• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.9
• /
• pp.5281-5286
• /
• 2013

Purpose: Prostate cancer caused by the abnormal disorderly growth of prostatic acinar cells is the most prevalent cancer of men in western countries. We aimed to screen out differentially expressed genes (DEGs) and explore small molecule drugs for prostate cancer. Materials and Methods: The GSE3824 gene expression profile of prostate cancer was downloaded from Gene Expression Omnibus database which including 21 normal samples and 18 prostate cancer cells. The DEGs were identified by Limma package in R language and gene ontology and pathway enrichment analyses were performed. In addition, potential regulatory microRNAs and the target sites of the transcription factors were screened out based on the molecular signature database. In addition, the DEGs were mapped to the connectivity map database to identify potential small molecule drugs. Results: A total of 6,588 genes were filtered as DEGs between normal and prostate cancer samples. Examples such as ITGB6, ITGB3, ITGAV and ITGA2 may induce prostate cancer through actions on the focal adhesion pathway. Furthermore, the transcription factor, SP1, and its target genes ARHGAP26 and USF1 were identified. The most significant microRNA, MIR-506, was screened and found to regulate genes including ITGB1 and ITGB3. Additionally, small molecules MS-275, 8-azaguanine and pyrvinium were discovered to have the potential to repair the disordered metabolic pathways, abd furthermore to remedy prostate cancer. Conclusions: The results of our analysis bear on the mechanism of prostate cancer and allow screening for small molecular drugs for this cancer. The findings have the potential for future use in the clinic for treatment of prostate cancer.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2014.02a
• /
• pp.376.2-376.2
• /
• 2014

마이크로볼로미터 적외선 센서는 인체감지, 전자부품의 품질검사, 에너지 절감, 산업시설감시 및 군사용으로 다양하게 적용되고 있다. 기존에 이러한 적외선 센서의 감지재료로 VOx 또는 비정질 Si이 가장 많이 사용되고 있으며, VOx는 감도가 높고, 세계적으로 가장 많이 사용되고 있는 물질이다. 본 연구에서는 기존의 VOx 박막 증착법을 개선하여 Zn 산화물 박막을 혼용한 적외선 감지재료를 이용한 마이크로볼로미터 제작 및 특성에 대해 보고한다. RF sputtering 방법으로 약 140 nm의 VOx/ZnO/VOx 샌드위치 박막을 증착하고, 산소분위기에서 열처리함으로써 온도저항계수(TCR)가 약 -3.0 %/K의 값을 갖는 특성을 구현하였다. 갓 증착된 V-Zn 박막에서는 XRD 스펙트럼에서는 V2O5 관련 피크가 주로 관측되었으며, 산소열처리에 의해 VO2 피크가 새롭게 관측되었다. 볼로미터 감지소자는 유효면적 $50{\times}50{\mu}m^2$ 으로 bulk micromaching 공정을 통해 제작하였다. Si 기판위에 SiNx 박막을 PECVD 장치를 이용하여 증착하였으며, 적외선 감지층으로 V-Zn 산화물을 RF sputtering 방법으로 증착하여 열처리 후 SiNx passivation 박막으로 보호하였다. 열적고립을 위해 패터닝 후 Si 기판을 KOH 용액을 이용하여 약 $20{\mu}m$ 식각하여 소자를 구현하였다. 제작된 소자의 특성을 평가한 결과 반응도는 1.57e+4 V/W, 탐지도는 $8.79e+7cmHz^{1/2}/W$를 얻을 수 있었다. 소자의 동작 특성을 평가하기 위해 진공 압력을 1e-3 torr 이하에서 thermoelectric cooler를 장착한 metal package를 제작하여 동작온도에 따른 특성을 평가하였다. 동작온도를 $10^{\circ}C{\sim}40^{\circ}C$로 하여 측정한 결과 동작온도가 증가할수록 신호전압은 감소함을 알 수 있었다.

• Polymer(Korea)
• /
• v.24 no.6
• /
• pp.837-844
• /
• 2000

The cure behavior of commercial epoxy molding compounds (EMC) commonly used for IC package was studied at constant cure temperatures as well as at constant heating rates using differential scanning calorimetry (DSC), rheometer, and dielectric analyzer (DEA). The cure kinetics were obtained using autocatalytic reaction model according to the Ryan Dutta method after assuming m+n equal to 2. The prediction of reaction rates by the model equation corresponded well to experimental data at all temperatures except for 10$0^{\circ}C$. The phase transitions such as gelation and vitrification occurred during network formation. At each isothermal cure temperature, $T_{g}$ was measured in accordance with cure time, and the vitrification point was attained when $T_{g}$ was equal to $T_{cure}$. The temperature dependence of gel points and vitrification points showed good agreement with Arrhenius relation. DEA using parallel plate electrode was effective for the monitoring of EMC cure. we knew that if the resin systems are materials of comparable quality, $_{gel}$$T_{g}$ is constant regardless of accelerator concentration in TTT (Time-Temperature-Transformation) diagram.

