• 한국응용과학기술학회지
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• 제36권3호
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• pp.726-736
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• 2019

본 연구의 목적은 대학병원간호사의 자기효능감, 업무수행능력이 직무만족도에 미치는 영향을 파악하기 위함이다. 연구대상은 C시에 소재한 대학병원에 근무하는 간호사 130명을 대상으로 구조화된 설문지를 이용하여 자료 수집하였다. 수집된 자료는 spss 25.0을 이용하여 평균, 표준편차, t-test, ANOVA, Pearson's correlation, 다중회귀분석을 통해 분석하였다. 연구결과 자기효능감은 5점 만점에 평균 3.24점, 업무수행능력은 5점 만점에 평균 2.74점, 직무만족도는 5점 만점에 평균 3.10점으로 나타났다. 자기효능감, 업무수행능력, 직무만족도과의 관계는 정적상관관계가 있었다. 직무만족도에 영향을 미치는 요인으로 자기효능감(${\beta}=.39$, p<.001), 30~34세의 연령(${\beta}=-.27$, p=.001), 근무부서 중 수술실(${\beta}=-.17$, p=.029), 내과병동(${\beta}=-.17$, p=.025), 미혼(${\beta}=-.20$, p=.012)순이었고, 모형의 설명력은 30.4%이었다. 본 연구결과를 바탕으로 병원간호사의 자기효능감, 연령, 근무부서 등을 고려한 직무만족도를 증진시키기는 프로그램 개발이 필요하다.

• 임상간호연구
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• 제24권1호
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• pp.103-112
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• 2018

Purpose: This study was to investigate the factors affecting smoking behavior in patients with pulmonary tuberculosis. Methods: The participants were 130 pulmonary tuberculosis patients at a national tuberculosis hospital. Using a descriptive survey design, data were collected from January to March in 2016 and were analyzed using binominal logistic regression. Results: As a result of a correlation analysis of the data, depression had a significant positive correlation with smoking (r=.19, p=.030), stress (r=.54, p<.001), respectively. And depression had a significant negative correlation with smoking-related self-efficacy (r=-.20, p=.023). Smoking-related self-efficacy, smoking (r=-.79, p<.001), and stress (r=-.23, p=.008) had a significant negative correlation with each other, respectively. The factors affecting the smoking behavior were smoking-related self-efficacy (OR=1.46, p<.001), sex (OR=67.36, p=.001), occupation (OR=17.51, p=.014), and depression (OR=1.16, p=.024). Those factors explained 84.7% (Negelkerke's $R^2=.847$) of pulmonary tuberculosis patients' smoking behavior. Conclusion: Developing and applying a prevention eduction for reducing depression and enhancing smoking-related self-efficacy may become a venue toward good prognosis of the patients with pulmonary tuberculosis.

• BMB Reports
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• 제48권3호
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• pp.159-165
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• 2015

Although the short isoform of ErbB3-binding protein 1 (Ebp1), p42 has been considered to be a potent tumor suppressor in a number of human cancers, whether p42 suppresses tumorigenesis of lung cancer cells has never been clarified. In the current study we investigated the tumor suppressor role of p42 in non-small cell lung cancer cells. Our data suggest that the expression level of p42 is inversely correlated with the cancerous properties of NSCLC cells and that ectopic expression of p42 is sufficient to inhibit cell proliferation, anchorage-independent growth, and invasion as well as tumor growth in vivo. Interestingly, p42 suppresses Akt activation and overexpression of a constitutively active form of Akt restores the tumorigenic activity of A549 cells that is ablated by exogenous p42 expression. Thus, we propose that p42 Ebp1 functions as a potent tumor suppressor of NSCLC through interruption of Akt signaling.

• Nuclear Engineering and Technology
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• 제43권5호
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• pp.459-468
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• 2011

The current solution to the problem of using cementitious material for sealing purposes in a final radioactive waste repository is to develop a low-pH cement grout. In this study, the material properties of a low-pH cement grout based on a recipe used at ONKALO are investigated by considering such factors as pH variation, compressive strength, dynamic modulus, and hydraulic conductivity by using silica fume and micro-cement. From the pH measurements of the hardened cement grout, the required pH (< pH 11) is obtained after 130 days of curing. Although the engineering properties of the low-pH cement grout used in this study are inferior to those of conventional high-pH cement grout, the utilization of silica fume and micro-cement effectively meets the long-term environmental and durability requirements for cement grout in a radioactive waste repository.

