• Applied Microscopy
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• v.51
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• pp.6.1-6.9
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• 2021

Histopathology is a well-established standard diagnosis employed for the majority of malignancies, including breast cancer. Nevertheless, despite training and standardization, it is considered operator-dependent and errors are still a concern. Fractal dimension analysis is a computational image processing technique that allows assessing the degree of complexity in patterns. We aimed here at providing a robust and easily attainable method for introducing computer-assisted techniques to histopathology laboratories. Slides from two databases were used: A) Breast Cancer Histopathological; and B) Grand Challenge on Breast Cancer Histology. Set A contained 2480 images from 24 patients with benign alterations, and 5429 images from 58 patients with breast cancer. Set B comprised 100 images of each type: normal tissue, benign alterations, in situ carcinoma, and invasive carcinoma. All images were analyzed with the FracLac algorithm in the ImageJ computational environment to yield the box count fractal dimension (Db) results. Images on set A on 40x magnification were statistically different (p = 0.0003), whereas images on 400x did not present differences in their means. On set B, the mean Db values presented promising statistical differences when comparing. Normal and/or benign images to in situ and/or invasive carcinoma (all p < 0.0001). Interestingly, there was no difference when comparing normal tissue to benign alterations. These data corroborate with previous work in which fractal analysis allowed differentiating malignancies. Computer-aided diagnosis algorithms may beneficiate from using Db data; specific Db cut-off values may yield ~ 99% specificity in diagnosing breast cancer. Furthermore, the fact that it allows assessing tissue complexity, this tool may be used to understand the progression of the histological alterations in cancer.

• Journal of the Ergonomics Society of Korea
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• v.31 no.6
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• pp.785-791
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• 2012

Objective: The aim of this study was to investigate the correlation between 3D visual fatigue and physiological measures by canonical correlation analysis enabling to categorical correlation. Background: Few studies have been conducted to investigate the physiological mechanism underlying the visual fatigue caused by processing 3D information which may make the cognitive mechanism overloaded. However, even the previous studies lack validation in terms of the correlation between physiological variables and the visual fatigue. Method: 9 Female and 6 male subjects with a mean age of $22.53{\pm}2.55$ voluntarily participated in this experiment. All participants were asked to report how they felt about their health sate at after viewing 3D. In addition, Low & Hybrid measurement test(Event Related Potential, Steady-state Visual Evoked Potential) and for evaluating cognitive fatigue before and after viewing 3D were performed. The physiological signal were measured with subjective fatigue evaluation before and after in watching the 3D content. For this study suggesting categorical correlation, all measures were categorized into three sets such as included Visual Fatigue set(response time, subjective evaluation), Autonomic Nervous System set(PPG frequency, PPG amplitude, HF/LF ratio), Central Nervous System set(ERP amplitude P4, O1, O2, ERP latency P4, O1, O2, SSVEP S/N ratio P4, O1, O2). Then the correlation of three variables sets, canonical correlation analysis was conducted. Results: The results showed a significant correlation between visual fatigue and physiological measures. However, different variables of visual fatigue were highly correlated to respective HF/LF ratio and to ERP latency(O2). Conclusion: Response time was highly correlated to ERP latency(O2) while the subjective evaluation was to HF/LF ratio. Application: This study may provide the most significant variables for the quantitative evaluation of visual fatigue using HF/LF ratio and ERP latency based human performance and subjective fatigue.

• The korean journal of orthodontics
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• v.44 no.4
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• pp.157-167
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• 2014

Objective: The purpose of this study was to evaluate the clinical efficacy of polymer- and rhodium-coated wires compared to uncoated wires by measuring the frictional forces using self-ligation brackets. Methods: 0.016-inch nickel titanium (NiTi) wires and $0.017{\times}0.025$-inch stainless steel (SS) wires were used, and the angulations between the brackets and wires were set to $0^{\circ}$, $5^{\circ}$, and $10^{\circ}$. Upper maxillary premolar brackets (Clippy-C$^{(R)}$) with a 0.022-inch slot were selected for the study and a tensile test was performed with a crosshead speed of 5 mm/min. The maximum static frictional forces and kinetic frictional forces were recorded and compared. Results: The maximum static frictional forces and the kinetic frictional forces of coated wires were equal to or higher than those of the uncoated wires (p < 0.05). The maximum static frictional forces of rhodium-coated wires were significantly higher than those of polymercoated wires when the angulations between the brackets and wires were set to (i) $5^{\circ}$ in the 0.016-inch NiTi wires and (ii) all angulations in the $0.017{\times}0.025$-inch SS wires (p < 0.05). The kinetic frictional forces of rhodium-coated wires were higher than those of polymer-coated wires, except when the angulations were set to $0^{\circ}$ in the 0.016-inch NiTi wires (p < 0.05). Conclusions: Although the frictional forces of the coated wires with regards to aesthetics were equal to or greater than those of the uncoated wires, a study under similar conditions regarding the oral cavity is needed in order to establish the clinical implications.

