• Title/Summary/Keyword: pal

Search Result 1,097, Processing Time 0.024 seconds

Effects of Naloxone on Morphine Analgesia and Spinal c-fos Expression in Rat Formalin Test (Naloxone이 흰쥐 Formalin Test에서 Morphine의 진통효과와 척수 c-fos 유전자 발현에 미치는 영향)

  • Song, Sun Ok;Seok, Je Hong;Lee, Deok Hee;Park, Dae Pal;Kim, Seong Yong;Lim, Jeong Sook;Song, Sun Kyo;Lee, Nam Hyuk
    • The Korean Journal of Pain
    • /
    • v.18 no.2
    • /
    • pp.124-132
    • /
    • 2005
  • Background: This study was performed to evaluate the dose-related effects of naloxone on morphine analgesia in the rat formalin test, and observe the correlation of pain behavior and spinal c-fos expression induced by a formalin injection. Methods: Fifty rats were divided into five groups; control, morphine (morphine pre-treated, intra-peritoneal injection of 0.1 mg of morphine 5 min prior to formalin injection), and three naloxone groups, which were divided according to the administered dose-ratio of naloxone to morphine 20 : 1 ($5{\mu}g$), 10 : 1 ($10{\mu}g$), and 1 : 1 ($100{\mu}g$) representing the low-, medium-, and high-dose naloxone groups, respectively, were injected intra-peritoneally 16 min after a formalin. A fifty ul of 5% formalin was injected into the right hind paw. All rats were observed for their pain behavior according to the number of flinches during phases 1 (2-3, 5-6 min) and 2 (1 min per every 5 min from 10 to 61 min). The spinal c-fos expression was quantitatively analyzed at 1 and 2 hours after the formalin injection using a real-time PCR. Results: The morphine pre-treated (morphine and three naloxone) groups during phase 1, and the morphine, low- and medium-dose naloxone groups during phase 2, showed significantly less flinches compared to those of the control (P < 0.05). In the three naloxone groups, the numbers of flinches were transiently reduced following the naloxone injection in the low- and medium-dose groups compared to those of the morphine group (P < 0.05). The duration of the reduced flinches was longer in the medium-dose group (P < 0.05). The high-dose group revealed immediate increases in flinches immediately after the naloxone injection compared to those of the morphine, low- and medium-dose groups (P < 0.05 for each). The spinal c-fos expression showed no significant patterns between the experimental groups. Conclusions: Our data suggest that relatively low-dose naloxone (1/20 to 1/10 dose-ratio of morphine) transiently potentiates morphine analgesia; whereas, high-dose (equal dose-ratio of morphine) reverses the analgesia, and the spinal c-fos expression does not always correlate with pain behavior in the rat formalin test.

Effects of Furosemide on perioperative Serum Osmolality and Electrolytes during Transurethral Resection of the Prostate (경요도 전립선 절제술시 투여한 Furosemide가 수술중, 후 혈중 나트륨 및 삼투질농도에 미치는 영향)

  • Kim, Sae-Yune;Roh, Un-Seok;Park, Dae-Pal
    • Journal of Yeungnam Medical Science
    • /
    • v.9 no.1
    • /
    • pp.110-120
    • /
    • 1992
  • The purpose of this study was to prevent the dilutional effect of excessive absorption of irrigating solution by using furosemide intraoperatively during transurethral resection of the prostate, 30 patients, who belonged to physical status II or III of ASA classification, were selected randomly and divided with two groups as follows : G1(N=15) : Not-administrated furosemide(control group) G2(N=15) : Administrated furosemide(Experimental group). All patients were premedicated with Hydroxyzine(1mg/kg, IM) and were performed continous epidural anesthesia with 2% lidocaine(1-1.5mg/segment). For irrigating solution, 5% D-sorbitol was used and Hartman's solution were given for maintenance fluid and fixed the height of irrigating container to 60 cm from symphysis pubis. With the starting of operation, 20mg furosemide was administrated to experimental group. The blood samples for the values of $Na^+$, $K^+$, Glucose and BUN were performed at the periods of preoperation, 10 min, 20 min, 30 min after the starting of operation and immediate postoperation. Based these data, serum osmolality and effective osmolality were calculated. The results were as follows : 1. The sodium concentration of control group was decreased statistically significantly at 10 min, 20 min, 30 min after the starting of operation and immediate postoperative period as comparing with the preoperation value(p<0.05). But that of experimental Group was not changed significantly. 2. The serum osmolality and effective osmolality were decreased statistically significantly at 30 min after the starting of operation and immediate postoperative period as comparing with the preoperation value(p<0.05). But those of experimental group were not changed significantly. These results show that the dilutional effect of excessive absorption of irrigating solution might be prevented by using furosemide intraopertively. And so we recommend the use of furosemide during TURP, especially in patients with congestive heart failure or renal failure.