• 대한화학회지
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• 제17권2호
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• pp.130-135
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• 1973

여러 pH에서 3,4-methylenedioxyphenylmethyllenemalonitrile의 가수분해속도상수를 자외선분광광도법에 의하여 측정하여 넓은 궤도 범위에서 잘 맞는 반응속도식을 구하였다. 이 속도식에 의하면 가수분해 반응메카니즘 특히 종전에 잘 규명된 바 없는 산성 용매 속에서의 반응 과정을 잘 설명할 수 있다. 즉 pH 5 이하에서는 물의 첨가로서 가수분해가 시작되며 pH 6∼8 사이에서는 물분자와 수산화이온의 첨가가 경쟁적으로 일어나나 pH 9 이상에서는 수산화이온만이 첨가된다. 한편 친핵성 시약과 촉매 역할을 겸하고 있는 수산화이온 및 물의 역할로 잘 설명할 수가 있었다.

• 농업과학연구
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• 제45권1호
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• pp.74-83
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• 2018

Four early-fattening Hanwoo steers weighing $247{\pm}13.5kg$ were used within a $4{\times}4$ Latin square design to establish a nutrient requirement for maintenance and to investigate nutritional changes in the steers under heat stress condition. The steers were fed four different energy level diets: 100% (control) and 100%, 115% and 130% of total digestible nutrients (TDN) requirement of the early-fattening Hanwoo steers for maintenance based on the Korean Feeding Standard for Hanwoo. The steers in the control were housed with no stress (temperature $24^{\circ}C$ and humidity 60%), whereas the steers in the other groups were under heat stress (temperature $30^{\circ}C$ and humidity 70%). True digestibilities of dry matter (DM) and other nutrients were not significantly (p > 0.05) affected by heat stress (i.e., control vs T100). This may be the result of a lower DM intake than that of the Korean feeding standard due to the establishment of the nutrients requirement under heat stress. Heat stress and different energy intake levels did not affect the blood metabolite concentrations. Average daily gain (ADG) for T100 (-69.6 g) was lower than that of the control (-44.6 g, numerically), T115 (44.6 g, p < 0.05) and T130 (83.3 g, p < 0.05), respectively. Based on the ADG and TDN intake, the equation (Y = 0.1814X + 111.5) for the TDN requirement of the early fattening Hanwoo steers for maintenance was calculated, indicating that 11.5% of TDN requirement for maintenance under heat stress may be additionally supplied.

• 한국식품과학회지
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• 제22권2호
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• pp.134-139
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• 1990

누룩으로부터 ${\beta}-galactosidase$ 활성을 가지는 균주를 순수분리하여 분리된 균주(NY-15)의 ${\beta}-galactosidase$를 정제하였다. 다량배양하여 모은 균체를 8%(v/v) toluene 처리에 의한 추출액을 정제의 출발 물질로 하여 acetone 침전에 의해서 탈지처리를 한 후 40-60%포화의 ammonium sulfate 분획을 하고 DEAE-cellulose, DEAE-Sephadex A-50의 이온교환 chromatography를 한 후 Agarose-PAPT를 이용한 affinity chromatography에 의해서 정제하였다. 이 정제법에 의해서 ${\beta}-galactosidase$는 조효소 추출액으로부터 40배 정제되었으며 회수율은 7.7%였나. 누룩 yeast의 ${\beta}-galactosidase$는 2개의 subunit로 되어 있으며, 각 subunit 분자량은 각각 96,000과 130,000이었다. 효소활성에의 최적 pH는 7.5이었고, 최적온도는 $40^{\circ}C$이었다.

• Clinical and Experimental Pediatrics
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• 제56권3호
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• pp.130-134
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• 2013

Purpose: Anthracyclines have been utilized in the treatment of children with acute lymphoblastic leukemia (ALL). Recent studies have shown that anthracyclines may induce toxicity in the vascular endothelium. This study was performed using brachial artery reactivity (BAR) to evaluate vascular endothelial function in ALL patients who were treated with anthracycline chemotherapy. Methods: We included 21 children with ALL who received anthracycline chemotherapy and 20 healthy children. The cumulative dose of anthracyclines in the ALL patients was $142.5{\pm}18.2/m^2$. The last anthracycline dose was administered to the patients 2 to 85 months prior to their examination using BAR. The diameter of the brachial artery was measured in both groups using echocardiography, and BAR was calculated as the percentage change in the arterial diameter after release of the cuff relative to the baseline vessel diameter. Results: In the anthracycline-treated group, BAR was observed to be $3.4%{\pm}3.9%$, which was significantly lower than that observed in the control group ($12.1%{\pm}8.0%$, P<0.05). The time elapsed after the last anthracycline treatment and the age at the time of treatment did not affect the change in BAR (P =0.06 and P =0.13, respectively). Conclusion: These results provided evidence that treatment of ALL patients with anthracycline results in endothelial dysfunction. A larger cohort study and a longer follow-up period will be required to clarify the relationship between endothelial dysfunction resulting from anthracycline treatment for childhood ALL and occurrence of cardiovascular diseases later in life.

