• 경영정보학연구
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• 제10권2호
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• pp.195-209
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• 2008

고객의 니즈가 시시각각 변화하는 경영환경에서 획일화된 매장관리 방법으로 매장의 수익성을 증대시키기에는 한계가 있다. 따라서 고객의 선호 변화를 예측하여 각 매장에 적절한 상품을 추천할 필요가 있다. 본 연구에서는 판매 데이터 분석을 통해 시간 순서를 고려한 상품 추천 및 매장관리 방법을 제안한다. 즉 자기조직화지도(Self Organizing Map) 알고리즘을 이용하여 매장의 판매 프로파일을 군집화하고, 매장 궤적의 예측을 통해 목표 매장을 관리하는 방법을 제시한다. 본 연구의 방법론을 검증하기 위해 (주)더페이스샵 판매데이터를 적용하여 평가하였으며, 평가결과 제시한 방법론은 화장품처럼 유행에 민감하고 라이프사이클이 짧은 특징을 지닌 상품을 판매하는 매장의 수익성 증대에 기여할 수 있을 것으로 기대된다.

• Journal of Communications and Networks
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• 제7권2호
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• pp.144-156
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• 2005

Video streaming over wireless networks is challenging due to node mobility and high channel error rate. In this paper, we propose a multi-source video streaming (MUVIS) system to support high quality video streaming service over IEEE 802.1l-based wireless networks. We begin by collocating a streaming proxy with the wireless access point to help leverage both the media server and peers in the WLAN. By tracking the peer mobility patterns and performing content discovery among peers, we construct a multi-source sender group and stream video using a rate-distortion optimized scheme. We formulate such a multi-source streaming scenario as a combinatorial packet scheduling problem and introduce the concept of asynchronous clocks to decouple the problem into three steps. First, we decide the membership of the multisource sender group based on the mobility pattern tracking, available video content in each peer and the bandwidth each peer allocates to the multi-source streaming service. Then, we select one sender from the sender group in each optimization instance using asynchronous clocks. Finally, we apply the point-to-point rate-distortion optimization framework between the selected sender-receiver pair. In addition, we implement two different caching strategies, simple caching simple fetching (SCSF) and distortion minimized smart caching (DMSC), in the proxy to investigate the effect of caching on the streaming performance. To design more realistic simulation models, we use the empirical results from corporate wireless networks to generate node mobility. Simulation results show that our proposed multi-source streaming scheme has better performance than the traditional server-only streaming scheme and that proxy-based caching can potentially improve video streaming performance.

• 생명과학회지
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• 제11권6호
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• pp.509-516
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• 2001

까마중의 부위별 DPPH free radical 소거활성은 뿌리에서 가장 높았고, 줄기, 전부위, 열매 잎 그리고 꽃 순으로 높았다. 추출방법간의 DPPH free radical 소거활성은 80%methanol에 침지하여 추출한것보다는 $80^{\circ}C$에서 80% meth-anol에 흰류추출한것이 높았다. Sephades LH-20 column chromatography에 의하여 분획된 L6의 DPPH free radical 소거활성은 ethy acetate 분획 추출물보다 6.7배 높았다. 분획물내의주요물질은 2, 6-methano-3-benzazocin-11-ol, 2[1h]-pyridinethione 및 2-hydroxy-5 methylbenzaldehyde로 phenolic 화 물이었다. 줄기와 뿌리의 POD및 SOD 활성은 타 부위에 비하여 높은 활성을 나타내었고, 생육기간에는 파종 후 60일후에서 활성이 가장 높았다. PODdmlehddnl gth 패턴은 뿌리에서 10개의 band로 가장 많았고 그중 8개의 band가 식물체의 부위별로 차이가 있어Tdmaul, SOD의 동위효소 패턴은 잎에 5개의 band로 가장 많았고 그중 2개의 band가 식물체의 부위별로 차이가 있었다.이가 있었다.

• 동의생리병리학회지
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• 제31권4호
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• pp.213-219
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• 2017

Atopic dermatitis (AD) is a common skin disease characterized by chronic and relapsing inflammatory dermatitis with immunological disturbances. Spleen deficiency (脾虛) is one of the major causes of AD, so development of animal model is required for AD research that reflects the pattern identification. The groups that we have used in this study included Senna folium extracts (SFE), 2,4-dinitrochlorobenzene (DNCB), and normal mice. Therefore, the present study was developed to atopic dermatitis mouse model with spleen deficiency in 2,4-dinitrochlorobenzene (DNCB) and senna leaves extracts induced AD in NC/Nga mice. The results demonstrated that senna leaves extract treatment significantly increased the dermatitis clinical score and epidermal thickness in AD-like skin lesions. We also proved beyond doubt that there was occurrence of erythema and skin moisture indices in the senna leaves extract groups. Further, we also found that the level of serum immunoglobulin E (IgE) in the senna leaves extract-treated group was increased. The amount of IL-4, IL-13, $TNF-{\alpha}$ and $TGF-{\beta}$ mRNA determined by real-time PCR was increased remarkably when senna leaves extract groups were treated on dorsal skin. Senna leaves extract groups significantly promoted the number of CD11B+/Gr-1 cell in skin, as well as the number of CD4+/CD8+ cell in dorsal skin compared with control. The review summarizes recent process in our understanding of the immunopathophysiology of spleen deficiency AD and the implications for spleen deficiency mouse models of AD on drug discovery from medical plants.

