• 한국지반신소재학회논문집
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• 제6권3호
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• pp.9-16
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• 2007

토양증기추출공법(SVE)은 불포화 지반상태에서 휘발성 유기화합물(VOCs)과 유류오염 물질을 제거하는데 효과적이고 경제적인 공법중의 하나이다. 본 연구에서는 기존 연약지반의 지반개량시 사용된 연직배수재(PVDs)를 토양증기추출시스템에 적용하여 짧은 공기배출거리로 최대한 신속하게 오염물질을 제거할 수 있게 하여 투기계수가 낮은 지반에서 오염된 토양을 효과적으로 복원할 수 있는 토양증기추출공법을 적용하는데 목적이 있다. 연직배수재를 이용한 토양증기추출시스템 적용시 실제 현장에서 나타나는 무한 경계 조건을 만족하기 위해서 실내에서 파일럿 규모의 오염복원 모형실험을 결과로 유한경계조건 시스템에서 이미지웰 중첩이론을 이용하여 압력분포를 가정하였다. 즉, 압력강하가 없는 일정수두 경계조건 상태와 토조의 상 하부와 같이 흐름이 없는 불투수경계조건 상태를 유지하기 위해서 이미지웰 중첩이론을 도입하여 경계조건을 수립하였다. 결과, 공기흐름률이 증가할수록 흐름비율도 증가하였다. 따라서 높은 흐름률에 대한 흐름비율도 더 커지게 되는 것이고, 최적화과정동안 공기흐름률은 측정 압력수두와 이미지웰 중첩이론으로부터 구해진 이론 압력수두의 오차율에 미치는 가장 중요한 인자로 판단된다.

• 대한기계학회논문집A
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• 제38권12호
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• pp.1317-1323
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• 2014

본 연구의 목적은 마찰교반용접된 Al7075-T651의 피로균열전파 거동에 미치는 시험편의 채취방향의 영향을 고찰하기 위한 것이다. 피로균열전파 실험은 마찰교반용접된 공시재로부터 모재와 용접재에 대하여 CT 시험편을 채취하여 일정응력확대계수범위 제어하에서 수행되었다. 균열이 용접선에 수직하여 전파하는 것(TL 시험편으로 명명)과 균열이 용접선과 나란히 전파하는 시험편(LT 시험편으로 명명)에 대하여 3가지 다른 응력확대계수범위에서 실험이 수행되었다. 시험편의 채취 방향에 따라 피로균열전파거동에 주요한 영향을 미침을 알 수 있었다. Paris 법칙에 적합시킨 결과 지수 m값은 WM-LT 시험편이 3.56으로 가장 높게 나타났다.

• Tissue Engineering and Regenerative Medicine
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• 제15권6호
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• pp.711-719
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• 2018

BACKGROUND: Collagen organization within tissues has a critical role in wound regeneration. Collagen fibril diameter, arrangements and maturity between connective tissue growth factor (CTGF) small interfering RNA (siRNA) and mismatch scrambled siRNA-treated wound were compared to evaluate the efficacy of CTGF siRNA as a future implement for scar preventive medicine. METHODS: Nanocomplexes of CTGF small interfering RNA (CTGF siRNA) with cell penetrating peptides (KALA and $MPG^{{\Delta}NLS}$) were formulated and their effects on CTGF downregulation, collagen fibril diameter and arrangement were investigated. Various ratios of CTGF siRNA and peptide complexes were prepared and down-regulation were evaluated by immunoblot analysis. Control and CTGF siRNA modified cells-populated collagen lattices were prepared and rates of contraction measured. Collagen organization in rabbit ear 8 mm biopsy punch wound at 1 day to 8 wks post injury time were investigated by transmission electron microscopy and histology was investigated with Olympus System and TS-Auto software. CONCLUSION: CTGF expression was down-regulated to 40% of control by CTGF siRNA/KALA (1:24) complexes (p<0.01) and collagen lattice contraction was inhibited. However, down-regulated of CTGF by CTGF $siRNA/MPG^{{\Delta}NLS}$ complexes was not statistically significant. CTGF KALA-treated wound appeared with well formed-basket weave pattern of collagen fibrils with mean diameter of $128{\pm}22nm$ (n = 821). Mismatch siRNA/KALA-treated wound showed a high frequency of parallel small diameter fibrils (mean $90{\pm}20nm$, n = 563). CONCLUSION: Controlling over-expression of CTGF by peptide-mediated siRNA delivery could improve the collagen orientation and tissue remodeling in full thickness rabbit ear wound.

