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Inhibitory effect of Korean mistletoes on the oxidative DNA damage  

Lee, So-Jin (School of Biotechnology and Bioengineering, Kangwon National University)
Lee, Mi-Kyoung (School of Biotechnology and Bioengineering, Kangwon National University)
Choi, Geun-Pyo (Dept. Food & Life Science, Gangwon Provincial University)
Kim, Na-Young (Dept. of Food and Nutrition, KyungHee Uni.)
Roh, Seong-Kyu (Dept. Physical Education, Kangwon National University)
Heo, Moon-Young (College of Pharmacy, Kangwon National University)
Kim, Jong-Dai (School of Biotechnology and Bioengineering, Kangwon National University)
Lee, Hyeon-Yong (School of Biotechnology and Bioengineering, Kangwon National University)
Lee, Jin-Ha (School of Biotechnology and Bioengineering, Kangwon National University)
Publication Information
Korean Journal of Medicinal Crop Science / v.11, no.2, 2003 , pp. 89-96 More about this Journal
Abstract
Korean mistletoes extracts were investigated for in vitro antioxidation activity, with 1,1-diphenyl-2-picrylhydrazine(DPPH), and an inhibitory effect on oxidative DNA damage by using comet assay. The Korean mistletoes were 4 different kinds classified by their host plants (Korean Viscum sp. in Quercus acutissima Carr., Korean Viscum sp. in Castanea crenata, Korean Viscum sp. in Betula platyphylla, and Korean Viscum sp. in Salix koreensis). The samples were extracted with ethanol, and fractonationed with n-butanol, ethyl acetate, chloroform, n-hexane, and second distilled water. Among them, ethyl acetate fraction from Korean Viscum sp. in Betula platyphylla showed the strongest activities to electron donating ability on 1,1-diphenyl-2-picrylhydrazyl(DPPH) and the protective effect on oxidative DNA damage.
Keywords
Viscum sp.; oxidative DNA damage; comet assay;
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