• Phonetics and Speech Sciences
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• v.12 no.3
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• pp.95-103
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• 2020

The current study aimed to identify the characteristics of speech rate and pause in children with spastic cerebral palsy (CP) and their relationships with speech intelligibility. In all, 26 children with CP, 4 with no speech motor involvement and age-appropriate language ability (NSMI-LCT), 6 with no speech motor involvement and impaired language ability (NSMI-LCI), 6 with speech motor involvement and age-appropriate language ability (SMI- LCT), and 10 with speech motor involvement and impaired language ability (SMI-LCI) participated in the study. Speech samples for the speech rate and pause analysis were extracted using a sentence repetition task. Acoustic analysis were made in Praat. First, it was found that regardless of the presence of language impairment, significant group differences between the NSMI and SMI groups were found in speech rate and articulation rate. Second, the SMI groups showed a higher ratio of pause time to sentence production time, more frequent pauses, and longer durations of pauses than the NSMI groups. Lastly, there were significant correlations among speech rate, articulation rate, and intelligibility. These findings suggest that slow speech rate is the main feature in SMI groups, and that both speech rate and articulation rate play important roles in the intelligibility of children with spastic CP.

• Proceedings of the KSPS conference
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• 1997.07a
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• pp.92-114
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• 1997

This study is aimed to grasp the actual problems of the perception of English rhythm and intonation structure by Korean University students who have studied English in the secondary schools for the past six years, and to establish the systems of English rhythm and intonation structure for the Korean students of English. For this study, the listening test is provided, and 100 students are chosen as the subjects of the study. The noticeable findings are summarized as follows: (1) Koreans perceive the words stress comparatively well in nonsense words, unfamiliar place names, and familiar word. (2) Koreans do not perceive the isochrony of English rhythm well enough. The perception of the sentence stress is very unstable, especially in the sentence involved in polysyllabic words, compound words, and 'emphatic stress' pr 'contrastive stress'(or in the different rhythmic patterns). (3) Koreans do not perceive the nucleus well enough. The perception of the nucleus is more stable in content words than in function words, at the end of a sentence than in the middle of a sentence, and in monosyllabic words than in the polysyllabic words. (4) Koreans do not perceive the boundary(or pause) of intonation group well enough. The perception of the pause is unstable in the long or complex sentence. (5) Koreans discriminate the meaning of English word stress comparatively well, especially in disyllabic words. But the discrimination is somewhat unstable in polysyllabic words and between 'adjective' and 'verb' (6) Koreans' discrimination of the intonation meaning is below the level. Koreans do not perceive the differences of intonation meaning according to the pitch accent or the focus. In conclusion, the writer will propose the procedures for the teaching of rhythm and intonation in the following order: word stress drill longrightarrowstressed and reduced syllables drilllongrightarrowrhythm group drilllongrightarrowthe varying rhythm drilllongrightarrowsentence stress drilllongrightarrownucleus drill longrightarrowintonation group drilllongrightarrowlong utterance drill of more than two intonation group.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.2
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• pp.343-350
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• 2009

This study aimed to evaluate the anti-asthmatic effects of Samjajihwang-tang (SJT) using OVA-induced asthmatic mice model. Asthmatic mice model was conducted by repeated challenge of OVA using C57BL/6 mice. Each group was treated with distilled water, SJT (400 mg/kg and 200 mg/kg) extract or cyclosporin A (10 mg/kg) for the later 8 weeks, Penh (plethysmography and enhanced pause), immune cells subpopulation, eotaxin, IL-5, TNF-${\alpha}$, Anti-OVA-lgE in BALF (bronchoalveolar lavage), and lung tissue was analyzed, No cytotoxicity of SJT was shown on hFCs (human fibroblast cells). Administration of SJT significantly decreased Penh levels comparing to control group. SJT treatment significantly ameliorated the increase of total cells number and eosinophil including of immune cell subpopulation of $CD3^+/CD69^+$, $CCR3^+$, $B220^+/CD22^+$, $B220^+/CD45^+$, and $B220^+/lgE^+$ cells in BALF comparing to control group. Eotaxin, IL-5, TNF-${\alpha}$, and Anti-OVA-lgE level in BALF were significantly decreased by SJT treatment too. Histopathological finding verified the improvement of infiltration of inflammatory cells and collagen tissue in the SJT groups comparing to control group. These results strongly suggest that SJT would be a effective candidate for herbal-originated anti-asthmatic drug. However, this drug should be further studied for characterization of the accurate action and underlying mechanisms using variant disease model in the future.

