• Journal of Pharmaceutical Investigation
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• v.21 no.3
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• pp.155-160
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• 1991

Particulate is the foreign insoluble material in injectable solution inadvertently present in a given product. Considerable efforts have been made to avoid or minimize particulate contamination by pharmaceutical manufacturers during the production of parenteral products. Particulate contamination of the parenteral products can occur mainly during the opening (cutting) the container immediately before clinical use. In this study, particulate contamination generated during the opening process of ampoules (conventional type, 1-point and color-break ampoules) was compared with that of a prefilled injectable container (prefilled syringe). The particles were examined under a microscope after filtration of the total fluids in the containers. Particles having wide range of size distribution were found from all the ampoules tested. The contamination from the I-point ampoule and colorbreak ampoule was much less than from the conventional ampoule. Glass particles generated by cutting the glass-made ampoules seemed a principal source of the particulate contamination. The glass-partiaulte contamination could be improved substantially by replacing the ampoule containers with the prefilled syringe. Prefilled syringe, which can be used without any cutting process. did not generate particulates during the use. Therefore, it was concluded that prefilled syringe is most preferable container for the small volume parenteral (SVP) fluids in terms of particulate contamination.

• KSTLE International Journal
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• v.8 no.1
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• pp.1-6
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• 2007

Chromatic device was developed using light emitting diodes, optic fibers and photodiodes. Chromatic ratio and total contamination parameters based on transmitted light intensity in Red, Green, and Blue wavelengths were used for oil chemical and particulate contamination assessment. Chromatic ratio criterion was found independent of the particulate contamination of oil; but depended on chemical degradation, being more sensitive for synthetic than mineral hydraulic oil. Total contamination index of the sensor depended on both the chemical degradation and particulate contamination of the oil; being most sensitive in blue wavelength, and least in the red. Test results for synthetic hydraulic oils monitored corroborated with results of other tests such as viscosity, total acid number, elemental optical emission spectroscopy, particulate counts and UV-VIS photospectrometry. Chromatic ratio showed a clearer indication of oil degradation, compared to key monitoring parameters such as total acid number, viscosity and particle counts. The results showed that these parameters are effective criteria for the condition monitoring of synthetic hydraulic oils.

• Journal of the Korean Society for Precision Engineering
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• v.20 no.4
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• pp.183-188
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• 2003

Particulate contamination is known to be a significant cause of failures of removable storage media. In this work, the effect of particles on the surface damage of removable hard disk media was investigated. The particles of different materials and size were introduced to the Head Disk Interface (HDI) using a particle injection system. It was round that the particles of particulate size and property serious damaged the media. This study showed that cleaning pad is effective for reducing particle contamination, except fer the particles of specific size and property. As a means to remove the particles of specific sire. the concept of using a stepped taper at the leading edge of the slider is proposed.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.946-949
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• 2002

Particulate contamination is known to be a significant cause of failures of removable storage media. In this work, The effect of particles on the surface damage of removable hard disk media was investigated. The particles of different materials and size were introduced to the head-disk interface using a particle injection system. It was found that the particles of particulate size and property serious damaged the media. This study showed that cleaning pad is effective for reducing particle contamination, except for the particles of specific size and property. As a means to removed the particles of specific size, the concept of using a stepped taper at the leading edge of the slider is proposed.

• Aerospace Engineering and Technology
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• v.2 no.1
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• pp.80-88
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• 2003

The present analysis quantifies the particulate contamination of KOMPSAT-2 satellite until in orbit life. Assumptions are defined about integration and test conditions and durations, then a budget is drawn. As KOMPSAT-2 activities are carried out in good cleanliness conditions, the particulate contamination budgets for satellite and instrument surfaces at BOL is fair. To summarise, in the baseline launch conditions (class 10,000) the contribution of satellite AIT and launch activities adds 500 PPM to MSC and STA apertures (telescope mirrors ; front lens ; baffle), 20,000 PPM to MSC and STA outer surfaces, 14 000 PPM to plate-form horizontal surfaces, 1400 PPM to plate-form vertical surfaces, 1000 PPM to plate-form radiators and less than 300 PPM to solar arra.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2000.06a
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• pp.24-33
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• 2000

The effect of particulate contamination on friction and wear between a negative-pressure picoslider / tri-pad nanoslider and laser-textured disk was studied. Particles of different concentration were injected at the head-disk interface consisting of disks with various textures and slider types at different speed. Durability increased and coefficient of friction decreased as the disk speed increased in a contaminated environment. Frictional characteristics and durability in the data zone were better for those of the laser-textured zone. It was also found that durability of head-disk interface (HDI)decreased as the particle concentration increased. The interface durability with a picoslider was better than that with a nanoslider at any condition in a contaminated environment. Based on the test results, mechanisms were proposed to explain the reasons why durability with a picoslider was superior to that with a nanoslider.

• Tribology and Lubricants
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• v.16 no.6
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• pp.469-476
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• 2000

The effect of particulate contamination on the friction and wear between a negative-pressure picoslider/tri-pad nanoslider and laser-textured disk was studied. Particles of different concentration were injected at the head-disk interface consisting of disks with various textures and slider types at different speed. Durability increased and coefficient of friction decreased as the disk speed increased in a contaminated environment. Frictional characteristics and durability in the data Bone were better than those in the laser-textured zone. It was also found that durability of head-disk interface (HDI) decreased as the particle concentration increased. The interface durability with a picoslider was better than that with a nanoslider at any condition in a contaminated environment. Based on the test results, mechanisms were proposed to explain the reasons why durability with a picoslider was superior to that with a nanoslider.

• Tribology and Lubricants
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• v.16 no.5
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• pp.395-402
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• 2000

The effect of particulate contamination on friction and wear between a negative-pressure picoslider and a laser-textured disk was studied. Particles of different concentrations, materials and sizes were injected to the head-disk interface (HDI), consisting of disks with various textures, at the same speed. In a contaminated environment, durability of head-disk interface gradually decreased as the particle concentration increased. Large particles caused HDI failure early and resulted in an extensive damage to the slider and disk surfaces. Hard particles also caused HDI failure earlier and damages more extensive than soft ones. Based on the test results, mechanisms of HDI failure with picoslider were presented.

• Environmental Analysis Health and Toxicology
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• v.13 no.1_2
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• pp.27-31
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• 1998

Motor vehicle exhaust is the major cause to the air contamination in Seoul. It includes many toxic chemicals to human health such as aidehyde, PAHs, benzene, xylene, toluene, benzo[a]pyrene, nickel, arsenic and cadmium in gasoline exhaust and formaldehyde, PAHs, 1,3-butadiene, benzene and particulate matter in diesel exhaust. Some chemicals out of them are classified as a human carcinogen. Many large diesel vehicles such as buses and trucks are drivened frequently in Seoul so that the air in Seoul is seriously contaminated by diesel exhaust, especially particulate matter. The amounts of particulate matter from large diesel vehicles may be estimated to be more than 50% of small dust in Seoul. The particles of particulate matter are coated with many toxic chemicals and some of these are considered as a human carcinogen. The cancer risk has to be throughly managed because the population density of Seoul is very high. Government should list hazardous air pollutants in Seoul, assess the exposure of people to toxic pollutants, especially carcinogens and manage human health risk.

• Journal of the Korean Society for Precision Engineering
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• v.19 no.8
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• pp.7-15
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• 2002