• Journal of Nutrition and Health
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• 제55권6호
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• pp.601-616
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• 2022

In the era of the fourth industrial revolution technology, the inclusion of personalized nutrition for healthcare (PNH), when establishing a healthcare platform to prevent chronic diseases such as obesity, diabetes, cerebrovascular and cardiovascular disease, pulmonary disease, and inflammatory diseases, enhances the national competitiveness of global healthcare markets. Furthermore, since the government experienced COVID-19 and the population dead cross in 2020, as well as numerous health problems due to an increasing super-aged Korean society, there is an urgent need to secure, develop, and utilize PNH-related technologies. Three conditions are essential for the development of PNH technologies. These include the establishment of causality between obesity genome (genotype) and prevalence (phenotype) in Koreans, validation of clinical intervention research, and securing PNH-utilization technology (i.e., algorithm development, artificial intelligence-based platform, direct-to-customer [DTC]-based PNH, etc.). Therefore, a national control tower is required to establish appropriate PNH infrastructure (basic and clinical research, cultivation of PNH-related experts, etc.). The post-corona era will be aggressive in sharing data knowledge and developing related technologies, and Korea needs to actively participate in the large-scale global healthcare markets. This review provides the importance of scientific evidence based on a huge dataset, which is the primary prerequisite for the DTC obesity gene-based PNH technologies to be competitive in the healthcare market. Furthermore, based on comparing domestic and internationally approved DTC obese genes and the current status of Korean obesity genome-based PNH research, we intend to provide a direction to PNH planners (individuals and industries) for establishing scientific PNH guidelines for the prevention of obesity.

• 대한지역사회영양학회지
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• 제28권5호
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• pp.376-391
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• 2023

Objectives: Our previously published study showed that a workplace nutrition intervention program with personalized goal setting and smartphone-based nutrition counseling improved dietary habits and physical activity in city bus drivers who were overweight/obese. This study explored the facilitators and barriers that participants faced in achieving their dietary and physical activity goals six months after the intervention. Methods: The study included bus drivers and dietitians who participated in the intervention program. Three focus group interviews were conducted with 10 bus drivers (divided by two groups based on their achievement of set goals) and five dietitians who had provided nutrition counseling. Results: Willpower was the most important intrapersonal facilitator for drivers to achieve their goals. Other factors that promoted behavioral changes were nutrition counseling by dietitians, trackable physical activity using smartwatches, and setting of practical and achievable goals. Meanwhile, the most important barriers identified were occupational factors such as long driving hours, short breaks, and shift work. Other barriers were environmental factors such as availability of snackable food, accessibility to convenience stores, and cold weather. Family and colleagues were perceived as both facilitators and barriers. In addition, dietitians identified a lack of knowledge about healthy diet as one of the barriers. Conclusions: Our results suggested that the workplace environment should be improved and that nutrition intervention programs at the workplace could encourage bus drivers to practice healthy eating habits. The facilitators and barriers identified in this study should be considered when planning a nutrition intervention program for bus drivers.

• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2004년도 Annual Meeting and International Symposium
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• pp.271-274
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• 2004

Nutritional genomics is a new field of study of how nutrition interacts with an individual's genome or individual responds to individual diets. Systematic approach of nutritional genomics will likely provide important clues about responders and non-responders. The current interest in personalizing health stems from the breakthroughs emerging in integrative technologies of genomics and epigenomics and the identification of genetic and epigentic diversity in individual's genetic make-up that are associated with variations in many aspects of health, including diet-related diseases. Microarray is a powerful screen system that is being also currently employed in nutritional research. Monitoring of gene expression at genome level is now possible with this technology, which allows the simultaneous assessment of the transcription of tens of thousands of genes and of their relative expression of pathological cells such tumor cells compared with that of normal cells. Epigenetic events such as DNA methylation can result in change of gene expression without involving changes in gene sequence. Recent developed technology of DNAarray-based methylation assay will facilitate wide study of epigenetic process in nutrigenomics. Some of the areas that would benefitfrom these technologies include identifying molecular targets (Biomarkers) for the risk and benefit assessment. These characterized biomarkers can reflect expose, response, and susceptibility to foods and their components. Furthermore the identified new biomarker perhaps can be utilized as a indicator of delivery system fur optimizing health.

