• Clinical and Experimental Pediatrics
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• 제64권6호
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• pp.286-292
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• 2021

Background: The effect of exposure to environmental factors on autism spectrum disorders (ASD), especially during pregnancy, is unclear. Purpose: This meta-analysis investigated the association between exposure to pesticides and polychlorinated biphenyls (PCBs) during pregnancy and ASD risk among children. Methods: We searched Scopus, PubMed, Web of Science, and ProQuest for articles published through September 2019. Random-effects models were used to examine the association among studies using pooled odds ratios (ORs) and their 95% confidence intervals (CI). I2 tests were used to measure interstudy heterogeneity. Results: The pooled OR indicated a significant association between PCB and pesticide exposure during pregnancy and ASD risk among children (OR, 1.80; 95% CI, 1.26-2.34; and OR, 1.20; 95% CI, 1.02-1.39), respectively. Conclusion: Findings of the present study indicate that exposure to pesticides and PCBs during pregnancy may affect the risk of ASD among children.

• 한국농공학회논문집
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• 제47권7호
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• pp.49-56
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• 2005

Contamination in the drainage channels and creeks with pesticides used in agriculture is of a major concern in many countries. In this study the stream pesticide model RIVWQ (chemical transport model for riverine environments) was assessed for its applicability in simulating pesticide fate in drainage channels. The model was successfully calibrated against field data collected on flows and pesticide concentrations for a drainage channel from a small catchment in the Murrumbidgee Irrigation Area of southwestern New South Wales. The effects of different pesticide loading scenarios from farm fields on channel water quality were analysed by the calibrated model. The model simulated the flow rates and the pesticide concentrations in the drainage channel well. The results of the model simulation suggest that the RIVWQ model can be effectively used for predicting pesticide fate in the drainage channels and exposure assessment of pesticide in the agricultural environment.

• 농약과학회지
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• 제20권2호
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• pp.172-180
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• 2016

본 연구는 국내 일부 농업인을 대상으로 유기인계 농약 노출수준과 농약살포 특성의 관련성을 규명하기 위하여 수행되었다. 소변시료를 채취하여 GC/MSD와 GC/MS/MS를 이용하여 분석하였으며, 소변 중 DMP, DMTP, DEP, DETP를 대상으로 검출률 및 노출수준을 평가 하였다. 검출률은 DMP, DMTP에서 캡이 없는 SS살포기가 캡이 있는 SS살포기보다 높았고, 보호구 착용률이 낮을수록 높았다. 노출수준은 동력 분무기가 가장 높았고, 캡이 있는 SS살포기에서 낮게 나타났다. 또한, 착용 보호구 개수가 증가할수록 노출수준이 낮아짐을 확인할 수 있었다. 검출률은 카이제곱, 노출수준 비교는 연령 및 살포방법을 보정한 GLM을 이용하여 분석하였다.

• 농약과학회지
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• 제19권1호
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• pp.41-46
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• 2015

본 연구는 상대적으로 농약을 많이 살포하는 고랭지 배추 농작업자를 대상으로 피레스로이드계 살충제의 노출에 영향을 미치는 요인을 생물학적 모니터링을 이용하여 평가하기 위하여 수행되었다. 강원도 고랭지 배추 작업을 하는 농업인을 대상으로 하여 농약 살포 다음날 아침 첫 소변을 받아서 요중 cis-, trans-DCCA, DBCA를 분석하였다. 농약 노출에 영향을 미칠 수 있는 요인으로는 풍속, 살포 위치, 보호구 착용 등을 조사하였다. 통계분석은 Kruskall Wallis로 시행하였다. 분석 결과, 고랭지 배추 작업자는 일반인보다 농약에 대한 노출이 많았으며, 풍속이 낮은 경우에는 살포자가 더 많이 노출되지만, 풍속이 높은 경우에는 살포자와 보조자간의 차이가 없었다.

• 한국환경농학회지
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• 제41권4호
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• pp.261-275
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• 2022

BACKGROUND: Prior to implementing a positive list system (PLS), there is a need to establish acceptable daily intake (ADI) and maximum residue limit (MRL) for veterinary drugs that have been approved a few decades ago in South Korea. On top of that, chronic dietary exposure assessment of veterinary drug residues should be performed to determine whether the use of these veterinary drugs would cause health concerns or not. METHODS AND RESULTS: To establish the ADI, the relevant toxicological data were collected from evaluation reports issued by international organizations. A slightly modified global estimate of chronic dietary exposure (GECDE) model was employed in the exposure assessment owing to the limited residual data. Therefore, only the ADI of ephedrine was established due to insufficient data for the other veterinary drugs. Thus, instead of ADI, the threshold of toxicological concern (TTC) value was used for the other drugs. Lastly, the hazard index (HI) was calculated, except for etizazole hydrochloride, due to the potential of mutagenicity. CONCLUSION(S): The HI values of ephedrine, menichlopholan, and anacolin were found to be as high as 6.4%, suggesting that chronic dietary exposure to the residues from these uses was unlikely to be a public health concern. Further research for exposure assessment of veterinary drug residues should be performed using up-todate Korean national health and nutrition examination survey (KNHANES) food consumption data. In addition, all relevant available data sources should be utilized for identifying the potentials of toxicity.

• 한국식품위생안전성학회:학술대회논문집
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• 한국식품위생안전성학회 2002년도 춘계학술발표대회 및 심포지움
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• pp.139-142
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• 2002

This study carried out to evaluate TMDI(theoretical maximum daily intake) and EDI(estimated daily intake) for Korean by using MRLs, food intake, residue data, and correction factors and compare with ADI(acceptable daily intake) in order to estimate the health risk based on the pesticide exposure.