  • PDF

Thiopental Prevents A Beta-Endorphin Response to Cardiopulmonary Bypass (체외순환전 투여된 Thiopental이 Beta-endorphin치 변화에 미치는 영향)

  • Song, Sun-Ok;Carr, Daniel B.;Park, Dae-Pal;Jee, Dae-Lim;Kim, Sae-Yeon
    • Journal of Yeungnam Medical Science
    • /
    • v.14 no.2
    • /
    • pp.350-358
    • /
    • 1997
  • We studied the effects of adding a single bolus(500 mg) of sodium thiopental to a continuous infusion of low-dose fentanyl on plasma beta-endorphin immunoreactivity(iBE) responses to cardiopulmonary bypass(CPB) in 28 patients undergoing elective coronary artery bypass grafting or valve procedures. Thiopental was injected just prior to the initiation of CPB. The iBE levels and the hemodynamic indices such, as mean arterial pressure, cardiac output and systemic vascular resistance were measured before CPB, at 30 min and again at 60 min after the initiation of the bypass. The results were as follows. After the initiation of CPB, iBE levels increased at 30 min and 60 min(P=0.006, P=0.004 respectively) in the control group, but not in the thiopental group. There were significant differences in the changes of iBE levels between the groups(F=8.7, G-G=0.002, P=0.001). The hemodynamic indices were similar in both groups. In conclusion, pretreatment with thiopental just before the initiation of CPB prevents the stress-induced beta-endorphin response to CPB.

  • PDF

Effect of Sulfur-containing Pesticides on the Arylsulfatase Activity in Soil (함유황(含硫黃) 농약(農藥)이 토양중(土壤中) Arylsulfatase의 활성(活性)에 미치는 영향(影響))

  • Lee, Sang Pal;Kim, Jang Eok;Hong, Jong Uck
    • Current Research on Agriculture and Life Sciences
    • /
    • v.8
    • /
    • pp.19-27
    • /
    • 1990
  • This study was conducted to investigate the effect of sulfur containing pesticides, captan, edifenphos, EPN, acephate, asulam, bentazone on arylsulfatase activity in soil incubated at $30^{\circ}C$ for 42 days with or without urea addition. The results obtained were as follows: When pesticides, captan, edifenphos, EPN, acephate, asulam, bentazone were treated in urea added and unadded soil, the activity of arylsulfatase was the highest at 7 days of incubation. The arylsulfatase activity in urea added soil was kept higher as compared with that of the urea unadded soil. When pesticides, captan, edifenphos, acephate, asulam, bentazone, were treated in urea added and unadded soil, the activity of arylsulfatase was inhibited at the entire experimental period. By the treatment of EPN in urea added and unadded soil, the arylsulfatase activity was decreased at the early stage of treatment, but increased after 28 days of incubation.

  • PDF

Auto-compatibility Analysis for Ka-band payload of COMS

  • Park, Jae-Woo;Lee, Seong-Pal;Baek, Myung-Jin
    • Journal of Satellite, Information and Communications
    • /
    • v.2 no.2
    • /
    • pp.41-47
    • /
    • 2007
  • The first geostationary satellite made by Korea, COMS, has the three different payload ; Meteorological sensor, Oceanographic sensor and Ka-band communication payload. There are Meteorological & Ocean Data Communication Subsystem(MODCS) and Telemetry, Command and Ranging Subsystem(TC&R) as other RF radiation sources. MODCS transmits and receives Meteo and Ocean measurement data from/to earth using L-band and TC&R using S-band. The Ka-band communication payload will provide high-speed multimedia services and communication services for natural disaster such as prediction, prevention, and recovery services in the government communications network.Ka-band beacon is for the earth antenna pointing and the experiment of rain fading. This paper gives the analysis results about the mutual radiation effect on Ka-band communication payload, Ka-band beacon, MODCS and TC&R. Up/Down link power and coupling factor including the geometrical position and distance of antenna, filter rejection and degradation factor due to the different polarization are considered. The results show MODCS and TC&R are compatible for Ka-band communication payload and Ka-band beacon does not interfere with MODCS and TC&R normal operation.

