• Journal of Acupuncture Research
• /
• v.27 no.2
• /
• pp.11-21
• /
• 2010

Objectives : We tried to investigate the effects of Carthami Semen(CF) pharmacopuncture and Bovis Calculus Fei Ursi(BU) pharmacopuncture on the heart rate variability(HRV) in adult men. As well as we tried to observe how CF pharmacopuncture and BU pharmacopuncture effect on the balance of the autonomic nervous system. Methods : We investigated on 40 healthy volunteers consisted of 20 subjects in CF pharmacopuncture group and 20 subjects in BU pharmacopuncture group respectively. We ruled out subjects whose vital sign isn't in normal range, yet they had taken a rest. The study established by a randomized, single-blind clinical trial. CF pharmacopuncture and BU pharmacopuncture was applied on each group. We measured HRV 7 times : baseline measurement and every 5 minutes for 30 minutes after injection. The SPSS 15.0 for Windows was used to analyze the data by the paired t-test(in group) and Independent sample t-test(between the groups). Results 1. After injection of CF pharmacopuncture, SDNN, Ln(TP), Ln(VLF) and Ln(LF) increased significantly, and Complexity, pNN50 decreased significantly. 2. After injection of BU pharmacopuncture, RMSSD, SDSD and HRV-index increased significantly. Conclusions : We suggest that CF pharmacopuncture activate sympathetic nervous system and BU pharmacopuncture tend to activate the autonomic nervous system.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.22 no.3
• /
• pp.136-142
• /
• 2014

Distinct features in heart rate signals during the driver's wake and sleep states could provide an initiative for the development of a safe driving systems such as drowsiness detecting sensor in a smart wheel. We measured ECG from health subjects ($23.5{\pm}2.5$ in age) during the wake and drowsiness states. The proposed method is able to detect R waves and R-R interval calculation in the ECG even when the signal includes in abnormal signals. Heart rate variability(HRV) was investigated for the time domain and frequency domains. The STD HR(0.029), NN50(0.044) and VLF power(0.0018) of the RR interval series of the subjects were significantly different from those of the control group (p < 0.05). In conclusion, there are changes in heart rate from wake to drowsiness that are potentially to be detected. The results in our study could be useful for the development of drowsiness detection sensors for effective real-time monitoring.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.26 no.5
• /
• pp.745-752
• /
• 2012

This study aims to show the change of Heart Rate Variability(HRV) and Pulse wave velocity(PWV) on menstruation in women at college. Heart Rate Variability(HRV) and Pulse wave velocity(PWV) of 122 women at college were measured at their menstruation and ordinary period. SDNN, RMSSD, SDSD, HRV Index(%), stress resistance and cardiac activity were significantly higher at their menstruation than ordinary period, but Total Power and pNN50(%) were opposite. The automatic nervous system balance and physical stress were decreased in groups without dysmenorrhea than with one. PWV(E-R) and PWV(E-L) were much higher at menstruation than ordinary period. PTT(F-R) and PTT(F-L) were decreased in groups without dysmenorrhea than with severe one. We demonstrated that menstruation can effect on Heart Rate Variability and Pulse wave velocity and dysmenorrhea can cause the imbalance of autonomic nervous system.

• Journal of the Korean Applied Science and Technology
• /
• v.41 no.2
• /
• pp.219-232
• /
• 2024

The aim of this study was to explore the impact of body mass index (BMI) and drumming exercise on autonomic nervous system function in adult women. Ten adult women (aged 30-50) were divided into two groups based on their BMI: a normal BMI group (Low BMI, LBMI < 23 kg/m²) and an overweight BMI group (High BMI, HBMI > 23 kg/m²). Both groups participated in a drumming exercise program, consisting of 50-minute sessions, three times a week, for a duration of 8 weeks. Body composition and heart rate variability were assessed before and after the 8-week exercise period. Heart rate variability was evaluated using linear analysis in the time domain and frequency domain. Additionally, non-linear analysis was conducted using a Poincaré plot. The autonomic nervous system index was determined by measuring parasympathetic nervous system index and sympathetic nervous system index. Following the 8-week intervention, the HBMI group exhibited a significant decrease in weight (p=0.034), BMI (p=0.044), body fat mass (p=0.032), and waist circumference (p=0.013) compared to the LBMI group. Furthermore, the HBMI group demonstrated significant increases in RMSSD (p=0.018) and TP (p=0.033) in linear analysis, as well as SD1 (p=0.018) in non-linear analysis and PNS Index (p=0.040) compared to the LBMI group. RMSSD, SD1, and PNS Index serve as indicators of parasympathetic nervous system activity in linear and non-linear analyses, respectively. These findings indicate that drumming exercise significantly enhances autonomic nervous system function in overweight women.