• Restorative Dentistry and Endodontics
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• 제22권1호
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• pp.170-180
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• 1997

Cariogenicity of the bacteria is attributed to their binding capacity to the teeth. Bacterial attachment to oral surfaces is an essential step for colonization and subsequently infection. Therefore, it is conceivable that caries prevention can be achieved fundamentally by inhibition of bacterial attachment. The rationale for caries prevention through the use of sugar substitutes or limited use of sugar has been revealed. Among many sugar substitutes, xylitol has been shown to exhibit the most profound cariostatic effect, inhibiting glucose metabolism and possibly binding of mutans streptococci. The purpose of this study was to examine the effect of xylitol on binding of different species of oral bacteria. The effect of xylitol on binding of [$^3H$]-labeled oral bacteria to hydroxyapatite coated with human saliva(SHA) as a model for the pellicle-coated tooth surfaces was investigated. The strains of oral bacteria used in this study were A. viscosus T14V, A. viscosus WVU627, P. gingivaiis 2561, P. gingivalis A7Al-28, S. gordonii G9B, S. gordonii Challis, S. sobrinus 6715, S. mutans UA101, S. mutans KPSK -2, S. mutans T8, and S. mutans UA130. The obtained results were as follows: 1. P. gingivalis A7 Al-28, S. mutans UA130, S. mutans T8 grown with xylitol showed greater binding to SHA than the organism grown without xylitol. Among these, S. mutans T8 showed the greatest rate of increase in its binding to SHA ; 8-fold increase in its binding with xylitol. 2. S. mutans KPSK -2 grown with xylitol showed 2 times lesser binding to SHA than the organism grown without xylitol. 3. Binding ability of the remaining strains grown with xylitol to SHA was almost same as that of the organisms grown without xylitol. The overall results suggest that use of xylitol in the oral cavity may affect the complex oral bacterial ecosystem.

• Clinics in Shoulder and Elbow
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• 제19권3호
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• pp.130-136
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• 2016

Background: A novel technique for the repair of tears of the upper subscapularis tendon-intraarticular knotless fixation-has been introduced recently. The purpose of this study was to evaluate the clinical and structural outcomes of arthroscopic intraarticular knotless fixation for the treatment of upper subscapularis tendon tears. Methods: We retrospectively analyzed the clinical and radiological outcomes of 27 patients who underwent arthroscopic intraarticular knotless fixation for upper subscapularis tendon tears. Finally, a total of 10 patients who could participate in at least a 6 month follow-up of magnetic resonance imaging evaluation and in a least 1-year follow-up on an outpatient basis were enrolled in our study. The mean age at the time of operation was 60.7 years, and the mean duration of follow-up was 14.7 months. Two patients had concomitant tears of the supraspinatus tendon and 8 patients had concomitant tears of the supraspinatus and the infraspinatus tendons. Results: The clinical and radiological outcomes improved after the patients had undertaken arthroscopic intraarticular knotless fixation. The mean visual analogue scale score for pain during motion improved from 6.7 preoperatively to 1.4 at the final follow-up (p<0.001). The mean Constant score improved from 59.3 preoperatively to 79.6 at the final follow-up, and the mean the University of California at Los Angeles score, from 21.7 to 30.2, respectively (p<0.001 and p<0.001). The upper subscapularis tendon tear was healed in every patient except one (90%), for the patient had suffered from a postoperative trauma that resulted in a retear. Conclusions: We found that arthroscopic intraarticular knotless fixation gives good clinical and structural outcomes for the repair of upper subscapularis tendon tears. Arthroscopic intraarticular knotless fixation provided such a reliable and efficient restoration of the subscapularis tendon footprint that we anticipate it will become a widely-used procedure for upper subscapularis tendon tears.