• 한국컴퓨터정보학회논문지
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• 제17권1호
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• pp.41-52
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• 2012

2005년도 국민건강영양조사에 의하면 우리나라 30세 이상의 인구에서 남자는 32.9%, 여자는 31,8%에서 대사증후군이 있는 것으로 보고되었다. 이러한 대사증후군은 유전적, 환경적 요인이 결합된 복합질환으로 다른 만성질환들과 같이 예방 및 관리에 중요성이 대두되고 있다. 본 연구에서는 시스템 아키텍처, 온톨로지와 Jena2.0 추론엔진을 사용하며 질병관련 가이드라인을 정리한 데이터를 통하여 서비스를 제안하였다. 본 논문에서는 상황에 따른 정확도 실험을 하였으며, 실험데이터는 930개의 데이터를 선별하여 실시하였다. 그 결과 상황데이터가 많을수록 맞춤형 서비스가 가능하다는 결과를 얻었으며, 대사증후군의 위험요소가 다양하기 때문에 여러 가지 상황데이터로서 맞춤형 서비스를 추천하는 것이 효과적으로 보인다.

• 한국산학기술학회논문지
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• 제14권11호
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• pp.5771-5777
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• 2013

최근 만성질환의 증대로 질병의 지속적인 관리에 대한 필요성이 대두되고 있으나 개인 맞춤형 식품섭취와 관련한 분석 연구는 미비하다. 본 연구에서 제시한 당뇨병 발생 위험도 분석 모델은 기존 상품 선호도 연구를 통해 검증된 유사도평가 방법인 피어슨 상관계수 산출을 이용하여 식품 선호도를 산출하고, 유병율 분석 연구 등에 활용된 로지스틱 회귀분석 방법을 이용하여 당뇨병발생 위험도를 제시하였다. 모델의 유의성 평가를 위해 당뇨 진단을 받은 환자 52명(남자: 22명, 여자: 30, 평균연령: 57(${\pm}13.2$)세)과 비교군과 비슷한 연령을 조건으로 무작위 추출된 52명(남자: 17명, 여자: 35, 평균연령: 58(${\pm}9.4$)세)의 t-검정을 통해 0.05 수준에서 유의함을 검증하였다. 이를 통해 식품섭취빈도에 따른 당뇨병 발생 위험도에 차이가 있음(p=0.046)을 확인할 수 있었다. 이 모델을 기반으로 분석된 정보는 스마트폰이나 웹을 이용한 개인 건강관리 시스템에 적용을 통해 새로운 개인 맞춤형 건강관리 방법으로 제시될 수 있다.

• 한국컴퓨터정보학회논문지
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• 제17권9호
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• pp.113-125
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• 2012

개인 맞춤형 식이 운동 콘텐츠 제공을 위해 1개 3차병원에서 제공하는 PHR(Personal Health Records)을 기반으로 건강관리 스마트폰 어플리케이션을 개발하였다. PHR의 상병명에 근거하여 각 질환과의 상관관계를 적용한 식이 운동 적합률 알고리즘을 통해 개인의 질환을 관리하기 위한 맞춤형 콘텐츠를 제공하며, 식사량과 운동량을 기록하여 섭취 소비한 칼로리를 기록하는 기능을 제공한다. 또한 사용자의 위치정보를 근거로 한, 음식점 위치 정보 및 해당 메뉴, 그에 따른 영양분석에 대한 정보를 제공하는 개인에게 적합한 콘텐츠를 이용하고 기록할 수 있는 서비스로써, 사용자의 상태와 편의성을 고려하여 유헬스 서비스를 제공할 수 있다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권2호
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• pp.71-79
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• 2013

The human-associated microbiota is diverse, varies between individuals and body sites, and is important in human health. Microbes in human body play an essential role in immunity, health, and disease. The human microbiome has been studies using the advances of next-generation sequencing and its metagenomic applications. This has allowed investigation of the microbial composition in the human body, and identification of the functional genes expressed by this microbial community. The gut microbes have been found to be the most diverse and constitute the densest cell number in the human microbiota; thus, it has been studied more than other sites. Early results have indicated that the imbalances in gut microbiota are related to numerous disorders, such as inflammatory bowel disease, colorectal cancer, diabetes, and atopy. Clinical therapy involving modulating of the microbiota, such as fecal transplantation, has been applied, and its effects investigated in some diseases. Human microbiome studies form part of human genome projects, and understanding gleaned from studies increase the possibility of various applications including personalized medicine.

