• Korean Journal of Biological Psychiatry
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• v.6 no.2
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• pp.153-160
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• 1999

Animal models can provide a useful tool for the study of some aspects of psychiatric disorders and their treatment. The four criteria for the evaluation of animal models of psychiatric disorders are as following : 1) similarity of inducing conditions 2) similarity of behavioral state 3) common underlying neurobiological mechanisms 4) reversal by clinically effective treatment techniques. Several animal models have been proposed for schizophrenia : phenylethylamine model, L-dopa model, hallucinogen model, cocaine model, amphetamine model, phencyclidine model, noradrenergic reward system lesion model, reticular stimulation model, social isolation model, conditioned avoidance reaction, catalepsy test, paw test, self-stimulation paradigms, latent inhibition paradigms, blocking paradigms, prepulse inhibition of the startle reflex, rodent interaction, social behavior in monkeys, hippocampal damage, high ambient pressure, and models using selective breeding. Among them, animals with bilateral lesion of the hippocampus may provide an adequate animal model for several symptoms of schizophrenia, and ketamine model can reproduce negative symptoms and cognitive deficits as well as positive symptoms of schizophrenia. In conclusion, no model of schizophrenia is entirely representative of the disease, and findings gleaned from model systems must be cautiously interpreted. Furthermore, the process of developing and validating animal models must work in concert with the process to identify reliable measures of human phenomenology.

• Journal of the Korean Geographical Society
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• v.30 no.2
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• pp.132-145
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• 1995

The Purpose of this study is to integrate two opposite paradigms, (development from above) and (development from below), by means of A. Giddenss (structuration theory) and to provide practical development strategies on the basis of integrated paradigm. The integration of these two opposite paradigms is in fact the internalization of epistemological overcoming of 'dependency', which means the structural transformation of dualistic thinking into monistic thinking that the enlargement of capitalist world-system can be 'development' and it may also be 'dependency'. Therefore the practical main issue of this integrated paradigm results in how peripheral countries should achieve self-reliant and continuous development under the circumstances of dependency. To achieve such development while resisting the growing arrogance of transnational capital, development strategies should be prepared to maker revitalized political community designed to fit a human scale and for the economy to be subordinated to the political will of the community. And at the same time the 'empowerment' of people should be strengthened.

• Cartoon and Animation Studies
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• s.30
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• pp.87-112
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• 2013

The effort to make the peaceful mood between South and North Korea that had started from so-called 'Sunshine Policy' of the People's Government since 1998, lasted until Rho Mu-hyun government. On the other hand, Lee Myung-bak government changed the policy toward North Korea to more practical and principle-oriented one than the previous two governments. By the shift of the policies, the industry of animation of South and North Korea has been influenced so much. The purpose of his study is to point out the crisis of the status of the animation industry of the Korean Peninsula through the change of the policies, and to propose one method of the new paradigm to the next government in order to build a turning point of South and North Korea animation exchange. First, the paradigms toward North Korea through the past governments are compared. Second, the result and situation of animation industry of South and North Korea are analyzed. Finally, by examining deducted problems, the forward policy toward North Korea and, by extension, the improvement direction and practical tasks of South and North Korea animation exchange policy are considered.

• Journal of Korean Society of Forest Science
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• v.97 no.4
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• pp.374-384
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• 2008

This study examined the attitudes of the Korean forest policy interest groups toward the new environmental paradigm and resources management paradigm which were emerged in western societies. The 1st survey was conducted for five interest groups (forest owners, timber industries, members of the Korean Alpine Club, members of the Korean Natural Parks Association, forestry experts) in 1995, and the 2nd survey was conducted in 2006 for three interest groups (forest owners, members of the Forest for Life, members of the Baekdudaegan Preservation Society). The survey results show that there are significant differences in attitudes and beliefs toward the new environmental and resources management paradigms among groups. The environmental conservation groups such as the members of the Alpine Club, Nature Parks Association, Forest for Life, Baekdudaegan Preservation Society favor the NEP and NRMP more than those of traditional forestry related groups such as forest owners and timber industries. But, there are no significant attitudinal changes among forestry related groups. This research provides valuable insights into understanding the attitudinal positions of the interest groups toward forest resources management and policy formulation in Korea.