• Speech Sciences
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• v.12 no.4
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• pp.129-139
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• 2005

This paper investigates any possible correlation between the information structure and the occurrence of clause internal pauses in the spontaneous discourse. One of the possible functions of pause is its capacity to signal the information structure of the discourse. However, this aspect was not much explored in Korean spontaneous speech. In the present study, information structure of spontaneous speech was defined for each word or word group on the basis of the information structure analysis model proposed by Van Donzel (1999) and Roulet (1991, 1997). Thus, at a local level (words or word groups) of discourse structure, a distinction was made between three types of information, new, given and inferable. The results showed that clause internal pauses tend to appear more frequently before new information than other types of information. However compared to the total number of words or word groups it was not noticed any specific ordering concerning different kind of information status and pausing. It was however found that clause internal pauses did not appear randomly. The majority of them occurred at the initial part of the clause or the sentence. This tendency was mostly related to the division of sentence (or clause) into topic and comment. Thus, the role of pauses as a marker of information structure seems to be less effective in spontaneous discourse.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.3
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• pp.590-598
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• 2009

The purpose of this research is to evaluate the effect of Mahaenggamseok-tang-gagambang (MGTG) on airway hyper- responsiveness (AHR), immune cells, cytokines and lung tissue in OVA-induced asthmatic mice. C578L/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (3times a week) for asthma sensitization and challenge. Two experimental groups were treated with different concentrations of MGTG (400 mg/kg and 200 mg/kg) extract and cyclosporin A (10 mg/kg) for the later 8 weeks. Enhanced pause (Penh) levels were measured by whole body plethysmography. Immune cells were analyzed by flow cytometer in peripheral blood monocyte cell (PBMC) and lung cells. The IL-1b, IL-12, IFN-${\gamma}$, OVA-lgE, IL-4, IL-5, TNF-${\alpha}$ were analyzed by ELISA kit in serum and splenocyte+a-cCDS/a-CD28. Enhanced pause (Penh) levels of the MGTG groups (400 mg/kg and 200 mg/kg) were decreased significantly compared with that of control group. The numbers of MGTG groups (400 mg/kg and 200 mg/kg) on lung total cells were decreased significantly compared with that of control group. The numbers of MGTG groups (400 mg/kg and 200 mg/kg) on $CD3^+/CD69^+$, $B220^+/CD22^+$, $B220^+/CD23^+$, $B220^+/lgE^+$, $CCR3^+$ cells were decreased significantly compared with that of control group. The number of MGTG group (400 mg/kg) on $CD3^+/CD49b^+$ cells was decreased significantly compared with that of control group. The level of MGTG groups (400 mg/kg and 200 mg/kg) on IL-4, IL-5, IL-12, TNF-${\alpha}$, OVA-lgE were decreased significantly compared with that of control group. The level of MGTG group (400 mg/kg) on IL-1b, IL-1S, OVA-lgE were decreased significantly compared with that of control group. These results demonstrate that MGTG could be a desirable alternative therapy for allergic asthma by inhibiting the expression of immune cells, the activation of inflammatory mediator.

• Korean Journal of Culture and Social Issue
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• v.12 no.2
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• pp.101-114
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• 2006

This study was examined the effective nonverbal behavior cues of detecting suspects' lies in the investigation scene. In order to search the suspects who drank the alcohol liquor without a permission, 18 soldiers were interviewed. 8 solders had drunken alcohol and had lied when was asked(lie group). The other 10 soldiers hadn't drunken alcohol and had told the truth(truth group). The mean frequencies of nonverbal behaviors were compared lie group with truth group. The following behaviors were measured by frequency: vocal characteristics (high pitch of voice, speech hesitations, speech error, frequency of pauses, period of pauses, latency period), facial characteristics (gaze, smile, touching face, blinking, facial micro-expression), body movement (illustrators, hand and finger movement, leg and foot movement, head movement, trunk movement, shifting position). As results, this study found that deception cues were periods and frequencies of pause, micro-expression, head movements. The lie group had less periods and frequencies of pause, and more micro-expression, head movements than truth group. But, this study didn't found Othello's error cues.

