• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.71-77
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• 2012

Mitochondrial dynamics and distribution is critical for their role in bioenergetics and cell survival. We investigated the consequence of altered fission/fusion on mitochondrial function and motility in INS-1E rat clonal ${\beta}$-cells. Adenoviruses were used to induce doxycycline-dependent expression of wild type (WT-Mfn1) or a dominant negative mitofusin 1 mutant (DN-Mfn1). Mitochondrial morphology and motility were analyzed by monitoring mitochondrially-targeted red fluorescent protein. Adenovirus-driven overexpression of WT-Mfn1 elicited severe aggregation of mitochondria, preventing them from reaching peripheral near plasma membrane areas of the cell. Overexpression of DN-Mfn1 resulted in fragmented mitochondria with widespread cytosolic distribution. WT-Mfn1 overexpression impaired mitochondrial function as glucose- and oligomycin-induced mitochondrial hyperpolarization were markedly reduced. Viability of the INS-1E cells, however, was not affected. Mitochondrial motility was significantly reduced in WT-Mfn1 overexpressing cells. Conversely, fragmented mitochondria in DN-Mfn1 overexpressing cells showed more vigorous movement than mitochondria in control cells. Movement of these mitochondria was also less microtubule-dependent. These results suggest that Mfn1-induced hyperfusion leads to mitochondrial dysfunction and hypomotility, which may explain impaired metabolism-secretion coupling in insulin-releasing cells overexpressing Mfn1.

• Journal of the Korean Geographical Society
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• v.41 no.6 s.117
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• pp.639-656
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• 2006

The purposes of this paper are to examine the mechanism of the new economic spaces and to suggest directions of geographical research in the knowledge-based information society. It introduces the background of the formation of the new economic spaces and examines network, embeddedness, and agglomeration and dispersion as mechanisms of the new economic spaces. Based on the result of case studies of Kangnam area, the most active innovation region in Korea, and of Sunchang, one of the backward regions in Korea, the paper points out that new economic spaces are now developing even in the peripheral areas. Considering the result of theoretical discussions and case studies, the paper suggests three directions for future geographical research such as research from a integrative viewpoint, development of new methodologies of geographical research, and policy directed research in geography.

• Journal of information and communication convergence engineering
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• v.8 no.5
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• pp.591-594
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• 2010

Control devices perform various works for us in many areas. The device is being utilized for precision movement of certain object. In as much as control devices are activated by means of motors, motor control is important.[1][2] Generally, servo motors capable of precision control are more frequently used than DC motors. Use of 3 motors allows 3- way movement. Medical controllers for surgical operation require high precision. [3][4][5][6] AX-12, a servo motor can realize various types of movement. AX-12 can be easily manufactured in the form of a robotic arm and has features that MCU and its peripheral circuits are simple. For precision movement, 3 motors can be controlled by use of a single joystick and 2 buttons, with movement angles being adjusted by having preset values in the program changed.[7][8] By virtue of this study, we have realized small precision robotic arm system utilizing single joystick and 2 buttons. This system can control the robotic arm in the direction desired by the user. The system has been designed such that a joystick controls 2 motors with the remaining motor being controlled by a button. Single MCU is tasked with both control and movement.[9] We have shown precision robotic arm system in the Figure contained in the conclusion part and made reference to results of analysis in there. It has also been demonstrated that the system can be utilized in the industry.[8]

• IEIE Transactions on Smart Processing and Computing
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• v.5 no.2
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• pp.100-106
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• 2016

Spectrum sensing is an integral part of cognitive radio, which seeks to address the perceived spectrum scarcity that is caused by inefficient utilization of the available spectrum. In this paper, a spectrum sensing system using energy detection for analog TV and FM broadcast transmitters as well as modified Integrated Services Digital Broadcasting Terrestrial (ISDB-T) signals is implemented on a software-defined radio platform using GNU' Not Unix (GNU) radio and the N200 Universal Software Radio Peripheral (USRP). Real-time implementation and experimental tests were conducted in Metro Cebu, a highly urbanized area in the southern part of the Philippines. Extensive tests and measurements were necessary to determine spectrum availability, particularly in the TV band. This is in support of the Philippine government' efforts to provide internet connectivity to rural areas. Experimental results have so far met IEEE 802.22 requirements for energy detection spectrum sensing. The designed system detected signals at -114 dBm within a sensing time of 100 ms. Furthermore, the required $P_d({\geq}90)$ and $P_{fa}({\leq}10)$ of the standard were also achieved with different thresholds for various signal sources representing primary users.

• The International Journal of Costume Culture
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• v.6 no.2
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• pp.93-104
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• 2003

The purpose of this study was to investigate the relationship between women's face satisfaction and makeup satisfaction, to disclose the differences of makeup satisfaction according to demographic variables, and to examine how makeup satisfaction was influenced by face satisfaction and demographic variables. The subjects were 200 women over age 17 living in Seoul and its peripheral areas. The results of this study were as follows: Face satisfaction were drawn three factors. Factor 1 was face contour satisfaction, Factor 2 was skin satisfaction, and Factor 3 was lips and eyes satisfaction. There were significant positive relationship between factors of face satisfaction and makeup satisfaction. Also, the face contour satisfaction was in positive correlation with satisfaction of features, and the skin satisfaction was in positive correlation with that of features. There were significant positive correlations between makeup satisfaction and face shape, eyes, nose, lips, chin, and cheek bone satisfaction. Face satisfaction didn't show significant difference according to demographic variables, but makeup satisfaction showed significant difference according to age and occupation. Face satisfaction was influenced by the facial face, clarity of skin, elasticity of skin, skin color, and ages. The explanatory power of the 4 variables were 24.5%. Makeup satisfaction was influenced by lips and eyes satisfaction, ages, and skin care level. The explanatory power of the 3 variables were 13.3%.