• 한국초등과학교육학회지:초등과학교육
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• 제18권2호
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• pp.21-33
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• 1999

The purpose of this study was to develop an Instrument for the Measurement of Cognitive Conflict Levels of students who confronted with an anomalous situation in science teaming. Anomalous situation is generated when students' prediction is disconsistent with the observed fact. In this study, the researchers identified 4 components of cognitive conflict and developed three items for each component. The items were developed and revised by four pilot tests. In the first pilot test, 55 elementary school students participated in the test In the second pilot test, 88 students of the 5th and 6th grader participated in the test. The instrument of measuring cognitive conflict levels was given to the subjects right after demonstrating anomalous situation. For the demonstration, two different problem situations were developed: one was a pulley problem and the other was electric bulbs in parallel. Answered reasons for each items were analyzed to assess students' understanding on each items. In third pilot test, 125 elementary school students participated in the test. A factor analysis of the responses was carried out and reliability of the test was assessed by calculating internal consistency values. The items were finalized by three pilot tests. After 1 month after the third pilot test, researchers conducted the finalized test items to 323 students of the 5th and 6th grader. The final instrument showed moderate reliability (Cronbach-α 0.82∼0.87) and good content validity(0.93). A factor analysis of the response was carried out. 4 main factors completely coincided with 4 components that we supposed to be the conducts of cognitive conflict. The instrument can provide a means for both teachers and researchers to assess the cognitive conflict of a large number of students within a single class period. The results can be used by teachers to better understand the process of conceptual change of their students and to match instruction and materials accordingly.

• Journal of Veterinary Science
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• 제21권3호
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• pp.45.1-45.15
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• 2020

Background: Feline mammary carcinoma is the third most common cancer that affects female cats. Objectives: The purpose of this study was to screen differential serum proteins in feline and clarify the relationship between them and the occurrence of feline mammary carcinoma. Methods: Chinese pastoral cats were used as experimental animals. Six serum samples from cats with mammary carcinoma (group T) and six serum samples from healthy cats (group C) were selected. Differential protein analysis was performed using a Label-free technique, while parallel reaction monitoring (PRM) was performed to verify the screened differential proteins. Results: A total of 82 differential proteins were detected between group T and group C, of which 55 proteins were down regulated and 27 proteins were up regulated. Apolipoprotein A-I, Apolipoprotein A-II (ApoA-II), Apolipoprotein B (ApoB), Apolipoprotein C-III (ApoC-III), coagulation factor V, coagulation factor X, C1q, albumen (ALB) were all associated with the occurrence of feline mammary carcinoma. Differential proteins were involved in a total of 40 signaling pathways, among which the metabolic pathways associated with feline mammary carcinoma were the complement and coagulation cascade and cholesterol metabolism. According to the Label-free results, ApoB, ApoC-III, ApoA-II, FN1, an uncharacterized protein, and ALB were selected for PRM target verification. The results were consistent with the trend of the label-free. Conclusions: This experimen is the first to confirm ApoA-II and ApoB maybe new feline mammary carcinoma biomarkers and to analyze their mechanisms in the development of such carcinoma in feline.

• 한국물환경학회지
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• 제40권5호
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• pp.215-228
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• 2024

Lakes are one of major sources of methane gas due to anaerobic decomposition of organic matter in sediments. Since methane released from lakes is a greenhouse gas, it is necessary to investigate factors affecting methane production of lakes. This study conducted field and incubation experiments in Lake Asan in August and October to determine effects of thermal stratification and sediment organic matter characteristics on methane production. Field experiments measured temperature and dissolved oxygen to determine the formation of thermal stratification of lakes. Methane and organic matter characteristics were analyzed using gas chromatography, Total Organic Carbon (TOC) analyzers, and fluorescence spectroscopy. Incubation experiments under anaerobic conditions used sediment and water samples from the same site. Field results showed higher methane fluxes in August and increased Dissolved Organic Carbon (DOC) concentration closer to Asan Bay seawall. Elevated methane fluxes and DOC concentration resulted from intensified anaerobic decomposition formed by thermal stratification. Incubation results indicated that sediment organic matter characteristics influenced methane flux between sites. Statistical analysis revealed that thermal stratification could be a primary factor affecting methane production of lakes. Characteristics of sediment organic matter with respect to quantity and quality could be factors influencing methane production of lakes. Results of this study can serve as fundamental data for predicting methane emissions from lakes due to climate change and for mitigating lake's contributions to global warming.

