• Investigative Magnetic Resonance Imaging
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• v.23 no.1
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• pp.17-25
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• 2019

We discuss recent advances in Gd-based $T_1$-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as $3mm^3$. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.

• Journal of the Korean Institute of Telematics and Electronics
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• v.23 no.6
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• pp.780-788
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• 1986

1.3\ulcorner GaInAsP BH(Buried Heterostructure) lasers were fabricated on the p-InP substrate. Two step chemical etching processes and melt-back etching technique during 2nd epitaxy were used for BH active layer. BH laser had the threshold current, Ith, of 72mA(23\ulcorner), peak wavelength of 1.2937\ulcorner, nd of 10-20%, and To of 85K. They operated in single mode under pulse condition up to 1.4 Ith. CW(DC) operation was successfully performed at room temperature.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.7 no.2
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• pp.163-169
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• 2004

Purpose: Many diagnostic modalities have been used for diagnosis of gastroesophageal reflux disease (GERD). Feeding materials during esophageal pH monitoring may interfere the result of examination and esophageal pH monitoring can not diagnose GER in case of alkaline reflux. The purpose of our study is to evaluate whether scintigraphy can substitiute 24 hr pH monitoring in children with GERD. Methods: From March 2002 to June 2003, 23 patients (12 boys and 11 girls, mean age 27 months) who have been admitted to Hanyang University Hospital presented with GER symptoms (recurrent vomiting, cough, chest pain, irritability) were included in the study. Scintigraphy and 24 hr pH monitoring were performed in all patients. Results: Six out of the 23 patients (26.1%) had evidence of GER on 24 hr pH monitoring, whereas nine of 23 patients (39.2%) exhibited GER by scintigraphy. Two out of the 23 patients could not be tested because of irritability. Three (14.3%) patients had evidence of GER on both 24 hr pH monitoring and scintigraphy, three (14.3%) patients on only 24 hr pH monitoring, six (28.6%) patients on only scintigraphy, and nine (42.9%) patients had no evidence of GER on both methods. No correlation was observed between 24 hr pH monitoring and scintigraphic results by Fisher's exact test (p=0.523) or Kendal's tau (t=0.678). Conclusion: The results of this study demonstrated that there was no correlation between 24 hr pH monitoring and scintigraphy. Therefore these modalities could be used as complementary tests to diagnose GERD.

• Biomolecules & Therapeutics
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• v.23 no.1
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• pp.84-89
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• 2015

We investigated the question of whether 7-oxygenated cholesterol derivatives could affect inflammatory and/or immune responses in atherosclerosis by examining their effects on expression of IL-23 in monocytic cells. $7{\alpha}$-Hydroxycholesterol ($7{\alpha}OHChol$) induced transcription of the TLR6 gene and elevated the level of cell surface TLR6 protein in THP-1 monocytic cells. Addition of an agonist of TLR6, FSL-1, to TLR6-expressing cells by treatment with $7{\alpha}OHChol$ resulted in enhanced production of IL-23 and transcription of genes encoding the IL-23 subunit ${\alpha}$ (p19) and the IL-12 subunit ${\beta}$ (p40). However, treatment with 7-ketocholesterol (7K) and $7{\beta}$-hydroxycholesterol ($7{\beta}OHChol$) did not affect TLR6 expression, and addition of FSL-1 to cells treated with either 7K or $7{\beta}OHChol$ did not influence transcription of the genes. Pharmacological inhibition of ERK, Akt, or PI3K resulted in attenuated transcription of TLR6 induced by $7{\alpha}OHChol$ as well as secretion of IL-23 enhanced by $7{\alpha}OHChol$ plus FSL-1. Inhibition of p38 MAPK or JNK resulted in attenuated secretion of IL-23. These results indicate that a certain type of 7-oxygenated cholesterol like $7{\alpha}OHChol$ can elicit TLR6-mediated expression of IL-23 by monocytic cells via PI3K/Akt and MAPKs pathways.

• The Journal of the Korea Contents Association
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• v.22 no.1
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• pp.591-600
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• 2022

This study examined the participation of the people with stroke living in the community in terms of productivity, leisure, and social domain, and identified the effect on disability acceptance and anxiety. For data collection, from October 2018 to January 2019, data on disability acceptance, anxiety, and participation were collected from 192 people with stroke who used welfare centers and community services. For general characteristics, t-test and one-way ANOVA were used to compare participation according to descriptive statistics and general characteristics. Pearson correlation analysis was used for correlation between variables, and multiple regression analysis was used to identify causality. As the result, factors affecting the productivity of participation were labor(β=.28, p<.001), de-emphasis on disability salience(β=.14, p<.05), compensatory(β=.22, p<.01), and subjective anxiety(β=-.35, p<.05), and the explanatory power was 33%(F=9.44, p<.001). Leisure was expressed as self-satisfaction with disability(β=.18, p<.05) and the compensatory(β=.18, p<.05), and had an explanatory power of 23%(F=6.32, p<.001). Social activity was labor(β=.19, p<.01), and subjective anxiety(β=-.51, p<.05), which showed 23%(F=6.05, p<.001) of explanatory power. This suggests the importance of psychosocial factors for a changed life after the onset of a stroke, and a practical approach is needed to construct and apply programs to improve participation.

