• Journal of Ginseng Research
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• 제48권3호
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• pp.310-322
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• 2024

Background: Osteosarcopenia is a common condition characterized by the loss of both bone and muscle mass, which can lead to an increased risk of fractures and disability in older adults. The study aimed to elucidate the response of various mouse strains to treatment with Rg3, one of the leading ginsenosides, on musculoskeletal traits and immune function, and their correlation. Methods: Six Collaborative Cross (CC) founder strains induced muscle atrophy and bone loss with dexamethasone (15 mg/kg) treatment for 1 month, and half of the mice for each strain were orally administered Rg3 (20 mg/kg). Different responses were observed depending on genetic background and Rg3 treatment. Results: Rg3 significantly increased grip strength, running performance, and expression of muscle and bone health-related genes in a two-way analysis of variance considering the genetic backgrounds and Rg3 treatment. Significant improvements in grip strength, running performance, bone area, and muscle mass, and the increased gene expression were observed in specific strains of PWK/PhJ. For traits related to muscle, bone, and immune functions, significant correlations between traits were confirmed following Rg3 administration compared with control mice. The phenotyping analysis was compiled into a public web resource called Rg3-OsteoSarco. Conclusion: This highlights the complex interplay between genetic determinants, pathogenesis of muscle atrophy and bone loss, and phytochemical bioactivity and the need to move away from single inbred mouse models to improve their translatability to genetically diverse humans. Rg3-OsteoSarco highlights the use of CC founder strains as a valuable tool in the field of personalized nutrition.

• 보건교육건강증진학회지
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• 제33권4호
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• pp.89-100
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• 2016

Objectives: Life style modification leads to decrease health risk and change of health status for person at health risk. This study aimed to suggest essential components and effective strategies for customized health management service to provide individual and risk group in public and private health care organizations. Methods: To systematic review the essential component of health management service, I performed to collect political legislation, research papers, reports, publication and public release for heath management service from 2008 to 2016. Essential components of heath management service were service scope, service design, organizations and applied technology. Results: Service cope was composed of health risk factors, such as smoking, drinking, nutrition, physical activity and weight control. Main strategies were customized health management services, personalized behavior modification programs, evidence-based service protocol, utilization of information and communications technology (ICT), multi-dimension and multi-level approach, and public and private organizations partnership through health policies and health care system. Conclusions: To make the most of the limited resources, it should require a systematic approach that focuses on continuous monitoring and partnership of health management service.

• 동아시아식생활학회지
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• 제22권6호
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• pp.720-733
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• 2012

This study was conducted to investigate the eating habits, self-perception of body image, and weight control behavior in Korean adolescents by gender. Data pertaining to 70,809 subjects(male 37,090, female 33,719) were obtained from the sixth Korea Youth Risk Behavior Web-based Survey(2010). The rate of skipping breakfast was 42.5% in male, and 45.8% in female students. The intake frequency of vegetable, milk, soda, fast food, and instant noddles was higher in male than female students. Moreover, 33% of male and 31.9% of female students considered themselves to be somewhat or very obese. Notably, 2.3% of underweight students considered themselves to be obese. Weight control measures were practiced in 44.6% of male, and 54.6% of female students. Meal restrictions were used more frequently to control weight by females, while exercise was used more by males. The perceived stress level was higher in female than male students, especially that due to appearance. Therefore, integrated and personalized high school nutrition programs according to gender should be implemented to establish proper body image perception and eating habits, as well as to develop selfesteem.

• 한국농촌간호학회지
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• 제12권1호
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• pp.13-27
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• 2017

Purpose: The purpose of this study is to identify health-related factors, especially for the elderly who are subject to visiting health care at vulnerable populations. Methods: Tools were Guide to Community Integrated Health Promotion Project 2016, Visit Health Care Health Interview Survey, measures of physical function, motor skills, composite mobility, BMI, and subjective fitness levels. Depression was measured with the Short Results: Older elders living alone were more vulnerable than those with living others. Elders with less education showed greater weakness but the difference was not significant. Average scores for frailty were 2.21 (healthy group), 7.66 (high-risk group) and 15.69 (frail group). Scores based on weakness level differed significantly with the exception of nutrition. Nine out of 10 elders in disadvantaged areas were in the frail group or at high risk. Conclusion: Results support the goal to maintain/improve physical/mental functions through individual management of high-risk/frail older adults at risk of becoming infirm. It is imperative to implement a public health care delivery system to ensure programs are operated effectively and personalized.

