• Natural Product Sciences
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• 제22권4호
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• pp.246-251
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• 2016

This study investigated the effects of (-)-sesamin on memory deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD). MPTP lesion (30 mg/kg/day, 5 days) in mice showed memory deficits including habit learning memory and spatial memory. However, treatment with (-)-sesamin (25 and 50 mg/kg) for 21 days ameliorated memory deficits in MPTP-lesioned mouse model of PD: (-)-sesamin at both doses improved decreases in the retention latency time of the passive avoidance test and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid, improved the decreased transfer latency time of the elevated plus-maze test, reduced the increased expression of N-methyl-D-aspartate (NMDA) receptor, and increased the reduced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-response element binding protein (CREB). These results suggest that (-)-sesamin has protective effects on both habit learning memory and spatial memory deficits via the dopaminergic neurons and NMDA receptor-ERK1/2-CREB system in MPTP-lesioned mouse model of PD, respectively. Therefore, (-)-sesamin may serve as an adjuvant phytonutrient for memory deficits in PD patients.

• 한국분무공학회지
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• 제17권3호
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• pp.146-151
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• 2012

This study was primarily focused on the experimental comparison of the particle emission characteristics for heavy duty engine. PM and particle number from various heavy duty engines and DPF type were analyzed with a golden particle measurement system recommended by the Particle Measurement Program. And the repeatability and reproducibility between test mode was analyzed. This study was conducted for the experimental comparison on particulate emission characteristics between the European and World-Harmonized test cycles for a heavy-duty diesel engine. To verify the particulate mass and particle number concentrations from various operating modes, ETC/ESC and WHTC/WHSC, both of which will be enacted in Euro VI emission legislation, were evaluated. Real-time particle formation of the transient cycles ETC and WHTC were strongly correlated with engine operating conditions and after-treatment device temperature. A higher particle number concentration during the ESC mode was ascribed to passive DPF regeneration and the thermal release of low volatile particles at high exhaust temperature conditions.

• Biomolecules & Therapeutics
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• 제9권2호
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• pp.88-95
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• 2001

(+)-Methamphetamine (METH) is a psychostimulant, which has been the most popular abused drug in Korea. The rewarding mechanism in METH abuse has been reported to be mediated by dopaminergic system. Recently, it has been reported that dopamine releaser (phentermine) plays a dominant role in the discriminative stimulus effects of METH, whereas 5-HT releaser (fenfluramine) can strongly modify METH self-administration. The present study is designed to assess the behavioral changes and the changes of the serotonin receptors in the brains of rats administered repeated of self-administered METH. The repeated administration of 1.0 mg/kg/day METH for 12 days increased locomotor activities, and there was no difference between i.v. and i.p. treatment. Rats had actively acquired METH self-administration for 3 weeks at 0.1 or 0.2 mg/kg/injection. Whereas, it was taken few days to acquire sucrose pellet self-administration. The binding of [$^3$H]-8-hydroxy-DPAT (5-H $T_{1A}$ receptors) and [$^3$H]-5-carboxytryptamine (5-H $T_{1B}$ receptors) to brain sections was examined. Both passive administration and self-administration of METH did not change significantly the serotonin receptors levels in hippocampus, striatum and nucleus accumbens. These results suggest that serotonin receptors may not change in the acquisition period of METH self-administration, and we are trying to investigate the serotonin receptors levels of brain in rats maintained of METH self-administration.n.n.

• 자원환경지질
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• 제56권4호
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• pp.409-419
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• 2023

산성광산배수 처리방법은 적극적 처리방식과 소극적 처리방식이 일반적으로 사용되고 있으며, 이때 발생되는 부산물인 슬러지는 국내에서 약 5천 톤/년으로 발생하고 있다. 본 연구는 적극적 처리방식 중 물리·화학적 처리방식으로 정화 후 발생되는 슬러지의 특성을 조사하여 재활용 가능여부를 검토하기 위함이다. 5개소(D, H, S, T, Y) 수질정화시설의 슬러지의 특성을 물리·화학적 분석을 통해 검토하였다. 그 결과 pH는 pH 5.86 ~ pH 7.89로 측정되었고, 수분함량은 51 % ~ 82 %로 분석되었으며, 입자크기는 대부분 25 ㎛보다 작은 미립자로 구성되었음을 확인할 수 있었다. ICP-OES를 이용한 슬러지 내 무기물질 분석결과, Al, Fe, Mn의 농도범위는 각각 1,189 mg/kg ~ 129,344 mg/kg, 106,132 mg/kg ~ 338,011 mg/kg, 3,472 mg/kg ~ 11,743 mg/kg로 조사되어 고농도로 존재함을 확인 할 수 있었다. 그 외 무기물질 중 중금속류에 대해서는 T-슬러지는 As와 Zn, D-슬러지는 Cd, H-슬러지는 Ni, S-슬러지는 Zn, Y-슬러지는 Cd의 농도가 토양오염우려기준을 초과하였다. 또한 슬러지의 용출 특성을 알기위해 폐기물 용출시험(KSLT) 및 TCLP 시험을 진행하였다. 슬러지 재활용시 용출되어 지하수에 미치는 영향 확인을 위해 지하수 수질기준(생활용수) 20개 항목에 대하여 수행하였다. 용출시험결과 특정유해물질 16개 항목에서 모두 불검출로 확인되었으며, 일반항목 4개 항목에 대해서는 모두 생활용수 기준치 이내로 만족하였다. XRD, SEM-EDS의 분석결과, 슬러지는 주로 방해석, 석영의 패턴을 보였으며, 높은 Fe, O의구성비율로철수산화물이높은비중을차지하는것으로보였다. 이를 통해서 비매체접촉형 방식의 재활용의 가능성이 있을 것으로 판단된다.