• Journal of IKEEE
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• v.23 no.3
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• pp.839-843
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• 2019

This paper demonstrates a variable capacitor using fluids as dielectric material and investigates the possibility of its application to a magnetic resonance microscopy's coil. The capacitor structure was integrated with a microfluidic channel and the capacitance was measured while changing the filling percentage of fluids in the channel. The measured capacitance when filling DI water and mineral oil was changed from 1.7 pF to 12 pF and from 1.7 pF to 2 pF, respectively.

• Journal of the Korean Applied Science and Technology
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• v.38 no.6
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• pp.1709-1721
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• 2021

This study identified the impact of career identity and career decision-making type on career preparation behavior in nursing students. The participants were 198 nursing students enrolled in the 3rd and 4th grades located in J province, and data were collected from June 14, 2021 to 27, 2021, using an online questionnaire. Data were analyzed with descriptive statistics, independent t-test, one-way ANOVA, Pearson's correlation, and hierarchical regression using SPSS/WIN 23.0 program. As a result, the mean score of career identity, rational type, intuitive type, dependent type, and career preparation behavior were 2.79(range 1~4), 3.78(range 1~5), 3.38(range 1~5), 3.01(range 1~5), and 3.51(range 1~5), respectively. Career preparation behavior was significantly correlated with career identity(r=.40, p<.001), rational type(r=.50, p<.001), intuitive type(r=.22, p=.002), and dependent type(r=-.20, p=.004). Factors influencing career preparation behavior were career identity(β=.23, p=.001), rational type(β=.31, p<.001), intuitive type(β=.27, p<.001), and dependent type(β=-.20, p=.002). These variables accounted for 24.6%p of the variance in career preparation behavior(F=11.93, p<.001). These research results suggest that it is necessary to establish a career identity and develop and apply a program that includes career guidance according to career decision-making type to improve the career preparation behavior of nursing students.

• Journal of Embryo Transfer
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• v.19 no.3
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• pp.275-282
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• 2004

This study was carried out to examine the effects of development media and those change on in vitro development (IVD) of porcine oocytes matured and fertilized in vitro. Putative embryos, which were matured in vitro in modified NCSU-23 (mNCSU-23) supplemented with 10％ porcine follicular fluid (pFF) and were fertilized in mTBM, were developed in vitro as the experimental scheme. The results are as follows. When porcine putative embryos were cultured in vitro in NCSU-23 or CZB/Pig-MEM, the percentage of oocytes cleaved was not different between two systems, but the percentage of blastocysts in NCSU-23 was significantly higher than in CZB/Pig-MEM (P<0.05). And when porcine putative embryos were cultured in vitro in NCSU-23 during 7 days with or without changing media at day 5, which was supplement with or without 10％ fetal bovine serum(FBS), the percentage of oocytes cleaved, blastocysts at day 6, and the cell number of ICM, TE and total of blastocysts at day 7 were not different among three treatments. As a result of this study, it is supposed that NCSU-23 be more favorable, to develop porcine embryos derived from IVM/IVF, than CZB/Pig-MEM, but that demonstration on the effects of changing medium with fresh one stand in need of the more experiments.

• Women's Health Nursing
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• v.23 no.1
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• pp.42-51
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• 2017

Purpose: This study was conducted to compare postoperative complications, hospitalization days and treatment expenses to postoperative prophylactic antibiotics administrated to hysterectomy or not. Methods: A retrospective survey study was performed with 128 cases in which elective hysterectomy had undergone. They were divided into two groups by identifying whether postoperative prophylactic antibiotics was administered for hysterectomy: a) one group who received postoperative prophylactic antibiotics and; b) those who did not. Data were collected using the electric medical record at a hospital and analyzed by SPSS 23.0 for $x^2$ test, t-test and ANCOVA. Results:Postoperative complications including wound infection (p=1.000), pneumonia (p=.496), hematoma (p=.530), and pneumoperitoneum (p=.496) showed no significant differences between two groups. Hospitalization days for the prophylactic antibioticsadministrated group were significantly longer than the non-administered for prophylactic antibiotics (p=.004). The treatment expenses of the prophylactic antibiotics-administrated group were significantly higher than those of the non-administered prophylactic antibiotics (F=4.31, p=.040). Conclusion: These results can be provided for the evidence of administrating postoperative prophylactic antibiotics to hysterectomy. Additionally, it can contribute to decreasing the medication errors caused by infrequently administrating postoperative prophylactic antibiotics as well as to lessening likelihood of infection of intravenous injection site.

• The Journal of the Korea Contents Association
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• v.13 no.4
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• pp.312-319
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• 2013

The purpose of this study was to evaluate the efficacy of gargle and toothpaste containing low concentration with sodium fluoride on the remineralization through the surface microhardness and mineral content in enamel. After 4 weeks-application, the enamel surface was measured using microhardness tester and the calcium (Ca) and phosphorous (P) concentration of mineral content by electron probe microanalyzer (EPMA) analysis. By combining fluoridated gargle with toothpaste, a remineralized enamel resulted in significantly significant differences among the four groups (p<0.05). The Ca change treated with 0.23% fluoridated toothpaste and 0.02% fluoridated gargle with 0.23% toothpaste demonstrated the highest among the other groups. In conclusion. the fluoridated gargle with toothpaste by low concentration showed a significantly greatest synergistic effect on remineralization of the enamel than the other groups.