• The Journal of Korean Physical Therapy
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• v.31 no.2
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• pp.111-116
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• 2019

Purpose: This study examined the effects of horse riding simulator exercise on the thickness changes in the transverse abdominis in normal adults. Methods: Forty-five healthy adults were recruited and randomized to a horseback riding simulation exercise group (n=15), a sling exercise group (n=15), and a trunk stabilization exercise group (n=15). A horseback riding simulator offers the indoor experience of horseback riding and mimics the rhythmic movement of horseback riding, thereby provided a virtual environment, such as riding a real horse on the front screen. The velocity of the horse riding simulator exercise was regulated within the subject's ability to control the exercise on the horse riding simulator. A sling exercise group performed sling exercise under the inspection of the experimenter. In the trunk stabilization exercise group, the subjects were instructed to perform the exercise accurately and pause the session when pain occurred during the intervention. The subjects in each group carried out the interventions three times per week for six weeks. The thickness of the transverse abdominis was measured using a pressure biofeedback unit and the ultrasound. Results: Significant differences in the thickness of transverse abdominis within the groups were observed between before and after the interventions. On the other hand, there were no differences in the parameters among the groups. Conclusion: Horse riding simulator exercise can be an alternative to trunk stabilization exercise by increasing the thickness of the transverse abdominis in healthy adults.

• Proceedings of the KSPS conference
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• 2004.05a
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• pp.245-249
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• 2004

The aim of this paper is to show the possibilities of the proficiency -based and integrated teaching of High School English reading and listening based on sense group and utterance restructuring. The proficiency -based and integrated listening and reading activities in stages are as follows. Step1, students fill in the blanks with strong or weak sounding words according to their abilities. Step2, speak along (track) based on restructuring and post-lexical phenomena while listening to the sentence. Step3, read and understand directly the passage, which have been marked the differentiated places where a native speaker of English would beat all likely to pause. Students need to listen to spoken English, so they recognize words in written and spoken form. They must be familiar with suprasegmental features, stress and rhythm, and post-lexical phenomena during reading activities.

• BMB Reports
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• v.36 no.3
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• pp.305-311
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• 2003

A modified actinomycin D was prepared with a hydroxyl group that replaced the amino group at the chromophore 2-position, a substitution known to strongly reduce affinity for double-stranded DNA. Interactions of the modified drug on single-stranded DNAs of the defined sequence were investigated. Competition assays showed that 2-hydroxyactinomycin D has low affinity for two oligonucleotides that have high affinities ($K_a\;=\;5-10{\times}10^6\;M^{-1}$ oligomer) for 7-aminoactinomycin D and actinomycin D. Primer extension inhibition assays performed on several single-stranded DNA templates totaling around 1000 nt in length detected a single high affinity site for 2-hydroxyactinomycin D, while many high affinity binding sites of unmodified actinomycin D were found on the same templates. The sequence selectivity of 2-hydroxyactinomycin D binding is unusually high and approximates the selectivity of restriction endonucleases. Binding appears to require a complex structure, including residues well removed from the polymerase pause site.

• Phonetics and Speech Sciences
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• v.6 no.4
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• pp.67-77
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• 2014

This study investigated (1) whether Korean learners of English use discourse-level prosody in L2 production as native speakers of English do, and (2) whether discourse-level prosody is also found in the Korean language, as is evident in the prosody of native speakers of English. The study compared the production of the same 15 sentences in two types of reading materials, sentence-level and discourse-level. This study analyzed the onset pitch, sentence mean pitch and pause length to examine the paratone (intonational paragraph) realization in discourse-level speech. The results showed that in L2 discourse-level prosody, the Korean speakers were limited in displaying paratone and did not made significant difference between sentence-level and discourse-level prosody. On the other hand, in L1 discourse-level text, both English and Korean participants demonstrated paratone using pitch. However, there were differences in using prosodic cues between two groups. In using pauses, the ES group paused longer before both the orthographically marked and not marked topic sentences. The KS group paused longer only before the orthographically marked topic sentence in both L1 and L2 text reading. In the comparison of sentence-level and discourse-level prosody, the topic sentences were marked by different prosodic cues. English participants used higher sentence mean pitch, and the Korean participants used higher onset pitch.