  • PDF

Cavity-type Beam Position Monitors for Future Accelerators (차세대 가속기용 공동형 빔위치 측정기 개발)

  • Kim S.H.;Park Y.J.;Hwang W.H.;Huang J.Y.;Honda Y.;Inoue Y.
    • Journal of the Korean Vacuum Society
    • /
    • v.15 no.4
    • /
    • pp.331-337
    • /
    • 2006
  • Cavity-type beam position monitors were developed in collaboration with KEK to use for the future accelerators such as international linear collider (ILC) or x-ray free electron laser (XFEL) in PAL. BPM components such as BPM cavity, beam tubes, waveguides and feedthroughs were assembled by brazing at the same time to reduce mechanical errors during the fabrication. There are four screwed pins around outer rim of the cavity for the tuning of cavity frequency and x-y isolation. The resonance frequency of BPM is 6.422 GHz, the inner diameter of cavity is 53.822 mm, and the range of mechanical adjusting is $+ / - 250{\mu}m$. The x-y isolation was measured better than -40 dB after tuned. Test results of signal forms, x-y isolations, sensitivities are satisfied within requirements for the KEK ATF2 beam line.

Current Status of Ginseng Cultivation and Soil Characteristics of Northeastern Three Provinces in China

  • Park, Yang Ho;Kim, Jang Uk;Kim, Dong Hwi;Sonn, Yeon Kyu;Yun, Jin Ha;Moon, Huhn Pal;Cho, Soo Yeon
    • Korean Journal of Soil Science and Fertilizer
    • /
    • v.49 no.6
    • /
    • pp.795-806
    • /
    • 2016
  • This study was conducted to improve the continuous techniques for international competitiveness of ginseng industry to Korea-China FTA negotiation and conclusion, and provide the basic information for ginseng industry development of Korea. It was carried out the visiting of the northeastern three provinces (Jilin, Liaoling and Heilongjang) in China for 3-year from 2014 to 2016 and observed the farmers' fields of ginseng cultivation with soil environmental status. The types of ginseng cultivation could be observed in small scales of 0.5~3.0 ha, in middle scales of 4.0~10.0 ha and in large scales of 30~700 ha with the kinds of imhasam, Chinese ginseng, Korean ginseng and western ginseng. Also ginseng was cultivated in newly reclaimed land of forest in two types of direct seeding and transplanting of ginseng seedlings. The field beds of ginseng growing were covered with vinyl films in arch design of 100~130 cm height and vinyl was painted in spraying with blue, green and yellow colours for shading. It was investigated in status of the physico-chemical properties of soils. The physical information on the field soils were silt loam, loam and sandy loam in soil textures, and some plain in low slope, some alluvial fan or local valley in forest of land topography. Soil pH ranged within 5.0~5.2, soil EC was $0.93{\sim}3.78dS\;m^{-1}$, organic matter was $37{\sim}35g\;kg^{-1}$, nitrate nitrogen $63{\sim}490mg\;kg^{-1}$, available $P_2O_5$ $55{\sim}163mg\;kg^{-1}$, and in exchangeable cations, K was 0.30~0.98, Ca was 6.5~14.0, Mg was $1.1{\sim}5.3cmol_c\;kg^{-1}$ in ranges. Farmers used the fertilizer for ginseng cultivation in 10~11 t of compost, $200{\sim}400kg\;ha^{-1}$ of complex fertilizer and $750kg\;ha^{-1}$ of oil cakes. The northeastern three provinces of China can use the newly lands with large areas of ginseng cultivation in soil sickness by continuous cropping. and the soil basic fertility is batter than that of Korean in standard guide of ginseng cultivation soil.