• The Korean Journal of Community Living Science
• /
• v.17 no.2
• /
• pp.3-14
• /
• 2006

This study intends to offer suggestions for improving the security and competitive power of traditional liquors by investing in the status of intellectual property rights. Merchandising and the marketing strategies of traditional liquor are also addressed. The data was collected through a questionnaire survey given to 101 CEOs of traditional liquor manufacturers. The major results of this study were as follows: The management types of traditional liquor manufacturers were classified as the company 57 (56.4%), the corporation or the union 29 (28.7%), domestic industry 10 (9.9%), and marketing community or technology center 5 (5.0%). The competitive power degree of traditional liquor products was classified as strength 30 (31.6%), usual 30 (31.6%), weakness 35 (36.8%). The elements of strong competitive power were taste, functional (wellbeing) character, and attractiveness of the brand name. On the other side, reasons for weakness in competitive power were the marketing system, price competitiveness, and advertisement. The trademark registration of the traditional liquor appeared with 53%. The reasons not to pursue a trademark registration included the complicated and unnecessary process of registration acquisition, high registration expenses, etc. The perceptions of CEOs about the consumer's brand awareness for their product were low with an average 2.97. Explanations included insufficient advertisement and public relations, unrefined trademark design, and the meaninglessness of brand names. The marketing strategy of traditional liquor manufacturers according to annual sales were as follows: Manufacturers with high sales emphasized marketing strategies that focused on functional character, traditional image, high quality in image and package materials and design, high price strategies based on quality, and various sale promotions.

• Korean journal of food and cookery science
• /
• v.25 no.1
• /
• pp.62-73
• /
• 2009

This study was conducted to evaluate the performance of sanitation management within school foodservice facilities and utilities in Gyeongbuk province. Data collection was carried out through surveys given to 200 school dietitians from the province. A total of 108 were usable, resulting in a 54.0% response rate. Statistical analyses were done using the SAS package program (version 8.2 for Windows). Of the study population, 58.3% had more than 10 years of work experience, and 64.8% worked in elementary schools. With regard to the style of foodservice system, 47.2% were urban and 46.3% were rural. Also, 89.8% of the school foodservices provided meals once a day. The performance of the sanitation management items of the facilities and utilities used to provide school foodservice was evaluated using a 5-point Likert scale. The average score for the 25 items was 3.35 points. 'HVAC system installed in foodservice establishment' had the lowest average score at 2.20 points. Whereas 'provide adequate storage capacity to allow refrigerating and freezing and an adequate thermometer is installed and temperatures monitored' had the highest average score at 4.19 points. Nine out of the 25 items were lower than the average score. The performance scores of high schools were significantly higher than those of elementary schools or middle schools for 'window materials are provided that are not liable to break' (p<0.001). The performance scores for urban style foodservices were significantly lower than for rural foodservices for 'floor of kitchen is constructed to maintain a dry system' (p<0.05). In response to questions on kitchen utensils and equipment, significant differences were shown according to the number of meals served per day in 21 out of 56 items, and the style of foodservice system showed significant differences in 14 of the 56 items. Foremost, to make better use of the foodservice facilities and utilities in Gyeongbuk province, immediate improvements should be made for management items in which the degree of performance was below the average score.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.38 no.1
• /
• pp.45-50
• /
• 2014

A vibration test coupon is prepared with nine plastic ball grid array packages on a printed circuit board using SnPb solders, and a random vibration test is conducted on the coupon. Life data from the test are analyzed, and it is shown that over the board, life data is location-dependent. For investigating this location dependency, a finite element model is developed and the equivalent stresses, which are defined based on the stress response functions at each node, are investigated. It is shown that one of the corner solder balls has the maximum equivalent stress at a package during the test. Finally, it is demonstrated that the maximum equivalent stress and durability life are inversely proportional.

