• Clinical and Experimental Reproductive Medicine
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• 제47권2호
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• pp.122-129
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• 2020

Objective: The survival of a semi-allogeneic fetus depends on several immunological mechanisms, and it has been suggested that recurrent pregnancy loss (RPL) could develop as a result of one or more immunological abnormalities. Methods: Compatibility between partners for human leukocyte antigen (HLA) genotypes and the relationships between maternal killer-cell immunoglobulin-like receptor (KIR) and paternal HLA-Bw4/Bw6 and HLA-C1/C2 supra-groups were investigated in 25 couples with RPL in comparison to healthy couples with children. HLA and KIR genotyping was performed using polymerase chain reaction with sequence-specific primers and/or sequence-specific oligonucleotides. Results: HLA class I incompatibility between partners, especially in HLA-B alleles, was more common in the RPL group (p= 0.01). HLA-C2 homozygosity was more frequent in the male partners of RPL couples than in other groups (p= 0.03). The KIR2DL5 gene frequency was significantly higher in both the female and male partners of RPL couples, whereas the KIR2DS3 gene frequency in male partners of RPL couples was significantly reduced (p= 0.03). The presence of KIR2DL3 in women with RPL was correlated with the presence of HLA-C2 alleles in their spouses (p= 0.03). Conclusion: Our data from a Turkish population suggest that male HLA-C2 homozygosity may play an important role in RPL. Additionally, an incidental match between male HLA-C2 and female HLA-C1 ligand KIR receptors might perturb the balance between activatory and inhibitory KIR-ligand interactions during pregnancy in couples affected by RPL. The roles of orphan KIR2DL5 and orphan KIR2DS3 in RPL remain obscure.

• 한국콘텐츠학회논문지
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• 제13권9호
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• pp.260-269
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• 2013

오늘날 남성노인들은 급변하는 세태에 적응해가면서 성역할정체감의 위기를 경험할 수 있으므로 이들의 관점에서 성역할정체감을 이해하기 위해 그 유형과 특성을 파악하고자 하였다. 주관적이고 개별화된 경험으로서의 성역할정체감을 확인하기 위해 Q 방법론을 적용하였다. 남성성과 여성성을 나타내는 40개의 Q표본을 이용하여 40명의 남성노인을 대상으로 자료 수집 및 분석을 실시하였다. 남성노인의 성역할정체감은 다음 네 가지 다양한 유형으로 확인되었다. 파워 표출형은 전통적인 남성성의 특성을 나타내는 유형으로 일을 추진함에 있어서 박력이 있으며 용감하고 지배적인 성향으로 카리스마를 겉으로 표출한다. 파워 과묵형 남성노인은 독립심이 강하고 소신이 있으나 이를 드러내기 보다는 묵묵히 행동으로 표현하는 성향을 지니고 있다. 파워 온정형 남성노인은 추진력 있게 큰 일을 잘 처리하며, 부드러운 성향의 소유자이다. 온정 돌봄형 남성노인은 가정과 아이를 돌보는 것에 보람을 느끼며, 남을 먼저 생각하는 이해심과 참을성이 있으며, 유순하고 부드러운 속성을 지니고 있다. 본 연구에서 분류된 노년기 남성의 성역할정체감 유형에 대한 결과를 바탕으로 성역할정체감 유형 별 심리사회적 적응양상, 건강행위, 신체 건강과 정신건강상태에 미치는 영향을 규명하는 연구가 필요하다.

• Journal of Genetic Medicine
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• 제14권1호
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• pp.18-22
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• 2017

Pseudohypoparathyroidism type 1b (PHP 1b) is the result of end organ resistance to parathyroid hormone (PTH) in the absence of any features of Albright's hereditary osteodystrophy. There are two subtypes of PHP 1b with different genetic mechanisms. One subtype is related to a maternally derived 3kb microdeletion involving STX 16 gene, and is inherited in an autosomal dominant mode. Familial autosomal dominant inheritance of PHP 1b is relatively rare. The other subtype is associated with more extensive loss of imprinting at the GNAS locus that affects at least one additional differential methylated (hypermethylation at neuroendocrine secretory protein and hypomethylation at antisense transcript and or extra-large stimulatory G protein region) without microdeletion of the STX 16 or AS gene. It can be sporadic due to an imprinting defect in the GNAS gene. In our case, an 8-year-old girl was referred for suspected PHP with no feature of Albright hereditary osteodystrophy. Blood test results revealed hypocalcemia and hyperphosphatemia. Elevated PTH was also checked. There was no family history of endocrine or developmental problem. Her intelligence was normal, but she had inferior sociability at that time. Based on above, we diagnosed a rare case of paternal uniparental disomy of the long arm of chromosome 20 as the cause of PHP 1b by microsatellite marker test of chromosome 20.