Study on the Natural Spat Collection of the Pen Shell, Atrina pectinata (키조개, Atrina pectinata의 자연채묘연구)

  • Son, Pal-Won;Ha, Dong-Soo;Lee, Chang-Hun;Jang, Dae-Soo;Kim, Dae-Kweon
    • The Korean Journal of Malacology
    • /
    • v.21 no.2 s.34
    • /
    • pp.113-120
    • /
    • 2005
  • In this experiment of natural Atrina pectinata spat collection, the number of the pen shell spats settled on a collector were 4.2, 6.8, and 2.7 in the first, second, and third year, respectively. The highest number of pen shell spat settled on the collector was observed in August, and the shell length of juvenile pen shells grew up to 42.5 mm six months after setting. The relation between shell length (SL) and days (D) after setting could be expressed as; SL = 0.3854D + 0.8423 ($r^2$ = 0.9764). The spats developed the best in depth of 10-20 m. Spat collectors in mesh size of $1{\times}2mm$ mm were better for spats to survive than the ones in $1{\times}1mm$. The most efficient material as substrate for the settlement of pen shell spat was a polyethylene monofilament in the spat collectors.

  • PDF

Indoor Tank Culture of the Abalone Haliotis discus hannai II. Effects of diets on the growth of young abalone (참전복 Haliotis discus hannai의 육상수조사육에 관한 연구 II. 먹이별 사육실험)

  • JEONG Seong-Chae;JEE Young-Ju;SON Pal-Won
    • Journal of Aquaculture
    • /
    • v.7 no.2
    • /
    • pp.77-87
    • /
    • 1994
  • The study was conducted to develop the suitable abalone's diets for the indoor tank culture. The young abalone Haliotis discus hannai Ino sized ca. 20, 30 and 40 nun in shell length were fed three different diets, dried sea mustard Undaria pinnatifida HARVEY (control), artificial diet and terrestrial plants e. g. Chinese cabbage and Perilla leaf for 2 years. The growth rate of abalones fed an artificial diet was slightly higher than that of abalones from the control. However, the growth rate of abalones from terrestrial plants was significantly lower than that of abalones fed a control or an artificial diet (P< 0.05). The daily feeding rate of young abalones from terrestrial plants was slightly higher than that of abalones from the control. While, that of abalones from an artificial diet was approximately $30\%$ of that of abalones from a control or a terrestrial plants diet. The feed efficiency of abalone from artificail diet was higher than that of abalones from a control or a terrestrial plants diet, and the smaller size of young abalone showed the higher the feed efficiency. The EFA index values ${{\sum}n9/(20:4n6+20:5n3+22:6n3}$ of the dried sea mustard and the artificial diet were 1.26 and 3.64, respectively. These values were favorable, but the value of terrestrial plant, Perilla leaf was 127.00 indicating poor EFA index for normal growth of abalone.

  • PDF

Studies on the Age and Growth fo Sun and Moon Scallop, Amusium japonicum japonicum (GMELIN) (해가리비, Amusium japonicum japonicum (GMELIN)의 연령과 성장에 관한 연구)

  • Son Pal-Won;Ha Dong-Soo;Rho Sum;Chang Dae-Soo
    • Journal of Aquaculture
    • /
    • v.9 no.4
    • /
    • pp.409-417
    • /
    • 1996
  • Age, annual growth pattern, and other ecologically important observations are reporting from the analysis of annual growth annuli of the sun and moon scallop, Amusium japonicum. Field survey made from 1993 to 1994 indicated that the sun and moon scallops are mostly distributed along the southern coast of Cheju-do, especially around the Sogwipo area. They inhabit on muddy sand bottom, at depth between 30 and 40 m where water temperature varies from 14 to $23^{\circ}C$ annually. The gonadal analysis indicated that the spawning mostly occurs during October and December and they exhibit multiple spawning peaks. The formation of annual growth annuli was found to be related with their spawning period. The shell growth on A. japonium japonicum appeared that their shell growth rate is comparatively faster than that of other scallops : 1. japonium japonicum reaches 6.28 cm in shell hight at the first year and 9.07 cm at the second year. The growth rate of gonadal somatic tissue was also found to be faster than growth rates of other scallops. One year old scallops weigh about 18.8 g, two and three year old scallops weigh 60 and 102.4 g. Based upon these observations, it is concluded that A. japonium japonicum can be a valuable species for aquaculture development due to their rapid growth.

  • PDF