• Title/Summary/Keyword: parallel torsion

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(-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion

  • Al-Ajmi, Nada;Al-Maghrebi, May;Renno, Waleed Mohammed
    • The Korean Journal of Physiology and Pharmacology
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    • v.17 no.4
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    • pp.259-265
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    • 2013
  • The anti-apoptotic effect of (-)-epigallocatechin-3-gallate (EGCG) during unilateral testicular torsion and detorsion (TT/D) was established in our previous study. In mice, the smallest inhibitor of apoptosis, survivin, is alternatively spliced into three variants, each suggested to have a unique function. Here, we assessed how EGCG exerts its protective effect through the expression of the different survivin splice variants and determined its effect on the morphology of the seminiferous tubules during TT/D. Three mouse groups were used: sham, TT/D+vehicle and TT/D treated with EGCG. The expression of the survivin variants (140 and 40) and other apoptosis genes (p53, Bax and Bcl-2) was measured with semi-quantitative RT-PCR. Histological analysis was performed to assess DNA fragmentation, damage to spermatogenesis and morphometric changes in the seminiferous tubules. In the TT/D+vehicle group, survivin 140 expression was markedly decreased, whereas survivin 40 expression was not significantly different. In parallel, there was an increase in the mRNA level of p53 and the Bax to Bcl-2 ratio in support of apoptosis induction. Histological analyses revealed increased DNA fragmentation and increased damage to spermatogenesis associated with decreased seminiferous tubular diameter and decreased germinal epithelial cell thickness in the TT/D+vehicle group. These changes were reversed to almost sham levels upon EGCG treatment. Our data indicate that EGCG protects the testis from TT/D-induced damage by protecting the morphology of the seminiferous tubules and modulating survivin 140 expression.

Effects of Neck and Pelvic Exercise Using Swiss Ball on Spinal Curve in Adults with Forward Head Posture (전방머리자세 대상자에 대한 목운동과 골반운동이 척추 굽이에 미치는 효과)

  • Bae, Won-Sik;Jang, Chel
    • Journal of The Korean Society of Integrative Medicine
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    • v.9 no.3
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    • pp.193-201
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    • 2021
  • Purpose : The purpose of this study was to compare the effect of pelvic exercise on the CVA and spinal curve in adults with forward head posture compared to the group using only neck exercise when pelvic exercise was performed in parallel with conventional neck exercise. Methods : GPS 400 and Formetric were used to identify craniovertebral angle (CVA), thoracic kyphosis, lumbar lordosis, and pelvic torsion and were measured by an experienced research manager. Forward head posture (FHP) was selected for people whose angle between the line connecting the ear ball and the seventh cervical spine and the horizontal line is 50 degrees or less. The 30 selected students were randomly divided into 15 experimental groups and 15 control groups. Mackenzie exercise and sling exercise were performed for neck exercise in both the experimental group and the control group, and pelvic exercise using a Swiss ball was additionally performed in the experimental group. All data collected in this study were analyzed using SPSS statistics 21.0. Cervical vetebral angle (CVA), thoracic kyphosis, lumbar lordosis, and pelvic torsion were compared at 0 weeks, 3 weeks, and 6 weeks for each measurement factor using ANOVA with repeated measures. For the statistical significance test, the significance level of α was set to .05. Results : The changes of pelvic torsion, thoracic kyphosis and CVA due to pelvic exercise using Swiss Ball and neck exercise were changed over time, but lumbar lordosis were not changed. And there were no significant differences among the groups. Conclusion : In conclusion, the pelvic correction exercise is considered to be an effective exercise for correcting the FHP and requires regular pelvic correction exercises. We expect the results to be used in clinical trials.

A STUDY ON DEVELOPMENT AND PHYSICAL PROPERTIES OF STAINLESS STEEL ORTHODONTIC WIRES MADE IN KOREA (국산(國産)스테인레스강선계(鋼線系) 교정용선재(矯正用線材)의 개발(開發)과 물리적(物理的) 성질(性質)에 관(關)한 연구(硏究))

  • Sung, Jae-Hyun;Kwon, Oh-Won;Kyung, Hee-Moon;Lee, Kee-Dae
    • The korean journal of orthodontics
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    • v.19 no.2
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    • pp.7-24
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    • 1989
  • The physical properties of seven sizes of control groups and experimental group in stainless steel orthodontic wires were studied in tension, hardness, bending, torsion and observation of microstructure. The wires (0.40-0.90mm dia.) of round type were tested in the as-received condition. The wires of control groups were TRU-CHROME and REMANIUM, and experimental group was SK wire which was developed by ourselves and made in Korea. The results were as follows; 1. The chemical compositions of control groups and experimental group were austenite stainless steel wires of SOS 304. 2. Higher values of tensile and yield strength in tension were control group I, experimental group, control group II. Maximum tensile and yield strength of experimental group were $203.63{\pm}1.41kg/mm^2$ in 0.70mm diameter and $148.96{\pm}4.88kg/mm^2$ in 0.60mm diameter, and maximum elongation was $5.20{\pm}0.57%$ in 0.45mm diameter. 3. Hardness values of experimental group were similar to control groups. Maximum hardness values were $596.2{\pm}13.66Hv$ in 0.45mm diameter wire of control group I, $590.5{\pm}20.08Hv$ in 0.50mm diameter wire of control group II, and $563.6{\pm}5.35Hv$ in 0.70mm diameter wire of experimental group. 4. Torsion properties of experimental group were similar to control group I and more than control group II. Maximum torsion cycles were $31.8{\pm}2.48$ in 0.45mm diameter of control group I, $17.4{\pm}4.84$ in 0.60mm diameter of control group II, and $24.6{\pm}3.04$ in 0.45mm diameter of experimental group. 5. Maximum bending cycles of experimental group were smaller than control groups. Maximum bending cycles were $9.00{\pm}0.00$ in 0.50mm diameter wire of control group I, $10.0{\pm}0.82$ in 0.40mm diameter wire of control group II, and $8.0{\pm}1.26$ in 0.50mm diameter wire of experimental group. 6. Microstructures of experimental and control groups co-existed with martensited austenite structure and elongated austenite structure. 7. The direction of wire fracture was propagated parallel to torsion direction typically and there was no probability showing wire fracture at inclusions and surface scratches. 8. The type of wire fracture was brittle fracture at initiation site and ductile fracture at core.