• Journal of Acupuncture Research
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• v.18 no.5
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• pp.60-69
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• 2001

Objective : Recent studies Suggested that there is a strong correlation between acupuncture stimulation and its related cortical activation. Anther study showed that either positive or negative BOLD effects could be observed depending on anatomical structure in acupuncture. Material and Methods : 1) Subjects and paradigms : Two separate stimulation paradigms were performed on five healthy (aged 22-23 yrs) in this study. First, the paradigm of acupuncture stimulation was that the acupuncture needle was inserted in acupoints KI6(照海), which is located in lateral side of the foot and then continuously twisted(補瀉를 除外한 捻轉法) for 70 seconds for 10 cycles of activation. During rest period (70 seconds), the needle was completed removed from acupoint. Total 60 cycles were performed and 10 images were obtained per cycle. Second, non-acupoint was randomly selected and the same paradigm was performed as acupoint stimulation. The stimulation protocol comprised 10 cycles of alternating activation and rest (10 images per cycle). Total 60 cycles were performed and each cycle take about 1.5 sec for motor task. Subjects take an at least 15 minutes break before starting anther paradigm. Conclusion : In this study, I investigated a new acupoint KI6(照海) which was known as motor - related acupoint and obtained an evidence that the stimulation of KI6(照海) resulted in negative BOLD response to stimulation.

• Journal of Acupuncture Research
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• v.21 no.6
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• pp.177-186
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• 2004

Introduction : Recent studies Suggested that there is a strong correlation between acupuncture stimulation and its related cortical activation. Anther study showed that either positive or negative BOLD effects could be observed depending on anatomical structure in acupuncture stimulation. In ttis study, we investigated a new acupoint $KI_6$ (照海), which was known as motor-related acupoint and obtained an evidence that the stimulation of $KI_6$ resulted in either negative or positive BOLD response to stimulation. Methods & Results : 1. Subjects and paradigms : Two separate stimulation paradigms were performed on five healthy (aged 22-23 yrs) in this study. First, the paradigm of acupuncture stimulation was that the acupuncture needle was inserted in acupoints $KI_6$, which is located in lateral side of the foot and then continuously twisted(補瀉를 除外한 捻轉法) for 70 seconds for 10 cycles of activation. During rest period (70 seconds), the needle was completed removed from acupoint. Total 60 cycles were performed and 10 images were obtained per cycle. Second, nonacupoint was randomly selected and the same paradigm was performed as acupoint stimulation. The stimulation protocol comprised 10 cycles of alternating. activation and rest (10 images per cycle). Total 60 cycles were performed and each cycle take about 1.5 sec for motor task. Subjects take an at least 15 minutes break before starting anther paradigm. 2. fMRI mapping : Multi-slice functional images were obtained on a 1.5T Magnetom Vision MRI scanner (Simens Medical, Erlangen, Germany) equipped with high performance whole-body gradients. The BOLD T2 * - weighted images were acquired with acho planar imaging sequence (TR = 1.2 sec, TE = 60 msec, and flip angle = $90_{\circ}$). The other sequence parameter are : FOV = 210 mm, matrix=$64{\times}128$ or $64{\times}64$, slice number=10 and slice thickness = 5 or 8 mm. the anatomic images were obtained with Spin-echo T1-weighted images. The resulting images were then anaiyzed with STIMULATE (CMRR, U. of Minnesota) to generate functional maps using a student T-test (p < 0.005) and cluster analysis. Both positive and negative response were evaluated. Conclusions : We have observed the activation of the motor cortex by stimulating motor-related acupoint ($KI_6$). Among five subjects, negative BOLD response was shown in four and positive response in one. All subjects showed positive response to conventional finger flexion-extension task. To understand the detailed mechanisms of correlation between acupuncture stimulation and BOLD fMRI changes and two typs of response, further study strongly required.

