• Title/Summary/Keyword: pH stability

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Preformulation Study of Aspalatone, a New Antithrombotic Agent (새로운 항혈전 약물인 아스팔라톤의 전처방화 연구)

  • 곽혜선;전인구
    • Biomolecules & Therapeutics
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    • v.8 no.4
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    • pp.332-337
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    • 2000
  • Physicochemical properties of aspalatone (acetylsalicylic acid maltol ester, AM), which has been recently found to have an antithrombotic effect, were studied in terms of solubility, dissolution, partition coefficient (Pc) and stability. The solubility of AM at 37$^{\circ}C$ was about 1.2 mg/ml and the P$_{c}$ value for n-octanol/water and chloroform/water was 11.4 and 382.6, respectively. Dissolution rates of AM at pH 1.2 and 6.8 were more than 80% within 30 min. The degradation of AM followed apparent first-order kinetics, and was dependent on temperature, pH and ionic strength. From the pH-rate profile, the optimal pH was found to be at around 4.0. Half-lives at pH 1.2 and 6.8 were 33.5 and 44.4 hr, respectively. The degradation rate of AM at pH 1.2 was somewhat faster than that of aspirin, but at pH 7.0, the degradation rate of AM was slower than that of aspirin.n.

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The Effect of Protein Extraction pH on the Functional Properteis of Seasame Protein Concentrates (단백질 추출 pH가 참깨 농축단백질의 기능적 특성에 미치는 영향)

  • 박정륭;김은정
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.24 no.4
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    • pp.619-624
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    • 1995
  • Sesame protein concentrate(SPC) was prepared from defatted sesame flour(DSF) at several different pH(2.0, 7.0, 9.0, 11.0) for protein extraction. Some of their functional properties were determined in order to compare the effects of pH during preparation of concentrates. Compared with DSF, nitrogen solubility was markedly improved in all SPC, and SPC extracted at pH 11.0 showed the highest solubility at all pH leaves examined. Fatabsorption was increased in all SPC prepared, but water absorption was decreased as the extraction pH of protein increased. The emulsifying properteis and foaming properties of SPC were remarkably higher than DSF. As the extraction pH of protein was increased, the emulsion activity was also increased, but emulsion stability was decreased. SPC extracted at pH 7.0 showed the highest foaming capacity on the other hand, the highest foaming stability was shown in SPC extracted at pH 2.0. As the protein extraction pH increased, the viscosity of the protein solution was increased. SPC extracted at pH 11.0 showed highest viscosity at all protein concentrations tested.

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Physicochemical Stability of Anthocyanins from a Korean Pigmented Rice Variety as Natural Food Colorants (천연색소로서 한국산 유색미 안토시아닌의 안정성 연구)

  • Yoon, Joo-Mi;Cho, Man-Ho;Hahn, Tae-Ryong;Paik, Young-Sook;Yoon, Hye-Hyun
    • Korean Journal of Food Science and Technology
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    • v.29 no.2
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    • pp.211-217
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    • 1997
  • The physical and chemical stability of anthocyanins from a Korean pigmented rice variety was investigated at various conditions of pH, temperature, metal ion, sugar, organic acid and light. The anthocyanin pigments were relatively stable with half-lives of 36 days (pH 2.0) and 17 days (pH 3.0), while they were decomposed in a day at neutral and basic pH of 7.0 and 9.0 at $25^{\circ}C$. The anthocyanins also showed high thermal stability at pH 3.0; the half-lives were 7.4 hr, 23.6 hr and 96.3 hr at $95^{\circ}C,\;75^{\circ}C\;and\;50^{\circ}$, respectively. Addition of di- and tri-valent metal ions at pH 3.0 resulted in the increase of color intensity and stability throughout 21 days of storage periods at $25^{\circ}C$. Most sugars added accelerated the degradation of anthocyanin pigments, so that fructose showed the greatest degradation effect on the pigments. Addition of citric acid at pH 3.0 increased stability of anthocyanins, while tartaric acid decreased stability. The anthocyanins were very sensitive on light irradiation with a degradation half-life of 14 hr under 20,000 lux-light dosage at pH 3.0.