• Korean Journal of Exercise Nutrition
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• v.24 no.4
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• pp.15-23
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• 2020

[Purpose] Lactate is a principal energy substrate for the brain during exercise. A single bout of high-intensity interval exercise (HIIE) can increase the blood lactate level, brain lactate uptake, and executive function (EF). However, repeated HIIE can attenuate exercise-induced increases in lactate level and EF. The lactate levels in the brain and blood are reported to be correlated with exercise-enhanced EF. However, research is yet to explain the cause-and-effect relationship between lactate and EF. This study examined whether lactate consumption improves the attenuated exercise-enhanced EF caused by repeated HIIE. [Methods] Eleven healthy men performed two sets of HIIE, and after each set, 30 min were given for rest and examination. In the 2^nd set, the subjects consumed experimental beverages containing (n = 6) and not containing (n = 5) lactate. Blood, cardiovascular, and psychological variables were measured, and EF was evaluated by the computerized color-word Stroop test. [Results] The lactate group had a higher EF (P < 0.05) and tended to have a higher blood lactate level (P = 0.082) than the control group in the 2^nd set of HIIE. Moreover, blood lactate concentration was correlated with the interference score (i.e., reverse score of EF) (r = -0.394; P < 0.05). [Conclusion] Our results suggest that the attenuated exercise-enhanced EF after repeated HIIE can be improved through lactate consumption. However, the role of lactate needs to be elucidated in future studies, as it can be used for improving athletes' performance and also in cognitive decline-related clinical studies.

• Journal of Life Science
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• v.21 no.1
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• pp.96-101
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• 2011

S-Adenosyl-L-methionine synthtase (SAM-s) catalyzes the biosynthesis of SAM from ATP and L-methionine. SAM plays important roles in the primary and secondary metabolism of cells. A metK encoding a SAM-s was searched from Streptomyces natalensis producing natamycin, a predominantly a strong antifungal agent, inhibiting the growth of both yeasts and molds and preventing the formation of aflatoxin in filamentous fungi. To obtain the metK of S. natalensis, PCR using primers designed from the two highly conserved regions for metK genes of Streptomyces strains was carried out, and an intact 1.2-kb metK gene of S. natalensis was cloned by genomic Southern hybridization with PCR product as a probe. To identify the function of the cloned metK gene, it was inserted into pSET152ET for its high expression in the Streptomyces strain, and then introduced into S. lividans TK24 as a host by transconjugation using E. coli ET12567(pUZ8002). The high expression of metK in S. lividans TK24 induced actinorhodin production on R5 solid medium, and its amount in R4 liquid medium was 10-fold higher than that by exconjugant including only pSET152ET.

• Communications for Statistical Applications and Methods
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• v.23 no.5
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• pp.385-397
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• 2016

The stress-strength models have been intensively investigated in the literature in regards of estimating the reliability ${\theta}$ = P(X > Y) using parametric and nonparametric approaches under different sampling schemes when X and Y are independent random variables. In this paper, we consider the problem of estimating ${\theta}$ when (X, Y) are dependent random variables with a bivariate underlying distribution. The empirical and kernel estimates of ${\theta}$ = P(X > Y), based on bivariate ranked set sampling (BVRSS) are considered, when (X, Y) are paired dependent continuous random variables. The estimators obtained are compared to their counterpart, bivariate simple random sampling (BVSRS), via the bias and mean square error (MSE). We demonstrate that the suggested estimators based on BVRSS are more efficient than those based on BVSRS. A simulation study is conducted to gain insight into the performance of the proposed estimators. A real data example is provided to illustrate the process.

• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4352-4360
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• 2011

A four dimensional quantitative structure activity relationship analysis was applied to a series of 50 flavonoid inhibitors of $p56^{lck}$ protein tyrosine kinase by the molecular comparative electron topological method. It was found that the -log (IC50) values of the compounds were highly dependent on the topology, size and electrostatic character of the substituents at seven positions of the flavonoid scaffold in this study. Depending on the negative or positive charge of the groups correctly embedded in these substituents, three-dimensional bio-structure to increase or decrease -log (IC50) values in the training set of 39 compounds was predicted. The test set of 11 compounds was used to evaluate the predictivity of the model. To generate 4D-QSAR model, the defined function groups and pharmacophore used as topological descriptors in the calculation of activity were of sufficient statistical quality ($R^2$ = 0.72 and $Q^2$ = 0.69). Ligand docking approach by using Dock 6.0. These compounds include many flavonoid analogs, They were docked onto human families of p56lck PTKs retrieved from the Protein Data Bank, 1lkl.pdb.

• Kyungpook Mathematical Journal
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• v.46 no.4
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• pp.553-563
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• 2006

Let A be a bounded linear operator acting on a Hilbert space H. The B-Weyl spectrum of A is the set ${\sigma}_{B{\omega}}(A)$ of all ${\lambda}{\in}\mathbb{C}$ such that $A-{\lambda}I$ is not a B-Fredholm operator of index 0. Let E(A) be the set of all isolated eigenvalues of A. Recently in [6] Berkani showed that if A is a hyponormal operator, then A satisfies generalized Weyl's theorem ${\sigma}_{B{\omega}}(A)={\sigma}(A)$\E(A), and the B-Weyl spectrum ${\sigma}_{B{\omega}}(A)$ of A satisfies the spectral mapping theorem. In [51], H. Weyl proved that weyl's theorem holds for hermitian operators. Weyl's theorem has been extended from hermitian operators to hyponormal and Toeplitz operators [12], and to several classes of operators including semi-normal operators ([9], [10]). Recently W. Y. Lee [35] showed that Weyl's theorem holds for algebraically hyponormal operators. R. Curto and Y. M. Han [14] have extended Lee's results to algebraically paranormal operators. In [19] the authors showed that Weyl's theorem holds for algebraically p-hyponormal operators. As Berkani has shown in [5], if the generalized Weyl's theorem holds for A, then so does Weyl's theorem. In this paper all the above results are generalized by proving that generalizedWeyl's theorem holds for the case where A is an algebraically ($p,\;k$)-quasihyponormal or an algebarically paranormal operator which includes all the above mentioned operators.

• The Journal of Korean Physical Therapy
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• v.31 no.4
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• pp.193-198
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• 2019

Purpose: This study examined the effects of plank exercise combined with breathing and arm exercises on the external oblique, internal oblique, and transverse abdominal muscle thickness. Methods: Thirty healthy adults consisting of 12 males and 18 females from K area were divided into a plank exercise combined with breathing and arm exercises group (n = 15) and a plank exercise only group (n=15). The changes in muscle thickness before the exercise and four and eight weeks after the exercise were analyzed using a two-way repeated analysis of variance (ANOVA). The significance level was set to ${\alpha}=0.05$. Post-hoc t-tests were conducted to detect the interactions between the time and groups, and the significance level was set to ${\alpha}=0.01$. Results: According to the experimental results, the external oblique abdominal muscle showed significant differences over time (p<0.05). The internal oblique abdominal muscle also showed significant differences over time and in the interactions between the time and groups (p<0.05). The transverse abdominal muscle showed significant differences over time, in the interactions between time and groups, and in the changes between the groups (p<0.05). Conclusion: The results indicated that plank exercise combined with breathing and arm movement exercises led to increases in the abdominal muscle thickness. These types of exercises may be useful in lumbar stabilization rehabilitation treatment.

• Journal of the Korean Society of Clothing and Textiles
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• v.46 no.4
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• pp.613-623
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• 2022

This study developed a functional prototype jacket designed to reduce loads on the upper extremities of workers performing repetitive motions in the same posture for extended periods of time. Dynamic taping lines were applied to the upper extremities, and three dimensional (3D) supporters were inserted in the abdomen and back waist areas corresponding to the core muscles. Clothing pressure on the upper-extremity dynamic taping lines was set to two levels (proto P1 and proto P2), and the 3D supporters were designed in three types (proto FW, proto FW/BW, proto FW/BW/BBX). According to the subjective pressure perceived on each part of the upper extremities, the level proto P1 pressure was preferred. The proto FW/BW/BBX 3D supporter was rated as excellent, and the perceived pressure was ranked as satisfactory. The prototype jacket performed upper-extremity load reduction when the upper-extremity clothing-pressure level was set to 1.8 kPa, 2.1 kPa, and 2.4 kPa on the upper arm, forearm, and wrist regions, respectively, and when 3D supporters were installed in the abdomen and back of the waist with the addition of a back band.