• 한국콘텐츠학회논문지
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• 제11권7호
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• pp.298-305
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• 2011

본 논문의 목적은 안락사의 개괄적인 의미와 형태를 살펴보고 논쟁의 핵심이 되는 안락사의 찬반론을 통해 형법적으로 고찰하고, 현행 안락사 법제의 필요성과 제도적 정립에 관하여 검토하여야 할 사항을 모색하고자 한다. 현대의 의학은 눈부신 발전을 통해 치료가 불가능한 환자들을 치료할 수 도 있고 인공적인 생명유지장치를 통해 생명을 인위적으로 연장시킬 수도 있게 되었다. 이러한 의료환경의 변화는 안락사와 관련된 일련의 형법적 논의를 넘어 안락사의 허용범위도 점점 확장되어 가고 있으며 의료시술도 소극적인 면에서 적극적 면까지 논의가 되어 가고 있는 실정이다. 이에 법적, 윤리적 문제를 뒤로하고 현행 법체계에서 보다 명확한 기준이 될 수 있는 현실적인 방안이 모색 되어야 함은 시대적 요청이라 할 수 있다. 따라서 법제도화에 필요한 사항을 검토하여 보고 생명존엄성에 관한 가치들을 재정립하고자 한다.

• 한국물환경학회지
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• 제27권2호
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• pp.167-177
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• 2011

Oil이나 Gas생산시 발생하는 Produced water의 양은 미국 내에서만 연간 수십억 배럴에 육박한다. 이러한 Produced water의 재이용을 위한 첫 번째 과제는 유해 유기물질을 제거하는 것으로, 본 연구에서는 수중의 BTEX를 가스상태로 변화시킨 후 Vapor phase biofilter (VPB)로 분해, 제거 효능을 평가하였다. VPB 시스템은 짧은 기간의 시스템 shutdown에는 거의 영향을 받지 않는 것으로 나타났다. 그러나 주입 되는 농도가 Peak 형태를 가질때는 제거효능의 저하가 관찰 되었으며, 이중 Benzene이 가장 민감하게 반응하였다. 이를 위한 해결책으로 GAC로 충진된 Buffering Column이 사용되었으며, 이는 peak 형태의 유입농도 Profile을 완만한 형태로 buffering하는 역할을 하였다. 현장 적용을 통하여, 본 시스템이 Produced water내에 존재하는 용존 BTEX를 효과적으 로 제거할 수 있음을 확인하였다.

• 한국전문물리치료학회지
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• 제21권1호
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• pp.47-54
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• 2014

The aim of this study was to compare the duration of hamstring flexibility improvement after 3 stretching interventions in people with limited hamstring flexibility. Twenty-two subjects (12 men, 10 women) with limited hamstring flexibility of the dominant leg received 3 stretching interventions- modified dynamic stretching (MDS), hold-relax (HR), and static stretching (SS)-in a random order. All the subjects received all 3 interventions at intervals of at least 24 hours to minimize any carry-over effect. Modified dynamic stretching was applied as a closed kinetic chain exercise in the supine position by using the sling suspension system (Redcord Trainer(R)). The SS and HR interventions were individually performed in the straight leg raising (SLR) position, and all 3 interventions were performed for 3 minutes. Outcome measures included passive knee extension (PKE) measurements. Five post-test measurements were recorded for all subjects at 3, 6, 9, 15, and 30 minutes after the interventions. MDS was associated with a significant increase in knee extension range of motion even at 30 minutes post-treatment. In contrast, the HR and SS stretching methods showed increased hamstring flexibility for only 6 minutes post-treatment. Improvements in the range of motion of knee extension (indicating enhancement in hamstring flexibility) with MDS were maintained longer than those with the HR and SS interventions. Therefore, MDS may be more effective than the other interventions for maintaining hamstring flexibility.