• 여성건강간호학회지
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• 제26권2호
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• pp.161-170
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• 2020

Purpose: This study was conducted to identify the influences of the attitudes of pregnant women and their husbands towards sex during pregnancy on sexual function. Additional purpose was to compare the frequency of sexual dysfunction according to gender and gestational trimester and to describe the changes in sexual behavior according to the gestational trimester. Methods: In this study, 231 pregnant couples completed self-report questionnaires during their visits to women's hospitals or community health centers. The questionnaires assessed general characteristics, maternal/paternal sexual attitudes towards sex during pregnancy (Maternal Sex during Pregnancy Scale, MSP/Paternal Sex during Pregnancy Scale, PSP), and sexual function (using the Female Sexual Function Index and International Index of Erectile Function, respectively). Multiple regression analysis was done to test the research model using SPSS version 23.0. Results: In this study, 74.9% of pregnant women and 38.5% of their husbands reported sexual dysfunction. Sexual dysfunction was prevalent in pregnant women in the first trimester and prevalent in husbands in the third trimester. MSP (β=.44, p<.001) in pregnant women and PSP (β=.39, p<.001) and being in the first trimester (β=.17, p=.012) in husbands influenced sexual function during pregnancy. In the first trimester, the scores for attitudes towards sex during pregnancy were the lowest in pregnant women, while they were the highest in their husbands. Conclusion: Positive attitudes about sex during pregnancy are important for sexual function in pregnant couples. Because the difference in attitudes towards sex during pregnancy between pregnant women and their husbands was greatest in the first trimester, sexual health interventions need to be provided in early pregnancy.

• 대한유전성대사질환학회지
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• 제20권2호
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• pp.44-49
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• 2020

가성부갑상샘기능저하증(pseudohypoparathyroidism, PHP)은 부갑상샘호르몬에 대해 표적 기관이 저항성을 가지며, 저칼슘혈증과 고인산혈증을 특징으로 하는 질병이다. PHP의 원인은 자극형 G 단백의 신호전달이 문제인데, α-아형을 인코딩하는 GNAS 유전자와 GNAS 유전자 상부의 각인 이상으로 발생한다. 가족력 없이 발생하는 산발성 PHP 1b형은 GNAS 유전자 상류 다발 지역의 메칠화 이상으로, 그 중 일부는 모계 유전형이 소실되고, 부계 유전형만이 표현된다. 본 논문에서는 간헐적 강직을 주소로 내원한 10.8세 남아에서 발생한 20번 염색체 장완의 부계 단친성 이염색체에 의한 산발성 PHP 1b형의 증례를 고찰해보고자 한다.

• Human Ecology Research
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• 제61권3호
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• pp.319-333
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• 2023

The purpose of this study was to examine which sibling and parent-child characteristics were associated with siblisng warmth and conflict among Korean young adults. The data came from an online survey of Koreans aged 19-34 years who had at least one sibling and two living parents. We conducted a multilevel regression analysis using data from 193 men with 305 siblings and 203 women with 286 siblings. The results showed that, for men, the levels of warmth were higher when the sibling was younger, when they received more frequent financial and instrumental support from the sibling, and when maternal favoritism was relatively lower. Women reported higher levels of warmth when the sibling was a sister, when they provided more frequent support for the sibling, when they had a more affectionate relationship with the mother, and when paternal favoritism was lower. As for sibling conflict, the number of siblings was positively associated with the levels of conflict among both men and women. Maternal affection was negatively related with conflict for men, and paternal favoritism was positively related to conflict for women. Interestingly, women's sibling warmth and conflict were both higher when the sibling was a sister, which meant that relationships between sisters tended to be ambivalent. This study contributes to our understandings of Koreans' sibling relationships in young adulthood.