• Child Health Nursing Research
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• 제29권4호
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• pp.300-312
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• 2023

Purpose: This study investigated knowledge of atopic dermatitis and food allergies, as well as health information literacy, among North Korean refugee mothers with preschool-age children and explored how these variables were related to participants' characteristics. Methods: A descriptive study design was used. Data from 130 North Korean refugee mothers were collected between January and March 2023. Results: The mean scores were 14.48 of 30 for atopic dermatitis knowledge; 2.77 of 10 for food allergy knowledge, and 56.95 of 80 for health information literacy. Significant differences were observed in knowledge of atopic dermatitis based on breastfeeding duration (F=4.12, p=.009), and in knowledge of food allergies based on mixed feeding (F=3.11, p=.049). Health information literacy showed significant relationships with education level (F=3.76, p=.026), occupation (F=3.99, p=.021), checking nutritional information (t=2.91, p=.004), mixed feeding (F=4.50, p=.014), and atopic dermatitis diagnosis (t=6.86, p=.001). Significant positive correlations were observed between atopic dermatitis knowledge, food allergy knowledge, and health information literacy. Conclusion: Personalized educational programs should be implemented to improve awareness of allergies and health information literacy among North Korean refugee mothers, which would help them find, evaluate, and understand health-related information. These programs should focus on providing nutrition and dietary education to promote healthy growth in children and prevent diseases.

• 한국식품영양과학회지
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• 제43권9호
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• pp.1325-1333
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• 2014

사상의학은 한국 고유의 전통 한의학으로 4가지 체질 즉 태양인, 태음인, 소음인, 소양인으로 분류한다. 새로운 기능성 생식제품을 개발하기 위하여 태음인(Taeumin), 소양인(Soyangin) 그리고 소음인(Soeumin)의 혈액으로부터 분리한 면역세포(림프구와 대식세포)를 이용하여 생식 원료(쌀, 보리, 율무, 콩, 팥, 차조, 가지, 무, 당근, 표고버섯, 양송이버섯, 목이버섯)와 생식제품의 면역 활성을 연구하였다. 생식원료와 생식제품 추출물들을 처리한 면역세포에서 세포 증식율, NO와 TNF-${\alpha}$의 증가를 면역 활성의 지표로 사용하였다. 쌀(milled rice), 팥(adzuki bean), 무(radish) 그리고 표고버섯(Lentinus edodes)을 태음인을 위한 생식 원료로 선택하였고, 보리(barley), 콩(soybean), 가지(eggplants) 그리고 양송이버섯(Agaricus bisporus)을 소양인을 위한 생식 원료로 선택하였으며, 율무(Job's tears), 팥(adzuki bean), 당근(carrot) 그리고 목이버섯(Auricularia auricula-judae)을 소음인을 위한 생식 원료로 선택하였다. 이러한 결과를 근거하여 생식제품 개발을 위하여 생식 원료의 종류와 배합비율을 달리하여 배합비 1~6(Mix 1~6)을 개발하였다. 태음인의 면역 활성은 배합비 1, 배합비 2, 배합비 3, 배합비 4, 배합비 5 또는 배합비 6 추출물을 처리한 면역세포 중에서 배합비 2(Mix 2; 쌀 60%, 팥 20%, 무 10%, 표고 10%) 추출물을 처리한 면역세포에서 가장 높았다. 소양인의 면역 활성은 6개의 배합비(Mix 1~6) 추출물 중에서 배합비 4(Mix 4: 보리 60%, 콩 20%, 가지 10%, 양송이 10%) 처리에 의해 최고로 높았다. 배합비 6(Mix 6: 율무 60%, 팥 20%, 당근 10%, 목이 10%)를 처리한 면역세포의 면역 활성 증가는 다른 5개의 추출물들(Mix 1~5)보다 높았다. 따라서 배합비 2, 4 그리고 6은 체질 맞춤형 면역 활성생식제품을 위한 혼합물로 사용할 수 있을 것이다.

• 한국콘텐츠학회논문지
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• 제20권9호
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• pp.503-510
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• 2020

본 연구는 금연을 통한 혈압조절이 중요한 고혈압 환자군과 정상 혈압군을 대상으로 각각의 금연의사와 관련된 요인을 파악하고 비교하기 위한 이차자료 분석 연구이다. 2010년부터 2018년까지 1,981명(고혈압 환자군 407명, 정상 혈압군 1,574명)을 대상으로 분석하였다. 교차분석에서 유의한 변수에 대한 다변량 로지스틱 회귀분석을 실시한 결과 고혈압 환자에서의 유의한 변수는 결혼상태, 교육수준, 주관적 건강상태, 최근 1주일간 한번에 적어도 10분 이상 걸은 날수이었으며, 정상 혈압군에서는 흡연량으로 두 군에서 차이를 보였다. 흡연자의 고혈압 여부 등 대상자의 특성에 따른 맞춤형 관리와 금연교육을 통해 효과를 높일 필요가 있으며, 심뇌혈관질환 등 이차적 질환으로의 발생이 가능한 고혈압 환자군 우선의 집중 교육을 통해 금연의사를 높여야 할 것이다.