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Effects of pH-Shift Processing and Microbial Transglutaminase on the Gel and Emulsion Characteristics of Porcine Myofibrillar System

  • Hong, Geun-Pyo;Chun, Ji-Yeon;Jo, Yeon-Ji;Choi, Mi-Jung
    • Food Science of Animal Resources
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    • v.34 no.2
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    • pp.207-213
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    • 2014
  • This study investigated the effects of microbial transglutaminase (MTGase) and pH-shift processing on the functional properties of porcine myofibrillar proteins (MP). The pH-shift processing was carried out by decreasing the pH of MP suspension to 3.0, followed by re-adjustment to pH 6.2. The native (CM) and pH-shifted MP (PM) was reacted with and without MTGase, and the gelling and emulsion characteristics were compared. To compare the pH-shifted MTGase-treated MP (PT), deamidation (DM) was conducted by reacting MTGase with MP at pH 3.0. Rigid thermal gel was produced by MTGase-treated native MP (CT) and PT. PM and DM showed the lowest storage modulus (G') at the end of thermal scanning. Both MTGase and pH-shifting produced harder MP gel, and the highest gel strength was obtained in PT. All treatments yielded lower than CM, and CT showed significantly higher yield than PM and DM treatments. For emulsion characteristics, pH-shifting improved the emulsifying ability of MP-stabilized emulsion, while the treatments had lower emulsion stability. PM-stabilized emulsion exhibited the lowest creaming stability among all treatments. The emulsion stability could be improved by the usage of MTGase. The results indicated that pH-shifting combined with MTGase had a potential application to modify or improve functional properties of MP in manufacturing of meat products.

Effects of Cutting Length on Fermentation Characteristics and Aerobic Stability of Whole Crop Rice Silage

  • Lee, Seong Shin;Joo, Young Ho;Choi, Jeong Seok;Jeong, Seung Min;Paradhipta, Dimas Hand Vidya;Noh, Hyeon Tak;Kim, Sam Churl
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.41 no.3
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    • pp.155-161
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    • 2021
  • This study was conducted to estimate the effect of different cutting lengths on fermentation characteristics and aerobic stability of whole crop rice (WCR) silage. The WCR was harvested at the yellow ripe stage (43.7%, DM), and then cut at 5 (R05), 10 (R10), and 20 cm (R20) of the theoretical length of cut with no cut WCR (R60). Each forage was ensiled into 20 L mini bucket silo (5 kg) for 150 days in quadruplicates. The cutting lengths were not affected the chemical compositions of WCR silage (p > 0.05). The pH (p < 0.001) and concentration of ammonia-N (p = 0.022) in WCR silage were increased linearly with the increase of cutting length. The concentration of lactate had quadratic effect (p = 0.007), which was highest in R20 silage (p < 0.05). The concentration of acetate was increased linearly (p = 0.014), but the concentration of butyrate was decreased linearly (p = 0.033). The lactic acid bacteria count was decreased linearly (p = 0.017), and yeast count had quadratic effect (p = 0.009), which was the highest in R20 silage (p < 0.05). Aerobic stability had strong quadratic effect (p < 0.001), which was the highest in R20 silage (p < 0.05). In conclusion, R60 silage had highest pH by a linear increase of ammonia-N concentration and led to low aerobic stability. While R20 silage had the lowest pH by high lactate concentration and led to high aerobic stability.

GENERALIZED STABILITIES OF CAUCHY'S GAMMA-BETA FUNCTIONAL EQUATION

  • Lee, Eun-Hwi;Han, Soon-Yi
    • Honam Mathematical Journal
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    • v.30 no.3
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    • pp.567-579
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    • 2008
  • We obtain generalized super stability of Cauchy's gamma-beta functional equation B(x, y) f(x + y) = f(x)f(y), where B(x, y) is the beta function and also generalize the stability in the sense of R. Ger of this equation in the following setting: ${\mid}{\frac{B(x,y)f(x+y)}{f(x)f(y)}}-1{\mid}$ < H(x,y), where H(x,y) is a homogeneous function of dgree p(0 ${\leq}$ p < 1).

