• The Korean Journal of Physiology and Pharmacology
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• v.1 no.2
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• pp.201-208
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• 1997

It is becoming increasingly clear that the inflammatory reaction can be ascribed to a complex array of mediators generated and released from activated phagocytes. In this study, the effect of PAF on interleukin-1(IL-1) activity by rat alveolar macrophages(AM) was examined using thymocyte proliferation assay in the supernate of sample obtained after 24 hr culture. When AM were cultured with PAF alone, no change in IL-1 activity was observed. However, the combined addition of PAF and muramyl dipeptide(MDP) or lipopolysaccharide(LPS) to AM cultures markedly enhanced IL-1 activity by 2-3 fold compared with AM cultures with the stimulant alone in a concentration dependent fashion. The peack effect was found at $10^{-8}$ M PAF with MDP and $10^{-14}$ M PAF with LPS. the effect of PAF was also tested in silica, toxic respirable dust, -added AM cultures as well as in the cultures containing bacterial compounds. Although silica did not stimulate the IL-1 activity, PAF could enhance IL-1 activity by 2 fold above the value of the silica-treated AM cultures with the peak response at $10^{-12}$ M PAF. Optimal enhancement of IL-1 activity occured when MDP and PAF were present together at the initiation of the 24 hr AM cultures. Additionaly, the biologically inactive precursor/metabolite of PAF, lyso-PAF failed to induce enhancement of IL-1 activity. When the specific, but structurally different PAF receptor antagonists, BN 52021($10^{-5}$ M) and CV 3988($10^{-5}$ M) was treated 15 min before addition of PAF($10^{-8}$ M) and MDP$(10\;{\mu}g/ml)$ to the AM cultures, it markedly inhibited the enhancement of IL-1 activity induced by PAF. The effects of these PAF antagonists were also observed in LPS$(10\;{\mu}g/ml)$-stimulated cells. Collectively, these data suggest that PAF enhances IL-1 activity by interaction with a specific receptor.

• Korean Journal of Materials Research
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• v.13 no.4
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• pp.271-278
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• 2003

Conventional backlight for liquid crystal display (LCD) uses mercury which leads to environmental pollution. In this study, characteristics of AC coplanar type mercury-free plasma flat lamp have been studied. Pollution-free Xe-He is adopted as a discharge gas system. Since the Xe gas has a lower efficiency in generating vacuum ultraviolet (VUV) than mercury, the improvement of luminance and luminous efficiency in the Xe gas system is very important. The electrode, dielectric, and phosphor layers constituting lamp are formed on the bottom glass by the screen printing method. The effects of pulse shape, on-time, and pulse frequency on the luminance and luminous efficiency have been examined. For Xe(5%)-He gas, the lamp exhibits higher efficiency with sharper pulse shape, higher peak voltage, and shorter pulse on-time (up to 2 $\mu\textrm{s}$). Higher efficiency and lower consumption of power were obtained at 30 kHz than at 60 kHz. The collision of ion to bottom electrodes is a dominant factor to raise the lamp temperature. Therefore the high voltage and low current discharge system is necessary for reduction of the lamp temperature as well as for enhancement of the luminous efficiency.

• Journal of the Korea Concrete Institute
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• v.16 no.4 s.82
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• pp.501-509
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• 2004

The proposed model can predict the compressive behaviors of concrete confined with fiber reinforced polymer (FRP) jacket. To model confining concrete by FRP jackets, the hypoelasticity-based constitutive law of concrete In tri-axial stress states has been presented. The increment of strength of concrete has been determined by the failure surface of concrete in tri-axial states, and its corresponding peak strain is computed by the strain enhancement factor that is proposed in the present study, Therefore, the newly proposed model is a load-dependent confinement model of concrete wrapped by FRP jackets to compare the previous models which are load-independent confinement models. The behavior of FRP jackets has been modeled using the mechanics of orthotropic laminated composite materials in two-dimension. The developed model is implemented into the incremental analysis of compressive tests. The verification study with several different experiments shows that the model is able to adequately capture the behavior of the compression test by including better estimations of the axial responses as well as the lateral response of FRP-confined concrete cylinders.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.61-64
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• 2015