• Journal of Chest Surgery
• /
• v.29 no.3
• /
• pp.303-310
• /
• 1996

From December of 1994 to April of 1995, we, SHUH Department of Pediatric Thoracic and Cardiovascular Surgery, studied effects of aprotinin. 95 patients were randomly divided into two groups : group I (n=47) with aprotinin and group ll (n=48) without aprotinin. Aprotinin was given as one shot injection to cardiopulmonary bypass perfusion solution with dose of 50,000 KIUikg. Laboratory data such as hemoglobin, hematocrit, BUH, creatinine, fibrinogen, electrolyte concentration, aPTT, PT, and AT R was checked preoperatively, 5 minutes after anesthesia, 5 minutes and 35 minutes after CPB circulation, and 5 minutes, 3 hours, and 24 hours after reperfusion. Also, chest-tube drainage, transfused amount of RBC, platelet concentrate, and fresh frozen plasma within first 24 hours postoperatively were checked and analyzed after transition nn body weight demension. Only RBC transfused postoperatively had statistical significance with P value of less than 0.001. Others had no difference statistical wise. Postoperative side effects of aprotinin was not detected weeks after the surgery and there was no reoperated patient due to postoperative bleeding.

• Journal of Acupuncture Research
• /
• v.26 no.5
• /
• pp.19-28
• /
• 2009

Objectives : We tried to investigate the effects of Panax Ginseng Radix pharmacopuncture and Zizyphi Spinosi Semen pharmacopuncture on human body with the Heart Rate Variability (HRV) in adult man. As well as we tried to investigate how safe Panax Ginseng Radix and Zizyphi Spinosi Semen pharmacopuncture on the the human being. Methods : We investigated on 44 healthy volunteers consisted of 16 subjects in Panax Ginseng Radix pharmacopuncture group, 13 subjects in Zizyphi Spinosi Semen pharmacopuncture group and 15 subjects in Normal Saline. We ruled out subjects who wasn't stable by rest, with in the limit of normal heart beat(60-120cycle/min). Study form was a randomized, clinical trial. Each group was injected Panax Ginseng Radix pharmacopuncture, Zizyphi Spinosi Semen pharmacopuncture and Normal Saline $0.2m{\ell}$ at $GB_{21}$(Kyonjong). We measured HRV on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 13.0 for windows was used to analyze the data by the paired t-test(in the group) and Anova test(among the groups) were used to verify the result. Results : 1. After Panax Ginseng Radix pharmacopuncture injection, SDNN was significantly high, pNN50 was significantly low, Ln(TP) was significantly high, Ln(VLF) was significantly high, Ln(LF) was significantly high at 30 minutes. 2. After Zizyphi Spinosi Semen pharmacopuncture injection, Complexity was significantly low, Ln(VLF) was significantly high at 30 minutes. 3. HRV-index made a significant difference between the Zizyphi Spinosi Semen pharmacopuncture and normal saline at 5 minutes(p=0.02). 4. There wasn's any pain the injected region and whole body, rubefaction, uredo, nausea, vomiting, colic, headache, dizziness within 24 hours. Measured data and mean value of Mean-HRV was within normal range. Conclusions : The results suggested that and Panax Ginseng Radix pharmacopuncture in healthy adult man tended to activate the vagus nervous system within normal range.

• Sleep Medicine and Psychophysiology
• /
• v.19 no.2
• /
• pp.68-76
• /
• 2012

Objectives: Sleep disorders cause changes of autonomic nervous system (ANS) which affect cardiovascular system. Primary insomnia (PI) makes acceleration of sympathetic nervous system (SNS) tone by sleep deficiency and arousal. Obstructive sleep apnea syndrome (OSAS) sets off SNS by frequent arousals and hypoxemias during sleep. We aimed to compare the changes of heart rate variability (HRV) indices induced by insomnia or sleep apnea to analyze for ANS how much to be affected by PI or OSAS. Methods: Total 315 subjects carried out nocturnal polysomnography (NPSG) were categorized into 4 groups - PI, mild, moderate and severe OSAS. Severity of OSAS was determined by apnea-hypopnea index (AHI). Then we selected 110 subjects considering age, sex and valance of each group's size [Group 1 : PI (mean age=$41.50{\pm}13.16$ yrs, AHI <5, n=20), Group 2 : mild OSAS (mean age=$43.67{\pm}12.11$ yrs, AHI 5-15, n=30), Group 3 : moderate OSAS (mean age $44.93{\pm}12.38$ yrs, AHI 16-30, n=30), Group 4 : severe OSAS (mean age=$45.87{\pm}12.44$ yrs, AHI >30, n=30)]. Comparison of HRV indices among the four groups was performed with ANCOVA (adjusted for age and body mass index) and Sidak post-hoc test. Results: We found statistically significant differences in HRV indices between severe OSAS group and the other groups (PI, mild OSAS and moderate OSAS). And there were no significant differences in HRV indices among PI, mild and moderate OSAS group. In HRV indices of PI and severe OSAS group showing the most prominent difference in the group comparisons, average RR interval were $991.1{\pm}27.1$ and $875.8{\pm}22.0$ ms (p=0.016), standard deviation of NN interval (SDNN) was $85.4{\pm}6.6$ and $112.8{\pm}5.4$ ms (p=0.022), SDNN index was $57.5{\pm}5.2$ and $87.6{\pm}4.2$ (p<0.001), total power was $11,893.5{\pm}1,359.9$ and $18,097.0{\pm}1,107.2ms^2$(p=0.008), very low frequency (VLF) was $7,534.8{\pm}1,120.1$ and $11,883.8{\pm}912.0ms^2$ (p=0.035), low frequency (LF) was $2,724.2{\pm}327.8$ and $4,351.6{\pm}266.9ms^2$(p=0.003). Conclusions: VLF and LF which were correlated with SNS tone showed more increased differences between severe OSAS group and PI group than other group comparisons. We could suggest that severe OSAS group was more influential to increased SNS activity than PI group.

