• 제목/요약/키워드: parallel torsion

검색결과 7건 처리시간 0.019초

(-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion

  • Al-Ajmi, Nada;Al-Maghrebi, May;Renno, Waleed Mohammed
    • The Korean Journal of Physiology and Pharmacology
    • /
    • 제17권4호
    • /
    • pp.259-265
    • /
    • 2013
  • The anti-apoptotic effect of (-)-epigallocatechin-3-gallate (EGCG) during unilateral testicular torsion and detorsion (TT/D) was established in our previous study. In mice, the smallest inhibitor of apoptosis, survivin, is alternatively spliced into three variants, each suggested to have a unique function. Here, we assessed how EGCG exerts its protective effect through the expression of the different survivin splice variants and determined its effect on the morphology of the seminiferous tubules during TT/D. Three mouse groups were used: sham, TT/D+vehicle and TT/D treated with EGCG. The expression of the survivin variants (140 and 40) and other apoptosis genes (p53, Bax and Bcl-2) was measured with semi-quantitative RT-PCR. Histological analysis was performed to assess DNA fragmentation, damage to spermatogenesis and morphometric changes in the seminiferous tubules. In the TT/D+vehicle group, survivin 140 expression was markedly decreased, whereas survivin 40 expression was not significantly different. In parallel, there was an increase in the mRNA level of p53 and the Bax to Bcl-2 ratio in support of apoptosis induction. Histological analyses revealed increased DNA fragmentation and increased damage to spermatogenesis associated with decreased seminiferous tubular diameter and decreased germinal epithelial cell thickness in the TT/D+vehicle group. These changes were reversed to almost sham levels upon EGCG treatment. Our data indicate that EGCG protects the testis from TT/D-induced damage by protecting the morphology of the seminiferous tubules and modulating survivin 140 expression.

전방머리자세 대상자에 대한 목운동과 골반운동이 척추 굽이에 미치는 효과 (Effects of Neck and Pelvic Exercise Using Swiss Ball on Spinal Curve in Adults with Forward Head Posture)

  • 배원식;장철
    • 대한통합의학회지
    • /
    • 제9권3호
    • /
    • pp.193-201
    • /
    • 2021
  • Purpose : The purpose of this study was to compare the effect of pelvic exercise on the CVA and spinal curve in adults with forward head posture compared to the group using only neck exercise when pelvic exercise was performed in parallel with conventional neck exercise. Methods : GPS 400 and Formetric were used to identify craniovertebral angle (CVA), thoracic kyphosis, lumbar lordosis, and pelvic torsion and were measured by an experienced research manager. Forward head posture (FHP) was selected for people whose angle between the line connecting the ear ball and the seventh cervical spine and the horizontal line is 50 degrees or less. The 30 selected students were randomly divided into 15 experimental groups and 15 control groups. Mackenzie exercise and sling exercise were performed for neck exercise in both the experimental group and the control group, and pelvic exercise using a Swiss ball was additionally performed in the experimental group. All data collected in this study were analyzed using SPSS statistics 21.0. Cervical vetebral angle (CVA), thoracic kyphosis, lumbar lordosis, and pelvic torsion were compared at 0 weeks, 3 weeks, and 6 weeks for each measurement factor using ANOVA with repeated measures. For the statistical significance test, the significance level of α was set to .05. Results : The changes of pelvic torsion, thoracic kyphosis and CVA due to pelvic exercise using Swiss Ball and neck exercise were changed over time, but lumbar lordosis were not changed. And there were no significant differences among the groups. Conclusion : In conclusion, the pelvic correction exercise is considered to be an effective exercise for correcting the FHP and requires regular pelvic correction exercises. We expect the results to be used in clinical trials.

국산(國産)스테인레스강선계(鋼線系) 교정용선재(矯正用線材)의 개발(開發)과 물리적(物理的) 성질(性質)에 관(關)한 연구(硏究) (A STUDY ON DEVELOPMENT AND PHYSICAL PROPERTIES OF STAINLESS STEEL ORTHODONTIC WIRES MADE IN KOREA)

  • 성재현;권오원;경희문;이기대
    • 대한치과교정학회지
    • /
    • 제19권2호
    • /
    • pp.7-24
    • /
    • 1989
  • The physical properties of seven sizes of control groups and experimental group in stainless steel orthodontic wires were studied in tension, hardness, bending, torsion and observation of microstructure. The wires (0.40-0.90mm dia.) of round type were tested in the as-received condition. The wires of control groups were TRU-CHROME and REMANIUM, and experimental group was SK wire which was developed by ourselves and made in Korea. The results were as follows; 1. The chemical compositions of control groups and experimental group were austenite stainless steel wires of SOS 304. 2. Higher values of tensile and yield strength in tension were control group I, experimental group, control group II. Maximum tensile and yield strength of experimental group were $203.63{\pm}1.41kg/mm^2$ in 0.70mm diameter and $148.96{\pm}4.88kg/mm^2$ in 0.60mm diameter, and maximum elongation was $5.20{\pm}0.57%$ in 0.45mm diameter. 3. Hardness values of experimental group were similar to control groups. Maximum hardness values were $596.2{\pm}13.66Hv$ in 0.45mm diameter wire of control group I, $590.5{\pm}20.08Hv$ in 0.50mm diameter wire of control group II, and $563.6{\pm}5.35Hv$ in 0.70mm diameter wire of experimental group. 4. Torsion properties of experimental group were similar to control group I and more than control group II. Maximum torsion cycles were $31.8{\pm}2.48$ in 0.45mm diameter of control group I, $17.4{\pm}4.84$ in 0.60mm diameter of control group II, and $24.6{\pm}3.04$ in 0.45mm diameter of experimental group. 5. Maximum bending cycles of experimental group were smaller than control groups. Maximum bending cycles were $9.00{\pm}0.00$ in 0.50mm diameter wire of control group I, $10.0{\pm}0.82$ in 0.40mm diameter wire of control group II, and $8.0{\pm}1.26$ in 0.50mm diameter wire of experimental group. 6. Microstructures of experimental and control groups co-existed with martensited austenite structure and elongated austenite structure. 7. The direction of wire fracture was propagated parallel to torsion direction typically and there was no probability showing wire fracture at inclusions and surface scratches. 8. The type of wire fracture was brittle fracture at initiation site and ductile fracture at core.

