Archives of Pharmacal Research
- Volume 18 Issue 2
- /
- Pages.75-78
- /
- 1995
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Stability of antineoplaston A10 in Aqueous Solution
- Oh, In-Joon (College of Pharmacy, Chonnam National University) ;
- Lee, Jeong-Min (College of Pharmacy, Chonnam National University) ;
-
Lee, Yong-Bok
(College of Pharmacy, Chonnam National University)
;
-
Shin, Sang-Chul
(College of Pharmacy, Chonnam National University)
;
- Choi, Bo-Gil (College of Pharmacy, Chonnam National University)
- Published : 1995.04.01
Abstract
The analysis method nad stability test of antineoplaston A10, a new anticancer drug candidate, were established. A10 and phenylacetyl- L-glutamine, one of the degradation products, can be detected by high-performance liquid chromatography. The degradation kinetics of antineoplaston A10 in aqueous solutions from pH 1 to 10 buffers were carried out at 40, 50 and 60.deg.C. Pseudo-first order kinetics were obtained throughout the entire pH ranges studied. The pH-rate profiles showed that antineoplaston A10 was very unstable in alkaline conditions and most stable at pH 4.