• 한국컴퓨터정보학회논문지
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• 제15권6호
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• pp.121-128
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• 2010

최근 마케팅이나 기업전략 분야에서 고객관리 및 점포관리 등의 업무를 위하여 GIS 기법을 적용한 다양한 응용시스템이 개발되고 있다. 그러나 기존의 시스템들은 대부분 개별점포나 고객 담당자의 경험치를 이용하여 이루어져 왔으며, 특정업종이나 특정 고객들에 대한 객관적인 분석시스템이 제시되지 않았다. 따라서 본 연구에서는 GIS 기법뿐만 아니라 시공간 데이터마이닝 기법을 적용한 gCRMs을 개발하였다. 본 시스템은 상권추출을 위한 새로운 시공간 데이터마이닝 기법을 개발하여 다양한 GIS 응용S/W의 개발이 가능하며, 상권에서 추출된 특성정보와 상권에서 발생하는 매출 등을 정성적, 정량적으로 평가할 수 있으며, 더 많은 다양한 지역에 적용하기 위한 일반화 기술의 원천기술을 획득하여 향후 기술을 이용한 각종 마케팅이 가능하다. 또한 도지시역의 변화를 예측하는 것과 같은 시계열분석 등의 모델링 툴을 개발하는 기초적인 기술을 제공할 수 있다.

• 안보군사학연구
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• 통권8호
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• pp.271-309
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• 2010

The main theme of this study is about North Korea's contemporary military strategy which remained a blind spot in the 21st century. Indeed, Pyongyang's contemporary military strategy is evolved from the logic of War. On the basis of this logic, this study examined North Korea's contemporary military strategy with three analytical frameworks. The first is the discovery of Clausewitz's dictums and application of the Trinitarian analysis on the Korean cases. During the course of applying Clausewitzian main dictum--War as continuation of politics, the methodological analysis on war played a important role generalizing the pattern and matrix of North Korea's strategic thinking and military strategy. In particular, Clausewitz's Trinitarian framework on war -Government (reason), Army (chance), People (passion)- was a universal framework to scrutinize the North Korean missile and nuclear strategy. The second is about the matrix of North Korea's military strategy, The study suggested the genealogical feature of Pyongyang's military strategy. In principle, the dictum of 'Military-First Politics' 1S the combination of the political philosophy, Chuch'e (self-reliance) of Kim Il Sung and Kin Jong Il reflected in the military readiness. As a result this analysis was able to equate Clausewitz's dictums to explain Pyongyang's idea of the nature of war in that North Korea's military strategy is the central instrument of delivery to achieve political objectives. The third is about the theoretical encounter of 'Clausewitz's Wonderful Trinity' and 'Remarkable Trinity on North Korea's contemporary strategy'. On the basis, three elements are connected to one of three groups in society; the people, the military, and the government. In order to apply the Clausewitz's Trinitarian analysis into Kim Jong Il's 'Military-First' strategy, two case studies (Missile and Nuclear strategy) were examined. The finding of this study is that Clausewitzian dictum in the 19th century is still valid in the 21st century as it provided plausible theoretical framework to explain the North Korean contemporary military strategy with a reminder that the nature and logic of war are fixed in the socially constructed state.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제4권11호
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• pp.499-508
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• 2015

높은 유틸리티 항목집합 마이닝은 트랜잭션 데이터베이스에서 사용자가 지정한 최솟값 이상의 유틸리티를 갖는 항목집합들을 항목의 수량과 가중치값을 동시에 고려하여 찾아내는 것이다. 최근에 연구된 유틸리티-리스트 기반의 높은 유틸리티 항목집합 마이닝 알고리즘은 많은 후보 항목집합들을 피하기 위해 제안되었으며 비용이 높은 조인 연산을 수행한다. 본 논문은 유틸리티-리스트 구조에 항목집합의 트랜잭션 유틸리티와 공통 유틸리티 속성을 추가한 새로운 알고리즘을 제안한다. 이 새로운 알고리즘은 조인 연산의 수를 줄이고 탐색 공간을 효과적으로 가지치기한다. 생성 데이터와 실 환경 데이터상의 실험 결과를 통해 제안된 알고리즘이 다른 최근 알고리즘들에 비해 실행 시간 면에서 아주 우수하고, 특히 데이터가 조밀하거나 항목집합의 길이가 긴 경우에 더 효율적이라는 것을 보여준다.