• 농약과학회지
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• 제14권2호
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• pp.110-115
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• 2010

본 연구에서는 우리나라 소비자를 대상으로 우리나라에서 재배된 과채류 섭취를 통한 neonicotinoid계 농약의 노출량을 확률적 접근법을 이용하여 평가하였다. 농약 잔류량을 2009년에 수행된 과채류 중 neonicotinoid계 농약 5종(acetamiprid, clothianidin, imidacloprid, thiacloprid, thiamethoxam)에 대한 모니터링 자료를 이용하였다. Neonicotinoid계 농약의 총 노출량을 개별 과채류별로 구분하여 확률적 평가를 실시한 결과 neonicotinoid계 농약 5종의 총 노출량의 극단값은 0.087~0.236 ${\mu}g$/kg/day의 범위를 보였다. 확정론적 접근법의 결과와 비교했을 때 총 노출량의 평균치는 거의 유사하게 나타났으며, 노출량의 $95^{th}$ percentile값에 서는 확률적 접근법의 결과가 확정론적 접근법의 결과에 비해 38.8 ~ 62.0%의 수준으로 낮게 나타났다. 총 노출량에 대한 민감도 분석을 실시한 결과, acetamiprid의 총 노출량은 딸기 섭취를 통한 노출량에 크게 영향을 받으며, 특히 딸기의 섭취량 보다는 딸기 중 acetamiprid 잔류량 수준에 더 크게 영향을 받는 것으로 나타났다. 이는 thiacloprid를 제외한 나머지 3종의 neonicotinoid계 농약에서 유사한 경향을 보였다.

• Toxicological Research
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• 제30권4호
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• pp.251-260
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• 2014

The number of farmers who have suffered from non-fatal acute pesticide poisoning has been reported to vary from 5.7% to 86.7% in South Korea since 1975. Absorption through the skin is the main route of exposure to pesticides for farmers who operate with them. Several in vitro tests using the skins of humans or animal and in vivo tests using laboratory animals are introduced for the assessment of human dermal absorption level of pesticides. The objective of this study is to evaluate and compare international guidelines and strategies of dermal absorption assessments and to propose unique approaches for applications into pesticide registration process in our situation. Until present in our situation, pesticide exposure level to operator is determined just using default value of 10 as for skin absorption ratio because of data shortage. Dermal absorption tests are requested to get exposure level of pesticides and to ultimately know the safety of pesticides for operators through the comparison with the value of AOEL. When the exposure level is higher than AOEL, the pesticide cannot be approved. We reviewed the skin absorption test guidelines recommended by OECD, EFSA and EPA. The EPA recommends assessment of skin absorption of pesticides for humans through the TPA which includes all the results of in vitro human and animal and animal in vivo skin absorption studies. OECD and EFSA, employ a tiered approach, which the requirement of further study depends on the results of the former stage study. OECD guidelines accept the analysis of pesticide level absorbed through skin without radioisotope when the recovery using the non-labeled method is within 80~120%. Various factors are reviewed in this study, including the origin of skin (gender, animal species and sites of skin), thickness, temperature and, etc., which can influence the integrity of results.

• 한국환경보건학회지
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• 제43권4호
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• pp.280-297
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• 2017

Objectives: We assessed pesticide exposure levels according to cultivation and crop type and investigated agricultural factors related to exposure. Methods: The participants, 341 male and 127 female farmers, were divided into three groups by cultivation crop type: chili greenhouse, cucumber greenhouse, and orchard. We collected questionnaires, socioeconomic characteristics and agricultural factors, and spot urine. Pesticide exposure was examined using four organophosphate and four pyrethroids urinary metabolites: dimethylphosphate, dimethylthiophosphate, diethylphosphate, diethylthiophosphate, Cis and Trans-3-(2-2dichlorovinyl)-2, 2-dimethylcyclopropane carboxylic acid, 3-phenoxybenzoic acid (3-PBA), Cis-3-(2-2dibrmovinyl)-2, and 2-dimethylcyclopropane carboxylic acid. Each metabolite was summed ${\Sigma}DAP$ and ${\Sigma}PY$ according to the chemical class. Results: Urinary metabolite detection rates and concentrations were similar between the greenhouse groups, but the orchard group was different. Similar 3-PBA detection rates were found in the three groups, but the geometric mean was very high in the orchard group compared to the two greenhouse groups. 3-PBA concentration in the orchard group was $4.11{\mu}g/g$ creatinine; the chili and cucumber greenhouse groups were 1.27 and $1.16{\mu}g/g$ creatinine, respectively. ${\Sigma}DAP$ was significantly associated with cultivation crop type and seasonal variation, but ${\Sigma}PY$ was not relevant. Conclusions: Our results suggest that cultivation and crop type may be correlated with different pesticide types and exposure levels. Furthermore, seasonal factors were related as potential factors influencing the level of organophosphate metabolites, but not for pyrethroid metabolites.

• 한국의류학회지
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• 제28권9_10호
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• pp.1292-1299
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• 2004

This survey was carried out on 256 smallholder farmers of the Jeonbuk Province to analyze their current behavior in pesticide usage and the use of protective clothing during spray work. The interviewees were at the age of about 50's in both males and females: they performed spray work mainly for their own farms. Many of them were not very well aware of the danger of pesticides and the adequate methods of pesticide handling. Water drinking and smoking during break time were the endangering factors of pesticide intoxication, reaching to 30-60% sprayers. Most of sprayers had experienced the exposures to pesticides during spray work and appealed some subjective clinical symptoms to the exposure, but they seldom sought medical treatments. More than 70% of respondents had not been wearing protective equipments during spray work. The results will be used as basic information in designing the improved protective clothing more acceptable by pesticide sprayers.