• 한국지역사회생활과학회지
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• 제23권4호
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• pp.523-535
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• 2012

This study was conducted to investigate and improve experiences regarding breastfeeding education. Questionnaires were distributed to 185 women with children 24 months of age and younger. The period of breastfeeding was about 7.2 months and showed significant differences (p<0.01) according to women's age. About 56% of the respondents participated in breastfeeding education. Women with 3 or more children showed the highest rates of participation compared to the women in other groups(p<0.05). The reason for nonparticipation showed significant differences (p<0.05) according to women's occupation. The biggest reason for nonparticipation was 'lack of time' for housewives and 'no information' for working women. The subjects of education were benefits(20%) and techniques(19%) of breastfeeding, breast care before and after delivery(15%), nutrition care for breastfeeding mothers(11%), etc. The teaching method used most frequently was lecturing(32%). Around 81% of women were not satisfied with their breastfeeding education. The most useful subject was breastfeeding techniques(59%). Thirty percent of women pointed out that 'assessing mother's milk quantity' was the subject which women wanted to learn but were not taught enough about. Around 76% of women wanted more education and preferred personalized education such as home visitation(35%) and personal counselling(27%). Desired education methods showed significant differences(p<0.05) according to women's occupations. 'Home visitation' was the most preferred method for housewives and 'personal counselling' for working women. These results showed breastfeeding education was not helpful for practical life. Therefore, breastfeeding education should reflect women's individual needs to heighten its effectiveness.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10683-10690
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• 2015

The big gap between efficacy of population level prevention and expectations due to heterogeneity and complexity of cancer etiologic factors calls for selective yet personalized interventions based on effective risk assessment. This paper documents our research protocol aimed at refining and validating a two-stage and web-based cancer risk assessment tool, from a tentative one in use by an ongoing project, capable of identifying individuals at elevated risk for one or more types of the 80% leading cancers in rural China with adequate sensitivity and specificity and featuring low cost, easy application and cultural and technical sensitivity for farmers and village doctors. The protocol adopted a modified population-based case control design using 72, 000 non-patients as controls, 2, 200 cancer patients as cases, and another 600 patients as cases for external validation. Factors taken into account comprised 8 domains including diet and nutrition, risk behaviors, family history, precancerous diseases, related medical procedures, exposure to environment hazards, mood and feelings, physical activities and anthropologic and biologic factors. Modeling stresses explored various methodologies like empirical analysis, logistic regression, neuro-network analysis, decision theory and both internal and external validation using concordance statistics, predictive values, etc..

• 지능정보연구
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• 제16권3호
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• pp.181-199
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• 2010

인구의 고령화 및 건강에 대한 관심이 증가됨에 따라 유헬스케어 서비스는 발병 후 관리관점에서 발병 전의 예방 관점으로 그 목적이 점차 이동하고 있다. 그러나 기존의 유헬스케어 서비스는 원격진료 차원의 의료 서비스 성격이 강하여, 만성 성인병과 같은 대사 증후군을 예방 및 관리하기에는 한계가 있을 뿐만 아니라, 관리자 중심의 단방향 서비스를 제공함으로 인해 사용들이 중도에 이용을 포기하는 비율이 높았다. 이와 같은 문제를 해결하기 위하여, 본 연구에서는 사회 네트워크를 이용한 사용자 기반 유헬스케어 서비스 추천 시스템을 제안하였으며, 실세계에서 유헬스케어 서비스 추천 시스템의 활용 가능성을 제시하기 위하여 실제 의료원에서 대사 증후군 예방 및 관리를 위해 처방한 식단 및 운동 정보를 기반으로 유비쿼터스 컴퓨팅 환경에서 적용가능한 시스템을 구현하였다. 본 연구에서 제안한 시스템은 사용자가 선호하지 않는 서비스가 네트워크를 통해 확산될 가능성을 낮추는 동시에 추천의 신뢰성 제고를 위해 네이버들이 이용한 서비스를 공유함으로써 전체적인 추천 품질을 높인다. 즉, 사용자의 식습관 및 운동습관 등과 같은 생활습관을 개선하기 위하여 사회 네트워크를 활용함으로써 사용자간의 자율협업을 통한 개인화된 추천이 가능하다. 따라서 본 연구에서 제안하는 유헬스케어 서비스 추천 시스템은 생활습관 개선을 위하여 사용자에게 적합한 식단 및 운동을 제공하고, 생활습관의 개선을 통해 만성 성인병과 같은 대사증후군을 사전에 예방할 수 있을 것으로 기대된다.