcampal CA1 area. In addition, pretreatments with WH and KU recovered the ischemia-induced reduction of AchE reactivity in the hippocampal CA1 area. These results demonstrated that KU, GA and WH have protective effects against ischimea-induced learning and memory impairments and that the efficacy was the order of WH>KU>GA in tratment of ischemia induced memory deficits. The present studies provide an evidence of KU, GA and WH as putative treatment of vascular dementia. Supported by a fund from the Ministry of Health and Welfare(HMP-00-OO-04-0004), and the Brain Korea 21 Project from Korean Ministry of Education, Korea.

• 대한임상독성학회지
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• 제12권2호
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• pp.63-69
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• 2014

Purpose: The aim of this study is to investigate the difference between male and female in some clinically meaningful aspects and to prevent intentional poisoning in children and adolescents. Methods: Retrograde medical records review of patients who visited the emergency department of two secondary hospitals for drug ingestion from March 2010 through March 2013 was performed. Unintentional ingestion or ingestion by others was excluded. Results: A total of 138 cases were reported, male 25.4% (n=35), female 74.6% (n=103). The reason for poisoning was intentional in 132 cases (95.7%) and misuse in six cases (4.3%). In female patients, non-prescription drugs was the most common cause of intentional poisoning (68.9%). Male patients tend to use life substances for intentional poisoning more frequently (20.0%) than female (3.9%). Seven male patients and 12 female patients had previous psychiatric history and 34.3% of male and 41.7% of female were consulted to the psychiatric department. Conclusion: Female adolescents are more likely to ingest drugs intentionally for suicide attempt than males of comparable ages. The drugs they ingested were, in many cases, obtained with ease from the drug store nearby and, remarkably, most of the drugs they obtained in that way were acetaminophen-containing. This suggests that some guidelines or control in the pharmacy that restrict children or adolescents from obtaining potentially or possibly life-threatening drugs might be necessary. In addition, education regarding drugs is thought to be necessary in school for teenagers as they tend to misuse them with incorrect acknowledgement.