• 동의생리병리학회지
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• 제25권1호
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• pp.37-47
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• 2011

This study was aimed to investigate the memory enhancing effect of Jeongjihwan against scopolamine-induced amnesia in C57BL/6 mice. To determine the effect of Jeongjihwan on the memory and cognitive function, we have injected scopolamine (1 mg/kg, i.p.) into C57BL/6 mice 30 min before beginning of behavior tests. We have conducted Y-maze, Morris water-maze, passive avoidance and fear conditioning tests to compare learning and memory functions. Scopolamine-induced behavior changes of memory impairment were significantly restored by oral administration of Jeongjihwan (100 or 200 mg/kg/day). To elucidate the molecular mechanism underlying the memory enhancing effect of Jeongjihwan, we have examined the antioxidant defense system and neurotrophic factors. Jeongjihwan treatment attenuated intracellular accumulation of reactive oxygen species and up-regulated mRNA and protein expression of antioxidant enzymes as assessed by RT-PCR and western blot analysis, respectively. Jeongjihwan also increased protein levels of brain-derived neurotrophic factor (BDNF) compared with those in the scopolamine-treated group. Furthermore, as an upstream regulator, the activation of cAMP response element-binding protein (CREB) via phosphorylation was assessed by Western blot analysis. Jeongjihwan elevated the phosphorylation of CREB (p-CREB), which seemed to be mediated partly by extracellular signal-regulated kinase1/2 (ERK1/2) and protein kinase B/Akt. These findings suggest that Jeongjihwan may have preventive and therapeutic potential in the management of amnesia.

• Restorative Dentistry and Endodontics
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• 제36권3호
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• pp.180-187
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• 2011

서론: 근관 치료의 성공을 위해 근관계 내에 남아있는 조직 잔사와 박테리아를 제거하는 것은 매우 중요하다. 그러나 충분한 근관 형성과 근관 세척을 하더라도 근관의 복잡한 형태로 인하여 근관 내 박테리아의 biofilm이나 괴사된 치수 조직이 남아 있게 된다. 근래 보다 효과적으로 근관 세척을 하기 위한 여러 가지 방법과 근관 세척을 위한 기구들이 개발되었다. 본 종설에서는 근관 치료 영역에서 사용되는 근관 세척 방법과 기구에 대해 고찰하고자 한다. 본론: 아래와 같은 기구와 방법이 논의된다. - syringe-needle irrigation, manual dynamic irrigation, brushes - sonic and ultrasonic irrigation, passive ultrasonic irrigation, rotary brush, RinsEndo, EndoVac, Laser 결론: 최근 근관 세척을 위한 기구와 세정 방법이 개발되었으나, syringe와 needle을 이용한 근관 세척법과 ultrasonic을 이용한 근관 세척법을 제외하고는 새로 개발된 많은 기구들의 임상적 치료 결과의 향상에 대한 근거 중심 연구가 아직은 부족하며, 어떠한 기구나 장치도 근관 내 잔사를 완벽하게 제거할 수는 없다. 효과적인 근관 세척을 위해서는 적절한 근관 세척제의 선택과 함께, 근관 세척제를 근관장까지 충분한 양이 도달할 수 있도록 적절한 근관 세척 기구와 방법을 선택하여야 한다.

• Journal of Microbiology and Biotechnology
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• 제21권8호
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• pp.874-883
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• 2011

Many studies have shown that the steamed root of Rehmannia glutinosa (SRG), which is widely used in the treatment of various neurodegenerative diseases in the context of Korean traditional medicine, is effective for improving cognitive and memory impairments. The purpose of this study was to examine whether SRG extracts improved memory defects caused by administering scopolamine (SCO) into the brains of rats. The effects of SRG on the acetylcholinergic system and proinflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses of SRG (50, 100, and 200 mg/kg, i.p.) for 14 days, 1 h before scopolamine injection (2 mg/kg, i.p.). After inducing cognitive impairment via scopolamine administration, we conducted a passive avoidance test (PAT) and the Morris water maze (MWM) test as behavioral assessments. Changes in cholinergic system reactivity were also examined by measuring the immunoreactive neurons of choline acetyltransferase (ChAT) and the reactivity of acetylcholinesterase (AchE) in the hippocampus. Daily administration of SRG improved memory impairment according to the PAT, and reduced the escape latency for finding the platform in the MWM. The administration of SRG consistently significantly alleviated memory-associated decreases in cholinergic immunoreactivity and decreased interleukin-$1{\beta}$ (IL-$1{\beta}$) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) mRNA expression in the hippocampus. The results demonstrated that SRG had a significant neuroprotective effect against the neuronal impairment and memory dysfunction caused by scopolamine in rats. These results suggest that SRG may be useful for improving cognitive functioning by stimulating cholinergic enzyme activities and alleviating inflammatory responses.