• Korean Journal of Veterinary Research
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• v.35 no.2
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• pp.375-381
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• 1995

Two intraocular tumors were identified in low and medium dosed groups of a carcinogenicity study using 200 males and 200 females Sprague-Dawley rats in Screening & Toxicology Research Center, Korea Research Institute of Chemical Technology. The tumors were grossly observed as white or yellow, unilateral nodules. They were approximately $1-2{\times}3-5mm$ in size. The tumors located in the region of iris and/or ciliary body invaded peripheral cornea. The microscopic features were usually composed of spindle cells arranged in parallel, forming gently curving bundles or whorls. The spindle cells had poorly defined cell boundaries, scant to moderate cytoplasm, fusiform nuclei and indistinct nucleoli. Mitotic figures were rare and areas of necrosis were present. The spindle cells had positive immunoreactivity for S-100 protein and vimentin but negative for desmin, collagen and HMB-45 antibody. In special histochemical studies, the spindle cells react with Gomori's stain for argyrophih fibers, Prussian blue stain for iron but negative with Masson-Fontana's stain for melanin granules. Ultrastructurally, cytoplasmic premelanosomes were not observed in the tumor cells due to the poor preservation of tumor masses. Based on the results, the tumors were diagnosed as amelanotic melanoma.

• The Journal of the Korean dental association
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• v.15 no.8
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• pp.611-615
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• 1977

The author observed histochemically the nature of the calcified tissue in the rabbit dental pulp, induced by pulpal injection of potassium permanganate. The pulp of rabbit mandibular incisors were exposed and enlarged by a dental hand reamer. The exposed pulps were injected with 0.05ml of 20mM solution of potassium permanganate dissolved in Ringer's solution in experimental tooth. Also the control tooth received a pulpal injection of 0.05ml of Ringer's solution. After pulpal injection, the tooth was plugged with a gutta-percha root canal point. The staining techniques were hematoxylin-eosin stain, van Gieson stain, PAS reaction, toluidine blue stain, alcian blue-hematoxylin stain and colloidal iron-picric acid stain. The results were as follows: 1. The pulp on experimental tooth showed osteodentin-like calcified tissue. Also, in some areas, false denticle-like substance were observed. 2. The central portion of the calcified matrix showed metachromasia in toluidine blue stain had strong staining capacity in alcian blue stain. 3. The peripheral portion of the calcified tissue revealed marked van Gieson positive reaction for collagen. But their staining ability in alcian blue was slight and metachromasia was not appeared.

• Journal of Navigation and Port Research
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• v.36 no.9
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• pp.715-720
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• 2012

This paper is to introduce the development of a LCD monitor-based pilots' ship handling simulator installed in the office of Korea Maritime Pilots Association. This simulator is composed of hardware which includes working server array, operation PC, monitor array, rudder, thruster and telegraph peripheral devices, and software which includes ship mathematical model software, ship conning software, image supporting software and so on. In this simulator, MMG mathematical model is used to create thirteen(13) ship models, which are based on sea trial data & pilots' opinion. According to requirements of pilots, virtual scenes of different port areas are built, and some required additional functions are also developed. By using this simulator, pilots can fulfill all kinds of training exercises, design of channel approaching ports, traffic safety analysis, prevention of accident research and other tasks, so as to grasp the characteristics of different ships, and accumulate experience for piloting.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.13 no.1
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• pp.70-74
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• 2010

We report a familial case of visceral larva migrans of Toxocara canis after eating raw chicken liver. A 9-year-old female ate raw chicken liver with her father and older brother and was admitted to the hospital with periumbilical pain, a mild fever, and headache. The total peripheral eosinophil count was 9,884/$mm^3$ and the total lgE concentration was 2,317 IU/dL. Chest and abdominal computed tomography (CT) scans demonstrated multiple, poorly-defined, small, nodular lesions scattered in the liver and lung parenchyma. Toxocara ELISA and Western blot tests were positive in the patient, and her father and brother. A liver biopsy revealed extensive eosinophilic infiltrations in the portal and lobular areas. She took albendazole for 5 days and was discharged in good condition. These results suggest that clinicians should consider foodborne toxocariasis in patients with multiple, small nodules in the liver and lung parenchyma with eosinophilia and a history of raw meat ingestion.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2005.06a
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• pp.513-517
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• 2005

This study examined the possibility of using striped field mice as a biological dosimeter or indicator for the environmental radio-surveillance. For this study, the external morphological characteristics and isoenzymic types of dark-striped field mice were studied after they were captured. Among the morphological external characteristics, the dark-brown coat, dark back stripe, head-to-tail length, tail length, and ear length matched the taxonomical characteristics of dark-striped field mice. The analyses on L-lactate dehydrogenase, aspartate aminotransferase, and malate dehydrogenese revealed that one species of dark-striped field mice, called Apodemus agrarius, was inhabitated throughout a wide range of Korea. On the other hand, A. agrarius and ICR mice to analyze their survival rate and frequency of micronuclei in peripheral polychromatic erythrocytes after irradiation (0, 0.5, 1, 3, 5, 7, 9 Gy). The $LD_{50/30}$ of A. agrarius and ICR mice were approximately 5 Gy and 7Gy, respectively. The results of the study reveal that wild A. agrarius have a high potential as a biological monitoring system to determine the impact of radiation effect in areas such as those within the vicinity of nuclear power plants.