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An Experimental Study on Reduction of Gear Rattle Noise for a Mini-bus with Diesel Engine (디젤엔진을 탑재한 소형버스의 기어 래틀 소음 저감에 관한 실험적 연구)

  • Jung, Jong-An;Cho, Chan-Ki
    • Journal of the Korean Society of Safety
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    • v.10 no.4
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    • pp.13-21
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    • 1995
  • On mini-bus with diesel engine, at idle rpm for taking measurement to reduce gear rattle noise, was tested by the three clutch disc samples by turns, then measured the fluctuation of revolution of engine & transmission and parallel vibration of differential gear & transmission. By analyzing the measured data, the gear rattle noise, the matching design and tuning technic of transmission are comprehended and established. Conclusions of this test are as follows ; (1) Fluctuation of revolution on transmission is greatly affected by torsion of clutch disc according to fluctuation of engine revolution transmit to transmission through clutch system. Especially, gear rattle noise can be reduced by minimaizing the fluctuation of the revolution of transmission using pre-damper type clutch disc. (2) The reason of gear rattle noise is higher in summer than winter and driving longer period than initial driving is due to affection by drag torque changing. So, it is necessary for manufacturer to choose proper oil to transmission. (3) It can be occurred jumping and crash noise by applying the pre-damper type clutch disc for reducing the gear rattle noise. So, it is necessary to do test with actual vehicle according to test procedure.

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Minimum stiffness of bracing for multi-column framed structures

  • Aristizabal-Ochoa, J. Dario
    • Structural Engineering and Mechanics
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    • v.6 no.3
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    • pp.305-325
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    • 1998
  • A method that determines the minimum stiffness of baracing to achieve non-sway buckling conditions at a given story level of a multi-column elastic frame is proposed. Condensed equations that evaluate the required minimum stiffness of the lateral and torsional bracing are derived using the classical stability functions. The proposed method is applicable to elastic framed structures with rigid, semirigid, and simple connections. It is shown that the minimum stiffness of the bracing required by a multi-column system depends on: 1) the plan layout of the columns; 2) the variation in height and cross sectional properties among the columns; 3) the applied axial load pattern on the columns; 4) the lack of symmetry in the loading pattern, column layout, column sizes and heights that cause torsion-sway and its effects on the flexural bucking capacity; and 5) the flexural and torsional end restrains of the columns. The proposed method is limited to elastic framed structures with columns of doubly symmetrical cross section with their principal axes parallel to the global axes. However, it can be applied to inelastic structures when the nonlinear behavior is concentrated at the end connections. The effects of axial deformations in beams and columns are neglected. Three examples are presented in detail to show the effectiveness of the proposed method.

Assessment of System Reliability and Capacity-Rating of Composite Steel Box-Girder Highway Bridges (합성 강 상자형 도로교의 체계신뢰성 해석 및 안전도평가)

  • Cho, Hyo Nam;Lee, Seung Jae;Kang, Kyoung Koo
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.13 no.2
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    • pp.51-59
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    • 1993
  • This paper develops practical and realistic reliability models and methods for the evaluation of system-reliability and system reliability-based rating of various types of box-girder bridge superstructures. The strength limit state model for box-girder bridges suggested in the paper are based on not only the basic flexural strength but also the strength interaction equations which simultaneously take into account flexure, shear and torsion. And the system reliability problem of box-girder superstructure is formulated as parallel-series models obtained from the FMA(Failure Mode Approach) based on major failure mechanisms or critical failure states of each girder. In the paper, an improved IST(Importance Sampling Technique) simulation algorithm is used for the system reliability analysis of the proposed models. This paper proposes a practical but rational approach for the evaluation of capacity rating in terms of the equivalent system-capacity rating corresponding to the estimated system-reliability index which is derived based on the concept of the equivalent FOSM(First Order Second Moment) form of system reliability index. The results of the reliability evaluation and rating of existing bridges indicate that the reserved reliability and capacity rating at system level are significantly different from those of element reliability or conventional methods especially in the case of highly redundant box-girder bridges.

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