• Genomics & Informatics
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• 제13권2호
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• pp.45-52
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• 2015

Acute myeloid leukemia is a well characterized blood cancer in which the unnatural growth of immature white blood cell takes place, where several genes transcription is regulated by the micro RNAs (miRNAs). Argonaute (AGO) protein is a protein family that binds to the miRNAs and mRNA complex where a strong binding affinity is crucial for its RNA silencing function. By understanding pattern recognition between the miRNAs-mRNA complex and its binding affinity with AGO protein, one can decipher the regulation of a particular gene and develop suitable siRNA for the same in disease condition. In the current work, HOXA9 gene has been selected from literature, whose deregulation is well-established in acute myeloid leukemia. Four miRNAs (mir-145, mir-126, let-7a, and mir-196b) have been selected to target mRNA of HOXA9 (NCBI accession No. NM_152739.3). The binding interaction between mRNAs and mRNA of HOXA9 gene was studied computationally. From result, it was observed mir-145 has highest affinity for HOXA9 gene. Furthermore, the interaction between miRNAs-mRNA duplex of all chosen miRNAs are docked with AGO protein (PDB ID: 3F73, chain A) to study their interaction at molecular level through an in silico approach. The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding of AGO-assisted miRNA based gene silencing mechanism in HOXA9 gene associated in acute myeloid leukemia computationally.

• Journal of Animal Science and Technology
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• 제56권7호
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• pp.23.1-23.7
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• 2014

Background: Scanning of the genome for selection signatures between breeds may play important role in understanding the underlie causes for observable phenotypic variations. The discovery of high density single nucleotide polymorphisms (SNPs) provide a useful starting point to perform genome-wide scan in pig populations in order to identify loci/candidate genes underlie phenotypic variation in pig breeds and facilitate genetic improvement programs. However, prior to this study genomic region under selection in commercially selected Berkshire and Korean native pig breeds has never been detected using high density SNP markers. To this end, we have genotyped 45 animals using Porcine SNP60 chip to detect selection signatures in the genome of the two breeds by using the $F_{ST}$ approach. Results: In the comparison of Berkshire and KNP breeds using the FDIST approach, a total of 1108 outlier loci (3.48%) were significantly different from zero at 99% confidence level with 870 of the outlier SNPs displaying high level of genetic differentiation ($F_{ST}{\geq}0.490$). The identified candidate genes were involved in a wide array of biological processes and molecular functions. Results revealed that 19 candidate genes were enriched in phosphate metabolism (GO: 0006796; ADCK1, ACYP1, CAMK2D, CDK13, CDK13, ERN1, GALK2, INPP1; MAK, MAP2K5, MAP3K1, MAPK14, P14KB, PIK3C3, PRKC1, PTPRK, RNASEL, THBS1, BRAF, VRK1). We have identified a set of candidate genes under selection and have known to be involved in growth, size and pork quality (CART, AGL, CF7L2, MAP2K5, DLK1, GLI3, CA3 and MC3R), ear morphology and size (HMGA2 and SOX5) stress response (ATF2, MSRB3, TMTC3 and SCAF8) and immune response (HCST and RYR1). Conclusions: Some of the genes may be used to facilitate genetic improvement programs. Our results also provide insights for better understanding of the process and influence of breed development on the pattern of genetic variations.

• 정보처리학회논문지D
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• 제15D권2호
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• pp.179-186
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• 2008

위치 기반 장치의 발전과, GIS 기능의 확장 그리고 위치 정보기술들의 정확성과 가용성이 증가함에 따라서 위치 기반 서비스들의 새로운 영역에 대한 새로운 가능성이 나타나게 되었다. 데이터의 시간과 공간 형태에 따라서 정의되는 Relationship에 기인하여 시공간 데이터 마이닝 영역에서 공간에 대한 지식 검색이 증가할 경우 매우 큰 문제에 직면한다. 이 논문에서는 모바일 환경에서 시공간 패턴 마이닝을 위한 알고리즘들을 제안한다. 이동 패턴들은 All_MOP와 Max_MOP 두 개의 알고리즘을 활용하여 생성된다. 이 알고리즘들은 먼저 모든 빈발 패턴들을 탐사한 후 오직 최대의 빈발 패턴만을 탐사한다. 아울러, 제안한 기법과 기존의 DFS_MINE 기법의 수행 시간 비교를 통하여 제안한 기법이 수행시간에서 다소 우수한 것을 나타낸다. 이러한 제안접근법은 관광 서비스, 교통 서비스 등과 같은 위치 기반 서비스 등에 활용할 수 있다.