Functional Properties of Mucilage and Pigment Extracted from Opuntia ficus-indica (선인장 열매로부터 추출된 점질물 및 색소의 기능성)

  • Lee, Sam-Pin;Whang, Key;Ha, Young-Duck
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.27 no.5
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    • pp.821-826
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    • 1998
  • Functional properties of mucilage and pigment extracted from Opuntia ficus-indica var. saboten were determined at various temperatures, pHs and alcohol concentrations. The crude mucilage extracted from pickly pear showed pH 4.2, 0.14% total acidity and 8.1% total soluble solid content(w/w, wet basis). Polysaccharide was purified from mucilage extract by isopropanol precipitation. Intrinsic viscosity of polysaccharide was 18.1dl/g and decreased with increasing KCl concentration. Relative viscosity and color stability of mucilage extract were determined with capillary viscometer and spectrophotometer at 534nm, respectively. In additions of 1~20%(v/v) ethanol, the red pigment of mucilage extract was very stable, but relative viscosity, increased gradually. For heating above 7$0^{\circ}C$, the stability of red pigment decreased drastically, but rheological property of mucilage was not changed. During storage, the red pigment was extremely unstable at above pH 8.3. At both pH 3.0 and pH 4.2, the red pigment was the most stable at 4$^{\circ}C$ for 18 days. In the case of storage at 37$^{\circ}C$, pigment of mucilage extract at pH 3.0 was destroyed more quickly than that at pH 4.2. Natural mucilage extract(pH 4.2) showed the good stability of red pigment at 3$0^{\circ}C$ for 10 days.

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Effects of Complex Agents and pH on the Deposition Behavior of Electroless Ni-Co-P Film (착화제와 pH가 무전해 Ni-Co-P 도금 피막의 석출거동에 미치는 영향)

  • Choi, Byuck-Keun;Yang, Seung-Gi;Shin, Ji-Wung;Hwang, Woon-Suk
    • Corrosion Science and Technology
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    • v.13 no.3
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    • pp.107-111
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    • 2014
  • Electroless plated Ni-Co-P films have been used to suppress the electromagnetic waves from magnetic recording media, and the suppression is known to be achieved with films made with optimized plating composition and plating condition. Effects of complexing agents on the deposition rate and bath stability of Ni-Co-P film were studied using sodium citrate, sodium tartrate and multi-complex agents containing both of them. Deposition of electroless Ni-Co-P platings was dependent upon the complexing agents. Deposition rate was twice when using sodium tartrate compared to that using sodium citrate. And it was slightly slower with multi-complex agents than with sodium tartrate, bath stability being declined in the former. Deposition rate increased with increasing pH until pH 11. Excellent bath stability and good deposition rate were obtained using multi-complex agent as sodium citrate 0.10 mol/L and sodium tartrate 0.15 mol/L in the electroless Ni-Co-P plating films.

Effect of Recycling Time on Stability of Colloidal Silica Slurry and Removal Rate in Silicon Wafer Polishing (연마 Recycling 시간에 따른 콜로이드 실리카 슬러리의 안정성 및 연마속도)

  • Choi, Eun-Suck;Bae, So-Ik
    • Journal of the Korean Ceramic Society
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    • v.44 no.2 s.297
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    • pp.98-102
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    • 2007
  • The stability of slurry and removal rate during recycling of colloidal silica slurry was evaluated in silicon wafer polishing. The particle size distribution, pH, and zeta potential were measured to investigate the stability of colloidal silica. Large particles appeared as recycling time increased while average size of slurry did not change. Large particles were identified by EDS(energy dispersive spectrometer) as foreign substances from pad or abraded silicon flakes during polishing. As the recycling time increased, pH of slurry decreased and removal rate of silicon reduced but zeta potential decreased inversely. Hence, it could be mentioned that decrease of removal rate is related to consumption of $OH^-$ ions during recycling. Attention should be given to the control of pH of slurry during polishing.

Stability of antineoplaston A10 in Aqueous Solution

  • Oh, In-Joon;Lee, Jeong-Min;Lee, Yong-Bok;Shin, Sang-Chul;Choi, Bo-Gil
    • Archives of Pharmacal Research
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    • v.18 no.2
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    • pp.75-78
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    • 1995
  • The analysis method nad stability test of antineoplaston A10, a new anticancer drug candidate, were established. A10 and phenylacetyl- L-glutamine, one of the degradation products, can be detected by high-performance liquid chromatography. The degradation kinetics of antineoplaston A10 in aqueous solutions from pH 1 to 10 buffers were carried out at 40, 50 and 60.deg.C. Pseudo-first order kinetics were obtained throughout the entire pH ranges studied. The pH-rate profiles showed that antineoplaston A10 was very unstable in alkaline conditions and most stable at pH 4.

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