• The Journal of Korean Society for School & Community Health Education
• /
• v.12 no.1
• /
• pp.117-129
• /
• 2011

Objectives: The purpose of this study was to introduce of the Urbani School Health Kit (USHK) and to investigate the adaptability to Korean situation. Methods: The authors analyzed the contents of USHK developed by the health promotion team at the Western Pacific Regional Office of World Health Organization (WHO WPRO) in collaboration with health promotion experts at University of the Philippine Open University, and by observing health classes using the USHK in Angono elementary school in Manila, Philippines. Results: The following are the characteristics of USHK: 1) The USHK was composed of a teacher's guide and six books targeted to two groups of children: ages 5~6 years and 10~12, and an integrated package containing materials that can be used to support health education and health promotion activities in elementary schools. 2) The USHK could be integrated in the curriculum to reduce the burden of teacher's class preparation time and help teachers conveying clear and accurate health messages in their classes. 3) Several evaluation tools such as pre-test post-test quizzes, self-evaluation tools, observer checklists, and evaluation interview protocols were developed to monitor and evaluate whether USHK was useful, helpful, and appropriate. Conclusions: We found that USHK was a practical tool for supporting health promotion in elementary schools and could be applicable to health promoting schools in Korea if it were modified to address Korean school health problems.

• Textile Coloration and Finishing
• /
• v.21 no.1
• /
• pp.1-9
• /
• 2009

A lot of research has been made over the recent decade to develop testing packages with antimicrobial properties to improve food safety. In this study, a new method, experimental device and technology for environmental corresponding packages of polypropylene (PP) film has been developed to provide effective temperature buffering during the transport/long-term storage of grains or foodstuffs from the supplier to the market. This quantitatively optimized mixing system enabled to produce PP films with the 700$\sim$1,400d (width;1.5$\sim$3mm, thickness;0.01$\sim$0.5mm). In the whole mixing systems, the finely-granulated inorganic illite and PP virgin chip for master batch (M/B) chip was calculated by digital measurement methods, and then the M/B chip for PP film was adapted through a air jet and PP grinding method. The prepared PP film was characterized with tensile strength and elongation, far infrared radiation (FIR) emissivity, antimicrobial activity and deodorization properties. The results revealed that the two differently grain-sized illite could be show homogeneously dispersed on PP chip surface, and as the increasing of illite content, the FIR emissivity and the anion emission rate of film was increasingly improved. In both of 325 and 1,500 mesh-sized illite contained PP chip, of course the antimicrobial activity was good. But the ultimate deodorization rate for ammonia gas of PP film were found to be approximately the same.

• Journal of Korean society of Dental Hygiene
• /
• v.12 no.4
• /
• pp.707-714
• /
• 2012

Objective : This study came to be carried out in order to develop oral health education program for maintaining adolescents' oral health and to be helpful for qualitative improvement in prevention program by surveying the awareness and behavior on preventive method of dental caries in adolescents. Method : The collected materials of totally 1,100 people who responded were carried out frequency analysis by using SPSS 12.0(Statistical Package for the Social Science). Results : 1. As for the results of awareness on fluoride effect and sealant effect, the students with response to 'effect of preventing decayed tooth' were indicated to be the highest. It was indicated to be the highest in girls as for gender and in the 2nd grade as for school year. (p<0.05). 2. As for the results of being created when eating sweet food and carbonated drink, the students with response as saying that 'a decayed tooth occurs well' were indicated to be the highest. 4. As for the results on the aim of visiting dental clinic, the students with response as saying of 'visiting for having treatment' when tooth is painful were indicated to be the highest. Conclusion : Synthesizing this study, the students' awareness on preventive method of dental caries was high. But the practice on regular check-up or diet was indicated to be low. Through oral health education, the adolescents should be not only delivered information or knowledge, but also changed habit and behavior.

• Journal of Biosystems Engineering
• /
• v.29 no.6 s.107
• /
• pp.501-507
• /
• 2004

Fruits we subjected to complex dynamic stresses in the transportation environment. During a long journey from the production area to markets, there is always some degree of vibration present. Vibration inputs are transmitted from the vehicle through the packaging to the fruit. Inside, these cause sustained bouncing of fruits against each other and container wall. These steady state vibration input may cause serious fruit injury, and this damage is particularly severe whenever the fruit inside the package is free to bounce, and is vibrated at its resonant frequency. The determination of the resonant frequencies of the fruit may help the packaging designer to determine the proper packaging system providing adequate protection for the fruit, and to understand the complex interaction between the components of fruit when they relate to expected transportation vibration inputs. The vibration characteristics of the pears in corrugated fiberboard container in transit were analyzed using FEM (finite element method) modeling, and the FEM modeling approach was first validated by comparing the results obtained from simulation and experiment for the pear in the frequency range 3 to 150 Hz and acceleration level of 0.25 G-rms and it was found that between simulated and measured frequencies of the pears have a relatively good agreement. It was observed that the fruit and vegetables in corrugated fiberboard container could be analyzed by finite element method. As the elastic modulus of the cushion materials of corrugated fiberboard pad and tray cup decreased, the first frequencies of upper and lower pears increased and the peak acceleration decreased.