• 한국수학교육학회지시리즈A:수학교육
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• 제59권4호
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• pp.405-420
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• 2020

학생들이 수학과 과학을 배울 때 개발 및 사용하는 지적 자원의 이론적 모형을 구성하였다. 9,300명의 미국 4학년 학생들의 수학 과학 성취도 평가의 응답을 통계적으로 분석하여 이 이론적 모델을 검증하였다. 그 결과는 이론적 모형이 타당함을 보여주며, 4학년 학생들의 과학 학습에서 인식적 실천은 수학 학습에서 인식적 실천의 발달에 영향을 준다.

• 대한기계학회논문집A
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• 제20권10호
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• pp.3048-3057
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• 1996

Analysis model containing two inclined surface cracks on semi-infinite elastic body is established and analyzed on the basis of linear fracture mechanics to examine mutual interference of two surface cracks. Muskhelishvili's complex stress functions are introduced and a set of singular integral equations is obtained for a dislocation density function. The stress intensity factors at crack tip are obtained by using the Gerasoulis'method. When two surface cracks are parallel and have the same length, the values of $K_1$and $\Delta K_11$(variation of $K_11$) for crack 1 and crack 2 decrease by the mutual interference of two surface cracks as the distance between the two surface cracks shortens. The effect of mutual interference is remarkable in high friction coefficient. In case that two surface cracks are parallel, the values of $K_1$and $\Delta K_11$for crack 2 decrease as the length ratio ot crack 2 to crack 1 becomes small. As the crack inclination angle rises, the value of $K_1$ and the mutual interference of $K_1$for crack 2 increase and the value of$\Delta K_11$ for crack 1 becomes smaller than that for crack 2.

• 조명전기설비학회논문지
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• 제21권6호
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• pp.55-64
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• 2007

본 논문은 부하직렬 고주파 공진 DC/DC 컨버터에 가변 가능한 공진커패시터를 병렬로 삽입한 LCC형 고주파 공진 DC/DC 컨버터의 특성과 설계 예를 나타내고 있으며, 또한 턴-오프시 스위칭 손실을 줄이기 위해 ZVS를 가지는 소프트 스위칭을 사용하였다. 제안 컨버터는 PFM(Pulse Frequency Modulation) 스위칭 패턴을 사용하여 동작되며, PFM 제어에 의해 제안 회로의 출력전압을 제어하였다. 병렬커패시터의 커패시턴스의 변화에 따라, DC/DC 컨버터의 분석은 일반적으로 무차원화 파라미터를 사용하여 나타내었고, 회로 동작 특성은 스위칭 주파수와 파라미터로 행하였다. 또한 본 논문은 특성평가에 의해 제안 DC/DC 컨버터의 동작 특성과 회로 설계 방법을 제시하였다. 더욱이 본 논문은 실험을 통해 이론 분석의 정당성을 입증하였다. 향후 제안한 DC/DC 컨버터는 반도체 및 FPD의 클린룸에 선형이동 시스템의 비접촉 전원장치에 적용 가능하다고 생각된다.

• 한국지반환경공학회 논문집
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• 제2권1호
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• pp.57-65
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• 2001

본 연구에서는 증축하천제방의 침투거동과 안정성을 평가하기 위하여, 증축부의 투수계수와 홍수시 강우로 인한 수위상승속도를 3가지 경우로 변화시켜 가면서 평행흐름조건에서 침투모형실험과 유한요소해석을 통한 침윤선 변화와 홍수직후의 수위급상승시 제체사면의 안정성을 분석하여 제체침식에 대한 사면의 불안정성을 검토하였다. 침투모형실험은 평행흐름조건에서 서로 다른 증축재료의 투수계수 $k_1$, $k_2$, $k_3$와 홍수시 발생 가능한 수위상승속도 $v_1$, $v_2$, $v_3$를 각각 변화시키며 수행되었다. 증축체제의 침투거동은 증축부의 투수계수가 클수록 초기 침투거리가 길고, 제체하류사면에 유출점이 점차로 상승하며 시간에 따른 안전율이 감소하면서 국부적인 붕괴로 이어지는 불안정한 침투거동을 보여준다. 또한, 제체사면의 붕괴양상은 수위상승속도가 증가할수록 붕괴발생높이와 붕괴깊이가 증가함을 보여준다.