• 원예과학기술지
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• 제31권6호
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• pp.790-797
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• 2013

배는 꽃이 진 후 꽃받침의 탈리가 품종에 따라 다르게 나타나는데 품종에 상관없이 꽃받침이 남아 있는 과실은 과정부가 비대하여 돌출하게 된다. 본 연구에서는 남방형 동양배 120품종, 북방형 동양배 52품종 및 서양배 34품종을 대상으로 꽃받침 탈리 여부에 따른 무체과 또는 유체과로의 발달 유무를 조사하고, 남방형 동양배 품종 간의 교배 조합 후대 실생의 유체과 발생률을 조사하여 꽃받침 탈리에 대한 유전 양식을 구명하고자 하였다. 일반적으로 유체과 발생률이 10% 이하이거나 유체과 발생률이 90% 이상인 품종의 비율이 무체과와 유체과가 혼재되어 발생하는 품종의 비율에 비해 상대적으로 높게 나타났다. 남방형 동양배, 북방형 동양배, 서양배순으로 유체과 발생률이 10% 이하인 품종의 비율이 높은 반면 서양배, 북방형 동양배, 남방형 동양배순으로 유체과 발생률이 90% 이상인 품종의 비율이 높았다. 꽃받침의 탈리 정도가 다른 품종 간의 교배에서 양친이 모두 유체과 발생률이 10% 이하인 경우에는 대부분의 후대가 유체과 발생률이 10% 이하인 실생이었으며, 양친이 모두 유체과 발생률이 90% 이상인 경우에는 대부분의 후대가 유체과 발생률이 높은 실생이었다. 무체과 품종이 화분친인 경우에는 종자친의 유체과 정도와 상관없이 무체과인 후대가 많은 반면, 종자친이 무체과이고 화분친이 다양한 수준의 유체과 발생률을 나타낸 교배 조합의 경우에는 후대에서 무체과와 유체과 실생의 비율이 유사한 경향을 보여 꽃받침의 탈리는 종자친보다는 화분친의 특성을 더 많이 나타내고 있음을 알 수 있었다. 이러한 결과로 볼 때, 꽃받침의 탈리 유무는 질적 형질이며 꽃받침의 탈리층 형성을 촉진하는 유전자들이 우성으로 작용하는 것으로 판단되었다.

• 대한가정학회지
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• 제48권9호
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• pp.103-111
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• 2010

The purpose of this study was to investigate the effects of perceived parental acceptance on social anxiety and depressive symptoms in children. Seven hundred and thirty eight 5th and 6th graders completed questionnaires. Regression analyses indicated that low levels of paternal acceptance was associated with higher social anxiety and depressive symptoms. Gender was a moderator of the effects of maternal acceptance on social anxiety and depressive symptoms. With high levels of maternal acceptance, girls were significantly less likely to report social anxiety and depressive symptoms, compared to boys. These results highlight the important role of parental acceptance in manifestations of social anxiety and depressive symptoms and clarify the relation of maternal acceptance to social anxiety and depressive symptoms as a function of gender.

• 가정과삶의질연구
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• 제23권5호
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• pp.93-102
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• 2005

The present study examined how demographic, paternal, and children's variables were associated with role satisfaction of Korean fathers with young children. Subjects were 236 fathers of 3-5 year old children living in Jeju island in Korea. Data were collected using questionnaires. Among demographic variables, father's income is an only variable that effects on role satisfaction. Role satisfaction is positively associated with child care, marital, job satisfaction, and child-rearing participation in terms of psychological variables. According to multiple regression, role satisfaction was positively predicted by income, gender, and adaptability of children. Moreover, day care, marital, job satisfaction and child-rearing participation were significant predictors of role satisfaction.

• 가정과삶의질연구
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• 제15권1호
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• pp.225-237
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• 1997

The Purpose of this study was to examine how children's perceptuions of parental childrearing behaviors and family support were related to their interpersonal problem-solving behaviors. 580 subjects of the 5th 6th grades filled out questionnaires concerning the three research variables. The data were analyzed through correlation analyses and regression analyses. The results were as follows: The significant correlations were found between parental warmth·acceptance and children's interpersonal problem-solving behavior and between family support and problem-solving behaviors. Problem-solving behaviors showed higher correlations with maternal warmths·acceptance than paternal behaviors and with opposite-sex parents behaviors than with same-sex parents behaviors. Family support predicted children's social problem-solving behaviors better than parental warmth·acceptance especially among boys.