The brightness of Io's magnetic footprint, an indicator of electromagnetic interaction at the satellite, appears to be strongly connected to the satellite's distance from the plasma equator. As a result, the brightest footprints were detected when Io is near the interception location between the satellite's orbital plane and the plasma equator. However, volcanic activities on Io show strong correlation with the equatorward shift of Jupiter's main auroral oval, consequently causing the disappearance of Io's footprint. The same conclusion was suggested via the observation of Jupiter's hectometric radio emission, called HOM, which closely corresponds to Jupiter's auroral activity. The plasma environment near the Jovian satellites was found to vary significantly at different observational epochs. The electron density increased by approximately a factor of three from the Voyager epoch (1979) to the Galileo epoch (1995), while the electron density was found to be significantly higher (~ 5 times) in the Cassini epoch (2001). In this current study, the magnetic footprints were clearly brighter ten years ago (from peak brightness in 1998-2001) than the footprints detected in 2007. For volcanic activities on Io in 2007, there are two clear activities in February and late May. The magnetic footprint appeared to be dimmer in March 2007, expected to be the result of volcano activities in Feb 2007. However, the magnetic footprint brightness in June appeared to be slightly brighter than the footprints observed in May. The reason could be the time delay between the brightening of the sodium nebula on approximately May 31st and, a while later, the enhancement of flux tube content peaking on approximately June 5th. On the other hand, Io's magnetic footprints were observed during June 1st - 10th when they may not yet have been affected by the increase in mass outflow due to the increase of plasma density.

• Journal of the Korea Society of Computer and Information
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• v.14 no.2
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• pp.37-44
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• 2009

In this paper, we propose an efficient method which improves the performance of transmission of PGA which is essential data for real-time earthquake monitoring system. Currently, above 120 earthquake stations were installed nationwide and additional installation is expected because the social interesting of earthquake hazard is rising. Real-time earthquake monitoring system checks earthquake occurrence by using PGA were calculated from acceleration data of each seismic station. An efficient method of PGA data transmission is key factor of real-time monitoring. The key idea of proposed method is to deal with each seismic station using an unique ID, to assign one bit to indicate whether a packet include a station's data or not. Proposed method can contain more station data and decrease the data loss compared to current method. To verify proposed method, we investigate the turnaround time and ratio of data loss using above 91000 packets. As results of experiment. the proposed method is proven that the method need more time about 50% but reduce the data loss about 87% as compared to previous method.

• Journal of the Korean Chemical Society
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• v.43 no.6
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• pp.636-643
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• 1999

Green-emission intensity of a $Zn_{2-x}Mn_xSiO_4$ phosphor, which is a potential candidate as a green component in PDP device, significantly increases provided that the compound is additionally heat treated at 900$^{\circ}C$ after solid state reaction at 1300$^{\circ}C$. In order to verify origin of such an intensity enhancement after the additional heat treatment in association with the electronic and local structural change at around Mn ions, the Mn K-edge X-ray absorption spectra were recorded. From the analyses of the preedge peak corresponding to $1s{\rightarrow}3d$ bound state transition and XANES spectrum, it is known that most Mn ions are in +2 oxidation state and substitute Zn ion site regardless of the thermal treatment. In addition, EXAFS analyses revealed that Mn ions formed $MnO_4$ tetrahedra with the Mn-O bond length shortened by 0.01${\AA}$ and with reduced Debye-Waller factor in the thermally treated sample.

• Tuberculosis and Respiratory Diseases
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• v.45 no.1
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• pp.169-175
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• 1998

Background: Heliox is known to decrease $PaCO_2$ in patients with increased airway resistance by increasing minute ventilation and reducing work of breathing(WOB). Besides these effect, heliox is expected to decrease functional anatomic dead space owing to improvement of peak expiratory flow rate(PEFR) and enhancement of gas distribution. We investigated whether heliox can decrease $PaCO_2$ even at the same minute ventilation (VE) and WOB with $N_2-O_2$ to speculate the effect of the heliox on the anatomic dead space. Material and Method: The subjects were 8 mechanically ventilated patients with asthma or upper airway obstruction(M : F=5 : 3, $68{\pm}10$years) who were under neuromuscular paralysis. The study was consisted of three 15-minutes phases: basal $N_2-O_2$ heliox and washout Heliox was administered via the low pressure inlet of servo 900C, and respiratory parameters were measured by pulmonary monitor(CP-100 pulmonary monitor, Bicore, Irvine, CA, USA). To obtain the same tidal volume(Vt) in heliox phase, the Vt on monitor was adjusted by the factor of relative flow rate of heliox to $N_2-O_2$. Dead space was calculated by Bohr equation. Results: 1) Vt, VE, peak inspiratory pressure(PIP) and peak inspiratory flow rate(PIFR) were not different between $N_2-O_2$ and heliox. 2) PEFR was higher on heliox($0.52{\pm}0.19$L/sec) than $N_2-O_2$($0.44{\pm}0.13$L/sec)(p=0.024). 3) $PaCO_2$(mmHg) were decreased with heliox($56.1{\pm}14.1$) compared to $N_2-O_2$($60.5{\pm}15.9$)(p=0.027). 4) Dead space ventilation(%) were decreased with heliox($73{\pm}9$ with $N_2-O_2$ and $71{\pm}10$ with heliox)(p=0.026). Conclusion: Heliox decreased $PaCO_2$ even at the same VE and WOB with $N_2-O_2$, and the effect was considered to be related with the reduction of anatomic dead space.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.20 no.4
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• pp.342-354
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• 2008