  • PDF

디젤엔진을 탑재한 소형버스의 기어 래틀 소음 저감에 관한 실험적 연구 (An Experimental Study on Reduction of Gear Rattle Noise for a Mini-bus with Diesel Engine)

  • 정종안;조찬기
    • 한국안전학회지
    • /
    • 제10권4호
    • /
    • pp.13-21
    • /
    • 1995
  • On mini-bus with diesel engine, at idle rpm for taking measurement to reduce gear rattle noise, was tested by the three clutch disc samples by turns, then measured the fluctuation of revolution of engine & transmission and parallel vibration of differential gear & transmission. By analyzing the measured data, the gear rattle noise, the matching design and tuning technic of transmission are comprehended and established. Conclusions of this test are as follows ; (1) Fluctuation of revolution on transmission is greatly affected by torsion of clutch disc according to fluctuation of engine revolution transmit to transmission through clutch system. Especially, gear rattle noise can be reduced by minimaizing the fluctuation of the revolution of transmission using pre-damper type clutch disc. (2) The reason of gear rattle noise is higher in summer than winter and driving longer period than initial driving is due to affection by drag torque changing. So, it is necessary for manufacturer to choose proper oil to transmission. (3) It can be occurred jumping and crash noise by applying the pre-damper type clutch disc for reducing the gear rattle noise. So, it is necessary to do test with actual vehicle according to test procedure.

  • PDF

Minimum stiffness of bracing for multi-column framed structures

  • Aristizabal-Ochoa, J. Dario
    • Structural Engineering and Mechanics
    • /
    • 제6권3호
    • /
    • pp.305-325
    • /
    • 1998
  • A method that determines the minimum stiffness of baracing to achieve non-sway buckling conditions at a given story level of a multi-column elastic frame is proposed. Condensed equations that evaluate the required minimum stiffness of the lateral and torsional bracing are derived using the classical stability functions. The proposed method is applicable to elastic framed structures with rigid, semirigid, and simple connections. It is shown that the minimum stiffness of the bracing required by a multi-column system depends on: 1) the plan layout of the columns; 2) the variation in height and cross sectional properties among the columns; 3) the applied axial load pattern on the columns; 4) the lack of symmetry in the loading pattern, column layout, column sizes and heights that cause torsion-sway and its effects on the flexural bucking capacity; and 5) the flexural and torsional end restrains of the columns. The proposed method is limited to elastic framed structures with columns of doubly symmetrical cross section with their principal axes parallel to the global axes. However, it can be applied to inelastic structures when the nonlinear behavior is concentrated at the end connections. The effects of axial deformations in beams and columns are neglected. Three examples are presented in detail to show the effectiveness of the proposed method.

합성 강 상자형 도로교의 체계신뢰성 해석 및 안전도평가 (Assessment of System Reliability and Capacity-Rating of Composite Steel Box-Girder Highway Bridges)

  • 조효남;이승재;강경구
    • 대한토목학회논문집
    • /
    • 제13권2호
    • /
    • pp.51-59
    • /
    • 1993
  • 본 연구에서는 각종 합성 강상자형 도로교에 대한 체계신뢰성 및 이에 기초한 내하력평가를 위하여 실용적이고 합리적인 신뢰성 모형과 해석방법을 개발하고자 한다. 합성 강상자형교의 신뢰성해석을 위해서는 휨강도 뿐만 아니라 휨, 전단 그리고 비틀림을 동시에 고려한 강도식에 기초하여 한계상태함수를 모형화 하였으며, 체계신뢰성 문제는 각 거더의 주요 파손기구에 기초한 FMA(Failure Mode Approach)방법을 사용하여 직 병렬 조합체계로서 정식화 하고 수치해석기법인 중요도표본추출기법(Importance Sampling Technique ; IST)을 사용하여 해석하였다. 특히 본 연구에서는 추정된 체계신뢰성지수를 일반적인 제 1계 2차모멘트(First Order Second Moment ; FOSM)방법의 형태로 표현하여 유도한 등가의 시스템 내하력으로서 합성 강상자형교의 내하력을 평가하는 실질적이고 합리적인 방법을 제안하였다. 기설 교량에 대한 내하력 및 안전도평가 결과 전체시스템으로서의 보유안전도와 내하력은 교량의 부정정성이 높아질수록 개별 요소의 경우에 비해서 그 차이가 크게 됨을 알 수 있었으며, 제안된 체계신뢰성에 기초한 내하력평가 방법은 기설 합성 강상자형교의 실질적인 내하력평가 방법을 위하여 합리적으로 사용될 수 있을 것으로 사료된다.

  • PDF