• The Korean Journal of Mycology
• /
• v.16 no.1
• /
• pp.1-8
• /
• 1988

Effect of suppression for zoosporangial germination and mycelial growth of Phyto­phthora capsici causing red pepper fruit rot, was carried out in vitro test by using $NH_4OH$ and $KNO_2$, as ammonium/ammonia, nitrite/nitrous acid and $CaCl_2$, as calcium ion. Results of in vitro tests with $NH_4OH$, $KNO_2$, and $CaCl_2$, mol solutions demonstrated that zoosporangial germination of P. capsici was inhibited about 15 to 50% compared with control, according to $NH_3$, HNO as nonionized form and $Ca^{+2}$ ions. Ammonia concentration$(NH_3)$ was proportionally increased by high pH level and mol concentration, whereas low pH and high mol concentration showed rather higher concentration of $HNO_2$. Ammonia were more toxic at pH 8 than at pH 7 under the same concentration, while nitrous acid$(HNO_2)$ was more toxic than at pH 8. The zoosporangial germination inhibition in the ammonium/ammonia and nitrite/nitrous acid solutions demonstrated that $NN_3$, and $HNO_2$, were primarily responsible for the inhibition at lower concentration and mor" toxic by increasing concentration. $Ca^{+2}$ ions showed that zoosporangial germination was inhibitory by high pH level and increasing mol concentration in comparison with buffer conlrol. pH levels affected to mycelial growth of the fungus, and especially, high pH caused rather retardation of mycelial growth. There was no definite inhibitory response of mycelial growth at various degree concentrations of the toxicant solutions.

• Journal of Biomedical Engineering Research
• /
• v.28 no.4
• /
• pp.503-511
• /
• 2007

Heart rate variability(HRV) is the clinical consequence of various influences of the autonomic nervous system(ANS) on heart beat. HRV can estimate the potential physiologic rhythm from the interval between consecutive beats(RR interval or HRV data), but cardiovascular system governed by ANS is in relation to respiration and autonomic regulation. It is known as RSA representing respiration-related HR rhythmic oscillation. Because the mechanism linking the variability of HR to respiration is complex, it has so far been unknown well. In this paper, we tried to evaluate 5-min RR interval segments under control of respiration in order to find out a proper respiration rate that can estimate the ANS function. 10 healthy volunteers were included to evaluate 5-min HRV data under 4 different respiration-controlled environments; 0.03Hz, 0.1Hz, 0.2Hz, and 0.4Hz respiration. HRV data were analyzed both in the frequency and the time domain, with cross-correlation coefficient(cross-coeff.) for HRV and respiration signal. The results showed maximum cross-coeff. of 0.84 at 0.1 Hz and minimum that of 0.16 at 0.4Hz respiration. Cross-coeff was decreased at a faster rate from 0.1Hz respiration. All mean SDNN, RMSSD, and pNN50 of time domain measures were 108.7ms, 71.85ms, and 28.47%, respectively, and LF, HF, and TP of frequency domain measures were $12,722ms^2,\;658.8ms^2$, and $7,836.64ms^2$ at 0.1Hz respiration, respectively. In conclusion, 0.1Hz respiration was observed to be very meaningful from time domain and frequency domain analysis in relation to respiration and autonomic regulation of the heart.

• Journal of Oriental Neuropsychiatry
• /
• v.17 no.2
• /
• pp.179-185
• /
• 2006

Objective : This research was designed to study the characteristics of heart rate variability in postpartum women compared with normal women. Method : HRV data of postpartum women were gathered from 255 women who was hospitalized for oriental postpartum treatments(Age : 25-35). HRV data of comparison group were gathered from 327 women who visited hospital to check up their health(Age : 25-35). The SPSS 12.0 for windows was used to analyze the date and the independent samples t-test was used to verify the result. Result : 1. Mean-RR and SDNN of postpartum women group significantly decreased compared with that of normal women group. But, Heart Rate of postpartum women group significantly increased compared with that of normal women group. 2. HRV-Index, RMSSD and SDSD of postpartum women group significantly decreased compared with that of normal women group. pNN50 of postpartum women group significantly increased compared with that of normal women group. 3. Ln(TP), Ln(VLF), Ln(LF) and Ln(HF) of postpartum women group significantly increased compared with that of normal women group. 4. There were no significant differences in Normal LF, Normal HF and LF/DF Ratio between postpartum women group and normal women group. Conclusion : The result suggest that the function of heart of postpartum women group significantly decreased compared with that of normal women group. Futhermore although the ANS maintained the balance in the range of normality, the sympathetic nervous system frequently revitalized which caused increasing the heart of pulsation.