• Preventive Nutrition and Food Science
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• 제22권1호
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• pp.1-8
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• 2017

About 20 chemical elements are nutritionally essential for humans with defined molecular functions. Several essential and nonessential biometals are either functional nutrients with antidiabetic actions or can be diabetogenic. A key question remains whether changes in the metabolism of biometals and biominerals are a consequence of diabetes or are involved in its etiology. Exploration of the roles of zinc (Zn) in this regard is most revealing because 80 years of scientific discoveries link zinc and diabetes. In pancreatic ${\beta}$- and ${\alpha}$-cells, zinc has specific functions in the biochemistry of insulin and glucagon. When zinc ions are secreted during vesicular exocytosis, they have autocrine, paracrine, and endocrine roles. The membrane protein ZnT8 transports zinc ions into the insulin and glucagon granules. ZnT8 has a risk allele that predisposes the majority of humans to developing diabetes. In target tissues, increased availability of zinc enhances the insulin response by inhibiting protein tyrosine phosphatase 1B, which controls the phosphorylation state of the insulin receptor and hence downstream signalling. Inherited diseases of zinc metabolism, environmental exposures that interfere with the control of cellular zinc homeostasis, and nutritional or conditioned zinc deficiency influence the pathobiochemistry of diabetes. Accepting the view that zinc is one of the many factors in multiple gene-environment interactions that cause the functional demise of ${\beta}$-cells generates an immense potential for treating and perhaps preventing diabetes. Personalized nutrition, bioactive food, and pharmaceuticals targeting the control of cellular zinc in precision medicine are among the possible interventions.

• 한국식품영양학회지
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• 제25권3호
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• pp.579-589
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• 2012

This study was performed to investigate the eating habit, body image, and weight control behavior by BMI in Korean female high school students. Data on the 16,574 subjects was obtained from the sixth Korea Youth Risk Behavior Web-based Survey (2010). Only 52.2% of the subjects had regular breakfast. The rate of skipping breakfast was higher in the underweight group than in the obese group, but the rate of skipping dinner was on the contrary to this. Underweight students had a higher intake frequency of fruits, fast food, instant noodle, and snacks than the obese groups. 3.5% of underweight students considered themselves to be overweight or obese. 53.4% of obese students considered themselves to be overweight. The experience of weight control increased according to BMI, but underweight students considered weight control as an effort to be slimmer. Meal restriction was used more frequently to control weight. The perceived stress level was higher in obese student, especially due to appearance. Therefore, an appropriate, integrated and personalized high school nutrition program should be established for proper body image perception and to develop the self-esteem of female high school students.

• Nutrition Research and Practice
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• 제12권2호
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• pp.118-128
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• 2018

BACKGROUND/OBJECTIVES: Glutathione s-transferase (GST) is involved in the formation of a multigene family comprising phase II detoxification enzymes, involved in the detoxification of reactive oxygen species. This study evaluated whether daily supplementation with kale juice could modulate levels of plasma antioxidant vitamins and oxidative stress-related parameters. We further examined whether this modulation was affected by combined GSTM1 and T1 polymorphisms. SUBJECTS/METHODS: Totally, 84 subclinical hypertensive patients having systolic blood pressure (BP) over 130 mmHg or diastolic BP over 85 mmHg, received 300 mL of kale juice daily for 6 weeks. Blood samples were drawn before start of study and after completion of 6 weeks. RESULTS: After supplementation, we observed significant decrease in DNA damage and increase in erythrocyte catalase activity in all genotypes. Plasma level of vitamin C was significantly increased in the wild/null and double null genotypes. The plasma levels of ${\beta}-carotene$, erythrocyte glutathione peroxidase activity, and nitric oxide were increased only in the wild/null genotype after kale juice supplementation. CONCLUSIONS: The effect of kale juice was significantly greater in the GSTM1 null genotype and wild/null genotype groups, suggesting possibility of personalized nutritional prescriptions based on personal genetics.