Some statistical characteristics of deepwater waves along the Korean coast have been investigated using various sources of wave measurement and hindcasting data. For very large waves comparable to design waves, it is recommended to use the average value of the empirical formulas proposed by Shore Protection Manual in 1977 and by Goda in 2003 for the relation between significant wave height and period. The standard deviation of significant wave periods non-dimensionalized with respect to the mean value for a certain significant wave height varies between 0.04 and 0.21 with a typical value of 0.1 depending upon different regions and different ranges of significant wave heights. The mean and standard deviation of the principal deepwater wave direction are presented at the 106 coastal grid points along the Korean coast. For relatively large waves, the probability density function of the directional spreading parameter $s_{max}$ is expressed as a lognormal distribution. The most suitable frequency spectrum in the Korean coast is the TMA spectrum. The probability density function of the peak enhancement factor $\gamma$ is also expressed as a lognormal distribution, with its mean value of 2.94, which is close to the value in the North Sea.

• Radiation Oncology Journal
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• v.21 no.3
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• pp.207-215
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• 2003

Purpose: Extracellular signal-regulated kinase (ERK), which is part of the mitogen-activated protin kinase cascade, opposes initiation of the apoptotic cell death which is programmed by diverse cytotoxic stimuli. In this regard, the inhibition of ERK may be useful in improving the therapeutic efficacy of established anticancer agents. Materials and Methods: Murine hepatocarcinoma, HCa-I is known to be highly radioresistant with a TCD50 (radiation dose yield in $50\%$ cure) of more than 80 Gy. Various anticancer drugs have been found to enhance the radioresponse of this particular tumor but none were successful. The objective of this study was to explore whether the selective inhibition of MEK could potentiate the antitumor efficacy of radiation in vivo, particularly in the case on radioresistant tumor. C3H/HeJ mice hearing $7.5\~8\;mm$ HCa-I, were treated with PD98059(intratumoral injection of $0.16\;\mug/50\;\mul$). Results: Downregulation on ERK by PD98059 was most prominent 1h after the treatment. In the tumor growth delay assay, the drug was found to Increase the effect of the tumor radioresponse with an enhancement factor (EF) of 1.6 and 1.87. Combined treatment of 25 Gy radiation with PD98059 significantly increased radiation induced apoptosis. The peak apoptotic index (number on apoptotic nuclei in 1000 nuclei X100) was $1.2\%$ in the case of radiation treatment alone, $0.9\%$ in the case of drug treatment alone and $4.9\%,\;5.3\%$ in the combination treatment group. An analysis of apoptosis regulating molecules with Western blotting showed upregulation of p53, p$p21^{WAF1/CIP1}\;and\;Bcl-X_s$ in the combination treatment group as compared to their levels in either the radiation alone or drug alone treatment groups. The level of other molecules such as $Bcl-X_L4, Bax and Bcl-2 were changed to a lesser extent. Conclusion: The selective inhibition of MEK in combination with radiation therapy may have potential benefit in cancer treatment.

• Korean Journal of Environmental Agriculture
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• v.22 no.2
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• pp.100-110
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• 2003

This study was conducted to evaluate influence of chemical properties in the riparian on the species diversity and to get plant information for enhancement of natural purification in Mankyeong River. The concentration of total nitrogen was high in Jeonju and Sam stream, while that of total nitrogen showed the highest peak in Winter. Concentrations of $NH_4-N$ was $0.01{\sim}0.06\;mg/L$ in Gosan and Soyang stream. The water quality of upstream along with Mankyeong River was suitable for the irrigation source. The riparian vegetation was investigated by Zurich-Montpellier school's method from June, 2001 to September, 2002. The number of riparian plants were 59 families, 129 genera, 165 species, 20 varieties in Gosancheon, on the while 53 families, 111 genera, 141 species, 19 varieties in Soyangcheon. The number of riparian plants in Bari basin was higher than that of other sites namely, 73 families, 134 genera, 218 species, 33 varieties. Riparian vegetation was consisted of 12 plant communities. The contents of organic matter, total nitrogen and electrical conductivity had negative relationship with species diversity (Species richness index, Heterogeneity index, Species evenness index Species number). On the while, species diversity had positive relationship with soil pH. Species diversify of the plant communities were affected by topography and disturbance.