• The Mathematical Education
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• v.61 no.4
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• pp.539-557
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• 2022

A research field develops by experiencing several turns of paradigms. Mathematics education research have experienced those turns as well. Still, the dominant perspective is that mathematics education research should be scientific and objective. In this article, I suggest that this need not to be the prime rule to follow and that the mathematics education field will fertile by discussing extraordinary cases which may seem controversal to be recognized as valid research work. To this end, I first briefly describe the necessity of open discussions among researchers for a field to develop. Then, I introduce fiction writing, a resesarch method derived from arts-based research, as an extraordinary case for open discussions. The benefit of Arts-based research is on that it takes an holistic approach to how we know by embracing emotion and emphathy as means for knowing. Because of this trait, arts-based research holds a powerful potential for influencing a wide range of people, both inside and outside of the resesarch field. Following this, I present a fiction about a prospective teacher who participated in an activity for designing educative curriculum materials. By doing so, I sought to provoke discussions among mathematics education researchers about what to include as a valid research work, possible standards for reviewing arts-based resesarch.

• BMB Reports
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• v.42 no.9
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• pp.568-573
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• 2009

Fatty acid oxidation (FAO) defects cause abnormal lipid accumulation in various tissues, which provides an opportunity to uncover novel genes that are involved in lipid metabolism. During a gene expression study in the riboflavin deficient induced FAO disorder in the chicken, we discovered the dramatic increase in mRNA levels of an uncharacterized gene, ANKRD9. No functions have been ascribed to ANKRD9 and its orthologs, although their sequences are well conserved among vertebrates. To provide insight into the function of ANKRD9, the expression of ANKRD9 mRNA in lipidperturbed paradigms was examined. The hepatic mRNA level of ANKRD9 was repressed by thyroid hormone ($T_3$) and fasting, elevated by re-feeding upon fasting. However, ANKRD9 mRNA level is reduced in response to apoptosis. Transient transfection assay with green fluorescent protein tagged- ANKRD9 showed that this protein is localized within the cytoplasm. These findings point to the possibility that ANKRD9 is involved in intracellular lipid accumulation.

• Korean Journal of Computational Design and Engineering
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• v.15 no.2
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• pp.124-135
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• 2010

PLM(Product Lifecycle Management) is one of innovative manufacturing paradigms which leverages e-business technologies to allow a company's product content to be developed and integrated with all company business process through the extended enterprise. In these days, most construction companies also make an effort to enhance their systems for creating, sharing and managing information to improve business efficiency through entire lifecycle of project execution. Because of different needs, business process and diverse engineering activities such as design, structural analysis, installing simulation, documents and data managements, a new paradigm for construction companies is needed to manage and share the entire workflow, and information in total project lifecycle. In this paper, we conducted user requirement and business process analysis of constructions to design C-PLM system which is a PLM system for effective management of civil project and engineering activities. Also, we implement C-PLM system based on commercial PDM system, and applied it to civil project as case studies.

• Journal of information and communication convergence engineering
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• v.8 no.2
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• pp.234-237
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• 2010

P300 component of the event-related potential(ERP) has been studied for theoretical, empirical, and clinical applications. Nowadays the 1-, 2-, and 3-stimulus oddball paradigms are used for eliciting P300 component of EEG in the auditory stimulus experiments. In this paper, we used a method to add one more stimulus to the 3-stimulus auditory paradigm. The adding stimulus has not the same volume but the same tone of the target stimulus. The 4-stimulus oddball paradigm to use two targets is used to elicit the P300 event-related potentials. In 4-stimulus oddball paradigm, an infrequent non-target (p=0.10) is presented in addition to two infrequent targets (p=0.10) and a frequent standard (p=0.70). Two target stimuli elicited a P300 component with a parietal maximum distribution. The amplitude of the P300 in target 2 was larger than that in target 1 and the latency of the P300 in target 2 was longer than that in target 1. The P300 component due to target 2 stimuli was larger than that due to target 1 stimuli. The experimental results approve that the 4-stimulus oddball paradigm can elicit P300 component clearly. The results are compared with the results of the traditional oddball paradigm.